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Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €


EC-Contrib. €






 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

id    polarization    th1    gain    combination    inhibitors    innate    thymic    lymphoid    balance    hypothesize    bound    thresholds    polarized    pivotal    th2    powerful    networks    pathogens    gene    architecture    adaptive    modifiers    defense    ratio    activate    inkt    regulatory    host    chromatin    effector    subsequent    innovative    interplay    tfs    epigenetic    heterogeneous    regulated    rewarding    tested    bifurcation    family    acquired    prior    programs    fates    explores    lineage    specification    protein    proteins    cellular    cells    idea    genes    single    lymphomas    hypothesis    throughput    human    tf    lineages    mechanisms    cd4    fellowship    regulators    indirectly    invariant    nkt    arms    microbial    independently    killer    technologies    population    critical    vaccination    dictate    populations    link    immunotherapeutic    differentiation    strategies    exposure    th17    lymphocyte    possess    transcription    separately    regulates    natural    form    accomplished    data   

Project "EpiNKT" data sheet

The following table provides information about the project.


Organization address
address: FLEMING STREET 34
postcode: 16672

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

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The information about "EPINKT" are provided by the European Opendata Portal: CORDIS opendata.

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