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epiGERMetics

Landscape of epigenetic control in early and late germ line development

Total Cost €

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EC-Contrib. €

0

Partnership

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 epiGERMetics project word cloud

Explore the words cloud of the epiGERMetics project. It provides you a very rough idea of what is the project "epiGERMetics" about.

species    technologies    zebrafish    me    gametogenesis    transcription    propagation    pcg    cell    talk    events    interdisciplinary    genomic    ultimately    differentiation    creates    angles    understand    line    cross    confident    expression    transmission    argonaute    germ    gene    acquired    believe    modifications    biology    supervisor    stone    regulate    somatic    silencing    hypothesis    vertebrates    techniques    life    reprogramming    extensive    generation    ectopically    identity    defects    sexually    material    translational    infertility    protected    polycomb    repressive    organisms    combine    cytoplasm    outside    scientist    maintaining    am    cooperation    stepping    cellular    undergo    regulation    regulated    precise    programs    background    establishing    developmental    cells    chromatin    survival    look    scientific    crossing    transcriptional    leads    reproducing    expertise    pivotal    point    perfect    epigenetic    creative    group    nucleus    genetic    model    proteins    skills    solid    misregulation    tumor    rna    independent    expert   

Project "epiGERMetics" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://molbio.science.ru.nl/about/molecular-biology/leonie-kamminga/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 177˙598.00

Map

 Project objective

Germ cells have unique role in development. They are the only cells required for the transmission of genetic material from generation to generation in sexually reproducing organisms. This makes them pivotal for the survival of species and ultimately for the propagation of life. Although germ cells undergo extensive cellular differentiation during gametogenesis, they are protected from somatic reprogramming. This requires precise control of transcriptional programs, misregulation of which leads to infertility and developmental defects. Moreover, germ cell-like properties acquired ectopically promote tumor formation. My aim is to understand how germ cell identity is controlled in vertebrates, using zebrafish as a genetic model. My hypothesis is that epigenetic control of gene expression is regulated in both the nucleus and cytoplasm of germ cells. In the nucleus, Polycomb Group (PcG) proteins regulate transcription by establishing repressive chromatin modifications. In the germ cytoplasm, translational regulation by Argonaute proteins, involved in RNA silencing pathways, is pivotal for maintaining germ cell identity. However, the events that facilitate cross-talk between the nucleus and germ cytoplasm are not known. Here, I propose to combine high-end developmental biology techniques with state-of-the art genomic technologies to investigate the cooperation between the PcG complex and Argonaute proteins during germ line development. I believe that the crossing point between my scientific interest (events outside the nucleus) and the expertise of my supervisor (regulation in the nucleus), creates a very solid background for this proposal. It will further develop my interdisciplinary skills and enhance my creative potential by allowing me to look at the regulation of germ cell identity from different angles. I am confident, that this proposal is the perfect stepping stone in becoming an independent scientist and an expert in the field of epigenetic gene regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Naomi D. Chrispijn, Karolina M. Andralojc, Charlotte Castenmiller, Leonie M. Kamminga
Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development
published pages: e0200316, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200316
PLOS ONE 13/7 2019-07-22

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