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RELENT SIGNED

RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RELENT project word cloud

Explore the words cloud of the RELENT project. It provides you a very rough idea of what is the project "RELENT" about.

rapid malignancy chronic influence effector individual pathogenic morbidity investigators initiation treatment supply uncover mortality reagents mass benefit smes patients individualized characterise rheumatoid translatable molecules deeper considerable uncontrolled immunosuppression relent seven disease inflammatory protein combine responsible models proteome tailor mechanisms subset biology australia translate cells antigen outcomes genome vivo cell clinical treatments ultimate group females immune predispose scientists arrays expertise health infection persistence combines signatures predict co abnormalities formed biomarker diseases association macrophages arthritis ageing males autoimmunity outcome vasculitis world secrete autoimmune dendritic multiplexed anticipate severe stratify multidisciplinary generate morbidities

Project "RELENT" data sheet

The following table provides information about the project.

Coordinator	MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	http://www.relent.eu
Total cost	6˙469˙522 €
EC max contribution	5˙999˙431 € (93%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-11-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	1˙133˙200.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	530˙390.00
3	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	524˙500.00
4	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	494˙237.00
5	EMC MICROCOLLECTIONS GMBH EMC MICROCOLLECTIONS GMBH Organization address address: Sindelfinger Str. 3 city: TUEBINGEN postcode: 72070 website: www.microcollections.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	471˙250.00
6	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	461˙250.00
7	UNIVERSITATSKLINIKUM BONN UNIVERSITATSKLINIKUM BONN Organization address address: VENUSBERG-CAMPUS 1 city: BONN postcode: 53127 website: www.ukb.uni-bonn.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	456˙242.00
8	Hycult biotechnology bv Hycult biotechnology bv Organization address address: Frontstraat 2A city: Uden postcode: 5405 PB website: www.hbt.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Uden)	participant	449˙937.00
9	PHENOCELL PHENOCELL Organization address address: 45 BOULEVARD MARCEL PAGNOL city: GRASSE postcode: 6130 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (GRASSE)	participant	443˙500.00
10	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	395˙635.00
11	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	389˙180.00
12	ARTTIC ARTTIC Organization address address: RUE DU DESSOUS DES BERGES 58A city: PARIS postcode: 75013 website: www.arttic.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	211˙532.00
13	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Organization address address: OSKAR VON MILLER RING 29 city: MUENCHEN postcode: 80333 website: www.gabo-mi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	38˙576.00
14	Mayo Clinic Mayo Clinic Organization address address: First Street SW 200 city: Rochester postcode: 55905 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Rochester)	participant	0.00
15	MONASH UNIVERSITY MONASH UNIVERSITY Organization address address: Wellington Road city: VICTORIA postcode: 3800 website: www.monash.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (VICTORIA)	participant	0.00

Map

Project objective

RELENT is multidisciplinary group of scientists and clinical investigators whose goal is to develop individualized treatment for chronic autoimmune diseases, such as rheumatoid arthritis and vasculitis, that cause considerable mortality and morbidity, both from uncontrolled disease and treatment associated co-morbidities, like infection and malignancy. This requires the need to stratify patients by their outcome and to tailor immunosuppression based on much deeper knowledge of the mechanisms that control initiation and persistence of the pathogenic immune responses. The RELENT Consortium has been formed to generate this knowledge with the ultimate goal of developing treatments tailored to the specific needs of individual patients. RELENT combines the resources of seven leading European Investigators and two from US and Australia whose expertise is not available elsewhere in the world but necessary for the ambitious work program. Three SMEs will supply specific reagents and translate the results to biomarker development. This will enable RELENT to deliver its four specific research aims, namely to: i) Combine subset analysis of genome wide association studies with classical cell biology to uncover pathways that influence and ii) use multiplexed antigen arrays, whole proteome analysis and rapid mass analysis to identify protein signatures that predict outcome and response to treatment in chronic autoimmune disease. iii) Characterise T and B cell abnormalities that predispose to autoimmunity and infection by studying the ageing immune system in health and disease. iv) Analyse pathogenic effector T cells and their control by macrophages and dendritic cells and the molecules they secrete using in vivo models. We anticipate to identify common mechanisms responsible for the persistence and outcomes in severe autoimmune and inflammatory diseases in females and males and that the results should be rapidly translatable into clinical practice for the benefit of patients.

Deliverables

List of deliverables.
Report on status of posting results in the study registry(s) for â€œANCA associated vasculitis is a relapsing disease; the role of regulatory B cellsâ€	Documents, reports	2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for â€œCD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritisâ€	Documents, reports	2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for â€œCambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)â€	Documents, reports	2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for â€œResearch into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)â€œ	Documents, reports	2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for â€œimmune ageing in health and diseaseâ€œ	Documents, reports	2020-04-07 20:28:28
Recruitment report update for â€œimmune ageing in health and diseaseâ€œ	Documents, reports	2020-04-07 20:28:27
Recruitment report update for â€œAV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)â€	Documents, reports	2020-04-07 20:28:27
Recruitment report update for â€œANCA associated vasculitis is a relapsing disease; the role of regulatory B cellsâ€	Documents, reports	2020-04-07 20:28:27
Report on status of posting results in the study registry(s) for â€œRELENT bank of induced pluripotent stem cellsâ€	Documents, reports	2020-04-07 20:28:27
Recruitment report update for â€œResearch into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)â€œ	Documents, reports	2020-04-07 20:28:27
Recruitment report update for â€œCambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)â€	Documents, reports	2020-04-07 20:28:27
All approvals package for â€œRELENT bank of induced pluripotent stem cellsâ€	Documents, reports	2020-04-07 20:28:27
Recruitment report update for â€œCD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritisâ€	Documents, reports	2020-04-07 20:28:27
Preparation of first bi-annual newsletter	Websites, patent fillings, videos etc.	2020-04-07 20:28:27
Report on dissemination and communication activities	Websites, patent fillings, videos etc.	2020-04-07 20:28:27
First study subject approvals package for â€œRELENT bank of induced pluripotent stem cellsâ€	Documents, reports	2020-04-07 20:28:27
Individualized press release for every partner	Websites, patent fillings, videos etc.	2020-04-07 20:28:27
Midterm recruitment report for â€œRELENT bank of induced pluripotent stem cellsâ€	Documents, reports	2020-04-07 20:28:27
Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster	Documents, reports	2020-04-07 20:28:27

Take a look to the deliverables list in detail: detailed list of RELENT deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	Hans-Joachim Anders, Brad Rovin A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis published pages: 493-501, ISSN: 0085-2538, DOI: 10.1016/j.kint.2016.05.017	Kidney International 90/3	2020-04-07
2019	Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01638	Frontiers in Immunology 10	2020-04-07
2019	Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01981	Frontiers in Immunology 10	2020-04-07
2019	Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica GÃ¶tzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Ã–nder Yildirim, Dieter E. Jenne Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-46206-8	Scientific Reports 9/1	2020-04-07
2016	Hans-Joachim Anders, Claudio Ponticelli Membranous nephropathy and the Henleâ€“Koch postulates published pages: 447-448, ISSN: 1759-5061, DOI: 10.1038/nrneph.2016.86	Nature Reviews Nephrology 12/8	2020-04-07
2019	Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania KÃ¼mpfel, Edgar Meinl The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01189	Frontiers in Immunology 10	2020-04-07
2019	Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, JÃ¼rgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury published pages: 1641-1658, ISSN: 1046-6673, DOI: 10.1681/asn.2018111143	Journal of the American Society of Nephrology 30/9	2020-04-07
2016	Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, JÃ¼rgen Floege, Steffen Frese, LoÃ¯c Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph ISN Nexus 2016 Symposia: Translational Immunology in Kidney Diseaseâ€”The Berlin Roadmap published pages: 327-339, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2016.06.009	Kidney International Reports 1/4	2020-04-07
2017	S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis published pages: 43-154, ISSN: 1937-6448, DOI: 10.1016/bs.ircmb.2016.12.001	International Review of Cell and Molecular Biology	2020-04-07
2016	Renate Kain, Reno Barth Systemische Vaskulitiden verstehen published pages: 1, ISSN: , DOI:	Medical Tribune Online	2020-04-07
2018	Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy018	Nephrology Dialysis Transplantation March 2018	2020-04-07
2017	Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches published pages: 638-645, ISSN: 1942-0870, DOI: 10.1080/19420862.2017.1290033	mAbs 9/4	2020-04-07
2018	Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika ÅÈ©gowska, Marcin SkoreÅ„ski, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin SieÅ„czyk, Adam Lesner, Francis Gauthier, Brice Korkmaz Exploiting the S4â€“S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis published pages: 1858-1870, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01416	Journal of Medicinal Chemistry 61/5	2020-04-07
2018	Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides published pages: 413-421, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2017.12.002	Autoimmunity Reviews 17/4	2020-04-07
2017	Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia CourrÃ¨ges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, CÃ©sar Evaristo, Friedrich Thaiss, Christian Kurts Prolonged IKKÎ² Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells published pages: 578-586, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.09.082	Cell Reports 21/3	2020-04-07
2018	Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck Parsimonious Charge Deconvolution for Native Mass Spectrometry published pages: 1216-1226, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.7b00839	Journal of Proteome Research 17/3	2020-04-07
2018	Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki Lymphatic exosomes promote dendritic cell migration along guidance cues published pages: jcb.201612051, ISSN: 0021-9525, DOI: 10.1083/jcb.201612051	The Journal of Cell Biology	2020-04-07
2017	Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes published pages: ji1601263, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1601263	The Journal of Immunology	2020-04-07
2017	Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc\'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases published pages: 52-67, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2017.02.009	Biochemical Pharmacology 131	2020-04-07
2017	Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers Towards precision medicine in ANCA-associated vasculitis published pages: 1332, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kex367	Rheumatology	2020-04-07
2017	Vojtech Franc, Yang Yang, Albert J. R. Heck Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation published pages: 3483-3491, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04527	Analytical Chemistry 89/6	2020-04-07
2018	Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis? published pages: 1366-1376, ISSN: 2326-5191, DOI: 10.1002/art.40520	Arthritis & Rheumatology 70/9	2020-04-07
2017	Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. MuÃ±oz-ElÃas, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis published pages: 1205, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01205	Frontiers in Immunology 8	2020-04-07
2016	Renate Kain \"\"\"RELENT\"\"Less on Target - von molekularen Mechanismen zur PrÃ¤zisionsmedizin\" published pages: 20-23, ISSN: , DOI:	Mitteilungen der Deutschen Gesellschaft fÃ¼r Nephrologie 2	2020-04-07
2016	Yveline Hamon, Monika Legowska, Virginie HervÃ©, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, MichÃ¨le Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie HeuzÃ©-Vourc\'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases published pages: 8486-8499, ISSN: 0021-9258, DOI: 10.1074/jbc.M115.707109	Journal of Biological Chemistry 291/16	2020-04-07
2017	Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen, Common coding variant in SERPINA1 increases the risk for large artery stroke published pages: 3613-3618, ISSN: 0027-8424, DOI: 10.1073/pnas.1616301114	Proceedings of the National Academy of Sciences 114/14	2020-04-07
2016	M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis published pages: e00425-e00425, ISSN: 0144-8463, DOI: 10.1042/BSR20160336	Bioscience Reports 36/6	2020-04-07
2018	Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer Checks and Balances in Autoimmune Vasculitis published pages: 315, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00315	Frontiers in Immunology 9	2020-04-07
2016	T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis published pages: , ISSN: 2045-2322, DOI: 10.1038/srep35413	Scientific Reports 6/1	2020-04-07
2017	Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-01894-y	Scientific Reports 7/1	2020-04-07
2017	Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders Reprint of â€œDual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritisâ€ published pages: 119-127, ISSN: 1521-6616, DOI: 10.1016/j.clim.2017.10.011	Clinical Immunology 185	2020-04-07
2017	Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf RisÃ©rus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ã„rnlÃ¶v, Hans-Joachim Anders Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans published pages: 43538, ISSN: 2045-2322, DOI: 10.1038/srep43538	Scientific Reports 7	2020-04-07
2017	Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients published pages: 136, ISSN: 1478-6362, DOI: 10.1186/s13075-017-1343-8	Arthritis Research & Therapy 19/1	2020-04-07
2017	Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing published pages: 418-435, ISSN: 0270-9295, DOI: 10.1016/j.semnephrol.2017.05.016	Seminars in Nephrology 37/5	2020-04-07
2018	Kain R. Deviation of antigen presentation through (auto)antibodies published pages: , ISSN: , DOI:	SÃ©minaire Hospitalo-Universitaire de Strasbourg 20/09/2018	2020-04-07
2018	Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika ÅÈ©gowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker Therapeutic targeting of cathepsin C: from pathophysiology to treatment published pages: 202-236, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.05.011	Pharmacology & Therapeutics 190	2020-04-07
2017	Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders Reprint of â€œDual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritisâ€ published pages: 119-127, ISSN: 1521-6616, DOI: 10.1016/j.clim.2017.10.011	Clinical Immunology 185	2020-04-07
2017	Hubert V. A new role of LAMP-2 in macroautophagy published pages: , ISSN: , DOI:	14/11/2017	2020-04-07
2018	Kain R. Deviation of antigen presentation through (auto)antibodies published pages: , ISSN: , DOI:	SÃ©minaire Hospitalo-Universitaire de Strasbourg 20/09/2018	2020-04-07
2018	Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika ÅÈ©gowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker Therapeutic targeting of cathepsin C: from pathophysiology to treatment published pages: 202-236, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.05.011	Pharmacology & Therapeutics 190	2020-04-07
2018	Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck Parsimonious Charge Deconvolution for Native Mass Spectrometry published pages: 1216-1226, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.7b00839	Journal of Proteome Research 17/3	2020-04-07
2018	Schulz S., Schachner H., Rees A., Kain R. Herbsttagung 2018 der Ã–GPath/IAP Austria published pages: 480-490, ISSN: 0172-8113, DOI: 10.1007/s00292-018-0470-6	Der Pathologe 39/5	2020-04-07
2019	Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. Oâ€™Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11255-0	Nature Communications 10/1	2020-04-07

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