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MoTriColor SIGNED

Molecularly guided trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of colorectal cancer (MoTriColor)

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MoTriColor project word cloud

Explore the words cloud of the MoTriColor project. It provides you a very rough idea of what is the project "MoTriColor" about.

beginning gene biomarkers clinical immunotherapeutic matching classification deregulated cms4 perform signature colorectal free consequently tgf profiles sound msi treatment predict populations prognosis ly2157299 ffpe survival signalling arm phenotypes biopsies mutant preclinical primary outcomes centre potentially monitoring equivalent tolerability rationale advantage inhibitor bevacizumab risk vinorelbine pd diagnostic worldwide expression treatments stage experimental progression presenting subgroups l1 types previously single liquid scientific biological select mpdl3280a cancer platform brafm endpoint beta solid benefit braf patients subtypes efficacy heterogeneous retrospective poor translated drug disease tumour combination label anti mutation assays basis patterns safety routine molecularly chemotherapy molecular therapies 50 therapy crc reveal

Project "MoTriColor" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON Organization address address: CALLE NAZARET 115-117 city: BARCELONA postcode: 8035 website: http://www.vhio.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.motricolor.eu
Total cost	5˙996˙992 €
EC max contribution	5˙996˙992 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON FUNDACIO PRIVADA INSTITUT D'INVESTIGACIO ONCOLOGICA DE VALL-HEBRON Organization address address: CALLE NAZARET 115-117 city: BARCELONA postcode: 8035 website: http://www.vhio.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	1˙147˙455.00
2	Agendia NV Agendia NV Organization address address: Science Park 406 city: Amsterdam postcode: 1098XH website: www.agendia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Amsterdam)	participant	905˙250.00
3	INSTITUT CATALA D'ONCOLOGIA INSTITUT CATALA D'ONCOLOGIA Organization address address: AV GRAN VIA DE L'HOSPITALET 199-203 city: L'HOSPITALET DEL LLOBREGAT postcode: 8908 website: www.iconcologia.net contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (L'HOSPITALET DEL LLOBREGAT)	participant	829˙320.00
4	STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS Organization address address: PLESMANLAAN 121 city: AMSTERDAM postcode: 1066 CX website: www.nki.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	771˙611.00
5	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	682˙125.00
6	EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL EUROPEAN ORGANISATION FOR RESEARCH AND TREATMENT OF CANCER AISBL Organization address address: Avenue E. Mounier 83 city: Brussels postcode: 1200 website: www.eortc.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Brussels)	participant	580˙500.00
7	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	277˙268.00
8	FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA FUNDACION PARA LA INVESTIGACION DEL HOSPITAL CLINICO DE LA COMUNITAT VALENCIANA, FUNDACION INCLIVA Organization address address: AV MENENDEZ PELAYO 4 city: VALENCIA postcode: 46010 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	271˙424.00
9	UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI Organization address address: VIALE ABRAMO LINCOLN 5 city: CASERTA postcode: 81100 website: www.unina2.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CASERTA)	participant	266˙143.00
10	L'AZIENDA SOCIO SANITARIA TERRITORIALE (ASST) GRANDE OSPEDALE METROPOLITANO NIGUARDA L'AZIENDA SOCIO SANITARIA TERRITORIALE (ASST) GRANDE OSPEDALE METROPOLITANO NIGUARDA Organization address address: PIAZZA OSPEDALE MAGGIORE 3 city: MILANO postcode: 20162 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	265˙896.00
11	AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA AZIENDA OSPEDALIERA OSPEDALE NIGUARDA CA' GRANDA Organization address address: PIAZZA OSPEDALE MAGGIORE 3 city: MILANO postcode: 20162 website: www.ospedaleniguarda.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	0.00

Map

Project objective

Colorectal cancer (CRC) is increasingly being recognized as a heterogeneous disease with distinct molecular subtypes. These subtypes have different biological processes at the basis of their disease and consequently their prognosis and responses to therapy are also different. We have previously developed molecular diagnostic assays using a single platform on routine FFPE tumour biopsies. These assays identify gene expression profiles with distinct prognosis and drug response phenotypes (CMS4/c-type, BRAF mutant-like, and MSI-like). Our overall objective is to develop targeted therapies more effective than the current therapies that do not take advantage of molecular classification of the disease to select patients for therapy. We therefore propose to perform 3 two-stage single arm multi-centre open-label phase II studies based on solid preclinical evidence and a sound scientific rationale for these subgroups of CRC patients: 1) combination of chemotherapy and a TGF-βR inhibitor (LY2157299) in patients presenting a C-type signature; 2) vinorelbine in patients with a BRAFm-like signature; and 3) an immunotherapeutic anti-PD-L1 drug (MPDL3280A) in combination with bevacizumab in patients with a MSI-like signature. The primary objectives of these studies are to determine the clinical efficacy (progression-free survival as primary endpoint), safety and tolerability of the experimental treatments in these molecularly selected populations. Mutation analysis at the beginning of treatment and monitoring by liquid biopsies might reveal further biomarkers that predict response in retrospective analysis. The project outcomes may have a significant impact in CRC patients with poor-risk prognosis worldwide as 40-50% of them present gene expression profiles matching one of the 3 approaches. Around 40,000 European CRC patients may potentially benefit from the results. Also, these may be translated to other cancer types with equivalent gene expression patterns/deregulated signalling pathways.

Publications

List of publications.
year	authors and title	journal	last update
2018	Anna Truini, Giovanni Germano, Alberto Bardelli Inactivation of DNA repairâ€”prospects for boosting cancer immune surveillance published pages: 91, ISSN: 1756-994X, DOI: 10.1186/s13073-018-0603-9	Genome Medicine 10/1	2020-04-22
2019	Alessio Amatu, Marta Schirripa, Federica Tosi, Sara Lonardi, Katia Bencardino, Erica Bonazzina, Laura Palmeri, Damiano Alfio PatanÃ¨, Elio Gregory Pizzutilo, Benedetta Mussolin, Francesca Bergamo, Giulia Alberti, Rossana Intini, Letizia Procaccio, Marco Arese, Silvia Marsoni, Michele Nichelatti, Vittorina Zagonel, Salvatore Siena, Alberto Bardelli, Fotios Loupakis, Federica Di Nicolantonio, Andrea High Circulating Methylated DNA Is a Negative Predictive and Prognostic Marker in Metastatic Colorectal Cancer Patients Treated With Regorafenib published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2019.00622	Frontiers in Oncology 9	2020-04-22
2019	Andrea Sartoreâ€Bianchi, Alessio Amatu, Luca Porcu, Silvia Ghezzi, Sara Lonardi, Francesco Leone, Francesca Bergamo, Elisabetta Fenocchio, Erika Martinelli, Beatrice Borelli, Federica Tosi, Patrizia Racca, Emanuele Valtorta, Emanuela Bonoldi, Cosimo Martino, Caterina Vaghi, Giovanna Marrapese, Fortunato Ciardiello, Vittorina Zagonel, Alberto Bardelli, Livio Trusolino, Valter Torri, Silvia Marsoni HER2 Positivity Predicts Unresponsiveness to EGFRâ€Targeted Treatment in Metastatic Colorectal Cancer published pages: 1395-1402, ISSN: 1083-7159, DOI: 10.1634/theoncologist.2018-0785	The Oncologist 24/10	2020-04-22
2019	Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer published pages: 6243-6259, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3440	Clinical Cancer Research 25/20	2020-04-22
2019	Elena Garralda, Rodrigo Dienstmann, Alejandro Piris-GimÃ©nez, Irene BraÃ±a, Jordi Rodon, Josep Tabernero New clinical trial designs in the era of precision medicine published pages: 549-557, ISSN: 1574-7891, DOI: 10.1002/1878-0261.12465	Molecular Oncology 13/3	2020-04-22
2018	J Seoane, L De Mattos-Arruda, E Le Rhun, A Bardelli, M Weller Cerebrospinal fluid cell-free tumour DNA as a liquid biopsy for primary brain tumours and central nervous system metastases published pages: 211-218, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy544	Annals of Oncology 30/2	2020-04-22
2019	Giorgio Corti, Alice Bartolini, Giovanni Crisafulli, Luca Novara, Giuseppe Rospo, Monica Montone, Carola Negrino, Benedetta Mussolin, Michela Buscarino, Claudio Isella, Ludovic Barault, Giulia Siravegna, Salvatore Siena, Silvia Marsoni, Federica Di Nicolantonio, Enzo Medico, Alberto Bardelli A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology published pages: 91-101.e3, ISSN: 1533-0028, DOI: 10.1016/j.clcc.2019.02.008	Clinical Colorectal Cancer 18/2	2020-04-22
2019	Gianluca Mauri, Andrea Sartore-Bianchi, Antonio-Giampiero Russo, Silvia Marsoni, Alberto Bardelli, Salvatore Siena Early-onset colorectal cancer in young individuals published pages: 109-131, ISSN: 1574-7891, DOI: 10.1002/1878-0261.12417	Molecular Oncology 13/2	2020-04-22
2019	Giulia Siravegna, Andrea Sartore-Bianchi, Rebecca J. Nagy, Kanwal Raghav, Justin I. Odegaard, Richard B. Lanman, Livio Trusolino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli Plasma HER2 ( ERBB2 ) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer published pages: 3046-3053, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3389	Clinical Cancer Research 25/10	2020-04-22
2019	Aparna R. Parikh, Ignaty Leshchiner, Liudmila Elagina, Lipika Goyal, Chaya Levovitz, Giulia Siravegna, Dimitri Livitz, Kahn Rhrissorrakrai, Elizabeth E. Martin, Emily E. Van Seventer, Megan Hanna, Kara Slowik, Filippo Utro, Christopher J. Pinto, Alicia Wong, Brian P. Danysh, Ferran Fece de la Cruz, Isobel J. Fetter, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffr Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers published pages: 1415-1421, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0561-9	Nature Medicine 25/9	2020-04-22
2019	Giuseppe Rospo, Annalisa Lorenzato, Nabil Amirouchene-Angelozzi, Alessandro MagrÃ¬, Carlotta Cancelliere, Giorgio Corti, Carola Negrino, Vito Amodio, Monica Montone, Alice Bartolini, Ludovic Barault, Luca Novara, Claudio Isella, Enzo Medico, Andrea Bertotti, Livio Trusolino, Giovanni Germano, Federica Di Nicolantonio, Alberto Bardelli Evolving neoantigen profiles in colorectal cancers with DNA repair defects published pages: 42, ISSN: 1756-994X, DOI: 10.1186/s13073-019-0654-6	Genome Medicine 11/1	2020-04-22
2018	G Siravegna, A Bardelli Failure is not final: ctDNA-guided rechallenge therapy in colorectal cancer published pages: 157-159, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy525	Annals of Oncology 30/2	2020-04-22
2019	Nicole M. Reilly, Luca Novara, Federica Di Nicolantonio, Alberto Bardelli Exploiting DNA repair defects in colorectal cancer published pages: 681-700, ISSN: 1574-7891, DOI: 10.1002/1878-0261.12467	Molecular Oncology 13/4	2020-04-22
2018	Giovanni Germano, Nabil Amirouchene-Angelozzi, Giuseppe Rospo, Alberto Bardelli The Clinical Impact of the Genomic Landscape of Mismatch Repairâ€“Deficient Cancers published pages: 1518-1528, ISSN: 2159-8274, DOI: 10.1158/2159-8290.cd-18-0150	Cancer Discovery 8/12	2020-04-22
2019	G Siravegna, B Mussolin, T Venesio, S Marsoni, J Seoane, C Dive, N Papadopoulos, S Kopetz, R B Corcoran, L L Siu, A Bardelli How liquid biopsies can change clinical practice in oncology published pages: , ISSN: 0923-7534, DOI: 10.1093/annonc/mdz227	Annals of Oncology	2020-04-22
2017	Andrea Sartore-Bianchi, Alessio Amatu, Erica Bonazzina, Stefano Stabile, Laura Giannetta, Giulio Cerea, Ilaria Schiavetto, Katia Bencardino, Chiara Funaioli, Riccardo Ricotta, Tiziana Cipani, Michele Schirru, Valentina Gambi, Laura Palmeri, Giulia Carlo-Stella, Francesca Rusconi, Sara Di Bella, Giovanni Burrafato, Andrea Cassingena, Emanuele Valtorta, Calogero Lauricella, Federica Pazzi, Alessandra Gambaro, Silvia Ghezzi, Giovanna Marrapese, Emiliana Tarenzi, Silvio Veronese, Mauro Truini, Angelo Vanzulli, Salvatore Siena Pooled Analysis of Clinical Outcome of Patients with Chemorefractory Metastatic Colorectal Cancer Treated within Phase I/II Clinical Studies Based on Individual Biomarkers of Susceptibility: A Single-Institution Experience published pages: 525-533, ISSN: 1776-2596, DOI: 10.1007/s11523-017-0505-6	Targeted Oncology 12/4	2020-04-22
2017	Giovanni Germano, Simona Lamba, Giuseppe Rospo, Ludovic Barault, Alessandro MagrÃ¬, Federica Maione, Mariangela Russo, Giovanni Crisafulli, Alice Bartolini, Giulia Lerda, Giulia Siravegna, Benedetta Mussolin, Roberta Frapolli, Monica Montone, Federica Morano, Filippo de Braud, Nabil Amirouchene-Angelozzi, Silvia Marsoni, Maurizio Dâ€™Incalci, Armando Orlandi, Enrico Giraudo, Andrea Sartore-Bianchi, Salvatore Siena, Filippo Pietrantonio, Federica Di Nicolantonio, Alberto Bardelli Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24673	Nature	2020-04-22
2018	Mariangela Russo, Simona Lamba, Annalisa Lorenzato, Alberto Sogari, Giorgio Corti, Giuseppe Rospo, Benedetta Mussolin, Monica Montone, Luca Lazzari, Sabrina Arena, Daniele Oddo, Michael Linnebacher, Andrea Sartore-Bianchi, Filippo Pietrantonio, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli Reliance upon ancestral mutations is maintained in colorectal cancers that heterogeneously evolve during targeted therapies published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04506-z	Nature Communications 9/1	2020-04-22
2017	Filippo Pietrantonio, Federica Di Nicolantonio, Alexa B Schrock, Jeeyun Lee, Sabine Tejpar, Andrea Sartore-Bianchi, Jaclyn F Hechtman, Jason Christiansen, Luca Novara, Niall Tebbutt, Giovanni FucÃ , Carlotta Antoniotti, Seung Tae Kim, Danielle Murphy, Rosa Berenato, Federica Morano, James Sun, Bosun Min, Philip J Stephens, Marissa Chen, Luca Lazzari, Vincent A Miller, Robert Shoemaker, Alessio Amatu, Massimo Milione, Jeffrey S Ross, Salvatore Siena, Alberto Bardelli, Siraj M Ali, Alfredo Falcone, Filippo de Braud, Chiara Cremolini ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer published pages: , ISSN: 0027-8874, DOI: 10.1093/jnci/djx089	JNCI: Journal of the National Cancer Institute 109/12	2020-04-22
2017	E Sanz-Garcia, G Argiles, E Elez, J Tabernero BRAF mutant colorectal cancer: prognosis, treatment, and new perspectives published pages: 2648-2657, ISSN: 0923-7534, DOI: 10.1093/annonc/mdx401	Annals of Oncology 28/11	2020-04-22
2017	S Siena, A Sartore-Bianchi, R Garcia-Carbonero, M Karthaus, D Smith, J Tabernero, E Van Cutsem, X Guan, M Boedigheimer, A Ang, B Twomey, B A Bach, A S Jung, A Bardelli Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer published pages: 119-126, ISSN: 0923-7534, DOI: 10.1093/annonc/mdx504	Annals of Oncology 29/1	2020-04-22
2018	S Siena, A Sartore-Bianchi, S Marsoni, H I Hurwitz, S J McCall, F Penault-Llorca, S Srock, A Bardelli, L Trusolino Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer published pages: 1108-1119, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy100	Annals of Oncology 29/5	2020-04-22
2018	Erika Martinelli, Teresa Troiani, Vincenzo Sforza, Giulia Martini, Claudia Cardone, Pietro Paolo Vitiello, Davide Ciardiello, Anna Maria Rachiglio, Nicola Normanno, Andrea Sartore-Bianchi, Silvia Marsoni, Alberto Bardelli, Salvatore Siena, Fortunato Ciardiello Sequential HER2 blockade as effective therapy in chemorefractory, HER2 gene-amplified, RAS wild-type, metastatic colorectal cancer: learning from a clinical case published pages: e000299, ISSN: 2059-7029, DOI: 10.1136/esmoopen-2017-000299	ESMO Open 3/1	2020-04-22
2017	Daniele Oddo, Giulia Siravegna, Annunziata Gloghini, Claudio Vernieri, Benedetta Mussolin, Federica Morano, Giovanni Crisafulli, Rosa Berenato, Giorgio Corti, Chiara Costanza Volpi, Michela Buscarino, Monica Niger, Philip D Dunne, Giuseppe Rospo, Emanuele Valtorta, Alice Bartolini, Giovanni FucÃ , Simona Lamba, Antonia Martinetti, Maria Di Bartolomeo, Filippo de Braud, Alberto Bardelli, Filippo Pietrantonio, Federica Di Nicolantonio Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer published pages: 347-352, ISSN: 0007-0920, DOI: 10.1038/bjc.2017.196	British Journal of Cancer 117/3	2020-04-22
2018	Clara Montagut, Guillem ArgilÃ©s, Fortunato Ciardiello, Thomas T. Poulsen, Rodrigo Dienstmann, Michael Kragh, Scott Kopetz, Trine Lindsted, Cliff Ding, Joana Vidal, Jenifer Clausell-Tormos, Giulia Siravegna, Francisco J. SÃ¡nchez-MartÃn, Klaus Koefoed, Mikkel W. Pedersen, Michael M. Grandal, Mikhail Dvorkin, Lucjan Wyrwicz, Ana Rovira, Antonio Cubillo, Ramon Salazar, FranÃ§oise Desseigne, Cristina Nadal, Joan Albanell, Vittorina Zagonel, Salvatore Siena, Guglielmo Fumi, Giuseppe Rospo, Paul Nadler, Ivan D. Horak, Alberto Bardelli, Josep Tabernero Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses published pages: e175245, ISSN: 2374-2437, DOI: 10.1001/jamaoncol.2017.5245	JAMA Oncology 4/4	2020-04-22
2018	Maider Ibarrola-Villava, AndrÃ©s Cervantes, Alberto Bardelli Preclinical models for precision oncology published pages: 239-246, ISSN: 0304-419X, DOI: 10.1016/j.bbcan.2018.06.004	Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1870/2	2020-04-22
2018	G Mauri, K Bencardino, A Sartore-Bianchi, S Siena Toxicity of oxaliplatin rechallenge in metastatic colorectal cancer published pages: 2143-2144, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy306	Annals of Oncology 29/10	2020-04-22
2017	Federica Tosi, Elena Magni, Alessio Amatu, Gianluca Mauri, Katia Bencardino, Mauro Truini, Silvio Veronese, Luciano De Carlis, Giovanni Ferrari, Michele Nichelatti, Andrea Sartore-Bianchi, Salvatore Siena Effect of KRAS and BRAF Mutations on Survival of Metastatic Colorectal Cancer After Liver Resection: A Systematic Review and Meta-Analysis published pages: e153-e163, ISSN: 1533-0028, DOI: 10.1016/j.clcc.2017.01.004	Clinical Colorectal Cancer 16/3	2020-04-22
2018	Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore-Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni Cappello, Andrea Bertotti, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Mariangela Russo, Antonella Balsamo, Mauro Truini, Federica Di Nicolantonio, Alessio Amatu, Erica Bonazzina, Silvia Ghezzi, Daniele Regge, Angelo Vanzulli, Livio Trusolino, Salvatore Siena, Silvia Marsoni, Alberto Bardelli Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer published pages: 148-162.e7, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.06.004	Cancer Cell 34/1	2020-04-22
2018	Giovanni Germano, Gianluca Mauri, Giulia Siravegna, Caroline Dive, Jackie Pierce, Federica Di Nicolantonio, Maurizio D\'Incalci, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer published pages: 80-83, ISSN: 1533-0028, DOI: 10.1016/j.clcc.2017.10.017	Clinical Colorectal Cancer 17/1	2020-04-22
2017	Sjors In â€™t Veld, Kim Duong, Mireille Snel, Anke Witteveen, InÃ¨s Beumer, Leonie Delahaye, Diederik Wehkamp, RenÃ© Bernards, Annuska Glas, Sun Tian A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers published pages: 16, ISSN: 2571-5135, DOI: 10.3390/ht6040016	High-Throughput 6/4	2020-04-22
2018	Sara Mainardi, Antonio Mulero-SÃ¡nchez, Anirudh Prahallad, Giovanni Germano, Astrid Bosma, Paul Krimpenfort, Cor Lieftink, Jeffrey D. Steinberg, Niels de Wit, Samuel GonÃ§alves-Ribeiro, Ernest Nadal, Alberto Bardelli, Alberto Villanueva, Rene Bernards SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo published pages: 961-967, ISSN: 1078-8956, DOI: 10.1038/s41591-018-0023-9	Nature Medicine 24/7	2020-04-22
2018	Ludovic Barault, Alessio Amatu, Giulia Siravegna, Agostino Ponzetti, Sebastian Moran, Andrea Cassingena, Benedetta Mussolin, Chiara FalcomatÃ , Alexandra M Binder, Carmen Cristiano, Daniele Oddo, Simonetta Guarrera, Carlotta Cancelliere, Sara Bustreo, Katia Bencardino, Sean Maden, Alice Vanzati, Patrizia Zavattari, Giuseppe Matullo, Mauro Truini, William M Grady, Patrizia Racca, Karin B Michels, Salvatore Siena, Manel Esteller, Alberto Bardelli, Andrea Sartore-Bianchi, Federica Di Nicolantonio Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer published pages: 1995-2005, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-313372	Gut 67/11	2020-04-22
2017	G. Rospo, G. Corti, G. Crisafulli, L. Novara, A. Bardelli Tracking colorectal cancer evolution in time and space published pages: 1163-1165, ISSN: 0923-7534, DOI: 10.1093/annonc/mdx127	Annals of Oncology 28/6	2020-04-22
2017	Riccardo Ricotta, Antonella Verrioli, Silvia Ghezzi, Luca Porcu, A Grothey, Alfredo Falcone, Eric Van Cutsem, Guillem ArgilÃ©s, Antoine Adenis, Marc Ychou, Carlo Barone, Olivier BouchÃ©, Marc Peeters, Yves Humblet, Laurent Mineur, Alberto F Sobrero, Joleen M Hubbard, Chiara Cremolini, Hans Prenen, Josep Tabernero, Hajer Jarraya, Thibault Mazard, Sophie Deguelte-Lardiere, Konstantinos Papadimitriou, Marc Van den Eynde, Alessandro Pastorino, Daniela Redaelli, Katia Bencardino, Chiara Funaioli, Alessio Amatu, Giulia Carlo-Stella, Valter Torri, Andrea Sartore-Bianchi, Angelo Vanzulli, Salvatore Siena Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study) published pages: e000111, ISSN: 2059-7029, DOI: 10.1136/esmoopen-2016-000111	ESMO Open 1/6	2020-04-22
2017	Nabil Amirouchene-Angelozzi, Charles Swanton, Alberto Bardelli Tumor Evolution as a Therapeutic Target published pages: 805-817, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-17-0343	Cancer Discovery 7/8	2020-04-22
2017	Giulia Siravegna, Elena Geuna, Benedetta Mussolin, Giovanni Crisafulli, Alice Bartolini, Danilo Galizia, Laura Casorzo, Ivana Sarotto, Maurizio Scaltriti, Anna Sapino, Alberto Bardelli, Filippo Montemurro Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases published pages: e000253, ISSN: 2059-7029, DOI: 10.1136/esmoopen-2017-000253	ESMO Open 2/4	2020-04-22
2017	Gabriele Picco, Consalvo Petti, Alessia Centonze, Erica Torchiaro, Giovanni Crisafulli, Luca Novara, Andrea Acquaviva, Alberto Bardelli, Enzo Medico Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions published pages: 293-303, ISSN: 1757-4676, DOI: 10.15252/emmm.201606773	EMBO Molecular Medicine 9/3	2020-04-22
2016	S. Arena, G. Siravegna, B. Mussolin, J. D. Kearns, B. B. Wolf, S. Misale, L. Lazzari, A. Bertotti, L. Trusolino, A. A. Adjei, C. Montagut, F. Di Nicolantonio, R. Nering, A. Bardelli MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations published pages: 324ra14-324ra14, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aad5640	Science Translational Medicine 8/324	2020-04-22
2016	A. Amatu, L. Barault, C. Moutinho, A. Cassingena, K. Bencardino, S. Ghezzi, L. Palmeri, E. Bonazzina, F. Tosi, R. Ricotta, T. Cipani, P. Crivori, R. Gatto, G. Chirico, G. Marrapese, M. Truini, A. Bardelli, M. Esteller, F. Di Nicolantonio, A. Sartore-Bianchi, S. Siena Tumor MGMT promoter hypermethylation changes over time limit temozolomide efficacy in a phase II trial for metastatic colorectal cancer published pages: 1062-1067, ISSN: 0923-7534, DOI: 10.1093/annonc/mdw071	Annals of Oncology 27/6	2020-04-22
2016	Beth O. Van Emburgh, Sabrina Arena, Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Giorgio Corti, Benedetta Mussolin, Federica Baldi, Michela Buscarino, Alice Bartolini, Emanuele Valtorta, Joana Vidal, Beatriz Bellosillo, Giovanni Germano, Filippo Pietrantonio, Agostino Ponzetti, Joan Albanell, Salvatore Siena, Andrea Sartore-Bianchi, Federica Di Nicolantonio, Clara Montagut, Alberto Bardelli Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer published pages: 13665, ISSN: 2041-1723, DOI: 10.1038/ncomms13665	Nature Communications 7	2020-04-22
2017	Filippo Pietrantonio, Claudio Vernieri, Giulia Siravegna, Alessia Mennitto, Rosa Berenato, Federica Perrone, Annunziata Gloghini, Elena Tamborini, Sara Lonardi, Federica Morano, Benedetta Picciani, Adele Busico, Chiara Costanza Volpi, Antonia Martinetti, Francesca Battaglin, Ilaria Bossi, Alessio Pellegrinelli, Massimo Milione, Chiara Cremolini, Maria Di Bartolomeo, Alberto Bardelli, Filippo de Braud Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer published pages: 2414-2422, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-1863	Clinical Cancer Research 23/10	2020-04-22
2017	Alberto Bardelli, Klaus Pantel Liquid Biopsies, What We Do Not Know (Yet) published pages: 172-179, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2017.01.002	Cancer Cell 31/2	2020-04-22
2016	D. Oddo, E. M. Sennott, L. Barault, E. Valtorta, S. Arena, A. Cassingena, G. Filiciotto, G. Marzolla, E. Elez, R. M. J. M. van Geel, A. Bartolini, G. Crisafulli, V. Boscaro, J. T. Godfrey, M. Buscarino, C. Cancelliere, M. Linnebacher, G. Corti, M. Truini, G. Siravegna, J. Grasselli, M. Gallicchio, R. Bernards, J. H. M. Schellens, J. Tabernero, J. A. Engelman, A. Sartore-Bianchi, A. Bardelli, S. Siena, R. B. Corcoran, F. Di Nicolantonio Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer published pages: 4504-4515, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-0396	Cancer Research 76/15	2020-04-22
2017	Rodrigo Dienstmann, Louis Vermeulen, Justin Guinney, Scott Kopetz, Sabine Tejpar, Josep Tabernero Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer published pages: 79-92, ISSN: 1474-175X, DOI: 10.1038/nrc.2016.126	Nature Reviews Cancer 17/2	2020-04-22
2017	G. Siravegna, A. Sartore-Bianchi, B. Mussolin, A. Cassingena, A. Amatu, L. Novara, M. Buscarino, G. Corti, G. Crisafulli, A. Bartolini, F. Tosi, M. Erlander, F. Di Nicolantonio, S. Siena, A. Bardelli Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor published pages: , ISSN: 0923-7534, DOI: 10.1093/annonc/mdx095	Annals of Oncology	2020-04-22
2017	Giulia Siravegna, Silvia Marsoni, Salvatore Siena, Alberto Bardelli Integrating liquid biopsies into the management of cancer published pages: , ISSN: 1759-4774, DOI: 10.1038/nrclinonc.2017.14	Nature Reviews Clinical Oncology	2020-04-22
2017	Mariangela Russo, Alberto Bardelli Lesion-Directed Therapies and Monitoring Tumor Evolution Using Liquid Biopsies published pages: a029587, ISSN: 2157-1422, DOI: 10.1101/cshperspect.a029587	Cold Spring Harbor Perspectives in Medicine 7/2	2020-04-22
2017	Takeo Fujii, Afsaneh Barzi, Andrea Sartore-Bianchi, Andrea Cassingena, Giulia Siravegna, Daniel D. Karp, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, Helen J. Huang, Silvio Veronese, Federica Di Nicolantonio, Sandeep Pingle, Cecile Rose T. Vibat, Saege Hancock, David Berz, Vladislava O. Melnikova, Mark G. Erlander, Rajyalakshmi Luthra, E. Scott Kopetz, Funda Meric-Bernstam, Salvatore Siena, Heinz-Josef Lenz, Alberto Bardelli, Filip Janku Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers published pages: , ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-2592	Clinical Cancer Research	2020-04-22

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The information about "MOTRICOLOR" are provided by the European Opendata Portal: CORDIS opendata.

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