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Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €


EC-Contrib. €






 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

inkt    tfs    adaptive    modifiers    populations    fellowship    lymphoid    balance    pathogens    effector    lineages    th1    id    innovative    pivotal    exposure    regulators    genes    rewarding    fates    strategies    tf    gain    tested    bifurcation    family    explores    mechanisms    subsequent    killer    invariant    natural    cells    polarized    critical    accomplished    lymphomas    prior    innate    gene    architecture    differentiation    powerful    acquired    arms    link    independently    cellular    th17    hypothesize    inhibitors    vaccination    throughput    heterogeneous    th2    ratio    form    proteins    chromatin    activate    regulates    technologies    cd4    defense    single    protein    microbial    nkt    dictate    networks    polarization    data    human    programs    specification    interplay    separately    bound    indirectly    hypothesis    immunotherapeutic    thresholds    lineage    thymic    combination    lymphocyte    regulatory    regulated    population    idea    host    possess    epigenetic    transcription   

Project "EpiNKT" data sheet

The following table provides information about the project.


Organization address
address: FLEMING STREET 34
postcode: 16672

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

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