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Targeting Cartilage Regeneration in joint and intervertebral disc diseases

Total Cost €


EC-Contrib. €






 TargetCaRe project word cloud

Explore the words cloud of the TargetCaRe project. It provides you a very rough idea of what is the project "TargetCaRe" about.

academia    expertise    inhibit    skilled    tissues    disadvantages    monitor    exclusively    compounds    musculoskeletal    local    clinical    moieties    doses    capacity    regenerative    tissue    circumventing    degeneration    scientists    people    15    disease    loaded    medicine    degenerated    body       cartilaginous    cells    biologically    young    tools    bio    combine    agents    economical    synthetic    drug    located    damaged       industry    biology    technologies    imaging    regeneration    treatment    injection    delivered    attracting    12    joint    training    strategies    molecular    seriously    diseased    markers    loading    retention    countries    disc    institutes    pain    pathology    network    cell    these    monitored    biological    chronic    acid    scientific    actives    antibodies    intervertebral    smart    hyaluronic    molecules    diseases    detect    impaired    active    carriers    hydrogels    osteoarthritis    stem    employing    back    regenerate    natural    techniques    shotgun    coupling    stimulate    etn    mobility    innovative    nanocarriers    vivo   

Project "TargetCaRe" data sheet

The following table provides information about the project.


Organization address
postcode: 3015 GD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website
 Total cost 3˙971˙459 €
 EC max contribution 3˙971˙459 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2019-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
5    AARHUS UNIVERSITET DK (AARHUS C) participant 290˙081.00
6    CARDIFF UNIVERSITY UK (CARDIFF) participant 273˙287.00
8    PROCORE LTD IL (NES ZIONA) participant 260˙300.00
9    PERCUROS BV NL (LEIDEN) participant 255˙374.00
11    UNIVERSITEIT MAASTRICHT NL (MAASTRICHT) participant 255˙374.00
12    Omics2Image NL (Amsterdam) partner 0.00


 Project objective

Mobility, important for well-being, is seriously impaired by chronic low back pain and osteoarthritis in many people due to degeneration of cartilaginous tissue of the intervertebral disc and joint. To develop a treatment for these diseases this ETN aims to combine expertise in novel highly advanced drug delivery carriers with dedicated targeting tools, state of the art imaging techniques and expertise in stem cell and joint biology by training 15 young scientists in 12 partner institutes located in 5 different countries. We aim to achieve regeneration of damaged and degenerated tissues by employing targeting strategies tailored both to the pathology and the tissues involved. Regeneration of diseased tissues will be achieved by loading biologically active agents in state-of-the-art nanocarriers. The biologically active agents will stimulate the body’s own capacity to regenerate by attracting local stem cells or inhibit degeneration. Targeting will be achieved by A] injection with synthetic or natural hydrogels loaded with the nanocarriers or B] coupling diseased tissue-specific antibodies and specific hyaluronic acid moieties to the nanocarriers. Delivery and retention will be monitored by advanced in vivo and molecular imaging techniques to monitor distribution of the delivered compounds at the tissue level, as well as detect biological markers of regeneration.

Major objectives: 1] To establish a network of scientists skilled in the use of smart nanocarriers, unique approach of targeting by disease-specific molecules and application of innovative imaging tools. Supported by generic scientific and training in economical and clinical valorisation, these researchers can further implement these technologies in the musculoskeletal or other areas, both in academia and industry. 2] To develop strategies exclusively targeting diseased tissues with controlled doses of bio-actives, circumventing the disadvantages of the current shotgun approaches in regenerative medicine.


List of deliverables.
15 young multidisciplinary European researchers with excellent networks, at least half of them found a suitable position in the area Other 2020-01-21 11:12:32
Website Websites, patent fillings, videos etc. 2020-01-21 11:12:29
Information for lay people, incl. patients via website Websites, patent fillings, videos etc. 2020-01-21 11:12:29
At least 30 publications in peer reviewed journals Documents, reports 2020-01-21 11:12:32
At least 40 presentations in international meetings Websites, patent fillings, videos etc. 2020-01-21 11:12:31
At least 3 articles in general press in at least 3 countries Documents, reports 2020-01-21 11:12:32
15 young European researchers trained in at least two disciplines, at least 90% (ready to be) graduated Other 2020-01-21 11:12:31

Take a look to the deliverables list in detail:  detailed list of TargetCaRe deliverables.


year authors and title journal last update
List of publications.
2017 Jacopo Oieni, Marcelle Machluf
Nanoghosts targeted delivery of RNA interference therapy for the treatment of Osteoarthritis
published pages: , ISSN: , DOI:
2017 Ruth Gussenhoven, Daan R.M.G. Ophelders, Matthew W. Kemp, Matthew S. Payne, Owen B. Spiller, Michael L. Beeton, Sarah J. Stock, Bertha Cillero-Pastor, Florian P.Y. Barré, Ron M.A. Heeren, Lilian Kessels, Bas Stevens, Bart P. Rutten, Suhas G. Kallapur, Alan H. Jobe, Boris W. Kramer, Tim G.A.M. Wolfs
The Paradoxical Effects of Chronic Intra-Amniotic Ureaplasma parvum Exposure on Ovine Fetal Brain Development
published pages: 472-486, ISSN: 0378-5866, DOI: 10.1159/000479021
Developmental Neuroscience 39/6 2020-01-21
2019 Florian Barré, Beatriz Rocha, Frédéric Dewez, Mark Towers, Paul Murray, Emmanuelle Claude, Berta Cillero-Pastor, Ron Heeren, Tiffany Porta Siegel
Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution
published pages: 38-48, ISSN: 1387-3806, DOI: 10.1016/j.ijms.2018.09.015
International Journal of Mass Spectrometry 437 2020-01-21
2019 Lennart R.S. Huizing, Shane R. Ellis, Bart W.A.M.M. Beulen, Florian P.Y. Barré, Paul B. Kwant, Rob J. Vreeken, Ron M.A. Heeren
Development and evaluation of matrix application techniques for high throughput mass spectrometry imaging of tissues in the clinic
published pages: 7-15, ISSN: 2376-9998, DOI: 10.1016/j.clinms.2019.01.004
Clinical Mass Spectrometry 12 2020-01-21
2018 F. Colella, Y. Cai, K. Howard, A. Roelofs, C. De Bari
YAP targeting in synovial MSCs as a novel therapeutic approach for osteoarthritis
published pages: S301, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.605
Osteoarthritis and Cartilage 26 2020-01-21
2018 M.L. Vainieri, D. Wahl, M. Alini, G.J.V.M. van Osch, S. Grad
Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies
published pages: 256-266, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.09.058
Acta Biomaterialia 81 2020-01-21
2018 ML Vainieri1,2, D Wahl 1, G Van Osch2, M Alini1, S Grad1
Novel ex-vivo osteochondral modelfor cartilage repair in mechanical stimulated joint bioreactor
published pages: , ISSN: , DOI:
2017 Andrea Lolli1, Kavitha Sivasubramaniyan1, Gerjo van Osch1,2
Establishment of a hydrogel-based antimiR-221 delivery system for in situ guidance of cartilage repair
published pages: , ISSN: , DOI:
2017 Domenico D\'Atri, Marcelle Machluf
Nano-ghosts delivery system and Link-N peptide, enhanced anti-inflammatory activity: a new approaches for the treatment of osteoarthritis
published pages: , ISSN: , DOI:
2017 Bernardo Antunes1,2, João Pedro Garcia3, Efrat Monsonego-Ornan2, Laura Creemers3, Avner Yayon1
Effects of FGF18 on OA human articular chondrocytes embedded in a novel FBG:HA hydrogel
published pages: , ISSN: , DOI:
2017 Gerben Stolk
Uniek onderzoek behandeling artroseL Slimme Medicijnen
published pages: 34-35, ISSN: , DOI:
Monitor nummer 4, jaargang 46 (4x per y 2020-01-21
2017 M.A. Suijkerbuijk, S. Çapar, N. Kops, D.E. Meuffels, G.J. van Osch, Y.M. Bastiaansen-Jenniskens
Inhibiting Stat Signaling Pathways as a Possible Therapy to Modulate Synovial Inflammation in Osteoarthritis
published pages: S271-S272, ISSN: 1063-4584, DOI: 10.1016/j.joca.2017.02.457
Osteoarthritis and Cartilage 25 2020-01-21
2018 Cai Y
Local and systemic delivery of gapmer antisense oligonucleotides for arthritis treatment
published pages: , ISSN: , DOI:
2018 M. Vainieri, K. Sivasubramaniyan, A. Lolli , D. Eglid , A. Yayon, E. Wexselblatt, M. Alini S. Grad , G. van Osch
P75 - Hyaluronic acid-based hydrogels promote mesenchymal stem cell ingrowth and cartilage production in vitro and in vivo.
published pages: , ISSN: , DOI:
2017 Mathijs Suijkerbuijk, Serdar Çapar, Nicole Kops, Duncan Meuffels, Gerjo van Osch, Yvonne Bastiaansen-Jenniskens
Inhibiting STAT signaling pathways in macrophages to improve tissue regeneration
published pages: , ISSN: , DOI:
2018 F.P. Barré, M. Paine, B. Flinders, M. Eveque-Mourroux, J. Garcia, S. Ellis, R.M. Heeren, L. Creemers, B. Cillero Pastor
Distribution, quantification and effects of triamcinolone acetonide in human osteoarthritic cartilage
published pages: S284-S285, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.574
Osteoarthritis and Cartilage 26 2020-01-21
2016 A. Lolli, R. Narcisi, E. Lambertini, L. Penolazzi, M. Angelozzi, G.J. van Osch, R. Piva
Depletion of the anti-chondrogenic regulators MIR-221 and slug: a novel approach to induce chondrogenesis
published pages: S39-S40, ISSN: 1063-4584, DOI: 10.1016/j.joca.2016.01.095
Osteoarthritis and Cartilage 24 2020-01-21
2018 Yunpeng Cai, Anna-Marie Makarova, Jesper Wengel, Kenneth A. Howard
Palmitoylated phosphodiester gapmer designs with albumin binding capacity and maintained in vitro gene silencing activity
published pages: e3025, ISSN: 1099-498X, DOI: 10.1002/jgm.3025
The Journal of Gene Medicine 20/7-8 2020-01-21
2018 J.P. Garcia1, A. Longoni2, L.B. Creemers1, M.W. Grinstaff3, J. Töyräs4, H. Weinans1,5, B. Pouran1,5
3D non-invasive bioimaging of cartilage tissue engineered constructs usingcontrast enhanced computed tomography
published pages: , ISSN: , DOI:
2018 A. Lolli (Rotterdam, Netherlands), K. Sivasubramaniyan (Rotterdam, Netherlands), M. Vainieri (Davos Platz, Switzerland), A. Yayon (Nes Ziona, Israel), G. Van Osch (Rotterdam, Netherlands)
P268 - Antimir-221 Loaded Fibrin/Hyaluronic Acid Hydrogel For The Guidance Of Endogenous Cartilage Repair
published pages: , ISSN: , DOI:
2018 Florian P.Y. Barré, Britt S.R. Claes, Frédéric Dewez, Carine Peutz-Kootstra, Helga F. Munch-Petersen, Kirsten Grønbæk, Anders H. Lund, Ron M.A. Heeren, Christophe Côme, Berta Cillero-Pastor
Specific Lipid and Metabolic Profiles of R-CHOP-Resistant Diffuse Large B-Cell Lymphoma Elucidated by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and in Vivo Imaging
published pages: 14198-14206, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b02910
Analytical Chemistry 90/24 2020-01-21
2018 A. Lolli, K. Sivasubramaniyan, M.L. Vainieri, D. Eglin, E. Wexselblatt, A. Yayon, S. Grad, M. Alini, G.J. van Osch
Hyaluronan-based hydrogel delivering antimiR-221 for the guidance of endogenous cartilage repair
published pages: S163, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.355
Osteoarthritis and Cartilage 26 2020-01-21
2018 J Oieni1, A Lolli2, GJVM van Osch2, M Machluf1
A novel nano-ghosts based system for targeted delivery of antimir-221 andstimulation of cartilage repair
published pages: , ISSN: , DOI:
2017 Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A. Howard
Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation
published pages: 1710-1717, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2017.05.009
Molecular Therapy 25/7 2020-01-21
2019 Massi L
. Enzyme and temperature dual-responsive polymer nanostructures towards the treatment of osteoarthritis
published pages: , ISSN: , DOI:
2017 M.Letizia Vainieri, Dieter Whal, Patrick Leuzo, Gerjo van Osch, Mauro Alini, Sibylle Grad
Novel ex-vivo osteochondral defect model in a joint bioreactor system for articular cartilage repair studies
published pages: , ISSN: , DOI:
2018 J. Garcia, J. Stein, Y. Cai, E. Wexselblatt, L. Creemers, J. Wengel, K. Howard, D. Saris, A. Yayon
Fibrin/hyaluronic acid hydrogel for combined delivery of gapmers and chondrocytes as a gene therapy approach for osteoarthritis
published pages: S145, ISSN: 1063-4584, DOI: 10.1016/j.joca.2018.02.313
Osteoarthritis and Cartilage 26 2020-01-21
2019 João Pedro Garcia, Jeroen Stein, Yunpeng Cai, Frank Riemers, Ezequiel Wexselblatt, Jesper Wengel, Marianna Tryfonidou, Avner Yayon, Kenneth A. Howard, Laura B. Creemers
Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis
published pages: 247-258, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.12.030
Journal of Controlled Release 294 2020-01-21
2018 BP Antunes1, 2, ML Vainieri3, E Monsonego-Ornan2, M Alini3, S Grad3, A Yayon1
Effects of mechanical stimulation combined with FGF18 on bovinechondrocytes embedded in a novel Fibrin:HA hydrogel
published pages: , ISSN: , DOI:
2017 Andrea Lolli, Letizia Penolazzi, Roberto Narcisi, Gerjo J.V.M. van Osch, Roberta Piva
Emerging potential of gene silencing approaches targeting anti-chondrogenic factors for cell-based cartilage repair
published pages: , ISSN: 1420-682X, DOI:
Cellular and Molecular Life Sciences 2020-01-21
2017 Yunpeng Cai, Elena López-Ruiz, Jesper Wengel, Laura B. Creemers, Kenneth A. Howard
A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis
published pages: 153-159, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.03.004
Journal of Controlled Release 253 2020-01-21
2016 Florian P. Y. Barré, Bryn Flinders, João P. Garcia, Imke Jansen, Lennart R. S. Huizing, Tiffany Porta, Laura B. Creemers, Ron M. A. Heeren, Berta Cillero-Pastor
Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
published pages: 12051-12059, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b02491
Analytical Chemistry 88/24 2020-01-21
2017 Florian P.Y. Barré, Ron M. A. Heeren, Nina Ogrinc Potočnik
Mass spectrometry imaging in nanomedicine: unravelling the potential of MSI for detection of nanoparticles in neuroscience
published pages: , ISSN: 1381-6128, DOI:
Current Pharmaceutical Design 23 2020-01-21

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