Explore the words cloud of the TargetCaRe project. It provides you a very rough idea of what is the project "TargetCaRe" about.
The following table provides information about the project.
Coordinator |
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | http://www.targetcare.eu |
Total cost | 3˙971˙459 € |
EC max contribution | 3˙971˙459 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2014 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2015 |
Duration (year-month-day) | from 2015-03-01 to 2019-02-28 |
Take a look of project's partnership.
# | ||||
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1 | ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM | NL (ROTTERDAM) | coordinator | 510˙748.00 |
2 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | participant | 546˙575.00 |
3 | AO-FORSCHUNGSINSTITUT DAVOS | CH (DAVOS PLATZ) | participant | 530˙453.00 |
4 | TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY | IL (HAIFA) | participant | 520˙601.00 |
5 | AARHUS UNIVERSITET | DK (AARHUS C) | participant | 290˙081.00 |
6 | CARDIFF UNIVERSITY | UK (CARDIFF) | participant | 273˙287.00 |
7 | THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN | UK (ABERDEEN) | participant | 273˙287.00 |
8 | PROCORE LTD | IL (NES ZIONA) | participant | 260˙300.00 |
9 | PERCUROS BV | NL (LEIDEN) | participant | 255˙374.00 |
10 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | participant | 255˙374.00 |
11 | UNIVERSITEIT MAASTRICHT | NL (MAASTRICHT) | participant | 255˙374.00 |
12 | Omics2Image | NL (Amsterdam) | partner | 0.00 |
13 | STICHTING NATIONAAL REUMAFONDS | NL (AMSTERDAM) | partner | 0.00 |
Mobility, important for well-being, is seriously impaired by chronic low back pain and osteoarthritis in many people due to degeneration of cartilaginous tissue of the intervertebral disc and joint. To develop a treatment for these diseases this ETN aims to combine expertise in novel highly advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in stem cell and joint biology by training 15 young scientists in 12 partner institutes located in 5 different countries. We aim to achieve regeneration of damaged and degenerated tissues by employing targeting strategies tailored both to the pathology and the tissues involved. Regeneration of diseased tissues will be achieved by loading biologically active agents in state-of-the-art nanocarriers. The biologically active agents will stimulate the body’s own capacity to regenerate by attracting local stem cells or inhibit degeneration. Targeting will be achieved by A] injection with synthetic or natural hydrogels loaded with the nanocarriers or B] coupling diseased tissue-specific antibodies and specific hyaluronic acid moieties to the nanocarriers. Delivery and retention will be monitored by advanced in vivo and molecular imaging techniques to monitor distribution of the delivered compounds at the tissue level, as well as detect biological markers of regeneration.
Major objectives: 1] To establish a network of scientists skilled in the use of smart nanocarriers, unique approach of targeting by disease-specific molecules and application of innovative imaging tools. Supported by generic scientific and training in economical and clinical valorisation, these researchers can further implement these technologies in the musculoskeletal or other areas, both in academia and industry. 2] To develop strategies exclusively targeting diseased tissues with controlled doses of bio-actives, circumventing the disadvantages of the current shotgun approaches in regenerative medicine.
15 young multidisciplinary European researchers with excellent networks, at least half of them found a suitable position in the area | Other | 2020-01-21 11:12:32 |
Website | Websites, patent fillings, videos etc. | 2020-01-21 11:12:29 |
Information for lay people, incl. patients via website | Websites, patent fillings, videos etc. | 2020-01-21 11:12:29 |
At least 30 publications in peer reviewed journals | Documents, reports | 2020-01-21 11:12:32 |
At least 40 presentations in international meetings | Websites, patent fillings, videos etc. | 2020-01-21 11:12:31 |
At least 3 articles in general press in at least 3 countries | Documents, reports | 2020-01-21 11:12:32 |
15 young European researchers trained in at least two disciplines, at least 90% (ready to be) graduated | Other | 2020-01-21 11:12:31 |
Take a look to the deliverables list in detail: detailed list of TargetCaRe deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Jacopo Oieni, Marcelle Machluf Nanoghosts targeted delivery of RNA interference therapy for the treatment of Osteoarthritis published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Ruth Gussenhoven, Daan R.M.G. Ophelders, Matthew W. Kemp, Matthew S. Payne, Owen B. Spiller, Michael L. Beeton, Sarah J. Stock, Bertha Cillero-Pastor, Florian P.Y. Barré, Ron M.A. Heeren, Lilian Kessels, Bas Stevens, Bart P. Rutten, Suhas G. Kallapur, Alan H. Jobe, Boris W. Kramer, Tim G.A.M. Wolfs The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development published pages: 472-486, ISSN: 0378-5866, DOI: 10.1159/000479021 |
Developmental Neuroscience 39/6 | 2020-01-21 |
2019 |
Florian Barré, Beatriz Rocha, Frédéric Dewez, Mark Towers, Paul Murray, Emmanuelle Claude, Berta Cillero-Pastor, Ron Heeren, Tiffany Porta Siegel Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution published pages: 38-48, ISSN: 1387-3806, DOI: 10.1016/j.ijms.2018.09.015 |
International Journal of Mass Spectrometry 437 | 2020-01-21 |
2019 |
Lennart R.S. Huizing, Shane R. Ellis, Bart W.A.M.M. Beulen, Florian P.Y. Barré, Paul B. Kwant, Rob J. Vreeken, Ron M.A. Heeren Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic published pages: 7-15, ISSN: 2376-9998, DOI: 10.1016/j.clinms.2019.01.004 |
Clinical Mass Spectrometry 12 | 2020-01-21 |
2018 |
F. Colella, Y. Cai, K. Howard, A. Roelofs, C. De Bari YAP targeting in synovial MSCs as a novel therapeutic approach for osteoarthritis published pages: S301, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.605 |
Osteoarthritis and Cartilage 26 | 2020-01-21 |
2018 |
M.L. Vainieri, D. Wahl, M. Alini, G.J.V.M. van Osch, S. Grad Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies published pages: 256-266, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.09.058 |
Acta Biomaterialia 81 | 2020-01-21 |
2018 |
ML Vainieri1,2, D Wahl 1, G Van Osch2, M Alini1, S Grad1 Novel ex-vivo osteochondral modelfor cartilage repair in mechanical stimulated joint bioreactor published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Andrea Lolli1, Kavitha Sivasubramaniyan1, Gerjo van Osch1,2 Establishment of a hydrogel-based antimiR-221 delivery system for in situ guidance of cartilage repair published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Domenico D\'Atri, Marcelle Machluf Nano-ghosts delivery system and Link-N peptide, enhanced anti-inflammatory activity: a new approaches for the treatment of osteoarthritis published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Bernardo Antunes1,2, João Pedro Garcia3, Efrat Monsonego-Ornan2, Laura Creemers3, Avner Yayon1 Effects of FGF18 on OA human articular chondrocytes embedded in a novel FBG:HA hydrogel published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Gerben Stolk Uniek onderzoek behandeling artroseL Slimme Medicijnen published pages: 34-35, ISSN: , DOI: |
Monitor nummer 4, jaargang 46 (4x per y | 2020-01-21 |
2017 |
M.A. Suijkerbuijk, S. Çapar, N. Kops, D.E. Meuffels, G.J. van Osch, Y.M. Bastiaansen-Jenniskens Inhibiting Stat Signaling Pathways as a Possible Therapy to Modulate Synovial Inflammation in Osteoarthritis published pages: S271-S272, ISSN: 1063-4584, DOI: 10.1016/j.joca.2017.02.457 |
Osteoarthritis and Cartilage 25 | 2020-01-21 |
2018 |
Cai Y Local and systemic delivery of gapmer antisense oligonucleotides for arthritis treatment published pages: , ISSN: , DOI: |
2020-01-21 | |
2018 |
M. Vainieri,
K. Sivasubramaniyan,
A. Lolli ,
D. Eglid ,
A. Yayon,
E. Wexselblatt,
M. Alini
S. Grad ,
G. van Osch P75 - Hyaluronic acid-based hydrogels promote mesenchymal stem cell ingrowth and cartilage production in vitro and in vivo. published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Mathijs Suijkerbuijk, Serdar Çapar, Nicole Kops, Duncan Meuffels, Gerjo van Osch, Yvonne Bastiaansen-Jenniskens Inhibiting STAT signaling pathways in macrophages to improve tissue regeneration published pages: , ISSN: , DOI: |
2020-01-21 | |
2018 |
F.P. Barré, M. Paine, B. Flinders, M. Eveque-Mourroux, J. Garcia, S. Ellis, R.M. Heeren, L. Creemers, B. Cillero Pastor Distribution, quantification and effects of triamcinolone acetonide in human osteoarthritic cartilage published pages: S284-S285, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.574 |
Osteoarthritis and Cartilage 26 | 2020-01-21 |
2016 |
A. Lolli, R. Narcisi, E. Lambertini, L. Penolazzi, M. Angelozzi, G.J. van Osch, R. Piva Depletion of the anti-chondrogenic regulators MIR-221 and slug: a novel approach to induce chondrogenesis published pages: S39-S40, ISSN: 1063-4584, DOI: 10.1016/j.joca.2016.01.095 |
Osteoarthritis and Cartilage 24 | 2020-01-21 |
2018 |
Yunpeng Cai, Anna-Marie Makarova, Jesper Wengel, Kenneth A. Howard Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity published pages: e3025, ISSN: 1099-498X, DOI: 10.1002/jgm.3025 |
The Journal of Gene Medicine 20/7-8 | 2020-01-21 |
2018 |
J.P. Garcia1, A. Longoni2, L.B. Creemers1, M.W. Grinstaff3, J. Töyräs4, H. Weinans1,5, B. Pouran1,5 3D non-invasive bioimaging of cartilage tissue engineered constructs usingcontrast enhanced computed tomography published pages: , ISSN: , DOI: |
2020-01-21 | |
2018 |
A. Lolli (Rotterdam, Netherlands),
K. Sivasubramaniyan (Rotterdam, Netherlands),
M. Vainieri (Davos Platz, Switzerland),
A. Yayon (Nes Ziona, Israel),
G. Van Osch (Rotterdam, Netherlands) P268 - Antimir-221 Loaded Fibrin/Hyaluronic Acid Hydrogel For The Guidance Of Endogenous Cartilage Repair published pages: , ISSN: , DOI: |
2020-01-21 | |
2018 |
Florian P.Y. Barré, Britt S.R. Claes, Frédéric Dewez, Carine Peutz-Kootstra, Helga F. Munch-Petersen, Kirsten Grønbæk, Anders H. Lund, Ron M.A. Heeren, Christophe Côme, Berta Cillero-Pastor Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging published pages: 14198-14206, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b02910 |
Analytical Chemistry 90/24 | 2020-01-21 |
2018 |
A. Lolli, K. Sivasubramaniyan, M.L. Vainieri, D. Eglin, E. Wexselblatt, A. Yayon, S. Grad, M. Alini, G.J. van Osch Hyaluronan-based hydrogel delivering antimiR-221 for the guidance of endogenous cartilage repair published pages: S163, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.355 |
Osteoarthritis and Cartilage 26 | 2020-01-21 |
2018 |
J Oieni1, A Lolli2, GJVM van Osch2, M Machluf1 A novel nano-ghosts based system for targeted delivery of antimir-221 andstimulation of cartilage repair published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation published pages: 1710-1717, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.05.009 |
Molecular Therapy 25/7 | 2020-01-21 |
2019 |
Massi L . Enzyme and temperature dual-responsive polymer nanostructures towards the treatment of osteoarthritis published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
M.Letizia Vainieri, Dieter Whal, Patrick Leuzo, Gerjo van Osch, Mauro Alini, Sibylle Grad Novel ex-vivo osteochondral defect model in a joint bioreactor system for articular cartilage repair studies published pages: , ISSN: , DOI: |
2020-01-21 | |
2018 |
J. Garcia, J. Stein, Y. Cai, E. Wexselblatt, L. Creemers, J. Wengel, K. Howard, D. Saris, A. Yayon Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis published pages: S145, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.313 |
Osteoarthritis and Cartilage 26 | 2020-01-21 |
2019 |
João Pedro Garcia, Jeroen Stein, Yunpeng Cai, Frank Riemers, Ezequiel Wexselblatt, Jesper Wengel, Marianna Tryfonidou, Avner Yayon, Kenneth A. Howard, Laura B. Creemers Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis published pages: 247-258, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.12.030 |
Journal of Controlled Release 294 | 2020-01-21 |
2018 |
BP Antunes1, 2, ML Vainieri3, E Monsonego-Ornan2, M Alini3, S Grad3, A Yayon1 Effects of mechanical stimulation combined with FGF18 on bovinechondrocytes embedded in a novel Fibrin:HA hydrogel published pages: , ISSN: , DOI: |
2020-01-21 | |
2017 |
Andrea Lolli, Letizia Penolazzi, Roberto Narcisi, Gerjo J.V.M. van Osch, Roberta Piva Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair published pages: , ISSN: 1420-682X, DOI: |
Cellular and Molecular Life Sciences | 2020-01-21 |
2017 |
Yunpeng Cai, Elena López-Ruiz, Jesper Wengel, Laura B. Creemers, Kenneth A. Howard A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis published pages: 153-159, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.03.004 |
Journal of Controlled Release 253 | 2020-01-21 |
2016 |
Florian P. Y. Barré, Bryn Flinders, João P. Garcia, Imke Jansen, Lennart R. S. Huizing, Tiffany Porta, Laura B. Creemers, Ron M. A. Heeren, Berta Cillero-Pastor Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging published pages: 12051-12059, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b02491 |
Analytical Chemistry 88/24 | 2020-01-21 |
2017 |
Florian P.Y. Barré, Ron M. A. Heeren, Nina Ogrinc PotoÄnik Mass spectrometry imaging in nanomedicine: unravelling the potential of MSI for detection of nanoparticles in neuroscience published pages: , ISSN: 1381-6128, DOI: |
Current Pharmaceutical Design 23 | 2020-01-21 |
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