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STEMpop SIGNED

Mechanisms of stem cell population dynamics and reprogramming

Total Cost €

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EC-Contrib. €

0

Partnership

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 STEMpop project word cloud

Explore the words cloud of the STEMpop project. It provides you a very rough idea of what is the project "STEMpop" about.

adult    organ    multipotent    progenitors    transform    resolution    fate    networks    resolve    cell    epidermis    medicine    monitoring    discover    deconstructing    local    mechanistic    organize    initiate    biology    invention    position    me    implications    hfsc    epidermal    druggable    fuel    carcinogenesis    populations    barriers    crosstalk    vitro    formed    renewing    niche    aim3    deregulated    regenerative    precise    hfscs    stem    maintenance    question    architecture    decisions    plasticity    cells    cancers    fundaments    coordinated    drive    phenotypic    fundamental    complexity    barrier    aim1    maintained    single    injuries    regenerated    scs    differentiation    puts    dynamic    clinically    uncover    paradigm    breakthrough    aim2    coupled    decipher    lack    how    behaviors    gene    bi    sc    directional    spatiotemporal    recapitulates    regulatory    outstanding    unprecedented    tissues    network    obstacle    dynamics    progeny    treatments    follicle    manipulation    therapies    multiple    hair    remodeling    signaling    epigenetic    repair    tissue    stereotyped    regeneration    self    population    regulation    reprogramming    overcome    culture   

Project "STEMpop" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙999˙918 €
 EC max contribution 1˙999˙918 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2023-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙999˙918.00

Map

 Project objective

How complex but stereotyped tissues are formed, maintained and regenerated through local growth, differentiation and remodeling is a fundamental open question in biology. Understanding how single cell behaviors are coordinated on the population level and how population-level dynamics is coupled to tissue architecture is required to resolve this question as well as to develop stem cell (SC) therapies and effective treatments against cancers. As a self-renewing organ maintained by multiple distinct SC populations, the epidermis represents an outstanding, clinically highly relevant research paradigm to address this question. A key epidermal SC population are the hair follicle stem cells (HFSCs) that fuel hair follicle regeneration, repair epidermal injuries and, when deregulated, initiate carcinogenesis. The major obstacle in mechanistic understanding of HFSC regulation has been the lack of an in vitro culture system enabling their precise monitoring and manipulation. We have overcome this barrier by developing a method for long-term maintenance of multipotent HFSCs that recapitulates the complexity of HFSC fate decisions and dynamic crosstalk between HFSCs and their progeny. This breakthrough invention puts me in the unique position to investigate how HFSCs self-organize into a network of SCs and progenitors through population-level signaling crosstalk and phenotypic plasticity. This project will uncover the spatiotemporal dynamics of HFSCs fate decisions and establish the role of the niche in this process (Aim1), decipher key gene-regulatory networks and epigenetic barriers that control phenotypic plasticity (Aim2), and discover druggable signaling networks that drive bi-directional reprogramming of HFSCs and their progeny (Aim3). By deconstructing complex tissue-level behaviors at an unprecedented spatiotemporal resolution this study has the potential to transform the fundaments of adult SC biology with immediate implications to regenerative medicine.

 Publications

year authors and title journal last update
List of publications.
2019 Yekaterina A Miroshnikova, Idan Cohen, Elena Ezhkova, Sara A Wickström
Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
published pages: 46-51, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.04.014
Current Opinion in Genetics & Development 55 2020-01-29
2019 Leah C. Biggs, Christine S. Kim, Yekaterina A. Miroshnikova, Sara A. Wickström
Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function
published pages: , ISSN: 0022-202X, DOI: 10.1016/j.jid.2019.06.137
Journal of Investigative Dermatology 2020-01-29

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The information about "STEMPOP" are provided by the European Opendata Portal: CORDIS opendata.

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