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Holographic super-resolution micro-endoscopy for in-vivo applications

Total Cost €


EC-Contrib. €






 LIFEGATE project word cloud

Explore the words cloud of the LIFEGATE project. It provides you a very rough idea of what is the project "LIFEGATE" about.

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Project "LIFEGATE" data sheet

The following table provides information about the project.


Organization address
address: Albert Einstein strasse 9
city: JENA
postcode: 7745

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙973 €
 EC max contribution 1˙997˙973 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2022-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
2    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 154˙518.00


 Project objective

Complexity of living matter currently poses the most significant barrier to modern in-vivo microscopy. Fuelled by various branches of life sciences, the race is now to increase the penetration depth of super-resolution imaging inside living organisms. Additionally, no high-resolution in-vivo imaging technique has ever been introduced into medical, particularly surgical practice. This proposal sets out to develop new, ultra-thin endoscopic devices exceeding by orders of magnitude the performance of the current state of the art, thus paving the way for acquiring high-quality images from unprecedented depths of the most delicate tissues of living organisms. A team of transdisciplinary experts will push the fundamental and technological limits of the enabling principle - holographic control of light propagation in multimode fibres. Through advanced analytical and numerical modelling and major advancement of experimental methods, the project will develop a powerful platform for fast and efficient recovery of randomised imagery, retrieved from both rigid and flexible single-fibre endoscopes. This ‘gate-through-life’ will enable the team to deploy several prominent light-based imaging methods, including super-resolution approaches, inside freely moving animal models and ultimately humans. Supported by partners with broad expertise in in-vivo imaging, I will apply this methodology in the first instance to Neuroscience. This will provide a new, minimally invasive window into fundamental processes behind sub-cellular-scale functional connectivity of neurons and onset of common disabling neuronal disorders such as Alzheimer’s disease. Lastly, I will introduce the first technological basis for keyhole clinical diagnostics, enabling intra-operative live histology and microsurgery. This new imaging capacity will be able to reach currently inaccessible regions of the human body, while providing images with sub-cellular resolution in-situ.


year authors and title journal last update
List of publications.
2018 Sergey Turtaev, Ivo T. Leite, Tristan Altwegg-Boussac, Janelle M. P. Pakan, Nathalie L. Rochefort, Tomáš Čižmár
High-fidelity multimode fibre-based endoscopy for deep brain in vivo imaging
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0094-x
Light: Science & Applications 7/1 2019-09-04
2018 Dirk E. Boonzajer Flaes, Jan Stopka, Sergey Turtaev, Johannes F. de Boer, Tomáš Tyc, Tomáš Čižmár
Robustness of Light-Transport Processes to Bending Deformations in Graded-Index Multimode Waveguides
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.120.233901
Physical Review Letters 120/23 2019-09-04
2017 Sergey Turtaev, Ivo T. Leite, Kevin J. Mitchell, Miles J. Padgett, David B. Phillips, Tomáš Čižmár
Comparison of nematic liquid-crystal and DMD based spatial light modulation in complex photonics
published pages: 29874, ISSN: 1094-4087, DOI: 10.1364/OE.25.029874
Optics Express 25/24 2019-09-04

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