Opendata, web and dolomites

NEUROMITO

Mitochondrial Dynamics and Local Protein Synthesis in Dendrites

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NEUROMITO project word cloud

Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.

shared    distributed    encoded    fluorescence    schuman    energy    found    dendritic    centralized    abundance    sequencing    transcriptomic    mass    facility    function    group    synaptic    demands    dendrites    compartmentalization    individual    regulation    examine    special    communication    coding    imaging    memory    dynamic    rnas    compartmentalize    presynaptic    proteins    erin    houses    proteome    spines    body    undergo    plasticity    neurons    regions    planck    microfluidic    little    techniques    local    lapse    lab    events    messenger    time    co    neuron    meet    biophysics    majority    nuclear    cells    performing    mechanism    axons    mitochondrial    employed    sensitive    purpose    protein    subcellular    isolated    brain    mitochondria    morphology    efficient    dictates    tools    culture    proteomic    visualize    compartments    dr    rna    experiments    translational    polarized    specialized    neurites    cell    transcriptome    chambers    transcriptomics    terminals    plays    translation    dynamics    met    molecular    elucidating    max    spectometry    invented    synthesis    platforms    somata    proteomics   

Project "NEUROMITO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://brain.mpg.de/institute/external-funding.html
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 159˙460.00

Map

 Project objective

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.

 Publications

year authors and title journal last update
List of publications.
2017 Vidhya Rangaraju, Susanne tom Dieck, Erin M Schuman
Local translation in neuronal compartments: how local is local?
published pages: 693-711, ISSN: 1469-221X, DOI: 10.15252/embr.201744045
EMBO reports 18/5 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NEUROMITO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NEUROMITO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

ASIQS (2019)

Antiferromagnetic spintronics investigated by quantum sensing techniques

Read More