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COSYN SIGNED

Comorbidity and Synapse Biology in Clinically Overlapping Psychiatric Disorders

Total Cost €

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EC-Contrib. €

0

Partnership

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 COSYN project word cloud

Explore the words cloud of the COSYN project. It provides you a very rough idea of what is the project "COSYN" about.

discriminate    variants    classification    diagnostic    decoding    platforms    industry    ameliorated    blinded    genomic    genetic    genome    clinician    samples    technologies    neurobiology    outstanding    syndrome    effect    cosyn    mechanisms    vitro    tools    comorbidities    clinic    neuroscience    double    bedside    scaled    multiple    patient    generate    neurons    standard    approved    create    place    precision    unravel    understand    therapeutics    capitalise    person    integrates    extensive    precisely    criteria    molecular    neurobiological    indicated    alterations    clue    assays    overlap    crossover    id    reproducibly    autism    screening    subtypes    recommend    pharma    biology    editing    bench    disease    utility    cells    models    cellular    patients    refine    synapses    rare    elucidate    medicine    comorbidity    compound    synaptic    intellectual    schizophrenia    cell    correct    symptom    carefully    clinical    academic    disability    dysfunction    neuronal    medication    intensive    personalised   

Project "COSYN" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website http://www.cosyn-precisionmedicine.eu
 Total cost 6˙000˙000 €
 EC max contribution 5˙925˙000 € (99%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 675˙000.00
2    STICHTING VU NL (AMSTERDAM) participant 1˙925˙000.00
3    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 800˙000.00
4    SYNAPTOLOGICS BV NL (AMSTERDAM) participant 650˙000.00
5    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 600˙000.00
6    LIFE AND BRAIN GMBH DE (BONN) participant 300˙000.00
7    CARDIFF UNIVERSITY UK (CARDIFF) participant 225˙000.00
8    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 225˙000.00
9    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 225˙000.00
10    CEGAT GMBH DE (TUBINGEN) participant 100˙000.00
11    H. LUNDBECK AS DK (VALBY) participant 75˙000.00
12    REGION HOVEDSTADEN DK (HILLEROD) participant 75˙000.00
13    VERENIGING SAMENWERKENDE OUDER- EN PATIENTENORGANISATIES NL (SOEST) participant 50˙000.00
14    F. HOFFMANN-LA ROCHE AG CH (BASEL) participant 0.00

Map

 Project objective

COSYN integrates outstanding European academic and three large Pharma to exploit genomic findings for intellectual disability (ID), autism, and schizophrenia. We capitalise on comorbidity, from clinic to cells and synapses, and have access to large existing samples. We focus on rare genetic variants of strong effect in patients with clinical comorbidity. Our aims are: (1) Understand comorbidity by comparing symptom and syndrome overlap with novel neurobiological criteria; (2) Elucidate mechanisms of comorbidity using neurobiology for the major genomic clue of synaptic dysfunction to unravel the cellular mechanisms of comorbidity; (3) Generate novel neuronal cell models by using advanced technologies to make neurons from carefully selected patients, and use genome editing to create or correct genetic variants. Multiple advanced neuroscience platforms are in place to evaluate an extensive set of molecular and cellular parameters, and to identify alterations in synaptic biology characteristic of ID, autism, and schizophrenia. These cellular models will, with Pharma partners, be up-scaled to provide “industry-standard” cellular assays for compound screening; (4) Refine diagnostic tools, use novel genomic and cellular features to improve disease classification and discriminate specific patient subtypes; and (5) Case studies in precision medicine: with Pharma partners, identify patients with a genetic change whose consequences can be reproducibly ameliorated in vitro by an approved medication. Recommend to the patient and clinician a double-blinded, N-of-one crossover case study to evaluate the clinical utility of a medication precisely indicated for that person. COSYN is an integrated, state-of-art, bench-to-bedside programme focused on personalised therapeutics. COSYN is a crucial next step in “decoding” the genetic findings via intensive focus on the clinical and molecular comorbidities of ID, autism, and schizophrenia.

 Deliverables

List of deliverables.
Outreach activities (debate) on the philosophy of using patient-own cells for a new generation of cellular models Documents, reports 2020-04-09 09:39:17

Take a look to the deliverables list in detail:  detailed list of COSYN deliverables.

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The information about "COSYN" are provided by the European Opendata Portal: CORDIS opendata.

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