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BacCellEpi SIGNED

Bacterial, cellular and epigenetic factors that control enteropathogenicity

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BacCellEpi" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙147˙500 €
 EC max contribution 1˙147˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2019-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙147˙500.00

Map

 Project objective

Understanding the establishment and persistence of bacterial infections in the gut requires integrating an ensemble of factors including bacterial and host components and the presence of other microorganisms. We will capitalize on 25 years of studies on the bacterium Listeria monocytogenes used as a model, to focus on three objectives which will significantly increase our knowledge of the bacterium, of the cell biology of infection and of the epigenetic reprogramming upon infection. Our aims are: - at the bacterial level : to describe for the first time, the proteomic landscape of a bacterium during switch from saprophytism to virulence. We will use a proteogenomic approach together with ribosome profiling, to analyze the translation of the whole transcriptome after bacterial growth in several conditions, including in vivo, in order to barcode all the proteins which play a role in infection. This will open the way to assess the role of 1) small proteins; 2) internal translation initiation sites ; 3) the coupling of transcription and translation. - at the host cell level : To decipher the molecular mechanisms underlying the dynamics and role in infection of host intracellular organelles, starting with mitochondria. - At the host epigenetic level : To explore how the microbe reprograms host transcription and how tolerance to a commensal such as Akkermansia muciniphila differs from responsiveness to a pathogen insult, at the level of histones and mRNA modifications by studying 1) chromatin remodeling, in particular histones modifications during infection ; 2) modifications of the epitranscriptome during Listeria infection and colonization with Akkermansia ; 3) whether there is an epigenetic memory of infection and colonization. This ambitious multidisciplinary project will not only generate new concepts in infection biology but also will unravel fundamental mechanisms in microbiology, cell biology, and epigenetics opening new avenues for further research.

 Publications

year authors and title journal last update
List of publications.
2018 Alessandro Pagliuso, Pascale Cossart, Fabrizia Stavru
The ever-growing complexity of the mitochondrial fission machinery
published pages: 355-374, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2603-0
Cellular and Molecular Life Sciences 75/3 2020-03-11
2019 J.J. Quereda, I.M. Rodríguez-Gómez, J. Meza-Torres, J. Gómez-Laguna, M.A. Nahori, O. Dussurget, L. Carrasco, P. Cossart, J. Pizarro-Cerdá
Reassessing the role of internalin B in Listeria monocytogenes virulence using the epidemic strain F2365
published pages: 252.e1-252.e4, ISSN: 1198-743X, DOI: 10.1016/j.cmi.2018.08.022
Clinical Microbiology and Infection 25/2 2020-03-11
2019 Allison H. Williams, Adam Redzej, Nathalie Rolhion, Tiago R. D. Costa, Aline Rifflet, Gabriel Waksman, Pascale Cossart
The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10782-0
Nature Communications 10/1 2020-03-11
2017 Quereda , Juan; Cossart , Pascale
Regulating Bacterial Virulence with RNA
published pages: 263-280, ISSN: , DOI: 10.1146/annurev-micro-030117-020335
Annual Review of Microbiology 2 2020-03-11
2018 Daryl Jason David, Alessandro Pagliuso, Lilliana Radoshevich, Marie-Anne Nahori, Pascale Cossart
Lmo1656 is a secreted virulence factor of Listeria monocytogenes that interacts with the sorting nexin 6–BAR complex
published pages: 9265-9276, ISSN: 0021-9258, DOI: 10.1074/jbc.RA117.000365
Journal of Biological Chemistry 293/24 2020-03-11
2017 David Ribet, Serena Boscaini, Clothilde Cauvin, Martin Siguier, Serge Mostowy, Arnaud Echard, Pascale Cossart
SUMOylation of human septins is critical for septin filament bundling and cytokinesis
published pages: 4041-4052, ISSN: 0021-9525, DOI: 10.1083/jcb.201703096
The Journal of Cell Biology 216/12 2020-03-11
2016 Jorge M. Pereira, Mélanie A. Hamon, Pascale Cossart
A Lasting Impression: Epigenetic Memory of Bacterial Infections?
published pages: 579-582, ISSN: 1931-3128, DOI: 10.1016/j.chom.2016.04.012
Cell Host & Microbe 19/5 2020-03-11
2017 Nathalie Rolhion, Pascale Cossart
How the study of Listeria monocytogenes has led to new concepts in biology
published pages: 621-638, ISSN: 1746-0913, DOI: 10.2217/fmb-2016-0221
Future Microbiology 12/7 2020-03-11
2015 Emanuele Libertini, Alice Lebreton, Goran Lakisic, Marie-Agnès Dillies, Stephan Beck, Jean-Yves Coppée, Pascale Cossart, Hélène Bierne
Overexpression of the Heterochromatinization Factor BAHD1 in HEK293 Cells Differentially Reshapes the DNA Methylome on Autosomes and X Chromosome
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2015.00339
Frontiers in Genetics 6 2020-03-11
2017 Mélodie Duval, Pascale Cossart
Small bacterial and phagic proteins: an updated view on a rapidly moving field
published pages: 81-88, ISSN: 1369-5274, DOI: 10.1016/j.mib.2017.09.010
Current Opinion in Microbiology 39 2020-03-11
2017 Andrzej Prokop, Edith Gouin, Véronique Villiers, Marie-Anne Nahori, Renaud Vincentelli, Mélodie Duval, Pascale Cossart, Olivier Dussurget
OrfX, a Nucleomodulin Required for Listeria monocytogenes Virulence
published pages: , ISSN: 2150-7511, DOI: 10.1128/mBio.01550-17
mBio 8/5 2020-03-11
2018 Juan J. Quereda, Christopher Andersson, Pascale Cossart, Jörgen Johansson, Javier Pizarro-Cerdá
Role in virulence of phospholipases, listeriolysin O and listeriolysin S from epidemic Listeria monocytogenes using the chicken embryo infection model
published pages: , ISSN: 1297-9716, DOI: 10.1186/s13567-017-0496-4
Veterinary Research 49/1 2020-03-11
2017 Mélodie Duval, Pascale Cossart, Alice Lebreton
Mammalian microRNAs and long noncoding RNAs in the host-bacterial pathogen crosstalk
published pages: 11-19, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2016.06.016
Seminars in Cell & Developmental Biology 65 2019-07-05
2017 David Ribet, Valérie Lallemand-Breitenbach, Omar Ferhi, Marie-Anne Nahori, Hugo Varet, Hugues de Thé, Pascale Cossart
Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection
published pages: e02179-16, ISSN: 2150-7511, DOI: 10.1128/mBio.02179-16
mBio 8/1 2019-07-05
2017 Francis Impens, Nathalie Rolhion, Lilliana Radoshevich, Christophe Bécavin, Mélodie Duval, Jeffrey Mellin, Francisco García del Portillo, M. Graciela Pucciarelli, Allison H. Williams, Pascale Cossart
N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes
published pages: 17005, ISSN: 2058-5276, DOI: 10.1038/nmicrobiol.2017.5
Nature Microbiology 2 2019-07-05
2016 Juan J. Quereda, Olivier Dussurget, Marie-Anne Nahori, Amine Ghozlane, Stevenn Volant, Marie-Agnès Dillies, Béatrice Regnault, Sean Kennedy, Stanislas Mondot, Barbara Villoing, Pascale Cossart, Javier Pizarro-Cerda
Bacteriocin from epidemic Listeria strains alters the host intestinal microbiota to favor infection
published pages: 5706-5711, ISSN: 0027-8424, DOI: 10.1073/pnas.1523899113
Proceedings of the National Academy of Sciences 113/20 2019-07-05
2017 Juan J. Quereda, Marie A. Nahori, Jazmín Meza-Torres, Martin Sachse, Patricia Titos-Jiménez, Jaime Gomez-Laguna, Olivier Dussurget, Pascale Cossart, Javier Pizarro-Cerdá
Listeriolysin S Is a Streptolysin S-Like Virulence Factor That Targets Exclusively Prokaryotic Cells In Vivo
published pages: e00259-17, ISSN: 2150-7511, DOI: 10.1128/mBio.00259-17
mBio 8/2 2019-07-05
2017 Christophe Bécavin, Mikael Koutero, Nicolas Tchitchek, Franck Cerutti, Pierre Lechat, Nicolas Maillet, Claire Hoede, Hélène Chiapello, Christine Gaspin, Pascale Cossart
Listeriomics: an Interactive Web Platform for Systems Biology of Listeria
published pages: e00186-16, ISSN: 2379-5077, DOI: 10.1128/mSystems.00186-16
mSystems 2/2 2019-07-05
2016 Javier Pizarro-Cerdá, Alain Charbit, Jost Enninga, Frank Lafont, Pascale Cossart
Manipulation of host membranes by the bacterial pathogens Listeria, Francisella, Shigella and Yersinia
published pages: 155-167, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2016.07.019
Seminars in Cell & Developmental Biology 60 2019-07-05
2017 Juan J. Quereda, Jazmín Meza-Torres, Pascale Cossart, Javier Pizarro-Cerdá
Listeriolysin S: A bacteriocin from epidemic Listeria monocytogenes strains that targets the gut microbiota
published pages: 1-8, ISSN: 1949-0976, DOI: 10.1080/19490976.2017.1290759
Gut Microbes 2019-07-05
2017 Julien Karim Malet, Pascale Cossart, David Ribet
Alteration of epithelial cell lysosomal integrity induced by bacterial cholesterol-dependent cytolysins
published pages: e12682, ISSN: 1462-5814, DOI: 10.1111/cmi.12682
Cellular Microbiology 19/4 2019-07-05
2016 Alice Lebreton, Pascale Cossart
RNA- and protein-mediated control of Listeria monocytogenes virulence gene expression
published pages: 460-470, ISSN: 1547-6286, DOI: 10.1080/15476286.2016.1189069
RNA Biology 14/5 2019-07-05
2016 Jorge M. Pereira, Mélanie A. Hamon, Pascale Cossart
A Lasting Impression: Epigenetic Memory of Bacterial Infections?
published pages: 579-582, ISSN: 1931-3128, DOI: 10.1016/j.chom.2016.04.012
Cell Host & Microbe 19/5 2019-07-05
2016 D. Dar, M. Shamir, J. R. Mellin, M. Koutero, N. Stern-Ginossar, P. Cossart, R. Sorek
Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteria
published pages: aad9822-aad9822, ISSN: 0036-8075, DOI: 10.1126/science.aad9822
Science 352/6282 2019-07-05
2016 Alessandro Pagliuso, To Nam Tham, Julia K Stevens, Thibault Lagache, Roger Persson, Audrey Salles, Jean‐Christophe Olivo‐Marin, Stéphane Oddos, Anne Spang, Pascale Cossart, Fabrizia Stavru
A role for septin 2 in Drp1‐mediated mitochondrial fission
published pages: 858-873, ISSN: 1469-221X, DOI: 10.15252/embr.201541612
EMBO reports 17/6 2019-07-05
2015 Juan J. Quereda, Javier Pizarro-Cerdá, Damien Balestrino, Alexandre Bobard, Anne Danckaert, Nathalie Aulner, Spencer Shorte, Jost Enninga, Pascale Cossart
A Dual Microscopy-Based Assay To Assess Listeria monocytogenes Cellular Entry and Vacuolar Escape
published pages: 211-217, ISSN: 0099-2240, DOI: 10.1128/AEM.02302-15
Applied and Environmental Microbiology 82/1 2019-07-05
2016 Goran Lakisic, Alice Lebreton, Renaud Pourpre, Olivia Wendling, Emanuele Libertini, Elizabeth J. Radford, Morwenna Le Guillou, Marie-France Champy, Marie Wattenhofer-Donzé, Guillaume Soubigou, Slimane Ait-Si-Ali, Jean Feunteun, Tania Sorg, Jean-Yves Coppée, Anne C. Ferguson-Smith, Pascale Cossart, Hélène Bierne
Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism
published pages: e1005898, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1005898
PLOS Genetics 12/3 2019-07-05
2017 Juan J. Quereda, Martin Sachse, Damien Balestrino, Théodore Grenier, Jennifer Fredlund, Anne Danckaert, Nathalie Aulner, Spencer Shorte, Jost Enninga, Pascale Cossart, Javier Pizarro-Cerdá
Assessing Vacuolar Escape of Listeria Monocytogenes
published pages: 173-195, ISSN: , DOI: 10.1007/978-1-4939-6673-8_11
Methods in Molecular Biology 2019-07-05
2017 Javier Pizarro-Cerdá, Dror Shlomo Chorev, Benjamin Geiger, Pascale Cossart
The Diverse Family of Arp2/3 Complexes
published pages: 93-100, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2016.08.001
Trends in Cell Biology 27/2 2019-07-05
2016 Javier Pizarro-Cerdá, Pascale Cossart
Cell Biology and Microbiology: A Continuous Cross-Feeding
published pages: 469-471, ISSN: 0962-8924, DOI: 10.1016/j.tcb.2016.04.008
Trends in Cell Biology 26/7 2019-07-05

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