Opendata, web and dolomites


Role of IFN-β in mitochondrial homeostasis and impact on Parkinson Disease

Total Cost €


EC-Contrib. €






 IFNBetaMito project word cloud

Explore the words cloud of the IFNBetaMito project. It provides you a very rough idea of what is the project "IFNBetaMito" about.

transferable    found    proteinopathies    lacking    disorder    homeostasis    pathological    biochemistry    parkinson    broaden    spontaneous    movement    expertise    neurons    accumulation    dynamics    deficits    physiopathology    protein    highlight    cells    therapy    pr    proteomic    drug    mechanisms    bodies    biochemical    transfer    scientific    lewy    skills    precisely    cytoplasmic    display    researcher    brains    supervised    mitochondria    defects    complemented    receptor    mechanism    ifn    neurodegenerative    neurodegeneration    treatments    despite    curative    expert    pd    beta    mice    molecular    disease    biology    ifnar    acquiring    independent    signalling    appearance    progressive    progress    behavioral    mitochondrial    shohreh    pathogenesis    4d    lesions    interferon    murine    prominent    laboratory    regulation    resembling    combination    host    ifnb    defective    navikas    accomplishment    inclusion    neurological    myself    issazadeh    3d    insights    neuronal    world    microscopy    engineered    cell   

Project "IFNBetaMito" data sheet

The following table provides information about the project.


Organization address
address: NORREGADE 10
postcode: 1165

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00


 Project objective

Parkinson disease (PD) is the most common progressive neurodegenerative movement disorder. Two prominent pathological features are associated with the neurological lesions: the appearance of cytoplasmic inclusion bodies called Lewy bodies, and defective mitochondria. Despite recent progress in understanding the pathogenesis of PD, no curative treatments are available. The host laboratory has very recently found a novel mechanism leading to PD: mice lacking interferon (IFN)-β (Ifnb–/–) or its receptor (Ifnar–/–) display spontaneous neurodegeneration and experience behavioral deficits resembling PD. In particular, Ifnb–/– neurons show mitochondrial defects with accumulation of defective mitochondria. The overall goal of this proposal is to determine the molecular mechanisms of mitochondria homeostasis controlled by IFN-β and how this is involved in PD. 1. I will characterize precisely the mitochondrial defects found in Ifnb–/– mice using a combination of 3D and 4D microscopy and biochemistry analysis. 2. I will identify the protein dynamics involved in the IFN-β regulation of mitochondria homeostasis, using proteomic analysis complemented by microscopy and biochemical studies on engineered cells. 3. I will determine the importance of this pathway in the physiopathology of PD by studying the impact of IFN-β on mitochondria in murine brains and using engineered mitochondrial transfer. The accomplishment of this project will provide new insights into IFN-β regulation of neuronal homeostasis and highlight novel drug targets for future therapy development against PD. The project will be supervised by Pr Shohreh Issazadeh-Navikas, a world-leading expert in the field of IFN-β signalling pathway. Through this work, I aim to broaden my scientific expertise by acquiring numerous technical and transferable skills and to establish myself as an independent researcher in the field of cell biology of proteinopathies.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IFNBETAMITO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IFNBETAMITO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

RegARcis (2020)

Role of the SWI/SNF complex in the Androgen Receptor cistrome regulation

Read More