Opendata, web and dolomites

IMMUNE-EXPRESS SIGNED

Proteasome-Mediated Gene Expression in Plant Immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMMUNE-EXPRESS project word cloud

Explore the words cloud of the IMMUNE-EXPRESS project. It provides you a very rough idea of what is the project "IMMUNE-EXPRESS" about.

regulation    precisely    functions    accumulates    translational    sa    immune    losses    transcriptome    orchestrated    spectrum    meeting    transcription    ubiquitin    expression    hormone    unlike    consequently    regulates    broad    specialized    suggest    mimics    demands    improvement    ligase    thousands    local    reprograms    transcriptional    plays    salicylic    detect    vertebrates    understand    establishes    protection    post    intimate    agents    self    acid    enzymes    attackers    ubiquitination    crl3    plant    infection    crop    nucleus    latest    timer    yield    ups    degradation    strategies    agriculture    poorly    genes    penalties    direct    commercial    cell    harnessed    induces    normal    individual    cellular    dynamic    ring    chain    full    cells    ranges    data    ligases    immunity    prioritize    worldwide    plants    largely    master    launching    mediated    reported    substrate    chart    exposed    genetic    nonetheless    uncover    pathogenic    flexibility    critical    perception    processive    chemical    roles    npr1    cullin3    systemic    proteasome    reprogramming    coactivator    gene    variety    modifying    thought   

Project "IMMUNE-EXPRESS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://spoel.bio.ed.ac.uk/
 Total cost 1˙499˙960 €
 EC max contribution 1˙499˙960 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2021-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 1˙499˙960.00

Map

 Project objective

Plants are continuously exposed to a wide variety of pathogenic attackers that cause major crop losses to agriculture worldwide. Unlike vertebrates that use specialized immune cells to detect non-self, each individual plant cell is thought to be capable of launching an effective immune response. Plant immune responses are largely orchestrated by the immune hormone, salicylic acid (SA), which accumulates upon infection and establishes both local and broad-spectrum systemic immunity. SA induces the reprogramming of thousands of genes to prioritize immune responses over normal cellular growth functions. Consequently, commercial SA mimics have been developed and applied as crop protection agents worldwide. Nonetheless, how SA reprograms the transcriptome remains poorly understood yet is critical for the design of improved crop protection strategies that avoid plant growth and yield penalties. SA-induced transcription reprogramming is largely mediated by NPR1, a master coactivator of gene expression. We recently reported that direct perception of SA by a Cullin3-RING ubiquitin ligase (CRL3) in the nucleus regulates the transcriptional activity of NPR1 by targeting it for degradation via the ubiquitin proteasome system (UPS). Our latest data suggest that ubiquitination by CRL3 and other ubiquitin chain modifying enzymes may be processive and establishes a transcriptional timer for NPR1 activity. This proposal aims to understand the flexibility and necessity of this transcriptional ubiquitin timer in meeting cellular demands for dynamic gene expression during SA-mediated plant immune responses. Moreover, we will uncover the full substrate ranges of SA-induced ubiquitin ligases and their post-translational regulation to precisely chart the intimate roles the UPS plays in coordinating plant immune gene expression. Importantly, these findings will provide novel chemical and genetic targets that can be harnessed in future crop improvement strategies.

 Publications

year authors and title journal last update
List of publications.
2017 Sophie Kneeshaw, Rumana Keyani, Valérie Delorme-Hinoux, Lisa Imrie, Gary J. Loake, Thierry Le Bihan, Jean-Philippe Reichheld, Steven H. Spoel
Nucleoredoxin guards against oxidative stress by protecting antioxidant enzymes
published pages: 8414-8419, ISSN: 0027-8424, DOI: 10.1073/pnas.1703344114
Proceedings of the National Academy of Sciences 114/31 2020-01-29
2016 Michael J Skelly, Lucas Frungillo, Steven H Spoel
Transcriptional regulation by complex interplay between post-translational modifications
published pages: 126-132, ISSN: 1369-5266, DOI: 10.1016/j.pbi.2016.07.004
Current Opinion in Plant Biology 33 2020-01-29
2018 Sophie Kneeshaw, Steven H. Spoel
Thioredoxin-Dependent Decomposition of Protein S-Nitrosothiols
published pages: 281-297, ISSN: , DOI: 10.1007/978-1-4939-7695-9_22
Methods in Molecular Biology 1747 2020-01-29
2018 Steven H Spoel
Orchestrating the proteome with post-translational modifications
published pages: 4499-4503, ISSN: 0022-0957, DOI: 10.1093/jxb/ery295
Journal of Experimental Botany 69/19 2020-01-29
2019 Capilla Mata-Pérez, Steven H. Spoel
Thioredoxin-mediated redox signalling in plant immunity
published pages: 27-33, ISSN: 0168-9452, DOI: 10.1016/j.plantsci.2018.05.001
Plant Science 279 2020-01-29
2019 Skelly MJ, Furniss JJ, Grey HL, Wong KW, Spoel SH
Dynamic ubiquitination determines transcriptional activity of the plant immune coactivator NPR1
published pages: , ISSN: , DOI: 10.1101/582296
BioRxiv 2020-01-29
2018 James J. Furniss, Heather Grey, Zhishuo Wang, Mika Nomoto, Lorna Jackson, Yasuomi Tada, Steven H. Spoel
Proteasome-associated HECT-type ubiquitin ligase activity is required for plant immunity
published pages: e1007447, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007447
PLOS Pathogens 14/11 2020-01-29
2018 Eleanor H G Adams, Steven H Spoel
The ubiquitin–proteasome system as a transcriptional regulator of plant immunity
published pages: 4529-4537, ISSN: 0022-0957, DOI: 10.1093/jxb/ery216
Journal of Experimental Botany 69/19 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNE-EXPRESS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNE-EXPRESS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More