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Mechanisms of stem cell population dynamics and reprogramming

Total Cost €


EC-Contrib. €






 STEMpop project word cloud

Explore the words cloud of the STEMpop project. It provides you a very rough idea of what is the project "STEMpop" about.

organ    position    population    architecture    druggable    sc    regenerative    deconstructing    behaviors    me    transform    epidermal    barriers    hair    aim1    drive    repair    bi    fundaments    fuel    question    recapitulates    cancers    reprogramming    barrier    complexity    signaling    hfscs    adult    differentiation    coordinated    aim2    culture    breakthrough    coupled    uncover    scs    single    therapies    formed    directional    fundamental    overcome    crosstalk    hfsc    epidermis    progeny    dynamics    regulatory    populations    tissue    dynamic    medicine    invention    maintained    vitro    precise    mechanistic    lack    obstacle    manipulation    stem    regeneration    carcinogenesis    monitoring    regulation    follicle    epigenetic    phenotypic    progenitors    biology    maintenance    plasticity    puts    clinically    gene    multiple    unprecedented    decipher    deregulated    cells    implications    cell    network    local    treatments    spatiotemporal    regenerated    decisions    paradigm    stereotyped    fate    remodeling    organize    multipotent    how    resolution    tissues    self    injuries    discover    initiate    renewing    niche    networks    resolve    aim3    outstanding   

Project "STEMpop" data sheet

The following table provides information about the project.


Organization address
postcode: 14

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙999˙918 €
 EC max contribution 1˙999˙918 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

How complex but stereotyped tissues are formed, maintained and regenerated through local growth, differentiation and remodeling is a fundamental open question in biology. Understanding how single cell behaviors are coordinated on the population level and how population-level dynamics is coupled to tissue architecture is required to resolve this question as well as to develop stem cell (SC) therapies and effective treatments against cancers. As a self-renewing organ maintained by multiple distinct SC populations, the epidermis represents an outstanding, clinically highly relevant research paradigm to address this question. A key epidermal SC population are the hair follicle stem cells (HFSCs) that fuel hair follicle regeneration, repair epidermal injuries and, when deregulated, initiate carcinogenesis. The major obstacle in mechanistic understanding of HFSC regulation has been the lack of an in vitro culture system enabling their precise monitoring and manipulation. We have overcome this barrier by developing a method for long-term maintenance of multipotent HFSCs that recapitulates the complexity of HFSC fate decisions and dynamic crosstalk between HFSCs and their progeny. This breakthrough invention puts me in the unique position to investigate how HFSCs self-organize into a network of SCs and progenitors through population-level signaling crosstalk and phenotypic plasticity. This project will uncover the spatiotemporal dynamics of HFSCs fate decisions and establish the role of the niche in this process (Aim1), decipher key gene-regulatory networks and epigenetic barriers that control phenotypic plasticity (Aim2), and discover druggable signaling networks that drive bi-directional reprogramming of HFSCs and their progeny (Aim3). By deconstructing complex tissue-level behaviors at an unprecedented spatiotemporal resolution this study has the potential to transform the fundaments of adult SC biology with immediate implications to regenerative medicine.


year authors and title journal last update
List of publications.
2019 Yekaterina A Miroshnikova, Idan Cohen, Elena Ezhkova, Sara A Wickström
Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
published pages: 46-51, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.04.014
Current Opinion in Genetics & Development 55 2020-01-29
2019 Leah C. Biggs, Christine S. Kim, Yekaterina A. Miroshnikova, Sara A. Wickström
Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function
published pages: , ISSN: 0022-202X, DOI: 10.1016/j.jid.2019.06.137
Journal of Investigative Dermatology 2020-01-29

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The information about "STEMPOP" are provided by the European Opendata Portal: CORDIS opendata.

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