EU H2020 Project "STEMPOP (Mechanisms of stem cell population dynamics and reprogramming)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/213762/index.html

STEMpop project word cloud

Explore the words cloud of the STEMpop project. It provides you a very rough idea of what is the project "STEMpop" about.

position regulatory fuel regenerated monitoring initiate multiple formed hfscs adult hfsc bi single stem obstacle network recapitulates directional treatments outstanding druggable transform organ populations cell resolve epidermis reprogramming scs how remodeling hair unprecedented spatiotemporal uncover epigenetic maintenance progenitors deregulated fundamental tissue discover aim2 dynamics fate decipher behaviors injuries medicine cells dynamic me implications clinically drive lack multipotent barriers progeny regeneration culture regulation paradigm therapies aim3 renewing organize carcinogenesis coordinated question biology complexity resolution deconstructing tissues decisions signaling coupled differentiation breakthrough self niche networks overcome population local aim1 architecture vitro stereotyped follicle maintained precise sc crosstalk plasticity manipulation fundaments repair invention gene phenotypic regenerative epidermal puts barrier cancers mechanistic

Project "STEMpop" data sheet

The following table provides information about the project.

Coordinator	HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Total cost	1˙999˙918 €
EC max contribution	1˙999˙918 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-05-01 to 2023-04-30

#	participants	country	role	EC contrib. [€]
1	HELSINGIN YLIOPISTO	FI (HELSINGIN YLIOPISTO)	coordinator	1˙999˙918.00

HELSINGIN YLIOPISTO

FI (HELSINGIN YLIOPISTO)

coordinator

1˙999˙918.00

Project objective

How complex but stereotyped tissues are formed, maintained and regenerated through local growth, differentiation and remodeling is a fundamental open question in biology. Understanding how single cell behaviors are coordinated on the population level and how population-level dynamics is coupled to tissue architecture is required to resolve this question as well as to develop stem cell (SC) therapies and effective treatments against cancers. As a self-renewing organ maintained by multiple distinct SC populations, the epidermis represents an outstanding, clinically highly relevant research paradigm to address this question. A key epidermal SC population are the hair follicle stem cells (HFSCs) that fuel hair follicle regeneration, repair epidermal injuries and, when deregulated, initiate carcinogenesis. The major obstacle in mechanistic understanding of HFSC regulation has been the lack of an in vitro culture system enabling their precise monitoring and manipulation. We have overcome this barrier by developing a method for long-term maintenance of multipotent HFSCs that recapitulates the complexity of HFSC fate decisions and dynamic crosstalk between HFSCs and their progeny. This breakthrough invention puts me in the unique position to investigate how HFSCs self-organize into a network of SCs and progenitors through population-level signaling crosstalk and phenotypic plasticity. This project will uncover the spatiotemporal dynamics of HFSCs fate decisions and establish the role of the niche in this process (Aim1), decipher key gene-regulatory networks and epigenetic barriers that control phenotypic plasticity (Aim2), and discover druggable signaling networks that drive bi-directional reprogramming of HFSCs and their progeny (Aim3). By deconstructing complex tissue-level behaviors at an unprecedented spatiotemporal resolution this study has the potential to transform the fundaments of adult SC biology with immediate implications to regenerative medicine.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yekaterina A Miroshnikova, Idan Cohen, Elena Ezhkova, Sara A WickstrÃ¶m Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis published pages: 46-51, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.04.014	Current Opinion in Genetics & Development 55	2020-01-29
2019	Leah C. Biggs, Christine S. Kim, Yekaterina A. Miroshnikova, Sara A. WickstrÃ¶m Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function published pages: , ISSN: 0022-202X, DOI: 10.1016/j.jid.2019.06.137	Journal of Investigative Dermatology	2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STEMPOP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STEMPOP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

Diverge (2019)

Generation of ultra-deep libraries of transcriptional activators for gene therapy

HyperCube (2020)

HyperCube: Gram scale production of ferrite nanocubes and thermo-responsive polymer coated nanocubes for medical applications and further exploitation in other hyperthermia fields