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ImmunityByPairDesign SIGNED

Design and redesign of a plant immune receptor complex

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ImmunityByPairDesign project word cloud

Explore the words cloud of the ImmunityByPairDesign project. It provides you a very rough idea of what is the project "ImmunityByPairDesign" about.

activation    richard    arabidopsis    pathogen    proteins    rrs1    protein    reconfigurations    elevate    tackle    defence    spectrometry    effectors    interactions    models    signalling    activate    resistance    understand    microbial    detect    receptors    host    molecules    designed    structural    nucleus    changing    regulation    electron    cryo    activated    modular    immune    capacities    biology    pairs    nlrs    acts    animal    converting    effector    perception    derivatives    poorly    intracellular    plant    cross    domain    mass    xl    ms    said    linking    solely    ligand    structure    release    ray    microscopy    complexes    principles    potentially    risk    dependent    feynman    crop    designing    paired    significance    cell    triggered    rps4    create    recognition    genetics    transcription    crystallography    nod    reveal    game    gain    molecular    receptor    negative    broad    domains    recognize    disease    detection    immunity    wrky   

Project "ImmunityByPairDesign" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website http://www.tsl.ac.uk/groups/jones-group/
 Total cost 2˙499˙978 €
 EC max contribution 2˙499˙978 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 1˙972˙649.00
2    JOHN INNES CENTRE UK (NORWICH) participant 527˙329.00

Map

 Project objective

This project will (1) reveal design principles of paired immune receptor complexes and (2) elevate plant disease resistance by enabling design of immune receptors with new recognition capacities.

Plant immunity is triggered upon pathogen detection by dedicated immune receptors. Like animal Nod-like receptors (NLRs), plant immune receptors have a modular structure and can work in pairs, both of which are required for defence activation upon recognition of specific pathogen proteins. How such intracellular immune receptor complexes activate defence solely upon recognition of microbial molecules is poorly understood.

Using novel high risk/high gain methods such as domain/domain cross-linking with mass spectrometry (XL-MS) and cryo-electron microscopy, as well as X-ray crystallography, genetics and cell biology, we will define at a structural level the domain/domain interactions within an immune receptor complex, and how these change upon pathogen perception. The Arabidopsis RPS4/RRS1 immune receptor acts in the cell nucleus to detect when pathogen effectors target WRKY transcription factors, converting effector interactions with the RRS1 WRKY domain into defence activation via RPS4. We will reveal the intra-molecular reconfigurations required for signalling and thus tackle a problem of broad significance, both for immune receptors, and for other intracellular receptors that are activated by ligand-dependent release from negative regulation.

We will also create and test derivatives of RPS4/RRS1 or related complexes that are designed to respond to effectors that target other host protein domains. As Richard Feynman said, “What I cannot create, I do not understand”. By designing immune receptors to recognize other pathogen effectors, we will test models of how plant immune receptors activate defence, but only upon effector recognition. This second objective is ambitious and high risk/high gain, but potentially game-changing for crop disease control.

 Publications

year authors and title journal last update
List of publications.
2017 Jonathan D. G. Jones, Mark J. Banfield
Two-faced TIRs trip the immune switch
published pages: 2445-2446, ISSN: 0027-8424, DOI: 10.1073/pnas.1700954114
Proceedings of the National Academy of Sciences 114/10 2020-02-12
2016 Zane Duxbury, Yan Ma, Oliver J. Furzer, Sung Un Huh, Volkan Cevik, Jonathan D.G. Jones, Panagiotis F. Sarris
Pathogen perception by NLRs in plants and animals: Parallel worlds
published pages: 769-781, ISSN: 0265-9247, DOI: 10.1002/bies.201600046
BioEssays 38/8 2020-02-12
2017 Richard Michelmore, Gitta Coaker, Rebecca Bart, Gwyn Beattie, Andrew Bent, Toby Bruce, Duncan Cameron, Jeffery Dangl, Savithramma Dinesh-Kumar, Rob Edwards, Sebastian Eves-van den Akker, Walter Gassmann, Jean T. Greenberg, Linda Hanley-Bowdoin, Richard J. Harrison, Jagger Harvey, Ping He, Alisa Huffaker, Scot Hulbert, Roger Innes, Jonathan D. G. Jones, Isgouhi Kaloshian, Sophien Kamoun, Fumiaki Ka
Foundational and Translational Research Opportunities to Improve Plant Health
published pages: 515-516, ISSN: 0894-0282, DOI: 10.1094/MPMI-01-17-0010-CR
Molecular Plant-Microbe Interactions 30/7 2020-02-12
2017 Rachel A. Hillmer, Kenichi Tsuda, Ghanasyam Rallapalli, Shuta Asai, William Truman, Matthew D. Papke, Hitoshi Sakakibara, Jonathan D. G. Jones, Chad L. Myers, Fumiaki Katagiri
The highly buffered Arabidopsis immune signaling network conceals the functions of its components
published pages: e1006639, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006639
PLOS Genetics 13/5 2020-02-12
2019 Jeffery L. Dangl, Jonathan D. G. Jones
A pentangular plant inflammasome
published pages: 31-32, ISSN: 0036-8075, DOI: 10.1126/science.aax0174
Science 364/6435 2020-02-12
2018 Yan Ma, Hailong Guo, Lanxi Hu, Paula Pons Martinez, Panagiotis N. Moschou, Volkan Cevik, Pingtao Ding, Zane Duxbury, Panagiotis F. Sarris, and Jonathan D. G. Jones
Distinct modes of derepression of anArabidopsisimmune receptor complex by two differentbacterial effectors
published pages: 10218-10227, ISSN: 1091-6490, DOI: 10.1073/pnas.1811858115
PNAS 41 2020-02-12

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