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Mitochondrial Dynamics and Local Protein Synthesis in Dendrites

Total Cost €


EC-Contrib. €






 NEUROMITO project word cloud

Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.

function    isolated    distributed    special    somata    morphology    synthesis    protein    mitochondria    majority    group    transcriptomics    time    chambers    rna    neurites    terminals    centralized    body    meet    neurons    employed    techniques    compartmentalize    subcellular    schuman    regions    brain    local    dr    plasticity    proteins    dynamic    events    platforms    visualize    presynaptic    shared    mass    microfluidic    dendrites    erin    dictates    compartmentalization    transcriptomic    transcriptome    plays    max    cells    regulation    mitochondrial    communication    cell    met    translation    little    dynamics    lapse    energy    efficient    sensitive    imaging    individual    coding    examine    planck    spines    elucidating    culture    facility    demands    spectometry    proteomics    compartments    axons    tools    experiments    specialized    translational    invented    synaptic    memory    found    abundance    nuclear    polarized    co    mechanism    undergo    fluorescence    performing    rnas    proteome    molecular    lab    encoded    dendritic    proteomic    sequencing    houses    neuron    messenger    purpose    biophysics   

Project "NEUROMITO" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.


year authors and title journal last update
List of publications.
2017 Vidhya Rangaraju, Susanne tom Dieck, Erin M Schuman
Local translation in neuronal compartments: how local is local?
published pages: 693-711, ISSN: 1469-221X, DOI: 10.15252/embr.201744045
EMBO reports 18/5 2019-06-13

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