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LIPSYNING SIGNED

Eat me microglia: lipid scrambling as a signal for synaptic pruning

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIPSYNING project word cloud

Explore the words cloud of the LIPSYNING project. It provides you a very rough idea of what is the project "LIPSYNING" about.

aberrant    synapses    right    neural    brains    primate    ptdser    excess    survive    months    plays    life    lipid    circuit    emerges    removal    signals    pruning    disease    generation    followed    mediate    made    tool    phosphatidylserine    interfering    lost    behavioural    signal    dependent    impaired    critical    mechanisms    circuits    models    final    aetiology    neuronal    light    formed    synapse    defective    disorders    identification    determines    phagocytic    engulfment    phospholipid    eliminated    interaction    majority    connectome    selectively    period    destined    refined    cell    molecular    morphological    hypothesize    brain    neurodevelopmental    me    microglial    six    surface    elimination    developmental    nervous    turned    cellular    presented    phagocytosis    contributes    therapy    shed    cortex    microglia    custom    maturation    scramblase    first    70    refinement    distinguishes    mouse    initiate    exposure    interactions    eat    wiring    connections    tightly    synaptic    mechanism    deficient    understand    observe    disrupted    recognition   

Project "LIPSYNING" data sheet

The following table provides information about the project.

Coordinator
VILNIAUS UNIVERSITETAS 

Organization address
address: UNIVERSITETO G. 3
city: VILNIUS
postcode: 1513
website: http://www.vu.lt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Lithuania [LT]
 Total cost 130˙779 €
 EC max contribution 130˙779 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2021-10-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VILNIAUS UNIVERSITETAS LT (VILNIUS) coordinator 130˙779.00

Map

 Project objective

The development of the nervous system is associated with the generation of excess neuronal synapses that is followed by their tightly controlled removal, a process known as synaptic pruning. In the primate cortex, for example, 70% of connections are selectively lost within the first six months of life. Why are so many synapses lost, what determines which synapses are eliminated, what are the molecular mechanisms involved, and what are the consequences of not getting it right? Recently, several studies have presented microglial phagocytosis as a mechanism for synapse elimination. Neural activity plays a role in synaptic pruning, but the neuronal “eat-me” signals that mediate phagocytic recognition and engulfment of synapses remain to be identified. We hypothesize that cell surface exposure of the lipid phosphatidylserine (PtdSer) is a key “eat-me” signal for synaptic pruning during development. Therefore we aim to define the role of PtdSer in synapse-microglia interaction and to assess the morphological, circuit maturation and behavioural effects of impaired PtdSer exposure in phospholipid scramblase-deficient brains. We propose to use novel custom-made tool to observe PtdSer exposure without interfering with PtdSer-dependent cellular interactions and two mouse models with disrupted PtdSer exposure to study how PtdSer contributes to circuit refinement. The identification of an “eat-me” signal will shed the light on what distinguishes synapses destined to be eliminated from those that survive and will be the first step in understanding why the majority of synapses are turned over during brain development before the final connectome emerges. As aberrant brain wiring during development is known to be defective in a wide range of neurodevelopmental disorders, understanding how circuits are formed and refined during developmental period will be critical to understand their aetiology and initiate the development of the therapy targeting molecular mechanisms of disease.

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The information about "LIPSYNING" are provided by the European Opendata Portal: CORDIS opendata.

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