LIFEGATE SIGNED
Holographic super-resolution micro-endoscopy for in-vivo applications
Total Cost €
0EC-Contrib. €
0Partnership
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Explore the words cloud of the LIFEGATE project. It provides you a very rough idea of what is the project "LIFEGATE" about.
Project "LIFEGATE" data sheet
The following table provides information about the project.
| Coordinator |
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙997˙973 € |
| EC max contribution | 1˙997˙973 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-11-01 to 2022-10-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. | DE (JENA) | coordinator | 1˙843˙454.00 |
| 2 | UNIVERSITY OF DUNDEE | UK (DUNDEE) | participant | 154˙518.00 |
Map
Project objective
Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice. This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms. A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes. This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans. Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease. Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Sergey Turtaev, Ivo T. Leite, Tristan Altwegg-Boussac, Janelle M. P. Pakan, Nathalie L. Rochefort, Tomáš Čižmár High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0094-x |
Light: Science & Applications 7/1 | 2019-09-04 |
| 2018 |
Dirk E. Boonzajer Flaes, Jan Stopka, Sergey Turtaev, Johannes F. de Boer, Tomáš Tyc, Tomáš Čižmár Robustness of Light-Transport Processes to Bending Deformations in Graded-Index Multimode Waveguides published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.120.233901 |
Physical Review Letters 120/23 | 2019-09-04 |
| 2017 |
Sergey Turtaev, Ivo T. Leite, Kevin J. Mitchell, Miles J. Padgett, David B. Phillips, Tomáš Čižmár Comparison of nematic liquid-crystal and DMD based spatial light modulation in complex photonics published pages: 29874, ISSN: 1094-4087, DOI: 10.1364/OE.25.029874 |
Optics Express 25/24 | 2019-09-04 |
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