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Smart Multimodal Microscopy for High-Throughput Developmental Biology in Real-Time

Total Cost €


EC-Contrib. €






 SmartMic project word cloud

Explore the words cloud of the SmartMic project. It provides you a very rough idea of what is the project "SmartMic" about.

fundamentally    fast    microscopy    platform    light    systematically    adaptively    draw    assemble    understand    time    sides    illumination    first    throughput    acquire    pumped    toxicity    cells    developmental    life    amount    microscopes    pushed    software    smart    reduces    embryos    acquisition    tissues    systematic    entirely    describe    multimodal    organisms    image    experiment    speeds    dramatically    spatial    detection    integrate    single    feeder    intact    breaking    inner    adaptive    fluorescence    fundamental    stereotypic    resolution    statistically    interplay    sheet    collect    living    reduce    stream    analyze    embryo    model    multiple    images    flexible    ground    hundreds    differ    limit    data    imaged    insights    microscope    plasticity    learns    workings    recording    questions    though    molecules    embryonic    establishing    seconds    hard    lack    temporal    photo    quest    spim    recorded    size    biology    disciplinary    automatically    samples    limits    diffraction   

Project "SmartMic" data sheet

The following table provides information about the project.


Organization address
city: Munich
postcode: 80539

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Fluorescence microscopy is a key technology in our quest to understand fundamental developmental processes of life. High-resolution images recorded in intact, living organisms deliver insights into the complex interplay of molecules, cells and tissues in real time. Even though the resolution of microscopes has been pushed beyond the diffraction limit, providing important insights into the inner workings of single cells, we still lack an understanding of plasticity in development: How does one embryo differ from another and how can we describe the 'average', stereotypic embryo? To address this long-standing multi-disciplinary challenge, we propose to develop an entirely novel microscopy hard- and software platform to systematically image and analyze embryos in real time. We will design and assemble a fast and flexible multimodal light-sheet microscope (SPIM) with adaptive illumination and detection from multiple sides. A fundamentally new concept of this proposal is the ability to adaptively change the recording's spatial and temporal resolution during the experiment: The microscope learns to acquire only the data of interest. Using a high-throughput sample feeder, many samples can be automatically pumped through the microscope and imaged within seconds for large-scale comparative developmental studies. Real-time processing will dramatically reduce the size of the data stream and thus, provide for the first time a platform to collect data from hundreds of samples. At the same time, by establishing a model for the observed embryo, we will integrate information from multiple samples to draw statistically relevant conclusions. Our ground-breaking concept of smart microscopy speeds up the acquisition, reduces the amount of data and limits photo-toxicity. It enables us to address fundamental questions in embryonic development that are out of reach by traditional methods. Smart microscopy will open up a new field of research: systematic real-time developmental biology.'

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The information about "SMARTMIC" are provided by the European Opendata Portal: CORDIS opendata.

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