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epiGERMetics

Landscape of epigenetic control in early and late germ line development

Total Cost €

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EC-Contrib. €

0

Partnership

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 epiGERMetics project word cloud

Explore the words cloud of the epiGERMetics project. It provides you a very rough idea of what is the project "epiGERMetics" about.

independent    ectopically    silencing    line    chromatin    gene    am    life    translational    creative    ultimately    cytoplasm    argonaute    model    understand    programs    cooperation    somatic    confident    creates    vertebrates    maintaining    cross    repressive    survival    supervisor    gametogenesis    genetic    germ    establishing    pivotal    generation    point    material    crossing    identity    expression    misregulation    events    scientist    nucleus    techniques    background    regulate    regulated    sexually    stone    combine    cells    reproducing    transmission    angles    polycomb    expert    acquired    technologies    cellular    pcg    epigenetic    hypothesis    organisms    cell    protected    reprogramming    proteins    transcriptional    talk    infertility    genomic    modifications    zebrafish    species    differentiation    group    me    scientific    leads    developmental    biology    transcription    extensive    undergo    skills    regulation    defects    rna    believe    tumor    stepping    precise    perfect    solid    outside    look    expertise    propagation    interdisciplinary   

Project "epiGERMetics" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://molbio.science.ru.nl/about/molecular-biology/leonie-kamminga/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 177˙598.00

Map

 Project objective

Germ cells have unique role in development. They are the only cells required for the transmission of genetic material from generation to generation in sexually reproducing organisms. This makes them pivotal for the survival of species and ultimately for the propagation of life. Although germ cells undergo extensive cellular differentiation during gametogenesis, they are protected from somatic reprogramming. This requires precise control of transcriptional programs, misregulation of which leads to infertility and developmental defects. Moreover, germ cell-like properties acquired ectopically promote tumor formation. My aim is to understand how germ cell identity is controlled in vertebrates, using zebrafish as a genetic model. My hypothesis is that epigenetic control of gene expression is regulated in both the nucleus and cytoplasm of germ cells. In the nucleus, Polycomb Group (PcG) proteins regulate transcription by establishing repressive chromatin modifications. In the germ cytoplasm, translational regulation by Argonaute proteins, involved in RNA silencing pathways, is pivotal for maintaining germ cell identity. However, the events that facilitate cross-talk between the nucleus and germ cytoplasm are not known. Here, I propose to combine high-end developmental biology techniques with state-of-the art genomic technologies to investigate the cooperation between the PcG complex and Argonaute proteins during germ line development. I believe that the crossing point between my scientific interest (events outside the nucleus) and the expertise of my supervisor (regulation in the nucleus), creates a very solid background for this proposal. It will further develop my interdisciplinary skills and enhance my creative potential by allowing me to look at the regulation of germ cell identity from different angles. I am confident, that this proposal is the perfect stepping stone in becoming an independent scientist and an expert in the field of epigenetic gene regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Naomi D. Chrispijn, Karolina M. Andralojc, Charlotte Castenmiller, Leonie M. Kamminga
Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development
published pages: e0200316, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200316
PLOS ONE 13/7 2019-07-22

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