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RELENT SIGNED

RELapses prevENTion in chronic autoimmune disease: common mechanisms and co-morbidities

Total Cost €

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EC-Contrib. €

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Partnership

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 RELENT project word cloud

Explore the words cloud of the RELENT project. It provides you a very rough idea of what is the project "RELENT" about.

cells    clinical    rheumatoid    translatable    macrophages    individual    world    pathogenic    seven    uncontrolled    health    arthritis    outcome    morbidities    anticipate    genome    rapid    predispose    group    australia    translate    stratify    cell    combines    autoimmunity    persistence    infection    influence    investigators    supply    vasculitis    responsible    patients    severe    biology    predict    biomarker    ultimate    morbidity    initiation    formed    antigen    ageing    mechanisms    uncover    individualized    smes    disease    autoimmune    chronic    signatures    relent    expertise    outcomes    inflammatory    scientists    females    males    deeper    effector    combine    generate    vivo    subset    diseases    molecules    association    mass    proteome    benefit    tailor    secrete    reagents    considerable    protein    characterise    treatments    abnormalities    malignancy    multiplexed    immune    co    treatment    models    immunosuppression    mortality    dendritic    arrays    multidisciplinary   

Project "RELENT" data sheet

The following table provides information about the project.

Coordinator
MEDIZINISCHE UNIVERSITAET WIEN 

Organization address
address: SPITALGASSE 23
city: WIEN
postcode: 1090
website: www.meduniwien.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.relent.eu
 Total cost 6˙469˙522 €
 EC max contribution 5˙999˙431 € (93%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2015-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MEDIZINISCHE UNIVERSITAET WIEN AT (WIEN) coordinator 1˙133˙200.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 530˙390.00
3    ACADEMISCH ZIEKENHUIS GRONINGEN NL (GRONINGEN) participant 524˙500.00
4    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 494˙237.00
5    EMC MICROCOLLECTIONS GMBH DE (TUEBINGEN) participant 471˙250.00
6    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 461˙250.00
7    UNIVERSITATSKLINIKUM BONN DE (BONN) participant 456˙242.00
8    Hycult biotechnology bv NL (Uden) participant 449˙937.00
9    PHENOCELL FR (GRASSE) participant 443˙500.00
10    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 395˙635.00
11    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 389˙180.00
12    ARTTIC FR (PARIS) participant 211˙532.00
13    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG DE (MUENCHEN) participant 38˙576.00
14    Mayo Clinic US (Rochester) participant 0.00
15    MONASH UNIVERSITY AU (VICTORIA) participant 0.00

Map

 Project objective

RELENT is multidisciplinary group of scientists and clinical investigators whose goal is to develop individualized treatment for chronic autoimmune diseases, such as rheumatoid arthritis and vasculitis, that cause considerable mortality and morbidity, both from uncontrolled disease and treatment associated co-morbidities, like infection and malignancy. This requires the need to stratify patients by their outcome and to tailor immunosuppression based on much deeper knowledge of the mechanisms that control initiation and persistence of the pathogenic immune responses. The RELENT Consortium has been formed to generate this knowledge with the ultimate goal of developing treatments tailored to the specific needs of individual patients. RELENT combines the resources of seven leading European Investigators and two from US and Australia whose expertise is not available elsewhere in the world but necessary for the ambitious work program. Three SMEs will supply specific reagents and translate the results to biomarker development. This will enable RELENT to deliver its four specific research aims, namely to: i) Combine subset analysis of genome wide association studies with classical cell biology to uncover pathways that influence and ii) use multiplexed antigen arrays, whole proteome analysis and rapid mass analysis to identify protein signatures that predict outcome and response to treatment in chronic autoimmune disease. iii) Characterise T and B cell abnormalities that predispose to autoimmunity and infection by studying the ageing immune system in health and disease. iv) Analyse pathogenic effector T cells and their control by macrophages and dendritic cells and the molecules they secrete using in vivo models. We anticipate to identify common mechanisms responsible for the persistence and outcomes in severe autoimmune and inflammatory diseases in females and males and that the results should be rapidly translatable into clinical practice for the benefit of patients.

 Deliverables

List of deliverables.
Report on status of posting results in the study registry(s) for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells” Documents, reports 2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis” Documents, reports 2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)” Documents, reports 2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“ Documents, reports 2020-04-07 20:28:28
Report on status of posting results in the study registry(s) for “immune ageing in health and disease“ Documents, reports 2020-04-07 20:28:28
Recruitment report update for “immune ageing in health and disease“ Documents, reports 2020-04-07 20:28:27
Recruitment report update for “AV-GWAS (Multi-Centre Genome-Wide Association Study of ANCA-associated vasculitis)” Documents, reports 2020-04-07 20:28:27
Recruitment report update for “ANCA associated vasculitis is a relapsing disease; the role of regulatory B cells” Documents, reports 2020-04-07 20:28:27
Report on status of posting results in the study registry(s) for “RELENT bank of induced pluripotent stem cells” Documents, reports 2020-04-07 20:28:27
Recruitment report update for “Research into Genetic variation AND Leucocyte Altered Function in health and disease (GANDALF)“ Documents, reports 2020-04-07 20:28:27
Recruitment report update for “Cambridge Hinxton Centre for Translational Research in Autoimmune Disease 2 (CHIC TRIAD2)” Documents, reports 2020-04-07 20:28:27
All approvals package for “RELENT bank of induced pluripotent stem cells” Documents, reports 2020-04-07 20:28:27
Recruitment report update for “CD4+ T cells and immune ageing, major players and predictors for disease activity in giant cell arteritis” Documents, reports 2020-04-07 20:28:27
Preparation of first bi-annual newsletter Websites, patent fillings, videos etc. 2020-04-07 20:28:27
Report on dissemination and communication activities Websites, patent fillings, videos etc. 2020-04-07 20:28:27
First study subject approvals package for “RELENT bank of induced pluripotent stem cells” Documents, reports 2020-04-07 20:28:27
Individualized press release for every partner Websites, patent fillings, videos etc. 2020-04-07 20:28:27
Midterm recruitment report for “RELENT bank of induced pluripotent stem cells” Documents, reports 2020-04-07 20:28:27
Launch of website, Twitter, Research Gate, LinkedIn, Account and general project flyer/poster Documents, reports 2020-04-07 20:28:27

Take a look to the deliverables list in detail:  detailed list of RELENT deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Hans-Joachim Anders, Brad Rovin
A pathophysiology-based approach to the diagnosis and treatment of lupus nephritis
published pages: 493-501, ISSN: 0085-2538, DOI: 10.1016/j.kint.2016.05.017
Kidney International 90/3 2020-04-07
2019 Rebeca Hid Cadena, Rosanne D. Reitsema, Minke G. Huitema, Yannick van Sleen, Kornelis S. M. van der Geest, Peter Heeringa, Annemieke M. H. Boots, Wayel H. Abdulahad, Elisabeth Brouwer
Decreased Expression of Negative Immune Checkpoint VISTA by CD4+ T Cells Facilitates T Helper 1, T Helper 17, and T Follicular Helper Lineage Differentiation in GCA
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01638
Frontiers in Immunology 10 2020-04-07
2019 Yannick van Sleen, Jacoba C. Graver, Wayel H. Abdulahad, Kornelis S. M. van der Geest, Annemieke M. H. Boots, Maria Sandovici, Elisabeth Brouwer
Leukocyte Dynamics Reveal a Persistent Myeloid Dominance in Giant Cell Arteritis and Polymyalgia Rheumatica
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01981
Frontiers in Immunology 10 2020-04-07
2019 Salome R. T. Rehm, Natalia F. Smirnova, Carmela Morrone, Jessica Götzfried, Annette Feuchtinger, John Pedersen, Brice Korkmaz, Ali Önder Yildirim, Dieter E. Jenne
Premedication with a cathepsin C inhibitor alleviates early primary graft dysfunction in mouse recipients after lung transplantation
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-46206-8
Scientific Reports 9/1 2020-04-07
2016 Hans-Joachim Anders, Claudio Ponticelli
Membranous nephropathy and the Henle–Koch postulates
published pages: 447-448, ISSN: 1759-5061, DOI: 10.1038/nrneph.2016.86
Nature Reviews Nephrology 12/8 2020-04-07
2019 Iris Marti Fernandez, Caterina Macrini, Markus Krumbholz, Paul J. Hensbergen, Agnes L. Hipgrave Ederveen, Stephan Winklmeier, Atay Vural, Asli Kurne, Dieter Jenne, Frits Kamp, Lisa Ann Gerdes, Reinhard Hohlfeld, Manfred Wuhrer, Tania Kümpfel, Edgar Meinl
The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01189
Frontiers in Immunology 10 2020-04-07
2019 Irina V. Grigorieva, Andre Oszwald, Elena F. Grigorieva, Helga Schachner, Barbara Neudert, Tammo Ostendorf, Jürgen Floege, Maja T. Lindenmeyer, Clemens D. Cohen, Ulf Panzer, Christof Aigner, Alice Schmidt, Frank Grosveld, Rajesh V. Thakker, Andrew Jackson Rees, Renate Kain
A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury
published pages: 1641-1658, ISSN: 1046-6673, DOI: 10.1681/asn.2018111143
Journal of the American Society of Nephrology 30/9 2020-04-07
2016 Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Steph
ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap
published pages: 327-339, ISSN: 2468-0249, DOI: 10.1016/j.ekir.2016.06.009
Kidney International Reports 1/4 2020-04-07
2017 S.K. Devarapu, G. Lorenz, O.P. Kulkarni, H.-J. Anders, S.R. Mulay
Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis
published pages: 43-154, ISSN: 1937-6448, DOI: 10.1016/bs.ircmb.2016.12.001
International Review of Cell and Molecular Biology 2020-04-07
2016 Renate Kain, Reno Barth
Systemische Vaskulitiden verstehen
published pages: 1, ISSN: , DOI:
Medical Tribune Online 2020-04-07
2018 Gerjan J Dekkema, Wayel H Abdulahad, Theo Bijma, Sarah M Moran, Louise Ryan, Mark A Little, Coen A Stegeman, Peter Heeringa, Jan Stephan Sanders
Urinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study
published pages: , ISSN: 0931-0509, DOI: 10.1093/ndt/gfy018
Nephrology Dialysis Transplantation March 2018 2020-04-07
2017 Yang Yang, Guanbo Wang, Ting Song, Carlito B. Lebrilla, Albert J. R. Heck
Resolving the micro-heterogeneity and structural integrity of monoclonal antibodies by hybrid mass spectrometric approaches
published pages: 638-645, ISSN: 1942-0870, DOI: 10.1080/19420862.2017.1290033
mAbs 9/4 2020-04-07
2018 Carla Guarino, Natalia Gruba, Renata Grzywa, Edyta Dyguda-Kazimierowicz, Yveline Hamon, Monika Łȩgowska, Marcin Skoreński, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Christine Kellenberger, Dieter E. Jenne, Marcin Sieńczyk, Adam Lesner, Francis Gauthier, Brice Korkmaz
Exploiting the S4–S5 Specificity of Human Neutrophil Proteinase 3 to Improve the Potency of Peptidyl Di(chlorophenyl)-phosphonate Ester Inhibitors: A Kinetic and Molecular Modeling Analysis
published pages: 1858-1870, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b01416
Journal of Medicinal Chemistry 61/5 2020-04-07
2018 Anouk von Borstel, Jan Stephan Sanders, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Cellular immune regulation in the pathogenesis of ANCA-associated vasculitides
published pages: 413-421, ISSN: 1568-9972, DOI: 10.1016/j.autrev.2017.12.002
Autoimmunity Reviews 17/4 2020-04-07
2017 Christoph Heuser, Janine Gotot, Eveline Christina Piotrowski, Marie-Sophie Philipp, Christina Johanna Felicia Courrèges, Martin Sylvester Otte, Linlin Guo, Jonathan Leo Schmid-Burgk, Veit Hornung, Annkristin Heine, Percy Alexander Knolle, Natalio Garbi, Edgar Serfling, César Evaristo, Friedrich Thaiss, Christian Kurts
Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells
published pages: 578-586, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.09.082
Cell Reports 21/3 2020-04-07
2018 Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Parsimonious Charge Deconvolution for Native Mass Spectrometry
published pages: 1216-1226, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.7b00839
Journal of Proteome Research 17/3 2020-04-07
2018 Markus Brown, Louise A. Johnson, Dario A. Leone, Peter Majek, Kari Vaahtomeri, Daniel Senfter, Nora Bukosza, Helga Schachner, Gabriele Asfour, Brigitte Langer, Robert Hauschild, Katja Parapatics, Young-Kwon Hong, Keiryn L. Bennett, Renate Kain, Michael Detmar, Michael Sixt, David G. Jackson, Dontscho Kerjaschki
Lymphatic exosomes promote dendritic cell migration along guidance cues
published pages: jcb.201612051, ISSN: 0021-9525, DOI: 10.1083/jcb.201612051
The Journal of Cell Biology 2020-04-07
2017 Dario Armando Leone, Andrea Peschel, Markus Brown, Helga Schachner, Miriam J. Ball, Marianna Gyuraszova, Ulrike Salzer-Muhar, Minoru Fukuda, Caterina Vizzardelli, Barbara Bohle, Andrew J. Rees, Renate Kain
Surface LAMP-2 Is an Endocytic Receptor That Diverts Antigen Internalized by Human Dendritic Cells into Highly Immunogenic Exosomes
published pages: ji1601263, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1601263
The Journal of Immunology 2020-04-07
2017 Carla Guarino, Yveline Hamon, C?cile Croix, Anne-Sophie Lamort, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Adam Lesner, Thomas Baranek, Marie-Claude Viaud-Massuard, Conni Lauritzen, John Pedersen, Nathalie Heuz?-Vourc\'h, Mustapha Si-Tahar, Erhan F?ratl?, Dieter E. Jenne, Francis Gauthier, Marshall S. Horwitz, Niels Borregaard, Brice Korkmaz
Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases
published pages: 52-67, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2017.02.009
Biochemical Pharmacology 131 2020-04-07
2017 Kornelis S M van der Geest, Elisabeth Brouwer, Jan-Stephan Sanders, Maria Sandovici, Nicolaas A Bos, Annemieke M H Boots, Wayel H Abdulahad, Coen A Stegeman, Cees G M Kallenberg, Peter Heeringa, Abraham Rutgers
Towards precision medicine in ANCA-associated vasculitis
published pages: 1332, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kex367
Rheumatology 2020-04-07
2017 Vojtech Franc, Yang Yang, Albert J. R. Heck
Proteoform Profile Mapping of the Human Serum Complement Component C9 Revealing Unexpected New Features of N -, O -, and C -Glycosylation
published pages: 3483-3491, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.6b04527
Analytical Chemistry 89/6 2020-04-07
2018 Kornelis S. M. van der Geest, Maria Sandovici, Yannick van Sleen, Jan-Stephan Sanders, Nicolaas A. Bos, Wayel H. Abdulahad, Coen A. Stegeman, Peter Heeringa, Abraham Rutgers, Cees G. M. Kallenberg, Annemieke M. H. Boots, Elisabeth Brouwer
Review: What Is the Current Evidence for Disease Subsets in Giant Cell Arteritis?
published pages: 1366-1376, ISSN: 2326-5191, DOI: 10.1002/art.40520
Arthritis & Rheumatology 70/9 2020-04-07
2017 Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad
Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis
published pages: 1205, ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01205
Frontiers in Immunology 8 2020-04-07
2016 Renate Kain
\"\"\"RELENT\"\"Less on Target - von molekularen Mechanismen zur Präzisionsmedizin\"
published pages: 20-23, ISSN: , DOI:
Mitteilungen der Deutschen Gesellschaft für Nephrologie 2 2020-04-07
2016 Yveline Hamon, Monika Legowska, Virginie Hervé, Sandrine Dallet-Choisy, Sylvain Marchand-Adam, Lise Vanderlynden, Michèle Demonte, Rich Williams, Christopher J. Scott, Mustapha Si-Tahar, Nathalie Heuzé-Vourc\'h, Gilles Lalmanach, Dieter E. Jenne, Adam Lesner, Francis Gauthier, Brice Korkmaz
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases
published pages: 8486-8499, ISSN: 0021-9258, DOI: 10.1074/jbc.M115.707109
Journal of Biological Chemistry 291/16 2020-04-07
2017 Rainer Malik, Therese Dau, Maria Gonik, Anirudh Sivakumar, Daniel J. Deredge, Evgeniia V. Edeleva, Jessica G?tzfried, Sander W. van der Laan, Gerard Pasterkamp, Nathalie Beaufort, Susana Seixas, Steve Bevan, Lisa F. Lincz, Elizabeth G. Holliday, Annette I. Burgess, Kristiina Rannikm?e, Jens Minnerup, Jennifer Kriebel, Melanie Waldenberger, Martina M?ller-Nurasyid, Peter Lichtner, Danish Saleheen,
Common coding variant in SERPINA1 increases the risk for large artery stroke
published pages: 3613-3618, ISSN: 0027-8424, DOI: 10.1073/pnas.1616301114
Proceedings of the National Academy of Sciences 114/14 2020-04-07
2016 M. Honarpisheh, J. Desai, J. A. Marschner, M. Weidenbusch, M. Lech, V. Vielhauer, H.-J. Anders, S. R. Mulay
Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis
published pages: e00425-e00425, ISSN: 0144-8463, DOI: 10.1042/BSR20160336
Bioscience Reports 36/6 2020-04-07
2018 Rebeca Hid Cadena, Wayel H. Abdulahad, G. A. P. Hospers, T. T. Wind, Annemieke M. H. Boots, Peter Heeringa, Elisabeth Brouwer
Checks and Balances in Autoimmune Vasculitis
published pages: 315, ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00315
Frontiers in Immunology 9 2020-04-07
2016 T. Dau, E. V. Edeleva, S. A. I. Seidel, R. A. Stockley, D. Braun, D. E. Jenne
Quantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep35413
Scientific Reports 6/1 2020-04-07
2017 Maia Tato, Santhosh V. Kumar, Yajuan Liu, Shrikant R. Mulay, Solange Moll, Bastian Popper, Jonathan N. Eberhard, Dana Thomasova, Arne Christian Rufer, Sabine Gruner, Wolfgang Haap, Guido Hartmann, Hans-Joachim Anders
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-01894-y
Scientific Reports 7/1 2020-04-07
2017 Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis”
published pages: 119-127, ISSN: 1521-6616, DOI: 10.1016/j.clim.2017.10.011
Clinical Immunology 185 2020-04-07
2017 Dominik Steubl, Santhosh V. Kumar, Maia Tato, Shrikant R. Mulay, Anders Larsson, Lars Lind, Ulf Risérus, Lutz Renders, Uwe Heemann, Axel C. Carlsson, Johan Ärnlöv, Hans-Joachim Anders
Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans
published pages: 43538, ISSN: 2045-2322, DOI: 10.1038/srep43538
Scientific Reports 7 2020-04-07
2017 Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad
Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients
published pages: 136, ISSN: 1478-6362, DOI: 10.1186/s13075-017-1343-8
Arthritis Research & Therapy 19/1 2020-04-07
2017 Holly L. Hutton, Stephen R. Holdsworth, A. Richard Kitching
ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing
published pages: 418-435, ISSN: 0270-9295, DOI: 10.1016/j.semnephrol.2017.05.016
Seminars in Nephrology 37/5 2020-04-07
2018 Kain R.
Deviation of antigen presentation through (auto)antibodies
published pages: , ISSN: , DOI:
Séminaire Hospitalo-Universitaire de Strasbourg 20/09/2018 2020-04-07
2018 Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
published pages: 202-236, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.05.011
Pharmacology & Therapeutics 190 2020-04-07
2017 Satish Kumar Devarapu, Santhosh Kumar VR, Khader Valli Rupanagudi, Onkar P. Kulkarni, Dirk Eulberg, Sven Klussmann, Hans-Joachim Anders
Reprint of “Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis”
published pages: 119-127, ISSN: 1521-6616, DOI: 10.1016/j.clim.2017.10.011
Clinical Immunology 185 2020-04-07
2017 Hubert V.
A new role of LAMP-2 in macroautophagy
published pages: , ISSN: , DOI:
14/11/2017 2020-04-07
2018 Kain R.
Deviation of antigen presentation through (auto)antibodies
published pages: , ISSN: , DOI:
Séminaire Hospitalo-Universitaire de Strasbourg 20/09/2018 2020-04-07
2018 Brice Korkmaz, George H. Caughey, Iain Chapple, Francis Gauthier, Josefine Hirschfeld, Dieter E. Jenne, Ralph Kettritz, Gilles Lalmanach, Anne-Sophie Lamort, Conni Lauritzen, Monika Łȩgowska, Adam Lesner, Sylvain Marchand-Adam, Sarah J. McKaig, Celia Moss, John Pedersen, Helen Roberts, Adrian Schreiber, Seda Seren, Nalin S. Thakker
Therapeutic targeting of cathepsin C: from pathophysiology to treatment
published pages: 202-236, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2018.05.011
Pharmacology & Therapeutics 190 2020-04-07
2018 Marshall Bern, Tomislav Caval, Yong J. Kil, Wilfred Tang, Christopher Becker, Eric Carlson, Doron Kletter, K. Ilker Sen, Nicolas Galy, Dominique Hagemans, Vojtech Franc, Albert J. R. Heck
Parsimonious Charge Deconvolution for Native Mass Spectrometry
published pages: 1216-1226, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.7b00839
Journal of Proteome Research 17/3 2020-04-07
2018 Schulz S., Schachner H., Rees A., Kain R.
Herbsttagung 2018 der ÖGPath/IAP Austria
published pages: 480-490, ISSN: 0172-8113, DOI: 10.1007/s00292-018-0470-6
Der Pathologe 39/5 2020-04-07
2019 Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11255-0
Nature Communications 10/1 2020-04-07

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ATHENA (2019)

Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies

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DECISION (2020)

DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

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miniNO (2020)

Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

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