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Multipoint Optical DEvices for Minimally invasive neural circuits interface

Total Cost €


EC-Contrib. €






Project "MODEM" data sheet

The following table provides information about the project.


Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙996˙250 €
 EC max contribution 1˙996˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

A primary goal of experimental neuroscience is to dissect the neural microcircuitry underlying brain function, ultimately to link specific neural circuits to behavior. There is widespread agreement that innovative new research tools are required to better understand the incredible structural and functional complexity of the brain. To this aim, optical techniques based on genetically encoded neural activity indicators and actuators have represented a revolution for experimental neuroscience, allowing genetic targeting of specific classes of neurons and brain circuits. However, for optical approaches to reach their full potential, we need new generations of devices better able to interface with the extreme complexity and diversity of brain topology and connectivity. This project aspires to develop innovative technologies for multipoint optical neural interfacing with the mammalian brain in vivo. The limitations of the current state-of-the-art will be surmounted by developing a radically new approach for modal multiplexing and de-multiplexing of light into a single, thin, minimally invasive tapered optical fiber serving as a carrier for multipoint signals to and from the brain. This will be achieved through nano- and micro-structuring of the taper edge, capitalizing on the photonic properties of the tapered waveguide to precisely control light delivery and collection in vivo. This general approach will propel the development of innovative new nano- and micro-photonic devices for studying the living brain. The main objectives of the proposals are: 1) Development of minimally invasive technologies for versatile, user-defined optogenetic control over deep brain regions; 2) Development of fully integrated high signal-to- noise-ratio optrodes; 3) Development of minimally invasive technologies for multi-point in vivo all-optical “electrophysiology” through a single waveguide; 4) Development of new optical methodologies for dissecting brain circuitry at small and large scale


year authors and title journal last update
List of publications.
2018 Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-22790-z
Scientific Reports 8/1 2019-06-19
2017 Ferruccio Pisanello, Gil Mandelbaum, Marco Pisanello, Ian A Oldenburg, Leonardo Sileo, Jeffrey E Markowitz, Ralph E Peterson, Andrea Della Patria, Trevor M Haynes, Mohamed S Emara, Barbara Spagnolo, Sandeep Robert Datta, Massimo De Vittorio, Bernardo L Sabatini
Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber
published pages: 1180-1188, ISSN: 1097-6256, DOI: 10.1038/nn.4591
Nature Neuroscience 20/8 2019-06-19
2018 Filippo Pisano, Marco Pisanello, Leonardo Sileo, Antonio Qualtieri, Bernardo L. Sabatini, Massimo De Vittorio, Ferruccio Pisanello
Focused ion beam nanomachining of tapered optical fibers for patterned light delivery
published pages: 41-49, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.03.023
Microelectronic Engineering 195 2019-06-19
2018 Alessandro Rizzo, Enrico Domenico Lemma, Filippo Pisano, Marco Pisanello, Leonardo Sileo, Massimo De Vittorio, Ferruccio Pisanello
Laser micromachining of tapered optical fibers for spatially selective control of neural activity
published pages: 88-95, ISSN: 0167-9317, DOI: 10.1016/j.mee.2018.02.010
Microelectronic Engineering 192 2019-06-19
2019 Ferruccio Pisanello
Implantable micro and nanophotonic devices: toward a new generation of neural interfaces
published pages: 110979, ISSN: 0167-9317, DOI: 10.1016/j.mee.2019.110979
Microelectronic Engineering 215 2019-08-05
2019 Marco Pisanello, Filippo Pisano, Minsuk Hyun, Emanuela Maglie, Antonio Balena, Massimo De Vittorio, Bernardo L. Sabatini, Ferruccio Pisanello
The Three-Dimensional Signal Collection Field for Fiber Photometry in Brain Tissue
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00082
Frontiers in Neuroscience 13 2019-05-22
2018 Mohamed S. Emara, Marco Pisanello, Leonardo Sileo, Massimo De Vittorio, Ferruccio Pisanello
A Wireless Head-mountable Device with Tapered Optical Fiber-coupled Laser Diode for Light Delivery in Deep Brain Regions
published pages: 1-1, ISSN: 0018-9294, DOI: 10.1109/tbme.2018.2882146
IEEE Transactions on Biomedical Engineering 2019-05-22
2018 Leonardo Sileo, Sebastian H. Bitzenhofer, Barbara Spagnolo, Jastyn A. Pöpplau, Tobias Holzhammer, Marco Pisanello, Filippo Pisano, Elisa Bellistri, Emanuela Maglie, Massimo De Vittorio, Patrick Ruther, Ileana L. Hanganu-Opatz, Ferruccio Pisanello
Tapered Fibers Combined With a Multi-Electrode Array for Optogenetics in Mouse Medial Prefrontal Cortex
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00771
Frontiers in Neuroscience 12 2019-05-22

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