Explore the words cloud of the CancerHetero project. It provides you a very rough idea of what is the project "CancerHetero" about.
The following table provides information about the project.
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
|Coordinator Country||Germany [DE]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-06-01 to 2020-05-31|
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|1||DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG||DE (HEIDELBERG)||coordinator||2˙000˙000.00|
It is now widely accepted that tumors are composed of heterogeneous population of cells, which contribute to many aspects of treatment resistance observed in clinic. Despite the acknowledgment of the tumor cell heterogeneity, little evidence was shown about complexity and dynamics of this heterogeneity in vivo, mainly because of lacking flexible genetic tools which allow sophisticated analysis in primary tumors. We recently developed a very efficient mouse somatic brain tumor model which have a full penetrance of high grade glioma development. Combination of this model with several transgenic mouse lines allow us to isolate and track different population of cells in primary tumors, most importantly, we also confirmed that this can be done on single cell level. Here I propose to use this set of valuable genetic tools to dissect the cellular heterogeneity in mouse gliomas. First we will perform several single cell lineage tracing experiment to demonstrate the contribution of brain tumor stem cell, tumor progenitors as well as the relatively differentiated cells, which will provide a complete data sets of clonal dynamics of different tumor cell types. Second we will further perform this tracing experiment with the presence of conventional chemotherapy. Third we will perform single cell RNA sequencing experiment to capture the molecular signature, which determines the cellular heterogeneity, discovered by single cell tracing. This result will be further validated by analysis of this molecular signatures in human primary tumors. We will also use our established in vivo target validation approach to manipulate the candidate molecular regulators to establish the functional correlation between molecular signature and phenotypic heterogeneity. This project will greatly improve our understanding of tumor heterogeneity, and possibly provide novel approaches and strategies of targeting human glioblastomas.
|year||authors and title||journal||last update|
Varun Venkataramani, Dimitar Ivanov Tanev, Christopher Strahle, Alexander Studier-Fischer, Laura Fankhauser, Tobias Kessler, Christoph KÃ¶rber, Markus Kardorff, Miriam Ratliff, Ruifan Xie, Heinz Horstmann, Mirko Messer, Sang Peter Paik, Johannes Knabbe, Felix Sahm, Felix T. Kurz, Azer Aylin AcikgÃ¶z, Frank HerrmannsdÃ¶rfer, Amit Agarwal, Dwight E. Bergles, Anthony Chalmers, Hrvoje Miletic, Sevin T
Glutamatergic synaptic input to glioma cells drives brain tumour progression
published pages: 532-538, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1564-x
Patricia Rusu, Chunxuan Shao, Anna Neuerburg, Azer Aylin AcikgÃ¶z, Yonghe Wu, Peng Zou, Prasad Phapale, Tchirupura S. Shankar, Kristina DÃ¶ring, Steffen Dettling, Huiqin KÃ¶rkel-Qu, GÃ¶zde Bekki, Barbara Costa, Te Guo, Olga Friesen, Magdalena Schlotter, Mathias Heikenwalder, Darjus F. Tschaharganeh, Bernd Bukau, GÃ¼nter Kramer, Peter Angel, Christel Herold-Mende, Bernhard Radlwimmer, Hai-Kun Liu
GPD1 Specifically Marks Dormant Glioma Stem Cells with a Distinct Metabolic Profile
published pages: 241-257.e8, ISSN: 1934-5909, DOI: 10.1016/j.stem.2019.06.004
|Cell Stem Cell 25/2||2020-02-06|
Ceren Duman, Kaneschka Yaqubi, Angelika Hoffmann, Azer Aylin AcikgÃ¶z, Andrey Korshunov, Martin Bendszus, Christel Herold-Mende, Hai-Kun Liu, Julieta Alfonso
Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation
published pages: 274-289.e5, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2019.04.004
|Cell Metabolism 30/2||2020-02-06|
Weijun Feng, Daisuke Kawauchi, Huiqin KÃ¶rkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-GonzÃ¡lez, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe CortÃ©s-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
published pages: 14758, ISSN: 2041-1723, DOI: 10.1038/ncomms14758
|Nature Communications 8||2019-05-31|
Yong-Sheng Cheng, Yue Zhuo, Katharina Hartmann, Peng Zou, Goezde Bekki, Heike Alter, Hai-Kun Liu
Autonomous Combinatorial Color Barcoding For Multiplexing Single Molecule RNA Visualization
published pages: , ISSN: , DOI: 10.1101/127373
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