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EpiNKT

Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

hypothesize    separately    lymphoid    immunotherapeutic    tested    dictate    bound    genes    throughput    technologies    regulated    regulates    acquired    networks    population    th17    indirectly    transcription    architecture    inhibitors    innate    host    proteins    balance    fellowship    tfs    gain    combination    activate    id    lineage    polarization    nkt    form    regulatory    critical    interplay    fates    possess    bifurcation    tf    mechanisms    killer    subsequent    natural    defense    thresholds    invariant    th1    inkt    hypothesis    lymphomas    idea    cellular    lymphocyte    modifiers    exposure    microbial    heterogeneous    epigenetic    data    strategies    lineages    rewarding    accomplished    explores    prior    specification    adaptive    effector    innovative    independently    chromatin    differentiation    programs    vaccination    polarized    thymic    populations    ratio    link    single    family    powerful    human    cd4    regulators    th2    pathogens    gene    protein    arms    pivotal    cells   

Project "EpiNKT" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.fleming.gr
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 164˙653.00

Map

 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

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The information about "EPINKT" are provided by the European Opendata Portal: CORDIS opendata.

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