Opendata, web and dolomites


Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes – Sofia ref.: 115797

Total Cost €


EC-Contrib. €






 INNODIA project word cloud

Explore the words cloud of the INNODIA project. It provides you a very rough idea of what is the project "INNODIA" about.

trial    collection    oversee    biosamples    biomarker    disease    clinicians    t1d    establishment    coordinated    phenotyped    cell    trials    recruit    diagnosis    collaborative    designed    stools    create    biobank    network    prevention    standardized    experts    discovery    move    preclinical    longitudinal    cure    genetic    biomarkers    relatives    oriented    phenotyping    models    joins    serum    immunology    accelerate    urine    companies    beta    breakthrough    historical    interventions    family    living    collected    innodia    closer    samples    subjects    children    progress    blood    vitro    diabetes    animal    public    prospective    appropriately    translation    biological    plasma    members    at    active    clinical    patients    registries    science    biology    medicines    risk    made    pathophysiology    diverse    pharmaceutical    recall    bioinformatics    provides    basic    populations    consented    translating    infrastructure    adults    regulators    metabolic    deep    expertise    biorepositories    individuals   

Project "INNODIA" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 35˙558˙967 €
 EC max contribution 17˙630˙000 € (50%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2014-01-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2022-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 2˙319˙083.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 1˙132˙000.00
6    REGION HOVEDSTADEN DK (HILLEROD) participant 1˙130˙450.00
10    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 518˙926.00
11    UNIVERSITA DEGLI STUDI DI SIENA IT (SIENA) participant 474˙189.00
12    TURUN YLIOPISTO FI (Turku) participant 468˙000.00
13    UNIVERSITA DI PISA IT (PISA) participant 423˙000.00
14    OULUN YLIOPISTO FI (OULU) participant 414˙750.00
16    OSLO UNIVERSITETSSYKEHUS HF NO (OSLO) participant 374˙887.00
17    UNIVERSITAET ULM DE (ULM) participant 357˙650.00
18    UNIVERCELL BIOSOLUTIONS SAS FR (TOULOUSE) participant 353˙000.00
20    KING'S COLLEGE LONDON UK (LONDON) participant 322˙789.00
21    CARDIFF UNIVERSITY UK (CARDIFF) participant 322˙416.00
23    MEDIZINISCHE UNIVERSITAT GRAZ AT (GRAZ) participant 291˙480.00
25    UNIVERZA V LJUBLJANI SI (LJUBLJANA) participant 259˙820.00
29    UNIVERSITETET I OSLO NO (OSLO) participant 3˙763.00
30    Eli Lilly and Company Limited UK (Basingstoke) participant 0.00
32    JDRF INTERNATIONAL US (NEW YORK) participant 0.00
33    NOVO NORDISK A/S DK (BAGSVAERD) participant 0.00


 Project objective

Preclinical type 1 diabetes (T1D) research has made important advances in recent years, but less progress has been made in translating findings from in vitro and animal models into effective clinical interventions. INNODIA aims to achieve a breakthrough in the way in which we study T1D to enable us to move closer towards prevention and cure of T1D. To this end, INNODIA joins together the leading European experts from the fields of basic and clinical T1D research, four leading pharmaceutical companies with strong expertise in the discovery and development of diabetes medicines and the two leading public organizations involved in T1D research into one comprehensive collaborative consortium. The clinicians in INNODIA oversee T1D registries and have access to large populations of children and adults with T1D and family members at increased risk of developing the disease. The basic science researchers are experts in beta-cell pathophysiology, immunology, biomarker discovery, bioinformatics, systems biology and clinical trial design. INNODIA will accelerate understanding of T1D through coordinated studies of unique clinical samples and translation-oriented preclinical models. This should deliver novel biomarkers and interventions for testing in appropriately designed trials, to be developed in active collaboration with regulators and patients. INNODIA provides access to unique historical biorepositories and will create the Clinical Sample Network, a clinical EU infrastructure to recruit T1D subjects at diagnosis and at-risk relatives. These individuals will be deep-phenotyped and will provide biosamples, allowing the establishment of a ‘living biobank’ of subjects consented for recall. They will be characterized using standardized clinical, genetic and metabolic phenotyping procedures, including prospective, longitudinal sample collection to facilitate novel biomarker discovery. Diverse biological samples (blood, plasma, serum, urine, stools, etc.) will be collected at


List of deliverables.
Discovery and pre-clinical validation of novel biomarkers of β-cell mass, dysfunction and death in human T1D Documents, reports 2020-03-11 13:00:36
Imaging tool for -cell inflammation/death Documents, reports 2020-03-11 13:00:36
Discovery and pre-clinical validation of biomarkers of immune activation and regulation in human T1D Documents, reports 2020-03-11 13:00:37
Launch public website Websites, patent fillings, videos etc. 2020-02-20 08:30:35
Development of novel approaches for in vivo β-cell imaging Documents, reports 2020-02-20 08:30:35
A comprehensive pan-European research network for the study of the aetiology and prevention of T1D Documents, reports 2020-02-20 08:30:35
EUnPOD functioning Documents, reports 2020-02-20 08:30:35
Successful start-up of the project - Kick Off Meeting Documents, reports 2020-02-20 08:30:35

Take a look to the deliverables list in detail:  detailed list of INNODIA deliverables.


year authors and title journal last update
List of publications.
2019 Johan Verhagen, Norkhairin Yusuf, Emma L. Smith, Emily M. Whettlock, Kerina Naran, Sefina Arif, Mark Peakman
Proinsulin peptide promotes autoimmune diabetes in a novel HLA-DR3-DQ2-transgenic murine model of spontaneous disease
published pages: 2252-2261, ISSN: 0012-186X, DOI: 10.1007/s00125-019-04994-8
Diabetologia 62/12 2020-03-06
2019 Mireia Ramos-Rodríguez, Helena Raurell-Vila, Maikel L. Colli, Maria Inês Alvelos, Marc Subirana-Granés, Jonàs Juan-Mateu, Richard Norris, Jean-Valery Turatsinze, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Jamie R. J. Inshaw, Piero Marchetti, Lorenzo Piemonti, Manel Esteller, John A. Todd, Thomas O. Metz, Décio L. Eizirik, Lorenzo Pasquali
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
published pages: 1588-1595, ISSN: 1061-4036, DOI: 10.1038/s41588-019-0524-6
Nature Genetics 51/11 2020-03-06
2019 Pociot F
Capturing residual beta cell function in type 1 diabetes
published pages: 28-32, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4768-y
Diabetologia 2019 Jan;62(1) 2020-02-20
2019 Yeo L, Pujol-Autonell I, Baptista R, Eichmann M, Kronenberg-Versteeg D, Heck S, Dolton G, Sewell AK, Härkönen T, Mikk ML, Toppari J, Veijola R, Knip M, Ilonen J, Peakman M
Circulating β cell-specific CD8+ T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes
published pages: , ISSN: 0009-9104, DOI: 10.1111/cei.13391
Clinical and Experimental Immunology 2019 Oct 29 2020-02-20
2019 Boss M, Buitinga M, Jansen TJ, Brom M, Visser EP, Gotthardt M
PET-based dosimetry of [68Ga]Ga-NODAGA-exendin-4 in humans, a tracer for beta cell imaging
published pages: 112–116, ISSN: 0161-5505, DOI: 10.2967/jnumed.119.228627
The Journal of Nuclear Medicine 2020 Jan; 61(1) 2020-02-20
2019 Aashiq H. Mirza, Simranjeet Kaur, Lotte B. Nielsen, Joachim Størling, Reza Yarani, Martin Roursgaard, Elisabeth R. Mathiesen, Peter Damm, Jens Svare, Henrik B. Mortensen, Flemming Pociot
Breast Milk-Derived Extracellular Vesicles Enriched in Exosomes From Mothers With Type 1 Diabetes Contain Aberrant Levels of microRNAs
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02543
Frontiers in Immunology 10 2020-02-20
2019 Jennie H. M. Yang, Leena Khatri, Marius Mickunas, Evangelia Williams, Danijela Tatovic, Mohammad Alhadj Ali, Philippa Young, Penelope Moyle, Vishal Sahni, Ryan Wang, Rejbinder Kaur, Gillian M. Tannahill, Andrew R. Beaton, Danielle M. Gerlag, Caroline O. S. Savage, Antonella Napolitano Rosen, Frank Waldron-Lynch, Colin M. Dayan, Timothy I. M. Tree
Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02547
Frontiers in Immunology 10 2020-02-20
2018 Tine Tesovnik, Jernej Kovac, Tinka Hovnik, Klemen Dovc, Nataša Bratina, Tadej Battelino, Katarina Trebušak Podkrajšek
Association of Glycemic Control and Cell Stress With Telomere Attrition in Type 1 Diabetes
published pages: 879, ISSN: 2168-6203, DOI: 10.1001/jamapediatrics.2018.1175
JAMA Pediatrics 172/9 2020-02-20
2020 Stéphane Demine, Andrea Alex Schiavo, Sandra Marín-Cañas, Piero Marchetti, Miriam Cnop, Decio L. Eizirik
Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
published pages: , ISSN: 1757-6512, DOI: 10.1186/s13287-019-1523-3
Stem Cell Research & Therapy 11/1 2020-02-20
2019 Laura Nigi, Carla Maccora, Francesco Dotta, Guido Sebastiani
From immunohistological to anatomical alterations of human pancreas in type 1 diabetes: New concepts on the stage
published pages: , ISSN: 1520-7552, DOI: 10.1002/dmrr.3264
Diabetes/Metabolism Research and Reviews 2020-02-20
2019 Giuseppina Emanuela Grieco, Noemi Brusco, Giada Licata, Laura Nigi, Caterina Formichi, Francesco Dotta, Guido Sebastiani
Targeting microRNAs as a Therapeutic Strategy to Reduce Oxidative Stress in Diabetes
published pages: 6358, ISSN: 1422-0067, DOI: 10.3390/ijms20246358
International Journal of Molecular Sciences 20/24 2020-02-20
2019 Giuliana Ventriglia, Francesca Mancarella, Guido Sebastiani, Dana P. Cook, Roberto Mallone, Chantal Mathieu, Conny Gysemans, Francesco Dotta
miR-409-3p is reduced in plasma and islet immune infiltrates of NOD diabetic mice and is differentially expressed in people with type 1 diabetes
published pages: , ISSN: 0012-186X, DOI: 10.1007/s00125-019-05026-1
Diabetologia 2020-02-20
2019 Johan Henriksson, Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation
published pages: 882-896.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.11.044
Cell 176/4 2020-02-20
2019 Desh Deepak Singh, R. David Hawkins, Riitta Lahesmaa, Subhash K. Tripathi
CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases
published pages: , ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2019.05.007
Seminars in Cell & Developmental Biology 2020-02-20
2019 Raphael Scharfmann, Willem Staels, Olivier Albagli
The supply chain of human pancreatic β cell lines
published pages: 3511-3520, ISSN: 0021-9738, DOI: 10.1172/jci129484
Journal of Clinical Investigation 129/9 2020-02-20
2019 Yue Ruan, Ruben H. Willemsen, Malgorzata E. Wilinska, Martin Tauschmann, David B. Dunger, Roman Hovorka
Mixed‐meal tolerance test to assess residual beta‐cell secretion: Beyond the area‐under‐curve of plasma C‐peptide concentration
published pages: 282-285, ISSN: 1399-543X, DOI: 10.1111/pedi.12816
Pediatric Diabetes 20/3 2020-02-20
2019 Isabella Piga, Bram Heijs, Simone Nicolardi, Laura Giusti, Lorella Marselli, Piero Marchetti, Maria Rosa Mazzoni, Antonio Lucacchini, Liam A. McDonnell
Ultra-high resolution MALDI-FTICR-MSI analysis of intact proteins in mouse and human pancreas tissue
published pages: 10-16, ISSN: 1387-3806, DOI: 10.1016/j.ijms.2017.11.001
International Journal of Mass Spectrometry 437 2020-02-20
2018 Laura Nigi, Giuseppina Grieco, Giuliana Ventriglia, Noemi Brusco, Francesca Mancarella, Caterina Formichi, Francesco Dotta, Guido Sebastiani
MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes
published pages: 3705, ISSN: 1422-0067, DOI: 10.3390/ijms19123705
International Journal of Molecular Sciences 19/12 2020-02-20
2018 Marco Bugliani, Farooq Syed, Flavia M.M. Paula, Bilal A. Omar, Mara Suleiman, Sandra Mossuto, Francesca Grano, Francesco Cardarelli, Ugo Boggi, Fabio Vistoli, Franco Filipponi, Paolo De Simone, Lorella Marselli, Vincenzo De Tata, Bo Ahren, Decio L. Eizirik, Piero Marchetti
DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes
published pages: 186-193, ISSN: 0303-7207, DOI: 10.1016/j.mce.2018.01.019
Molecular and Cellular Endocrinology 473 2020-02-20
2017 Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard Holl
Polycystic Ovary Syndrome (PCOS) in Juvenile and Adult Type 1 Diabetes in a German/Austrian Cohort
published pages: 661-668, ISSN: 0947-7349, DOI: 10.1055/s-0043-104701
Experimental and Clinical Endocrinology & Diabetes 125/10 2020-02-20
2019 Diego Balboa, Rashmi B. Prasad, Leif Groop, Timo Otonkoski
Genome editing of human pancreatic beta cell models: problems, possibilities and outlook
published pages: 1329-1336, ISSN: 0012-186X, DOI: 10.1007/s00125-019-4908-z
Diabetologia 62/8 2020-02-20
2019 Fabio Arturo Grieco, Andrea Alex Schiavo, Flora Brozzi, Jonas Juan-Mateu, Marco Bugliani, Piero Marchetti, Décio Eizirik
The microRNAs miR-211-5p and miR-204-5p modulate ER stress in human beta cells
published pages: , ISSN: 0952-5041, DOI: 10.1530/jme-19-0066
Journal of Molecular Endocrinology 2020-02-20
2018 Nicole Prinz, Anke Schwandt, Marianne Becker, Christian Denzer, Monika Flury, Maria Fritsch, Angela Galler, Andreas Lemmer, Matthias Papsch, Thomas Reinehr, Joachim Rosenbauer, Reinhard W. Holl
Trajectories of Body Mass Index from Childhood to Young Adulthood among Patients with Type 1 Diabetes—A Longitudinal Group-Based Modeling Approach Based on the DPV Registry
published pages: 78-85.e4, ISSN: 0022-3476, DOI: 10.1016/j.jpeds.2018.05.014
The Journal of Pediatrics 201 2020-02-20
2019 Niina Lietzén, Karoliina Hirvonen, Anni Honkimaa, Tanja Buchacher, Jutta E. Laiho, Sami Oikarinen, Magdalena A. Mazur, Malin Flodström-Tullberg, Eric Dufour, Amir-Babak Sioofy-Khojine, Heikki Hyöty, Riitta Lahesmaa
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells
published pages: 340-357, ISSN: 2589-0042, DOI: 10.1016/j.isci.2019.07.040
iScience 19 2020-02-20
2019 Subhash K. Tripathi, Tommi Välikangas, Ankitha Shetty, Mohd Moin Khan, Robert Moulder, Santosh D. Bhosale, Elina Komsi, Verna Salo, Rafael Sales De Albuquerque, Omid Rasool, Sanjeev Galande, Laura L. Elo, Riitta Lahesmaa
Quantitative Proteomics Reveals the Dynamic Protein Landscape during Initiation of Human Th17 Cell Polarization
published pages: 334-355, ISSN: 2589-0042, DOI: 10.1016/j.isci.2018.12.020
iScience 11 2020-02-20
2018 Barbara Bohn, Kirsten Mönkemöller, Dörte Hilgard, Axel Dost, Karl Otfried Schwab, Eggert Lilienthal, Elke Hammer, Kathrin Hake, Maria Fritsch, Bettina Gohlke, Carine de Beaufort, Reinhard W Holl
Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg
published pages: 937-944, ISSN: 1399-543X, DOI: 10.1111/pedi.12656
Pediatric Diabetes 19/5 2020-02-20
2019 Maikel L. Colli, Flavia M. Paula, Lorella Marselli, Piero Marchetti, Merja Roivainen, Decio L. Eizirik, Anne Op de beeck
Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells
published pages: 375-390, ISSN: 1662-811X, DOI: 10.1159/000496034
Journal of Innate Immunity 11/4 2020-02-20
2019 Pamela L. Toledo, Juha M. Torkko, Andreas Müller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
ICA512 RESP18 homology domain is a protein-condensing factor and insulin fibrillation inhibitor
published pages: 8564-8576, ISSN: 0021-9258, DOI: 10.1074/jbc.ra119.007607
Journal of Biological Chemistry 294/21 2020-02-20
2018 Daniel J. DeSalvo, Kellee M. Miller, Julia M. Hermann, David M. Maahs, Sabine E. Hofer, Mark A. Clements, Eggert Lilienthal, Jennifer L. Sherr, Martin Tauschmann, Reinhard W. Holl
Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative
published pages: 1271-1275, ISSN: 1399-543X, DOI: 10.1111/pedi.12711
Pediatric Diabetes 19/7 2020-02-20
2019 Mijke Buitinga, Tom Jansen, Inge van der Kroon, Wietske Woliner-van der Weg, Marti Boss, Marcel Janssen, Erik Aarntzen, Martin Béhé, Damian Wild, Eric Visser, Maarten Brom, Martin Gotthardt
Succinylated Gelatin Improves the Theranostic Potential of Radiolabeled Exendin-4 in Insulinoma Patients
published pages: 812-816, ISSN: 0161-5505, DOI: 10.2967/jnumed.118.219980
Journal of Nuclear Medicine 60/6 2020-02-20
2017 Anke Schwandt, Julia M. Hermann, Joachim Rosenbauer, Claudia Boettcher, Désirée Dunstheimer, Jürgen Grulich-Henn, Oliver Kuss, Birgit Rami-Merhar, Christian Vogel, Reinhard W. Holl
Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling Approach
published pages: 309-316, ISSN: 0149-5992, DOI: 10.2337/dc16-1625
Diabetes Care 40/3 2020-02-20
2018 Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl
Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry
published pages: 1354-1361, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4580-8
Diabetologia 61/6 2020-02-20
2018 Anke Schwandt, Dominik Bergis, Michael Denkinger, Katja S.C. Gollisch, Dirk Sandig, Harald Stingl, Stefan Zimny, Reinhard W. Holl
Risk factors for decline in renal function among young adults with type 1 diabetes
published pages: 940-946, ISSN: 1056-8727, DOI: 10.1016/j.jdiacomp.2018.07.007
Journal of Diabetes and its Complications 32/10 2020-02-20
2019 Niels H. Birkebaek, Julia M. Hermann, Lena Hanberger, Dimitrios Charalampopoulos, Reinhard W. Holl, Torild Skrivarhaug, Karin Aakesson, Justin T. Warner, Ann K. Drivvoll, Ann-Marie Svensson, Terence Stephenson, Sabine E. Hofer, Siri Fredheim, Siv J. Kummernes, Rakesh Amin, Birgit Rami-Merhar, Anders Johansen, Thomas M. Kapellen, Doerte Hilgard, Knut Dahl-Jørgensen, Elke Froehlich-Reiterer, Maria
Center Size and Glycemic Control: An International Study With 504 Centers From Seven Countries
published pages: e37-e39, ISSN: 0149-5992, DOI: 10.2337/dc18-1253
Diabetes Care 42/3 2020-02-20
2018 Lorraine Yeo, Alyssa Woodwyk, Sanjana Sood, Anna Lorenc, Martin Eichmann, Irma Pujol-Autonell, Rosella Melchiotti, Ania Skowera, Efthymios Fidanis, Garry M. Dolton, Katie Tungatt, Andrew K. Sewell, Susanne Heck, Alka Saxena, Craig A. Beam, Mark Peakman
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
published pages: 3460-3474, ISSN: 0021-9738, DOI: 10.1172/JCI120555
Journal of Clinical Investigation 128/8 2020-02-20
2016 Fabio Arturo Grieco, Guido Sebastiani, Jonas Juan-Mateu, Olatz Villate, Laura Marroqui, Laurence Ladrière, Ksenya Tugay, Romano Regazzi, Marco Bugliani, Piero Marchetti, Francesco Dotta, Décio L. Eizirik
MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells
published pages: 100-112, ISSN: 0012-1797, DOI: 10.2337/db16-0592
Diabetes 66/1 2020-02-20
2017 Kira Meyerovich, Natalia M. Violato, Makiko Fukaya, Violette Dirix, Nathalie Pachera, Lorella Marselli, Piero Marchetti, Andreas Strasser, Decio L. Eizirik, Alessandra K. Cardozo
MCL-1 Is a Key Antiapoptotic Protein in Human and Rodent Pancreatic β-Cells
published pages: 2446-2458, ISSN: 0012-1797, DOI: 10.2337/db16-1252
Diabetes 66/9 2020-02-20
2017 James Harbige, Martin Eichmann, Mark Peakman
New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
published pages: 12-20, ISSN: 0896-8411, DOI: 10.1016/j.jaut.2017.08.001
Journal of Autoimmunity 84 2020-02-20
2018 Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu, Lut Overbergh
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
published pages: 2337-2348, ISSN: 0012-1797, DOI: 10.2337/db18-0295
Diabetes 67/11 2020-02-20
2017 Daniel A. Cunha, Monia Cito, Fabio Arturo Grieco, Cristina Cosentino, Tatiana Danilova, Laurence Ladrière, Maria Lindahl, Andrii Domanskyi, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop
Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF)
published pages: 14977-14988, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.769877
Journal of Biological Chemistry 292/36 2020-02-20
2017 Laura Marroqui, Reinaldo S. Dos Santos, Anne Op de beeck, Alexandra Coomans de Brachène, Lorella Marselli, Piero Marchetti, Decio L. Eizirik
Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes
published pages: 656-667, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4201-3
Diabetologia 60/4 2020-02-20
2017 Inne Crèvecoeur, Saurabh Vig, Chantal Mathieu, Lut Overbergh
Understanding type 1 diabetes through proteomics
published pages: 571-580, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1345633
Expert Review of Proteomics 14/7 2020-02-20
2017 Reinaldo S Dos Santos, Laura Marroqui, Fabio A Grieco, Lorella Marselli, Mara Suleiman, Stefan R Henz, Piero Marchetti, Rasmus Wernersson, Decio L Eizirik
Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis
published pages: 2503-2521, ISSN: 0013-7227, DOI: 10.1210/en.2017-00104
Endocrinology 158/8 2020-02-20
2018 Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Francesco Dotta, Raphael Scharfmann, Bruno Kyewski, Roberto Mallone
Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
published pages: eaao4013, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aao4013
Science Immunology 3/20 2020-02-20
2018 Niina Lietzén, Lu Cheng, Robert Moulder, Heli Siljander, Essi Laajala, Taina Härkönen, Aleksandr Peet, Aki Vehtari, Vallo Tillmann, Mikael Knip, Harri Lähdesmäki, Riitta Lahesmaa
Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-24019-5
Scientific Reports 8/1 2020-02-20
2018 Ruben H Willemsen, Keith Burling, Peter Barker, Fran Ackland, Renuka P Dias, Julie Edge, Anne Smith, John Todd, Boryana Lopez, Adrian P Mander, Catherine Guy, David B Dunger
Frequent Monitoring of C-Peptide Levels in Newly Diagnosed Type 1 Subjects Using Dried Blood Spots Collected at Home
published pages: 3350-3358, ISSN: 0021-972X, DOI: 10.1210/jc.2018-00500
The Journal of Clinical Endocrinology & Metabolism 103/9 2020-02-20
2018 Pia Leete, Roberto Mallone, Sarah J. Richardson, Jay M. Sosenko, Maria J. Redondo, Carmella Evans-Molina
The Effect of Age on the Progression and Severity of Type 1 Diabetes: Potential Effects on Disease Mechanisms
published pages: , ISSN: 1534-4827, DOI: 10.1007/s11892-018-1083-4
Current Diabetes Reports 18/11 2020-02-20
2018 Alexandra Coomans de Brachène, Reinaldo S. Dos Santos, Laura Marroqui, Maikel L. Colli, Lorella Marselli, Raghavendra G. Mirmira, Piero Marchetti, Decio L. Eizirik
IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells
published pages: 636-640, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4536-4
Diabetologia 61/3 2020-02-20
2018 Flavia M. M. Paula, Nayara C. Leite, Patricia C. Borck, Ricardo Freitas-Dias, Miriam Cnop, Mara P. T. Chacon-Mikahil, Claudia R. Cavaglieri, Piero Marchetti, Antonio C. Boschero, Claudio C. Zoppi, Decio L. Eizirik
Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis
published pages: 1524-1536, ISSN: 0892-6638, DOI: 10.1096/fj.201700710R
The FASEB Journal 32/3 2020-02-20
2017 Miriam Cnop, Tomasz Klupa, Nikolaos Tentolouris, Anna Novials, Rémy Burcelin, Mischa van Eimeren
Europe has to step up its efforts to produce innovative and safe diabetes technology
published pages: 2532-2533, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4455-4
Diabetologia 60/12 2020-02-20
2018 Francesco Dotta, Giuliana Ventriglia, Isaac V. Snowhite, Alberto Pugliese
published pages: 237-245, ISSN: 1752-296X, DOI: 10.1097/MED.0000000000000420
Current Opinion in Endocrinology & Diabetes and Obesity 25/4 2020-02-20
2017 Alexander Balhuizen, Sam Massa, Iris Mathijs, Jean-Valery Turatsinze, Jens De Vos, Stéphane Demine, Catarina Xavier, Olatz Villate, Isabelle Millard, Dominique Egrise, Carmen Capito, Raphaël Scharfmann, Pieter In’t Veld, Piero Marchetti, Serge Muyldermans, Serge Goldman, Tony Lahoutte, Luc Bouwens, Decio L. Eizirik, Nick Devoogdt
A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-15417-2
Scientific Reports 7/1 2020-02-20
2018 Jonàs Juan-Mateu, Maria Inês Alvelos, Jean-Valéry Turatsinze, Olatz Villate, Esther Lizarraga-Mollinedo, Fabio Arturo Grieco, Laura Marroquí, Marco Bugliani, Piero Marchetti, Décio L. Eizirik
SRp55 Regulates a Splicing Network That Controls Human Pancreatic β-Cell Function and Survival
published pages: 423-436, ISSN: 0012-1797, DOI: 10.2337/db17-0736
Diabetes 67/3 2020-02-20
2018 Sergio Gonzalez-Duque, Marie Eliane Azoury, Maikel L. Colli, Georgia Afonso, Jean-Valery Turatsinze, Laura Nigi, Ana Ines Lalanne, Guido Sebastiani, Alexia Carré, Sheena Pinto, Slobodan Culina, Noémie Corcos, Marco Bugliani, Piero Marchetti, Mathieu Armanet, Marc Diedisheim, Bruno Kyewski, Lars M. Steinmetz, Søren Buus, Sylvaine You, Daniele Dubois-Laforgue, Etienne Larger, Jean-Paul Beressi, Graziella Bruno, Francesco Dotta, Raphael Scharfmann, Decio L. Eizirik, Yann Verdier, Joelle Vinh, Roberto Mallone
Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors
published pages: 946-960.e6, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.07.007
Cell Metabolism 28/6 2020-02-20
2018 Maikel L. Colli, Jessica L.E. Hill, Laura Marroquí, Jessica Chaffey, Reinaldo S. Dos Santos, Pia Leete, Alexandra Coomans de Brachène, Flavia M.M. Paula, Anne Op de Beeck, Angela Castela, Lorella Marselli, Lars Krogvold, Knut Dahl-Jorgensen, Piero Marchetti, Noel G. Morgan, Sarah J. Richardson, Décio L. Eizirik
PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction
published pages: 367-375, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2018.09.040
EBioMedicine 36 2020-02-20
2018 Stéphane Demine, Alexander Balhuizen, Vinciane Debaille, Lieke Joosten, Maïté Fereau, Satya Chilla, Isabelle Millard, Raphaël Scharfmann, Dominique Egrise, Serge Goldman, Piero Marchetti, Martin Gotthardt, Sophie Laurent, Carmen Burtea, Decio Eizirik
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa
published pages: 2100, ISSN: 1420-3049, DOI: 10.3390/molecules23092100
Molecules 23/9 2020-02-20
2018 Maria Inês Alvelos, Jonàs Juan-Mateu, Maikel Luis Colli, Jean-Valéry Turatsinze, Décio L. Eizirik
When one becomes many-Alternative splicing in β-cell function and failure
published pages: 77-87, ISSN: 1462-8902, DOI: 10.1111/dom.13388
Diabetes, Obesity and Metabolism 20 2020-02-20
2018 Emily K. Sims, Carmella Evans-Molina, Sarah A. Tersey, Decio L. Eizirik, Raghavendra G. Mirmira
Biomarkers of islet beta cell stress and death in type 1 diabetes
published pages: 2259-2265, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4712-1
Diabetologia 61/11 2020-02-20
2018 Chantal Mathieu, Riitta Lahesmaa, Ezio Bonifacio, Peter Achenbach, Timothy Tree
Immunological biomarkers for the development and progression of type 1 diabetes
published pages: 2252-2258, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4726-8
Diabetologia 61/11 2020-02-20
2018 Diego Balboa, Jonna Saarimäki-Vire, Daniel Borshagovski, Mantas Survila, Päivi Lindholm, Emilia Galli, Solja Eurola, Jarkko Ustinov, Heli Grym, Hanna Huopio, Juha Partanen, Kirmo Wartiovaara, Timo Otonkoski
Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.38519
eLife 7 2020-02-20
2018 Reinaldo S. Dos Santos, Laura Marroqui, Teresa Velayos, Ane Olazagoitia-Garmendia, Amaia Jauregi-Miguel, Ainara Castellanos-Rubio, Decio L. Eizirik, Luis Castaño, Izortze Santin
DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway
published pages: , ISSN: 0012-186X, DOI: 10.1007/s00125-018-4782-0
Diabetologia 2020-02-20
2017 Christina Reinauer, Joachim Rosenbauer, Christina Bächle, Christian Herder, Michael Roden, Sian Ellard, Elisa De Franco, Beate Karges, Reinhard Holl, Jürgen Enczmann, Thomas Meissner
The Clinical Course of Patients with Preschool Manifestation of Type 1 Diabetes Is Independent of the HLA DR-DQ Genotype
published pages: 146, ISSN: 2073-4425, DOI: 10.3390/genes8050146
Genes 8/5 2020-02-20
2018 Denise Müller, Tanja Telieps, Anne Eugster, Christina Weinzierl, Manja Jolink, Anette-Gabriele Ziegler, Ezio Bonifacio
Novel minor HLA DR associated antigens in type 1 diabetes
published pages: 87-91, ISSN: 1521-6616, DOI: 10.1016/j.clim.2018.07.001
Clinical Immunology 194 2020-02-20
2018 Piero Marchetti, Mara Suleiman, Lorella Marselli
Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
published pages: 770-774, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4546-x
Diabetologia 61/4 2020-02-20
2018 Masaya Oshima, Klaus-Peter Knoch, Marc Diedisheim, Antje Petzold, Pierre Cattan, Marco Bugliani, Piero Marchetti, Pratik Choudhary, Guo-Cai Huang, Stefan R. Bornstein, Michele Solimena, Olivier Albagli-Curiel, Raphael Scharfmann
Virus-like infection induces human β cell dedifferentiation
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.97732
JCI Insight 3/3 2020-02-20
2018 Elina Hakonen, Vikash Chandra, Christopher L. Fogarty, Nancy Yiu-Lin Yu, Jarkko Ustinov, Shintaro Katayama, Emilia Galli, Tatiana Danilova, Päivi Lindholm, Aki Vartiainen, Elisabet Einarsdottir, Kaarel Krjutškov, Juha Kere, Mart Saarma, Maria Lindahl, Timo Otonkoski
MANF protects human pancreatic beta cells against stress-induced cell death
published pages: 2202-2214, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4687-y
Diabetologia 61/10 2020-02-20

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