Explore the words cloud of the LIFEGATE project. It provides you a very rough idea of what is the project "LIFEGATE" about.
The following table provides information about the project.
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
|Coordinator Country||Germany [DE]|
|Total cost||1˙997˙973 €|
|EC max contribution||1˙997˙973 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-11-01 to 2022-10-31|
Take a look of project's partnership.
|1||LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.||DE (JENA)||coordinator||1˙843˙454.00|
|2||UNIVERSITY OF DUNDEE||UK (DUNDEE)||participant||154˙518.00|
Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice. This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms. A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes. This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans. Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease. Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ.
|year||authors and title||journal||last update|
Sergey Turtaev, Ivo T. Leite, Tristan Altwegg-Boussac, Janelle M. P. Pakan, Nathalie L. Rochefort, TomÃ¡Å¡ ÄŒiÅ¾mÃ¡r
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0094-x
|Light: Science & Applications 7/1||2019-09-04|
Dirk E. Boonzajer Flaes, Jan Stopka, Sergey Turtaev, Johannes F. de Boer, TomÃ¡Å¡ Tyc, TomÃ¡Å¡ ÄŒiÅ¾mÃ¡r
Robustness of Light-Transport Processes to Bending Deformations in Graded-Index Multimode Waveguides
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.120.233901
|Physical Review Letters 120/23||2019-09-04|
Sergey Turtaev, Ivo T. Leite, Kevin J. Mitchell, Miles J. Padgett, David B. Phillips, TomÃ¡Å¡ ÄŒiÅ¾mÃ¡r
Comparison of nematic liquid-crystal and DMD based spatial light modulation in complex photonics
published pages: 29874, ISSN: 1094-4087, DOI: 10.1364/OE.25.029874
|Optics Express 25/24||2019-09-04|
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