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InCeM SIGNED

Research Training Network on Integrated Component Cycling in Epithelial Cell Motility

Total Cost €

0

EC-Contrib. €

0

Partnership

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 InCeM project word cloud

Explore the words cloud of the InCeM project. It provides you a very rough idea of what is the project "InCeM" about.

integrating    competencies    resolution    mathematical    17    biological    disease    coming    science    experimental    recording    careers    ing    successful    clinical    health    monitoring    motile    edge    components    cells    business    clarifying    industry    fundamental    models    multidisciplinary    11    motility    training    inducing    incem    cutting    time    data    stage    public    microscopic    involve    underlying    ultimate    breakthroughs    space    cellular    train    sciences    tissue    academic    driving    beneficiaries    theoretical    predicting    image    physical    signals    prepare    endow    carcinogenesis    coordinated    chemical    network    migration    tools    mechanisms    wound    environments    pivotal    technologies    cancer    repair    invasion    innovative    multiple    epithelial    techniques    manipulate    private    israel    15    clinically    universities    master    countries    cell    mechanistic    exactly    structural    cycling    team    healing    esrs   

Project "InCeM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM AACHEN 

Organization address
address: Pauwelsstrasse 30
city: AACHEN
postcode: 52074
website: www.ukaachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://incem.rwth-aachen.de
 Total cost 3˙866˙665 €
 EC max contribution 3˙866˙665 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) coordinator 498˙432.00
2    THE UNIVERSITY OF SUSSEX UK (BRIGHTON) participant 546˙575.00
3    SOFTWARE COMPETENCE CENTER HAGENBERG GMBH AT (HAGENBERG) participant 511˙868.00
4    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) participant 498˙432.00
5    ANDOR TECHNOLOGY LIMITED UK (BELFAST) participant 273˙287.00
6    GRADIENTECH AB SE (UPPSALA) participant 263˙659.00
7    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 260˙300.00
8    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 260˙300.00
9    IBIDI GMBH DE (PLANEGG MARTINSRIED) participant 249˙216.00
10    UNIVERSITAET DUISBURG-ESSEN DE (ESSEN) participant 249˙216.00
11    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) participant 170˙249.00
12    STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS NL (AMSTERDAM) participant 85˙124.00
13    BAYER CROPSCIENCE AG DE (MONHEIM) partner 0.00
14    CARL ZEISS MICROSCOPY GMBH DE (Jena) partner 0.00
15    Center for Entrepeneurship DE (MUNCHEN) partner 0.00
16    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) partner 0.00
17    Isaac Newton Institute for Mathematical Sciences UK (Cambridge) partner 0.00
18    Johann Radon Institute for Computational and Applied Mathematics AT (Linz) partner 0.00
19    LfB DE (Münster) partner 0.00
20    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) partner 0.00
21    NETHERLANDS TRANSLATIONAL RESEARCH CENTER BV NL (OSS) partner 0.00
22    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN DE (BONN) partner 0.00
23    SIRION BIOTECH GMBH DE (PLANEGG MARTINSRIED) partner 0.00
24    TISSUEGNOSTICS GMBH AT (VIENNA) partner 0.00
25    TTOPSTART BV NL (UTRECHT) partner 0.00
26    UNIVERSITEIT UTRECHT NL (UTRECHT) partner 0.00
27    UNIVERSITY OF MANITOBA CA (MANITOBA) partner 0.00
28    Uppsala Innovation Centre SE (Uppsala) partner 0.00
29    UPPSALA UNIVERSITET SE (UPPSALA) partner 0.00

Map

 Project objective

Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multiple components coordinated by structural, chemical and physical signals in terms of time and space. To accomplish breakthroughs in this field, researchers are needed who (i) master cutting-edge experimental techniques for monitoring the different cellular processes at high resolution and (ii) have competencies in theoretical science for integrating the resulting data sets into mechanistic mathematical models for predicting motile cell behaviour. The Research Training Network on Integrated Component Cycling in Epithelial Cell Motility (InCeM) aims to endow up-and-coming researchers with exactly these competencies. They will be able to develop and apply innovative devices for microscopic recording, image processing techniques, data analysis tools and modelling procedures for mechanistic understanding of cell migration. InCeM will focus on epithelial cells, since inducing motility in this cell type is clinically relevant for wound healing and cancer invasion. The ultimate goal is to control and manipulate cell migration for clinical applications. A dedicated multidisciplinary team of 11 beneficiaries from universities (4), research institutions (4) and industry (3), based in 5 European countries and Israel, together with 17 associated partners from the public and private sector, will train 15 Early Stage Researchers (ESRs) to use the relevant technologies and sciences and will offer business training to prepare them for successful careers in both academic and non-academic environments.

 Deliverables

List of deliverables.
PhD theses Documents, reports 2019-07-10 14:42:08
Sustainability Documents, reports 2019-07-10 14:42:08
Communication 1 Documents, reports 2019-07-10 14:42:08
Communication Documents, reports 2019-07-10 14:42:08

Take a look to the deliverables list in detail:  detailed list of InCeM deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 D. J. Huels, L. Bruens, M. C. Hodder, P. Cammareri, A. D. Campbell, R. A. Ridgway, D. M. Gay, M. Solar-Abboud, W. J. Faller, C. Nixon, L. B. Zeiger, M. E. McLaughlin, E. Morrissey, D. J. Winton, H. J. Snippert, J. van Rheenen, O. J. Sansom
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
published pages: Article number 1, ISSN: 2041-1723, DOI: 10.1038/s41467-018-03426-2
Nature Communications 9/1 2019-07-10
2017 Massimo Frittelli, Anotida Madzvamuse, Ivonne Sgura, Chandrasekhar Venkataraman
Lumped finite elements for reaction–cross-diffusion systems on stationary surfaces
published pages: 3008-3023, ISSN: 0898-1221, DOI: 10.1016/j.camwa.2017.07.044
Computers & Mathematics with Applications 74/12 2019-07-10
2018 Maria Alieva, Jacco van Rheenen, Marike L. D. Broekman
Potential impact of invasive surgical procedures on primary tumor growth and metastasis
published pages: 319-331, ISSN: 0262-0898, DOI: 10.1007/s10585-018-9896-8
Clinical & Experimental Metastasis 35/4 2019-07-10
2016 A. Madzvamuse, A. H. Chung
Analysis and Simulations of Coupled Bulk-surface Reaction-Diffusion Systems on Exponentially Evolving Volumes
published pages: 4-32, ISSN: 1760-6101, DOI: 10.1051/mmnp/201611502
Mathematical Modelling of Natural Phenomena 11/5 2019-07-10
2017 Maria Alieva, Andreia S. Margarido, Tamara Wieles, Erik R. Abels, Burcin Colak, Carla Boquetale, Herke Jan Noordmans, Tom J. Snijders, Marike L. Broekman, Jacco van Rheenen
Preventing inflammation inhibits biopsy-mediated changes in tumor cell behavior
published pages: 7529, ISSN: 2045-2322, DOI: 10.1038/s41598-017-07660-4
Scientific Reports 7/1 2019-07-10
2019 Dmytro Kotsur, Roman Yakobenchuk, Rudolf Leube, Reinhard Windoffer, Julian Mattes
An algorithm for individual intermediate filament tracking
published pages: , ISSN: , DOI:
SAMBA: SIPAIM - MICCAI BIOMEDICAL WORKSHOP 2019-07-10
2018 Eduard Campillo-Funollet, Chandrasekhar Venkataraman, Anotida Madzvamuse
Bayesian Parameter Identification for Turing Systems on Stationary and Evolving Domains
published pages: 1-24, ISSN: 0092-8240, DOI: 10.1007/s11538-018-0518-z
Bulletin of Mathematical Biology 2019-07-10
2018 Wakil Sarfaraz, Anotida Madzvamuse
Domain-Dependent Stability Analysis of a Reaction–Diffusion Model on Compact Circular Geometries
published pages: 1830024, ISSN: 0218-1274, DOI: 10.1142/s0218127418300240
International Journal of Bifurcation and Chaos 28/08 2019-07-10
2017 Wakil Sarfaraz, Anotida Madzvamuse
Classification of parameter spaces for a reaction-diffusion model on stationary domains
published pages: 33-51, ISSN: 0960-0779, DOI: 10.1016/j.chaos.2017.05.032
Chaos, Solitons & Fractals 103 2019-07-10
2017 Rudolf E. Leube, Marcin Moch, Reinhard Windoffer
Intracellular Motility of Intermediate Filaments
published pages: a021980, ISSN: 1943-0264, DOI: 10.1101/cshperspect.a021980
Cold Spring Harbor Perspectives in Biology 9/6 2019-07-10
2018 Anne PORA
Impact of keratin network regulation on migrating cells
published pages: , ISSN: , DOI:
2019-07-10
2015 Toshio Sekimura, Chandrasekhar Venkataraman, Anotida Madzvamuse
A Model for Selection of Eyespots on Butterfly Wings
published pages: e0141434, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0141434
PLOS ONE 10/11 2019-07-10
2018 Katerina Lomanov, Jesus Martinez del Rincon, Paul Miller, Hugh Gribben
LAP-based tracking for focal adhesions
published pages: , ISSN: , DOI:
Irish Machine Vision and Image Processing Conference Proceedings 2018: Proceedings Yearly 2019-07-10
2018 Arianna Fumagalli, Saskia J E Suijkerbuijk, Harry Begthel, Evelyne Beerling, Koen C Oost, Hugo J Snippert, Jacco van Rheenen, Jarno Drost
A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression
published pages: 235-247, ISSN: 1754-2189, DOI: 10.1038/nprot.2017.137
Nature Protocols 13/2 2019-07-10
2018 Massimo Frittelli, Anotida Madzvamuse, Ivonne Sgura, Chandrasekhar Venkataraman
Numerical Preservation of Velocity Induced Invariant Regions for Reaction–Diffusion Systems on Evolving Surfaces
published pages: 971-1000, ISSN: 0885-7474, DOI: 10.1007/s10915-018-0741-7
Journal of Scientific Computing 77/2 2019-07-10
2018 Laura Murphy, Chandrasekhar Venkataraman, Anotida Madzvamuse
Parameter identification through mode isolation for reaction–diffusion systems on arbitrary geometries
published pages: 1850053, ISSN: 1793-5245, DOI: 10.1142/s1793524518500535
International Journal of Biomathematics 11/04 2019-07-10
2018 Sander C Steenbeek, Thang V Pham, Joep de Ligt, Anoek Zomer, Jaco C Knol, Sander R Piersma, Tim Schelfhorst, Rick Huisjes, Raymond M Schiffelers, Edwin Cuppen, Connie R Jimenez, Jacco van Rheenen
Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles
published pages: e98357, ISSN: 0261-4189, DOI: 10.15252/embj.201798357
The EMBO Journal 37/15 2019-07-10
2018 Gloria Fabris, Alessandro Lucantonio, Nico Hampe, Erik Noetzel, Bernd Hoffmann, Antonio DeSimone, Rudolf Merkel
Nanoscale Topography and Poroelastic Properties of Model Tissue Breast Gland Basement Membranes
published pages: 1770-1782, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.09.020
Biophysical Journal 115/9 2019-07-10
2018 Martin Rümmele
CSI-Krebs: So findet man die passende Therapie
published pages: 4-5, ISSN: , DOI:
medianet Dossier - health economy 10/2018 2019-07-10
2018 Scott Rata, Maria F. Suarez Peredo Rodriguez, Stephy Joseph, Nisha Peter, Fabio Echegaray Iturra, Fengwei Yang, Anotida Madzvamuse, Jan G. Ruppert, Kumiko Samejima, Melpomeni Platani, Monica Alvarez-Fernandez, Marcos Malumbres, William C. Earnshaw, Bela Novak, Helfrid Hochegger
Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells
published pages: 3824-3832.e6, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.09.059
Current Biology 28/23 2019-07-10
2016 Anotida Madzvamuse, Hussaini Ndakwo, Raquel Barreira
Stability analysis of reaction-diffusion models on evolving domains: The effects of cross-diffusion
published pages: 2133-2170, ISSN: 1078-0947, DOI: 10.3934/dcds.2016.36.2133
Discrete and Continuous Dynamical Systems 36/4 2019-07-10
2016 Feng Wei Yang, Chandrasekhar Venkataraman, Vanessa Styles, Verena Kuttenberger, Elias Horn, Zeno von Guttenberg, Anotida Madzvamuse
A computational framework for particle and whole cell tracking applied to a real biological dataset
published pages: , ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2016.02.008
Journal of Biomechanics February 2016 2019-07-10
2016 Anotida Madzvamuse, Andy H.W. Chung
The bulk-surface finite element method for reaction–diffusion systems on stationary volumes
published pages: 9-21, ISSN: 0168-874X, DOI: 10.1016/j.finel.2015.09.002
Finite Elements in Analysis and Design 108 2019-07-10
2016 Anotida Madzvamuse, Sharon R. Lubkin
A note on how to develop interdisciplinary collaborations between experimentalists and theoreticians
published pages: 20160069, ISSN: 2042-8898, DOI: 10.1098/rsfs.2016.0069
Interface Focus 6/5 2019-07-10
2017 Melanie Graessl, Johannes Koch, Abram Calderon, Dominic Kamps, Soumya Banerjee, Tomáš Mazel, Nina Schulze, Jana Kathrin Jungkurth, Rutuja Patwardhan, Djamschid Solouk, Nico Hampe, Bernd Hoffmann, Leif Dehmelt, Perihan Nalbant
An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns
published pages: 4271-4285, ISSN: 0021-9525, DOI: 10.1083/jcb.201706052
The Journal of Cell Biology 216/12 2019-07-10
2016 Rodrigo Hernández Vera, Emil Schwan, Nikos Fatsis-Kavalopoulos, Johan Kreuger
A Modular and Affordable Time-Lapse Imaging and Incubation System Based on 3D-Printed Parts, a Smartphone, and Off-The-Shelf Electronics
published pages: e0167583, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0167583
PLOS ONE 11/12 2019-07-10
2016 A. Madzvamuse, A. H. Chung
Analysis and Simulations of Coupled Bulk-surface Reaction-Diffusion Systems on Exponentially Evolving Volumes
published pages: 4-32, ISSN: 1760-6101, DOI: 10.1051/mmnp/201611502
Mathematical Modelling of Natural Phenomena 11/5 2019-07-10
2016 Yang, F, Venkataraman, C, Styles, V and Madzvamuse, A
A robust and efficient adaptive multigrid solver for the optimal control of phase field formulations of geometric evolution laws.
published pages: 65-92, ISSN: 1815-2406, DOI: 10.4208/cicp.240715.080716a
Communications in Computational Physics 2/17 2019-07-10
2016 Nicole Schwarz, Rudolf Leube
Intermediate Filaments as Organizers of Cellular Space: How They Affect Mitochondrial Structure and Function
published pages: 30, ISSN: 2073-4409, DOI: 10.3390/cells5030030
Cells 5/3 2019-07-10
2017 Saskia J.E. Suijkerbuijk, Jacco van Rheenen
From good to bad: Intravital imaging of the hijack of physiological processes by cancer cells
published pages: 328-337, ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2017.04.015
Developmental Biology 428/2 2019-07-10
2018 D. Cusseddu, L. Edelstein-Keshet, J.A. Mackenzie, S. Portet, A. Madzvamuse
A coupled bulk-surface model for cell polarisation
published pages: , ISSN: 0022-5193, DOI: 10.1016/j.jtbi.2018.09.008
Journal of Theoretical Biology 2019-07-10
2017 Kritika Sahni, Dmytro Kotsur, Georg Dreissen, Dr. Julian Mattes, Dr. Bernd Hoffmann, Prof. Dr. Rudolf Merkel, Galiya Sakaeva
MIGRATION COMPONENT DYNAMICS AND FRONT-REAR INTERPLAY
published pages: , ISSN: , DOI:
3rd International Symposium on Mechanobiology 2017 2019-07-10
2017 Galiya Sakaeva, Dmytro Kotsur, Kritika Sahni, Georg Dreissen, Julian Mattes, Bernd Hoffmann, Rudolf Merkel
POLARIZED EPITHELIAL CELL MIGRATION DEPENDS ON REAR END STRESS FIBER TENSION
published pages: , ISSN: , DOI:
3rd International Symposium on Mechanobiology 2017 2019-07-10

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