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Als-on-a-chip

A tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening

Total Cost €

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EC-Contrib. €

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Partnership

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 Als-on-a-chip project word cloud

Explore the words cloud of the Als-on-a-chip project. It provides you a very rough idea of what is the project "Als-on-a-chip" about.

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Project "Als-on-a-chip" data sheet

The following table provides information about the project.

Coordinator
IDRYMA TECHNOLOGIAS KAI EREVNAS 

Organization address
address: N PLASTIRA STR 100
city: IRAKLEIO
postcode: 70013
website: www.forth.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.imbb.forth.gr/en/about-imbb/communicate-with-imbb-2/personel-directory-2/item/2416-tzeranis-dimitrios
 Total cost 164˙653 €
 EC max contribution 164˙653 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-09-30   to  2017-09-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) coordinator 164˙653.00

Map

 Project objective

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease, which affects approximately 2 per 100000 people. Currently, there is no ALS treatment. The main tool for preclinical ALS studies is the hSOD1G93A mouse. However, despite promising results in this model, all candidate drugs failed in clinical trials. These failures have been partly attributed to differences in the physiology of human and mice nerve cells, and the inability of the established drug design approach to block ALS pathology. There is urgent need for new tools that will complement this mouse model, improve understanding of ALS pathology, and suggest better leads for clinical trials. The objective of the proposed study is to develop a tissue-on-a-chip platform for systems-level studies of ALS pathology and drug screening. The system is built around a novel thin porous scaffold, where systems of normal or ALS-type mouse and human motor neurons will be cultured inside an appropriate 3D ECM analog, and their response (intracellular signaling, cell processes, cell-cell communication) to stimuli panels in the presence of drugs will be quantified via high-throughput proteomics and fluorescent imaging. Acquired data will be interpreted by modifications of state-of-the-art system biology tools. The outcomes of the proposed research can lead to new ALS treatments by identifying new drug targets (via mechanistic description of ALS pathology), and by developing better ways to evaluate candidate drugs before clinical trials (via comparing drug response in human and mouse cells). Results can be translated to other neurodegenerative diseases. Finally, the proposal offers an opportunity to a promising researcher to relocate from MIT to Greece, collaborate with a leading neurobiology lab in a world-class environment and a systems pharmacology SME, and translate his research via two startup companies. The host envisions the opportunity for a tenure-track faculty position for the experienced researcher.

 Publications

year authors and title journal last update
List of publications.
2017 A. Gkousioudi, D. S. Tzeranis, G. P. Kanakaris, M. Saloufas, L. G. Alexopoulos
Quantifying Cartilage Biomechanical Properties Using a Linearized Frequency-Domain Method
published pages: 2061-2074, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1861-1
Annals of Biomedical Engineering 45/9 2019-06-14
2017 Ioannis V. Yannas, Dimitrios S. Tzeranis, Peter T. C. So
Regeneration of injured skin and peripheral nerves requires control of wound contraction, not scar formation
published pages: 177-191, ISSN: 1067-1927, DOI: 10.1111/wrr.12516
Wound Repair and Regeneration 25/2 2019-06-14

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