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LIFEGATE SIGNED

Holographic super-resolution micro-endoscopy for in-vivo applications

Total Cost €

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EC-Contrib. €

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Partnership

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 LIFEGATE project word cloud

Explore the words cloud of the LIFEGATE project. It provides you a very rough idea of what is the project "LIFEGATE" about.

endoscopes    images    onset    deploy    technological    microsurgery    moving    endoscopic    transdisciplinary    light    complexity    push    magnitude    human    fuelled    branches    introduce    lastly    penetration    methodology    organisms    numerical    first    retrieved    ultra    living    modern    team    platform    operative    randomised    depths    sciences    histology    orders    delicate    recovery    flexible    imaging    vivo    alzheimer    sub    inside    inaccessible    resolution    ultimately    disorders    diagnostics    acquiring    minimally    functional    disabling    quality    animal    technique    powerful    broad    clinical    tissues    keyhole    basis    models    analytical    connectivity    life    fast    exceeding    capacity    cellular    additionally    window    live    neuroscience    gate    unprecedented    super    holographic    poses    experts    performance    body    imagery    humans    fibres    expertise    thin    paving    situ    experimental    neuronal    propagation    single    surgical    limits    fibre    microscopy    invasive    multimode    efficient    prominent    disease    regions    neurons    instance    race    medical    fundamental    rigid    barrier   

Project "LIFEGATE" data sheet

The following table provides information about the project.

Coordinator
LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. 

Organization address
address: Albert Einstein strasse 9
city: JENA
postcode: 7745
website: www.ipht-jena.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙973 €
 EC max contribution 1˙997˙973 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. DE (JENA) coordinator 1˙843˙454.00
2    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 154˙518.00

Map

 Project objective

Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice. This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms. A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes. This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans. Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease. Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ.

 Publications

year authors and title journal last update
List of publications.
2018 Sergey Turtaev, Ivo T. Leite, Tristan Altwegg-Boussac, Janelle M. P. Pakan, Nathalie L. Rochefort, Tomáš Čižmár
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0094-x
Light: Science & Applications 7/1 2019-09-04
2018 Dirk E. Boonzajer Flaes, Jan Stopka, Sergey Turtaev, Johannes F. de Boer, Tomáš Tyc, Tomáš Čižmár
Robustness of Light-Transport Processes to Bending Deformations in Graded-Index Multimode Waveguides
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.120.233901
Physical Review Letters 120/23 2019-09-04
2017 Sergey Turtaev, Ivo T. Leite, Kevin J. Mitchell, Miles J. Padgett, David B. Phillips, Tomáš Čižmár
Comparison of nematic liquid-crystal and DMD based spatial light modulation in complex photonics
published pages: 29874, ISSN: 1094-4087, DOI: 10.1364/OE.25.029874
Optics Express 25/24 2019-09-04

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The information about "LIFEGATE" are provided by the European Opendata Portal: CORDIS opendata.

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