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epiGERMetics

Landscape of epigenetic control in early and late germ line development

Total Cost €

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EC-Contrib. €

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Partnership

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 epiGERMetics project word cloud

Explore the words cloud of the epiGERMetics project. It provides you a very rough idea of what is the project "epiGERMetics" about.

model    silencing    background    confident    interdisciplinary    proteins    am    nucleus    undergo    life    expression    extensive    transcriptional    leads    combine    identity    infertility    outside    crossing    talk    material    generation    regulated    translational    cytoplasm    rna    ectopically    perfect    transmission    propagation    protected    transcription    chromatin    expert    line    developmental    stepping    pcg    techniques    events    scientific    repressive    regulation    skills    ultimately    cellular    epigenetic    genetic    expertise    zebrafish    scientist    gametogenesis    regulate    precise    acquired    reprogramming    programs    me    tumor    maintaining    vertebrates    establishing    angles    cells    hypothesis    cell    look    modifications    defects    reproducing    polycomb    biology    technologies    cooperation    germ    pivotal    solid    species    creative    gene    group    survival    argonaute    believe    point    somatic    organisms    differentiation    stone    cross    understand    sexually    misregulation    independent    genomic    supervisor    creates   

Project "epiGERMetics" data sheet

The following table provides information about the project.

Coordinator
STICHTING KATHOLIEKE UNIVERSITEIT 

Organization address
address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ
website: www.radboudumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://molbio.science.ru.nl/about/molecular-biology/leonie-kamminga/
 Total cost 177˙598 €
 EC max contribution 177˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-10-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) coordinator 177˙598.00

Map

 Project objective

Germ cells have unique role in development. They are the only cells required for the transmission of genetic material from generation to generation in sexually reproducing organisms. This makes them pivotal for the survival of species and ultimately for the propagation of life. Although germ cells undergo extensive cellular differentiation during gametogenesis, they are protected from somatic reprogramming. This requires precise control of transcriptional programs, misregulation of which leads to infertility and developmental defects. Moreover, germ cell-like properties acquired ectopically promote tumor formation. My aim is to understand how germ cell identity is controlled in vertebrates, using zebrafish as a genetic model. My hypothesis is that epigenetic control of gene expression is regulated in both the nucleus and cytoplasm of germ cells. In the nucleus, Polycomb Group (PcG) proteins regulate transcription by establishing repressive chromatin modifications. In the germ cytoplasm, translational regulation by Argonaute proteins, involved in RNA silencing pathways, is pivotal for maintaining germ cell identity. However, the events that facilitate cross-talk between the nucleus and germ cytoplasm are not known. Here, I propose to combine high-end developmental biology techniques with state-of-the art genomic technologies to investigate the cooperation between the PcG complex and Argonaute proteins during germ line development. I believe that the crossing point between my scientific interest (events outside the nucleus) and the expertise of my supervisor (regulation in the nucleus), creates a very solid background for this proposal. It will further develop my interdisciplinary skills and enhance my creative potential by allowing me to look at the regulation of germ cell identity from different angles. I am confident, that this proposal is the perfect stepping stone in becoming an independent scientist and an expert in the field of epigenetic gene regulation.

 Publications

year authors and title journal last update
List of publications.
2018 Naomi D. Chrispijn, Karolina M. Andralojc, Charlotte Castenmiller, Leonie M. Kamminga
Gene expression profile of a selection of Polycomb Group genes during zebrafish embryonic and germ line development
published pages: e0200316, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200316
PLOS ONE 13/7 2019-07-22

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