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ONCORNET SIGNED

ONCOgenic Receptor Network of Excellence and Training

Total Cost €

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EC-Contrib. €

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Partnership

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Project "ONCORNET" data sheet

The following table provides information about the project.

Coordinator
STICHTING VU 

Organization address
address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV
website: www.vu.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.oncornet.eu
 Total cost 3˙893˙983 €
 EC max contribution 3˙893˙983 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING VU NL (AMSTERDAM) coordinator 510˙748.00
2    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 546˙575.00
3    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 546˙575.00
4    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 525˙751.00
5    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 512˙091.00
6    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) participant 498˙432.00
7    GRIFFIN DISCOVERIES BV NL (AMSTERDAM) participant 255˙374.00
8    ARGEN-X BE (ZWIJNAARDE) participant 250˙560.00
9    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) participant 247˙872.00
10    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 0.00
11    24 Media Labs NL (Rotterdam) partner 0.00
12    ACTELION PHARMACEUTICALS LTD CH (ALLSCHWIL) partner 0.00
13    ALMAC SCIENCES LIMITED UK (CRAIGAVON) partner 0.00
14    Cisbio Bioassays FR (CODOLET) partner 0.00
15    Euroscreen S.A. BE (Gosselies) partner 0.00
16    Vivia Biosystmes S.L. ES (VALLADOLID) partner 0.00

Map

 Project objective

Cancer is a leading health concern. There is a need to fully understand the fundamental processes underlying development of cancer. There is increasing evidence that G protein-coupled receptors (GPCRs) and their associated signalling cascades are involved in both cancer progression and metastasis. As oncogenic GPCRs are likely to be amenable to manipulation via drugs they are ideal therapeutic targets. In ONCORNET (Oncogenic Receptor Network of Excellence and Training) we propose to target two oncogenic GPCRs; the chemokine receptors CXCR4 and CXCR7. These are highly expressed in a range of tumours and yet their role in cancer progression is not well understood. We will focus on unravelling how CXCR4 and CXCR7 are or can be modulated (small molecules, pepducins, nanodies) and investigate the effects on oncogenic responses. This represents crucial knowledge that we currently do not have and yet may well provide potential leads for drug development and commercialisation. ONCORNET will bring together the leading research scientists and labs in Europe with an interest in GPCRs and 15 early stage researchers. We will employ all the latest multidisciplinary research technologies to understand the role of these GPCRs in cancer and develop CXCR4 and CXCR7 tools for diagnostic and therapeutic purposes. Importantly, developed approaches can be extrapolated to other oncogenic GPCRs. The ONCORNET consortium will offer an extensive multidisciplinary training programme to the ESRs to ensure that they can operate in today’s drug discovery programmes. This will include both research (e.g. drug discovery, proteomics, imaging, modelling) and transferable (e.g. entrepreneurship, writing, media training) skill sets –that is rarely offered at PhD level. We will train ESRs to develop the next generation of multidisciplinary scientists with skills that are highly demanded by many of today’s employers in drug development industries.

 Deliverables

List of deliverables.
Open meetings organized Other 2020-04-01 17:55:45
Output Websites, patent fillings, videos etc. 2020-04-01 17:55:45
Supervisory board of Network Other 2020-04-01 17:55:44
Mid-Term Review meeting Documents, reports 2020-04-01 17:55:44
Progress Report Documents, reports 2020-04-01 17:55:43
Draft Periodic Report Documents, reports 2020-04-01 17:55:44
Ethics Documents, reports 2020-04-01 17:55:44
ONCORNET website Websites, patent fillings, videos etc. 2020-04-01 17:55:43

Take a look to the deliverables list in detail:  detailed list of ONCORNET deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Joyce Koenen, Francoise Bachelerie, Karl Balabanian, Geraldine Schlecht-Louf, Carmen Gallego
Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.
published pages: mol.118.115329, ISSN: 0026-895X, DOI: 10.1124/mol.118.115329
Molecular Pharmacology 2020-04-01
2016 Bas van der Woning, Gitte De Boeck, Christophe Blanchetot, Vladimir Bobkov, Alex Klarenbeek, Michael Saunders, Magali Waelbroeck, Toon Laeremans, Jan Steyaert, Anna Hultberg, Hans De Haard
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops
published pages: 1126-1135, ISSN: 1942-0870, DOI: 10.1080/19420862.2016.1189050
mAbs 8/6 2020-04-01
2017 Orestis Faklaris, Joyce Heuninck, Amandine Falco, Elise Goyet, Jurriaan M. Zwier, Jean-Philippe Pin, Bernard Mouillac, Julie Perroy, Thierry Durroux
Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding
published pages: , ISSN: , DOI: 10.1007/7355_2017_2
Topics in Medicinal Chemistry 2020-04-01
2017 Laura Nogués, Clara Reglero, Verónica Rivas, María Neves, Petronila Penela, Federico Mayor
G-Protein–Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer
published pages: 220-228, ISSN: 0026-895X, DOI: 10.1124/mol.116.107185
Molecular Pharmacology 91/3 2020-04-01
2019 Maria Neves, Amos Fumagalli, Jelle van den Bor, Philippe Marin, Martine J Smit, Federico Mayor
The role of ACKR3 in breast, lung and brain cancer.
published pages: mol.118.115279, ISSN: 0026-895X, DOI: 10.1124/mol.118.115279
Molecular Pharmacology 2020-04-01
2018 Vladimir Bobkov, Aurelien M. Zarca, Anneleen Van Hout, Marta Arimont, Jordi Doijen, Magdalena Bialkowska, Elisa Toffoli, Alex Klarenbeek, Bas van der Woning, Hans J. van der Vliet, Tom Van Loy, Hans de Haard, Dominique Schols, Raimond Heukers, Martine J. Smit
Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions
published pages: 413-424, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.10.014
Biochemical Pharmacology 158 2020-04-01
2018 Anneleen Van Hout, Alex Klarenbeek, Vladimir Bobkov, Jordi Doijen, Marta Arimont, Chunxia Zhao, Raimond Heukers, Rebecca Rimkunas, Chris de Graaf, Theo Verrips, Bas van der Woning, Hans de Haard, Joseph B. Rucker, Kurt Vermeire, Tracy Handel, Tom Van Loy, Martine J. Smit, Dominique Schols
CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry
published pages: 402-412, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.10.015
Biochemical Pharmacology 158 2020-04-01
2018 Laura Nogués, Julia Palacios-García, Clara Reglero, Verónica Rivas, María Neves, Catalina Ribas, Petronila Penela, Federico Mayor
G protein-coupled receptor kinases (GRKs) in tumorigenesis and cancer progression: GPCR regulators and signaling hubs
published pages: 78-90, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2017.04.013
Seminars in Cancer Biology 48 2020-04-01
2019 I. Adlere, S. Sun, A. Zarca, L. Roumen, M. Gozelle, C. Perpiñá Viciano, B. Caspar, M. Arimont, J.P. Bebelman, S.J. Briddon, C. Hoffmann, S.J. Hill, M.J. Smit, H.F. Vischer, M. Wijtmans, C. de Graaf, I.J.P. de Esch, R. Leurs
Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists
published pages: 631-649, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2018.10.060
European Journal of Medicinal Chemistry 162 2020-04-01
2017 Raymond H. de Wit, Raimond Heukers, Hendrik J. Brink, Angela Arsova, David Maussang, Pasquale Cutolo, Beatrijs Strubbe, Henry F. Vischer, Françoise Bachelerie, Martine J. Smit
CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome
published pages: 35-44, ISSN: 0022-3565, DOI: 10.1124/jpet.117.242735
Journal of Pharmacology and Experimental Therapeutics 363/1 2020-04-01
2017 Marta Arimont, Shan-Liang Sun, Rob Leurs, Martine Smit, Iwan J. P. de Esch, Chris de Graaf
Structural Analysis of Chemokine Receptor–Ligand Interactions
published pages: 4735-4779, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01309
Journal of Medicinal Chemistry 60/12 2020-04-01
2017 Beatrice Oehler, Milad Mohammadi, Cristina Perpina Viciano, Dagmar Hackel, Carsten Hoffmann, Alexander Brack, Heike L. Rittner
Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats
published pages: , ISSN: 1662-5099, DOI: 10.3389/fnmol.2017.00242
Frontiers in Molecular Neuroscience 10 2020-04-01
2017 Nikaïa Smith, Nicolas Pietrancosta, Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole, Jean-Philippe Herbeuval
Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement
published pages: , ISSN: 2041-1723, DOI: 10.1038/ncomms14253
Nature Communications 8/1 2020-04-01
2019 Amos Fumagalli, Aurelien Zarca, Maria Neves, Birgit Caspar, Stephen J Hill, Federico Mayor, Martine J Smit, Philippe Marin
CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status
published pages: mol.118.115360, ISSN: 0026-895X, DOI: 10.1124/mol.118.115360
Molecular Pharmacology 2020-04-01
2016 Laura Nogués, Clara Reglero, Verónica Rivas, Alicia Salcedo, Vanesa Lafarga, Maria Neves, Paula Ramos, Marta Mendiola, Alberto Berjón, Kostas Stamatakis, Xiao Zhen Zhou, Kun Ping Lu, David Hardisson, Federico Mayor, Petronila Penela
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis
published pages: 132-145, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2016.09.030
EBioMedicine 13 2020-04-01
2019 Timo W.M. De Groof, Vladimir Bobkov, Raimond Heukers, Martine J. Smit
Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs
published pages: 15-24, ISSN: 0303-7207, DOI: 10.1016/j.mce.2019.01.021
Molecular and Cellular Endocrinology 484 2020-04-01

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