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Mitochondrial Dynamics and Local Protein Synthesis in Dendrites

Total Cost €


EC-Contrib. €






 NEUROMITO project word cloud

Explore the words cloud of the NEUROMITO project. It provides you a very rough idea of what is the project "NEUROMITO" about.

lapse    compartmentalization    fluorescence    energy    spines    schuman    messenger    synthesis    mitochondrial    facility    coding    houses    mechanism    cells    sequencing    found    invented    terminals    plasticity    neurons    time    microfluidic    presynaptic    spectometry    isolated    cell    visualize    specialized    morphology    compartments    regulation    rnas    transcriptomic    max    dictates    synaptic    co    little    nuclear    special    compartmentalize    met    biophysics    chambers    transcriptome    examine    abundance    memory    plays    transcriptomics    shared    function    mitochondria    translation    meet    undergo    group    experiments    techniques    subcellular    lab    demands    majority    erin    neurites    molecular    dendritic    encoded    proteome    events    sensitive    local    dynamics    communication    distributed    imaging    dr    translational    proteomics    dendrites    rna    purpose    dynamic    body    proteins    employed    culture    efficient    individual    polarized    tools    neuron    brain    planck    platforms    performing    mass    protein    regions    proteomic    elucidating    centralized    somata    axons   

Project "NEUROMITO" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2017-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Neurons are specialized cells with polarized morphology. Efficient function dictates that the molecular events crucial for synaptic communication are not centralized at the cell body but distributed to individual subcellular compartments - dendrites, dendritic spines, axons, presynaptic terminals. Local protein synthesis in dendrites is one such mechanism that plays a significant role in synaptic plasticity and memory. However, little is known on how the high-energy demands of local protein synthesis are met at dendrites and spines.Mitochondria, the 'energy houses' of cells, are found in great abundance in neurons. Mitochondria are associated with: nuclear-encoded messenger RNAs for local translation of great majority of mitochondrial proteins; non-coding RNAs for translational regulation of its protein abundance. To meet the local energy demands of protein synthesis, it is likely that mitochondria compartmentalize at dendritic regions and undergo dynamic changes in their proteome and transcriptome. My research project aims at elucidating the dynamics of mitochondria during high-energy demands of local protein synthesis. I will be performing experiments to examine mitochondrial compartmentalization in dendrites. Since simple fluorescence time-lapse imaging is not sensitive enough to visualize mitochondrial dynamics, I will use state-of-the-art imaging tools available in Dr. Erin Schuman’s lab for my experiments. I will also exploit the special neuron culture platforms, Microfluidic chambers, co-invented in the Schuman lab, for this purpose. In addition, I will be performing proteomic and transcriptomic analysis of mitochondria isolated from somata and neurites. To this end, I will use the shared protein mass spectometry facility of the Max Planck Institute for Brain Research and Biophysics for mitochondrial proteomics and the advanced RNA sequencing techniques employed in the Schuman group for mitochondrial transcriptomics.


year authors and title journal last update
List of publications.
2017 Vidhya Rangaraju, Susanne tom Dieck, Erin M Schuman
Local translation in neuronal compartments: how local is local?
published pages: 693-711, ISSN: 1469-221X, DOI: 10.15252/embr.201744045
EMBO reports 18/5 2019-06-13

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