Explore the words cloud of the MolStruKT project. It provides you a very rough idea of what is the project "MolStruKT" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||1˙499˙932 €|
|EC max contribution||1˙499˙932 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
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|1||LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN||DE (MUENCHEN)||coordinator||1˙499˙932.00|
Accurate chromosome segregation in eukaryotes requires the assembly of the macromolecular kinetochore complex at centromeres to attach chromosomes to the mitotic spindle. The kinetochore proteins are organized in stable subcomplexes that bind to dynamic microtubules and ensure fidelity of sister chromatid separation through feedback control. Characterizing the kinetochore structure will significantly advance our understanding of chromosome segregation and how defects in this process can lead to aneuploidy, which is associated with tumorigenesis. X-ray crystallography has provided detailed insights into the function of subcomplexes, however, a molecular analysis of the native kinetochore subunit architecture is still missing. I have recently combined chemical cross-linking with mass spectrometry (CXMS) which allows for the first time the topological analysis of native macromolecular protein structures by a comprehensive set of distance restraints. Applying this approach to kinetochores assembled on budding yeast minichromosomes I aim to elucidate the architecture of the native centromere-assembled kinetochore complex and analyze how tension sensing by the chromosomal passenger complex is integrated into the structure. Secondly, the systematic analyses of changes in phosphorylation levels and in protein stoichiometries of soluble and nucleosome-associated human kinetochore complexes will reveal how the tight temporal control of assembling a functional kinetochore in mitosis is achieved. Thirdly, I will investigate the architecture of the centromere-associated network of kinetochore proteins by CXMS to unveil its role in directing CENP-A replenishment at mitotic exit in order to maintain centromere identity through generations. The analysis of the native kinetochore structure in different functional states will provide fundamental mechanistic insights and help us to understand how this architecture confers fidelity to centromere propagation and chromosome segregation.
|year||authors and title||journal||last update|
Josef FischbÃ¶ck-Halwachs, Sylvia Singh, Mia Potocnjak, GÃ¶tz Hagemann, Victor Solis-Mezarino, Stephan Woike, Medini Ghodgaonkar-Steger, Florian Weissmann, Laura D Gallego, Julie Rojas, Jessica Andreani, Alwin KÃ¶hler, Franz Herzog
The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.42879
Shyamal Mosalaganti, Jenny Keller, Anika Altenfeld, Michael Winzker, Pascaline Rombaut, Michael Saur, Arsen Petrovic, Annemarie Wehenkel, Sabine Wohlgemuth, Franziska MÃ¼ller, Stefano Maffini, Tanja Bange, Franz Herzog, Herbert Waldmann, Stefan Raunser, Andrea Musacchio
Structure of the RZZ complex and molecular basis of its interaction with Spindly
published pages: 961-981, ISSN: 0021-9525, DOI: 10.1083/jcb.201611060
|The Journal of Cell Biology 216/4||2019-04-18|
Alexander Heuck, Sonja Schitter-Sollner, Marcin JÃ³zef Suskiewicz, Robert Kurzbauer, Juliane Kley, Alexander Schleiffer, Pascaline Rombaut, Franz Herzog, Tim Clausen
Structural basis for the disaggregase activity and regulation of Hsp104
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.21516
Seychelle M Vos, David PÃ¶llmann, Livia Caizzi, Katharina B Hofmann, Pascaline Rombaut, Tomasz Zimniak, Franz Herzog, Patrick Cramer
Architecture and RNA binding of the human negative elongation factor
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.14981
Elisabeth Schmidtmann, Tobias Anton, Pascaline Rombaut, Franz Herzog, Heinrich Leonhardt
Determination of local chromatin composition by CasID
published pages: 476-484, ISSN: 1949-1034, DOI: 10.1080/19491034.2016.1239000
Victor Solis-Mezarino, Franz Herzog
compleXView: a server for the interpretation of protein abundance and connectivity information to identify protein complexes
published pages: W276-W284, ISSN: 0305-1048, DOI: 10.1093/nar/gkx411
|Nucleic Acids Research 45/W1||2019-04-18|
Herzog, Franz; Jenni, Simon; Rombaut, Pascaline; Musacchio, Andrea; Overlack, Katharina; vanÂ Gerwen, Suzan; Stege, Patricia; Vetter, Ingrid; Wohlgemuth, Sabine; Dimitrova, YoanaÂ N.; Harrison, StephenÂ C.; John, Juliane; Petrovic, Arsen; Keller, Jenny; Liu, Yahui
Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores
published pages: 1028â€“1040.e15, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.10.005
John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef FischbÃ¶ck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan, Doro Vogt, Sabine Wohlgemuth, Franz Herzog, Andrea Musacchio
Insights from biochemical reconstitution into the architecture of human kinetochores
published pages: 249-253, ISSN: 0028-0836, DOI: 10.1038/nature19333
Petrovic, Arsen; Musacchio, Andrea; Liu, Yahui; Keller, Jenny; Rombaut, Pascaline; Mosalaganti, Shyamal; Herzog, Franz; Raunser, Stefan
Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster
published pages: , ISSN: 2046-2441, DOI: 10.1098/rsob.150236
|Open Biology 2||2019-05-27|
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