Opendata, web and dolomites

PRIISM-HD SIGNED

Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PRIISM-HD project word cloud

Explore the words cloud of the PRIISM-HD project. It provides you a very rough idea of what is the project "PRIISM-HD" about.

network    physiology    phenotype    syndrome    driving    glucose    exemplified    morgan    regulate    normal    skeletal    potent    generation    strategy    muscle    molecular    currently    actions    lipid    ir    pathogenesis    lipidomic    proteomic    manipulation    therapeutic    collaborative    characterisations    resistant    toronto    patients    carolyn    disciplinary    locally    underpinning    dysregulated    chemists    precise    metabolic    complementary    university    sensitivity    diabetes    dramatically    pharmacological    intramyocellular    outgoing    integrating    gcs    metabolism    mechanisms    excess    researcher    expertise    glucocorticoids    dr    analytical    impacts    employs    understand    biologists    integrative    profiling    uncover    cummins    vitro    pharmacologists    vivo    homeostasis    urgent    t2dm    insulin    genetic    mediating    supervisor    cushing    prevalence    resistance    sk    modulators    significantly    regulating    gc    dovetail    unclear    nicely    unifying    stuart   

Project "PRIISM-HD" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.birmingham.ac.uk/staff/profiles/metabolism-systems/Morgan-Stuart.aspx
 Total cost 255˙349 €
 EC max contribution 255˙349 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2020-11-11

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 255˙349.00
2    THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO CA (TORONTO) partner 0.00

Map

 Project objective

Currently, there is an urgent need to understand the pathogenesis underpinning insulin resistance (IR) and type 2 diabetes (T2DM), due to their dramatically increasing prevalence. Glucocorticoids (GCs) are potent modulators of skeletal (Sk) muscle insulin sensitivity, as exemplified in patients with GC excess, Cushing’s syndrome, who develop IR and T2DM. Importantly, increased GC generation locally in muscle may contribute to the phenotype in T2DM patients. Although the precise molecular mechanisms driving IR in both T2DM and Cushing’s syndrome are unclear, dysregulated lipid metabolism is a common feature of insulin resistant muscle. This proposal aims to identify how GCs regulate intramyocellular lipid metabolism, and how this impacts on muscle insulin sensitivity. In addition, we will test a novel therapeutic target involved in mediating the metabolic actions of GCs, recently described by Dr Carolyn Cummins, the supervisor of the outgoing phase of this proposal. The complementary expertise in integrative molecular physiology of Dr Cummins, and of the Experienced Researcher, Dr Stuart Morgan, dovetail nicely within an established multi-disciplinary collaborative network of pharmacologists, molecular biologists and analytical chemists at the University of Toronto that have a unifying goal to uncover novel mechanisms regulating IR. Specifically, this proposal employs a systems approach by integrating both in vivo and in vitro pharmacological and genetic manipulation, with lipidomic/proteomic profiling and in-depth molecular characterisations. This novel strategy will significantly advance our understanding of key processes regulating insulin sensitivity in Sk muscle, a process essential for normal glucose homeostasis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRIISM-HD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRIISM-HD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Widow Spider Mating (2020)

Immature mating as a novel tactic of an invasive widow spider

Read More  

GLORIOUS (2019)

Digital Poetry in Today’s Russia: Canonisation and Translation

Read More  

Kidney-Treg (2020)

Characterisation and impact of kidney-resident Tregs in kidney physiology and pathologies

Read More