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BARREL

Barrel Assemblies of Membrane Active Artificial Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BARREL project word cloud

Explore the words cloud of the BARREL project. It provides you a very rough idea of what is the project "BARREL" about.

enzyme    spectroscopy    gain    md    strategies    content    toxicity    chances    toxic    antibiotic    assemblies    structural    oligomers    mechanism    foldamer    host    exploited    persistent    position    solution    development    waxs    outreach    foldamers    ideal    bacteria    potentially    molecular    tools    bota    cells    relationships    scaffold    professionally    model    antibiotics    antimicrobial    assemble    lab    showing    bilayer    structures    fundamentals    expertise    oligomer    scattering    designed    rational    characterisation    light    dormant    interactions    govern    diversity    hydrophilic    function    environment    optimal    experimental    barrel    excellent    membrane    protect    structure    sheet    polarized    hindering    qm    constructs    prof    parts    theoretical    natural    saxs    resistance    compounds    lipid    hope    equipped    peptides    tenured    coupled    ray    lipophilic    attila    additional    computationally    positive    internal    techniques    scaffolds    membranes    slow    peptide   

Project "BARREL" data sheet

The following table provides information about the project.

Coordinator
TERMESZETTUDOMANYI KUTATOKOZPONT 

Organization address
address: MAGYAR TUDOSOK KORUTJA 2
city: BUDAPEST
postcode: 1117
website: www.ttk.mta.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Project website http://palyazat.ttk.mta.hu/ttk/
 Total cost 146˙239 €
 EC max contribution 146˙239 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TERMESZETTUDOMANYI KUTATOKOZPONT HU (BUDAPEST) coordinator 146˙239.00

Map

 Project objective

Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important. As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant. For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content. Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs. However, this mechanism is not understood, greatly hindering rational development of similar compounds. My main research goal is to reach insight into the structure-function relationships of the barrel molecular scaffold and to gain understanding of how its ability to protect internal parts from the environment may contribute to toxicity. To approach this problem, I aim to design and study foldamer oligomer assemblies. I hope to define the fundamentals of how peptide - lipid bilayer interactions govern formation of potentially toxic oligomers at a molecular level. This may be exploited for developing new antimicrobial compounds. Foldamers are highly similar to natural peptides in terms of structural diversity, thus they are ideal model systems, in several cases showing antibiotic activity and enzyme resistance. The computationally designed, structures will be studied with experimental methods in model membranes. I have experience with theoretical (QM&MD) and experimental tools (polarized light spectroscopy). However, characterisation of solution phase membrane systems requires use of additional techniques and I aim to learn more into X-ray scattering methods (SAXS,WAXS). In the lab of Prof. Attila Bota, I will have optimal conditions to gain expertise with these. The Host Institute will also provide a professionally organized and equipped environment, where I would have excellent chances to be offered a tenured position. I expect that the results and the planned outreach activities will have a positive impact on EU research.

 Publications

year authors and title journal last update
List of publications.
2016 Johan R. Johansson, Tamás Beke-Somfai, Anna Said Stålsmeden, and Nina Kann
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
published pages: , ISSN: 0009-2665, DOI:
Chemical Reviews 2019-07-24
2017 Ferenc Zsila, Szilvia Bősze, Kata Horváti, Imola Cs. Szigyártó and Tamás Beke-Somfaia
Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15
published pages: , ISSN: 2046-2069, DOI:
RSC Advances 2019-07-24

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