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Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €


EC-Contrib. €






 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

lineages    thresholds    networks    th17    data    rewarding    transcription    regulates    activate    exposure    adaptive    separately    id    tf    polarized    innovative    powerful    invariant    dictate    microbial    tested    accomplished    th1    polarization    effector    vaccination    protein    cellular    lymphocyte    balance    indirectly    throughput    fellowship    form    bifurcation    killer    immunotherapeutic    regulatory    possess    hypothesize    family    subsequent    ratio    specification    single    heterogeneous    arms    lymphoid    chromatin    natural    lineage    cells    pivotal    population    innate    hypothesis    technologies    inkt    gene    genes    human    fates    lymphomas    tfs    thymic    explores    differentiation    prior    acquired    nkt    bound    gain    mechanisms    architecture    link    populations    th2    proteins    regulated    cd4    modifiers    idea    host    independently    combination    defense    programs    pathogens    regulators    strategies    epigenetic    critical    interplay    inhibitors   

Project "EpiNKT" data sheet

The following table provides information about the project.


Organization address
address: FLEMING STREET 34
postcode: 16672

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

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