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MIP4CELL SIGNED

Molecular Imprinting mediated regulation of cell behavior and related biomedical applications

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MIP4CELL" data sheet

The following table provides information about the project.

Coordinator
MALMO UNIVERSITET 

Organization address
address: NORDENSKIOLDSGATAN 1
city: MALMOE
postcode: 205 06
website: www.mah.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://www.mah.se/Forskning/Sok-pagaende-forskning/Molecular-Imprinting-mediated-regulation-of-cell-behavior-and-related-biomedical-applications/
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MALMO UNIVERSITET SE (MALMOE) coordinator 185˙857.00

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 Project objective

Tissue engineering or regenerative medicine, with its ultimate aim of developing true human replacement parts, has recently made enormous progress. The field refers to the use of human cells to replace or regenerate tissues or organs. Ideally, biomaterials for tissue engineering should efficiently mimic functionalities of the natural extracellular matrix (ECM). Hence surfaces of biomaterials should be engineered for dynamic control of cell behaviour. The objective of this proposal is to exploit molecular imprinting as a dynamic methodology for biofunctionalization and tissue engineering. Building on our previous proof of concept demonstration of systems for cell sheet harvesting, we expect to hereby obtain dynamic biofunctionalization of surfaces and overcome limitations of currently used methodologies (e.g. ligand leaching in non-covalent approach, loss of bioactivity in covalent approach, and lack of means for dynamic control of cells adhesion in both). The specific objectives of the proposal are as follows: 1) To establish bioimprinted hydrogels with thermo-responsive affinity to bioactive cell adhesive peptide as a generic platform for dynamically regulating cell adhesion and migration. 2) To develop thermo-responsive DNA aptamer imprinted hydrogels for dynamic recognition of specific cells via cell-aptamer interactions, and using as a platform for capture and release tumor cells. Therefore, this proposal will mimic the in vivo dynamic characters of the ECM and allow to obtain controllable cell behaviours in artificial biomaterials, thus having potential applications in medical diagnostic and regenerative medicine. Bringing together a highly talented and creative experienced researcher, who has already contributed decisively to the field, with a leading research group in the field of molecular imprinting and biomedicine will allow for the aforementioned objectives to be successfully accomplished.

 Publications

year authors and title journal last update
List of publications.
2017 Guoqing Pan, Sudhirkumar Shinde, Sing Yee Yeung, Miglė Jakštaitė, Qianjin Li, Anette Gjörloff Wingren, Börje Sellergren
Inside Back Cover: An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell-Biomaterial Interactions (Angew. Chem. Int. Ed. 50/2017)
published pages: 16091-16091, ISSN: 1433-7851, DOI: 10.1002/anie.201710972
Angewandte Chemie International Edition 56/50 2019-06-14
2015 Wei Chen, Yue Ma, Jianmin Pan, Zihui Meng, Guoqing Pan, Börje Sellergren
Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives
published pages: 1689-1715, ISSN: 2073-4360, DOI: 10.3390/polym7091478
Polymers 7/12 2019-06-14
2017 Guoqing Pan, Sudhirkumar Shinde, Sing Yee Yeung, Miglė Jakštaitė, Qianjin Li, Anette Gjörloff Wingren, Börje Sellergren
An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell-Biomaterial Interactions
published pages: 15959-15963, ISSN: 1433-7851, DOI: 10.1002/anie.201708635
Angewandte Chemie International Edition 56/50 2019-06-14

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The information about "MIP4CELL" are provided by the European Opendata Portal: CORDIS opendata.

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