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EpiNKT

Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

bound    lymphocyte    architecture    gene    fellowship    epigenetic    lineage    regulated    th17    immunotherapeutic    activate    pivotal    form    regulatory    tf    invariant    separately    prior    ratio    polarized    cellular    cells    tested    chromatin    population    mechanisms    possess    thresholds    nkt    genes    indirectly    dictate    hypothesize    th2    defense    strategies    hypothesis    transcription    bifurcation    independently    innate    rewarding    arms    innovative    specification    inkt    regulates    thymic    host    combination    effector    tfs    killer    throughput    cd4    data    differentiation    inhibitors    family    link    explores    critical    lymphoid    balance    natural    modifiers    single    lineages    microbial    protein    interplay    id    human    adaptive    idea    heterogeneous    populations    networks    exposure    pathogens    vaccination    powerful    lymphomas    proteins    gain    polarization    acquired    th1    programs    regulators    fates    accomplished    subsequent    technologies   

Project "EpiNKT" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.fleming.gr
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 164˙653.00

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 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

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