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NEUROMITO

Mitochondrial Dynamics and Local Protein Synthesis in Dendrites

Total Cost €

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EC-Contrib. €

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Partnership

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 NEUROMITO project word cloud

Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.

distributed    brain    performing    compartmentalization    transcriptome    transcriptomics    abundance    purpose    dynamic    cell    demands    memory    morphology    synthesis    axons    plays    visualize    special    met    nuclear    dendrites    compartments    spines    messenger    translational    events    culture    dendritic    polarized    schuman    shared    protein    rna    translation    centralized    coding    dictates    sensitive    imaging    mitochondrial    encoded    regulation    sequencing    invented    proteome    dynamics    houses    meet    mass    presynaptic    techniques    microfluidic    elucidating    examine    spectometry    biophysics    max    lapse    local    majority    time    communication    plasticity    dr    synaptic    tools    experiments    neurites    somata    little    efficient    rnas    fluorescence    facility    compartmentalize    subcellular    individual    energy    co    neurons    neuron    proteins    mitochondria    planck    undergo    specialized    platforms    mechanism    regions    cells    employed    erin    isolated    lab    body    proteomics    function    found    group    terminals    transcriptomic    chambers    molecular    proteomic   

Project "NEUROMITO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://brain.mpg.de/institute/external-funding.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.

 Publications

year authors and title journal last update
List of publications.
2017 Vidhya Rangaraju, Susanne tom Dieck, Erin M Schuman
Local translation in neuronal compartments: how local is local?
published pages: 693-711, ISSN: 1469-221X, DOI: 10.15252/embr.201744045
EMBO reports 18/5 2019-06-13

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