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BARREL

Barrel Assemblies of Membrane Active Artificial Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BARREL project word cloud

Explore the words cloud of the BARREL project. It provides you a very rough idea of what is the project "BARREL" about.

toxicity    bacteria    cells    coupled    potentially    natural    characterisation    scattering    fundamentals    showing    assemblies    additional    equipped    mechanism    internal    structure    resistance    diversity    techniques    slow    md    oligomers    environment    protect    barrel    designed    assemble    positive    peptides    persistent    structures    attila    spectroscopy    hindering    molecular    gain    expertise    position    waxs    exploited    polarized    govern    strategies    ray    bota    toxic    host    antibiotic    antibiotics    qm    ideal    scaffolds    model    hydrophilic    dormant    enzyme    development    theoretical    solution    lipid    excellent    outreach    function    compounds    interactions    peptide    parts    tools    membranes    relationships    professionally    computationally    content    bilayer    antimicrobial    prof    constructs    structural    chances    hope    foldamer    scaffold    tenured    oligomer    saxs    foldamers    lipophilic    rational    membrane    lab    light    optimal    experimental    sheet   

Project "BARREL" data sheet

The following table provides information about the project.

Coordinator
TERMESZETTUDOMANYI KUTATOKOZPONT 

Organization address
address: MAGYAR TUDOSOK KORUTJA 2
city: BUDAPEST
postcode: 1117
website: www.ttk.mta.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Project website http://palyazat.ttk.mta.hu/ttk/
 Total cost 146˙239 €
 EC max contribution 146˙239 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TERMESZETTUDOMANYI KUTATOKOZPONT HU (BUDAPEST) coordinator 146˙239.00

Map

 Project objective

Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important. As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant. For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content. Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs. However, this mechanism is not understood, greatly hindering rational development of similar compounds. My main research goal is to reach insight into the structure-function relationships of the barrel molecular scaffold and to gain understanding of how its ability to protect internal parts from the environment may contribute to toxicity. To approach this problem, I aim to design and study foldamer oligomer assemblies. I hope to define the fundamentals of how peptide - lipid bilayer interactions govern formation of potentially toxic oligomers at a molecular level. This may be exploited for developing new antimicrobial compounds. Foldamers are highly similar to natural peptides in terms of structural diversity, thus they are ideal model systems, in several cases showing antibiotic activity and enzyme resistance. The computationally designed, structures will be studied with experimental methods in model membranes. I have experience with theoretical (QM&MD) and experimental tools (polarized light spectroscopy). However, characterisation of solution phase membrane systems requires use of additional techniques and I aim to learn more into X-ray scattering methods (SAXS,WAXS). In the lab of Prof. Attila Bota, I will have optimal conditions to gain expertise with these. The Host Institute will also provide a professionally organized and equipped environment, where I would have excellent chances to be offered a tenured position. I expect that the results and the planned outreach activities will have a positive impact on EU research.

 Publications

year authors and title journal last update
List of publications.
2016 Johan R. Johansson, Tamás Beke-Somfai, Anna Said Stålsmeden, and Nina Kann
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
published pages: , ISSN: 0009-2665, DOI:
Chemical Reviews 2019-07-24
2017 Ferenc Zsila, Szilvia Bősze, Kata Horváti, Imola Cs. Szigyártó and Tamás Beke-Somfaia
Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15
published pages: , ISSN: 2046-2069, DOI:
RSC Advances 2019-07-24

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