Opendata, web and dolomites

epiGERMetics

Landscape of epigenetic control in early and late germ line development

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 epiGERMetics project word cloud

Explore the words cloud of the epiGERMetics project. It provides you a very rough idea of what is the project "epiGERMetics" about.

creates    stone    vertebrates    transcription    solid    chromatin    biology    polycomb    cross    am    regulation    pivotal    hypothesis    developmental    epigenetic    life    gene    skills    leads    silencing    infertility    background    stepping    repressive    rna    cells    regulated    maintaining    species    confident    sexually    expert    zebrafish    proteins    pcg    argonaute    scientist    look    supervisor    outside    combine    material    gametogenesis    extensive    undergo    creative    protected    crossing    modifications    transmission    group    precise    establishing    tumor    identity    ectopically    generation    events    cellular    technologies    scientific    reproducing    propagation    reprogramming    ultimately    programs    nucleus    survival    interdisciplinary    acquired    somatic    genomic    translational    expertise    angles    genetic    believe    point    independent    line    misregulation    model    transcriptional    talk    differentiation    cell    me    perfect    regulate    germ    organisms    techniques    cytoplasm    understand    cooperation    expression    defects   

Project "epiGERMetics" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://molbio.science.ru.nl/about/molecular-biology/leonie-kamminga/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 177˙598.00

Map

 Project objective

Germ cells have unique role in development. They are the only cells required for the transmission of genetic material from generation to generation in sexually reproducing organisms. This makes them pivotal for the survival of species and ultimately for the propagation of life. Although germ cells undergo extensive cellular differentiation during gametogenesis, they are protected from somatic reprogramming. This requires precise control of transcriptional programs, misregulation of which leads to infertility and developmental defects. Moreover, germ cell-like properties acquired ectopically promote tumor formation. My aim is to understand how germ cell identity is controlled in vertebrates, using zebrafish as a genetic model. My hypothesis is that epigenetic control of gene expression is regulated in both the nucleus and cytoplasm of germ cells. In the nucleus, Polycomb Group (PcG) proteins regulate transcription by establishing repressive chromatin modifications. In the germ cytoplasm, translational regulation by Argonaute proteins, involved in RNA silencing pathways, is pivotal for maintaining germ cell identity. However, the events that facilitate cross-talk between the nucleus and germ cytoplasm are not known. Here, I propose to combine high-end developmental biology techniques with state-of-the art genomic technologies to investigate the cooperation between the PcG complex and Argonaute proteins during germ line development. I believe that the crossing point between my scientific interest (events outside the nucleus) and the expertise of my supervisor (regulation in the nucleus), creates a very solid background for this proposal. It will further develop my interdisciplinary skills and enhance my creative potential by allowing me to look at the regulation of germ cell identity from different angles. I am confident, that this proposal is the perfect stepping stone in becoming an independent scientist and an expert in the field of epigenetic gene regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Naomi D. Chrispijn, Karolina M. Andralojc, Charlotte Castenmiller, Leonie M. Kamminga
Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development
published pages: e0200316, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200316
PLOS ONE 13/7 2019-07-22

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EPIGERMETICS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EPIGERMETICS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

CORRELATION (2020)

Characterization and prediction of service-level traffic for future sliced mobile network

Read More