Opendata, web and dolomites

EpiNKT

Transcriptional and epigenetic control of innate-like T lymphocyte development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EpiNKT project word cloud

Explore the words cloud of the EpiNKT project. It provides you a very rough idea of what is the project "EpiNKT" about.

prior    lineages    killer    hypothesis    bound    gain    transcription    combination    rewarding    balance    specification    th2    nkt    exposure    proteins    protein    subsequent    idea    tfs    fates    hypothesize    ratio    fellowship    populations    critical    host    regulates    differentiation    networks    form    throughput    data    link    polarization    population    adaptive    innate    lymphomas    epigenetic    inhibitors    family    independently    architecture    single    lymphocyte    id    natural    gene    separately    cd4    technologies    programs    cells    vaccination    tested    regulatory    explores    heterogeneous    genes    regulators    chromatin    effector    regulated    mechanisms    acquired    innovative    th1    modifiers    th17    immunotherapeutic    pivotal    inkt    dictate    lymphoid    arms    thresholds    pathogens    cellular    bifurcation    accomplished    lineage    tf    activate    indirectly    powerful    polarized    possess    defense    strategies    microbial    human    thymic    interplay    invariant   

Project "EpiNKT" data sheet

The following table provides information about the project.

Coordinator
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING 

Organization address
address: FLEMING STREET 34
city: VARI-ATHENS
postcode: 16672
website: www.fleming.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.fleming.gr
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-08-31   to  2017-08-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING EL (VARI-ATHENS) coordinator 164˙653.00

Map

 Project objective

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins, 2) Determine the epigenetic chromatin states and 3) Determine the role of chromatin modifiers in developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the Applicant will gain knowledge in the implementation of high-throughput technologies to study the interplay between TFs-chromatin regulators-chromatin architecture in lymphocyte differentiation.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPINKT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPINKT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

PaSION (2018)

A longitudinal assessment of treatment experience, symptoms and potential associations with biomarkers in cancer patients undergoing immune checkpoint inhibitor therapy

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More