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BRIDGES

Bioinformatic approaches to identify and detect both disease- and drug-related genomic alterations in breast cancer patients

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BRIDGES project word cloud

Explore the words cloud of the BRIDGES project. It provides you a very rough idea of what is the project "BRIDGES" about.

prognostic throughput sought alterations researcher implications inter cancer bank predictive driver metastatic data detect power breast model genomics proportion resistance efforts fundamental highlighted plasma significantly amount leads association unmet constitute reinforcing expanding overtreatment significance invasively disease guide matchless xenografts patients pharmacogenomics dimensional invasive quality incurable treatment medicine drug acquired women causes bio healthcare heterogeneity showing computational therapeutic integrating progression tools associations tumor intrinsic 3000 cutting edge strategy screenings clinical monitor life altered mutation molecular portfolio genetic patient recapitulate personalized monitoring classifications mining translational considerably trial

Project "BRIDGES" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.cruk.cam.ac.uk/research-groups/caldas-group
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2017-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

Breast cancer is the most common cancer among European women showing high clinical and molecular heterogeneity. Current clinical management causes patients overtreatment with implications on both patients’ quality of life and healthcare costs. Moreover, intrinsic or acquired tumor resistance to treatment leads to incurable metastatic progression in a significant proportion of patients. Advances in cancer genomics highlighted a high inter- and intra-tumor genetic heterogeneity, reinforcing the need for a mutation-based personalized treatment and a way to non-invasively monitor evolving disease. This project will significantly contribute in addressing such unmet challenge aiming 1) to identify altered breast cancer driver pathways, 2) to study their association with drug response and 3) to develop tools for a non-invasive assessment of such alterations. By integrating multi-dimensional molecular data from more than 3000 cases, driver pathways will be identified and their association with previous breast cancer classifications as well as their prognostic significance will be studied. Their predictive power will be investigated in a matchless bio-bank of Patient Derived Xenografts, a much more reliable pre-clinical model, able to recapitulate inter- and intra-tumor heterogeneity observed in patients. Multi-dimensional molecular data and high throughput drug screenings are available and will be integrated to identify novel pharmacogenomics associations. Mining of such amount of data will allow defining a portfolio of relevant breast cancer alterations that will be sought in plasma of patients from the DETECT trial, towards a non-invasive monitoring able to guide therapeutic strategy. Development and application of cutting-edge computational approaches is fundamental to reach above aims and it will constitute a major part of the efforts, considerably expanding Experienced Researcher's know-how in the field of cancer genomics and translational medicine.

Publications

List of publications.
year	authors and title	journal	last update
2017	Maurizio Callari, Stephen-John Sammut, Leticia De Mattos-Arruda, Alejandra Bruna, Oscar M. Rueda, Suet-Feung Chin, Carlos Caldas Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers published pages: , ISSN: 1756-994X, DOI: 10.1186/s13073-017-0425-1	Genome Medicine 9/1	2019-07-24
2016	Alejandra Bruna, OscarÂ M. Rueda, Wendy Greenwood, AnkitaÂ Sati Batra, Maurizio Callari, RajbirÂ Nath Batra, Katherine Pogrebniak, Jose Sandoval, JohnÂ W. Cassidy, Ana Tufegdzic-Vidakovic, Stephen-John Sammut, Linda Jones, Elena Provenzano, Richard Baird, Peter Eirew, James Hadfield, Matthew Eldridge, Anne McLaren-Douglas, Andrew Barthorpe, Howard Lightfoot, MarkÂ J. Oâ€™Connor, Joe Gray, Javier Cortes, Jose Baselga, Elisabetta Marangoni, AlanaÂ L. Welm, Samuel Aparicio, Violeta Serra, MathewÂ J. Garnett, Carlos Caldas A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds published pages: 260-274.e22, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.08.041	Cell 167/1	2019-07-24

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The information about "BRIDGES" are provided by the European Opendata Portal: CORDIS opendata.