Opendata, web and dolomites

NEUROMITO

Mitochondrial Dynamics and Local Protein Synthesis in Dendrites

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NEUROMITO project word cloud

Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.

lab    meet    messenger    imaging    techniques    distributed    biophysics    facility    coding    special    events    planck    cells    little    co    spectometry    visualize    demands    microfluidic    undergo    compartments    local    specialized    purpose    invented    cell    neurons    shared    proteins    examine    efficient    transcriptomics    centralized    time    group    proteomics    neuron    employed    tools    dynamic    nuclear    translation    function    proteomic    morphology    elucidating    sensitive    max    majority    somata    dendrites    terminals    plays    subcellular    found    erin    translational    dictates    body    rnas    mitochondria    mitochondrial    synaptic    platforms    transcriptomic    polarized    schuman    synthesis    rna    houses    compartmentalize    molecular    neurites    compartmentalization    isolated    spines    presynaptic    energy    dr    plasticity    abundance    proteome    protein    brain    fluorescence    met    culture    axons    lapse    performing    chambers    encoded    dynamics    individual    experiments    dendritic    mass    regions    regulation    transcriptome    memory    communication    sequencing    mechanism   

Project "NEUROMITO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://brain.mpg.de/institute/external-funding.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.

 Publications

year authors and title journal last update
List of publications.
2017 Vidhya Rangaraju, Susanne tom Dieck, Erin M Schuman
Local translation in neuronal compartments: how local is local?
published pages: 693-711, ISSN: 1469-221X, DOI: 10.15252/embr.201744045
EMBO reports 18/5 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEUROMITO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NEUROMITO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NeuroTick (2019)

The neuroscience of tickling: cerebellar mechanisms and sensory prediction

Read More  

EGeoCC (2019)

Ethnic geography and civil conflict

Read More  

Topo-circuit (2019)

Exploring topological phenomenon in RF circuits

Read More