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CHROMTOPOLOGY SIGNED

Understanding and manipulating the dynamics of chromosome topologies in transcriptional control

Total Cost €

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EC-Contrib. €

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Partnership

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 CHROMTOPOLOGY project word cloud

Explore the words cloud of the CHROMTOPOLOGY project. It provides you a very rough idea of what is the project "CHROMTOPOLOGY" about.

genome    chromosome    distal    expression    development    chromatin    regulation    ins    regions    engineer    topology    organize    sized    transcription    questions    topologically    acting    denoted    configurations    optogenetics    understand    sequences    regulated    exists    anchor    technologies    dna    architectures    gene    combination    folded    transcriptional    underlying    discretely    shown    cells    metazoan    megabase    variabilities    imaging    contact    status    genes    cell    interactions    eukaryotic    direct    enhancers    seem    organization    loops    altered    paradigm    histone    novo    de    domains    genetic    fundamental    modifications    crispr    time    epigenetic    screens    accompanying    folding    unknown    genomes    knock    nuclei    single    resolution    trans    striking    give    tagging    super    engineered    consequence    view    regulatory    repair    tads    function    correlation    anticipate    environment    correlate    influence    tightly    groundbreaking    replication    accessible    kinetics    regulates    loci    tad    packaged    hi    textbook    interplay   

Project "CHROMTOPOLOGY" data sheet

The following table provides information about the project.

Coordinator
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE 

Organization address
address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404
website: www.igbmc.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.igbmc.fr/research/department/2/team/118/
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) coordinator 1˙500˙000.00

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 Project objective

Transcriptional regulation of genes in eukaryotic cells requires a complex and highly regulated interplay of chromatin environment, epigenetic status of target sequences and several different transcription factors. Eukaryotic genomes are tightly packaged within nuclei, yet must be accessible for transcription, replication and repair. A striking correlation exists between chromatin topology and underlying gene activity. According to the textbook view, chromatin loops bring genes into direct contact with distal regulatory elements, such as enhancers. Moreover, we and others have shown that genomes are organized into discretely folded megabase-sized regions, denoted as topologically associated domains (TADs), which seem to correlate well with transcription activity and histone modifications. However, it is unknown whether chromosome folding is a cause or consequence of underlying gene function. To better understand the role of genome organization in transcription regulation, I will address the following questions:

(i) How are chromatin configurations altered during transcriptional changes accompanying development? (ii) What are the real-time kinetics and cell-to-cell variabilities of chromatin interactions and TAD architectures? (iii) Can chromatin loops be engineered de novo, and do they influence gene expression? (iv) What genetic elements and trans-acting factors are required to organize TADs?

To address these fundamental questions, I will use a combination of novel technologies and approaches, such as Hi-C, CRISPR knock-ins, ANCHOR tagging of DNA loci, high- and super-resolution single-cell imaging, genome-wide screens and optogenetics, in order to both study and engineer chromatin architectures. These studies will give groundbreaking insight into if and how chromatin topology regulates transcription. Thus, I anticipate that the results of this project will have a major impact on the field and will lead to a new paradigm for metazoan transcription control.

 Publications

year authors and title journal last update
List of publications.
2020 Yousra Ben Zouari, Angeliki Platania, Anne M. Molitor, Tom Sexton
4See: A Flexible Browser to Explore 4C Data
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.01372
Frontiers in Genetics 10 2020-03-11
2019 Yousra Ben Zouari, Anne M. Molitor, Natalia Sikorska, Vera Pancaldi, Tom Sexton
ChiCMaxima: a robust and simple pipeline for detection and visualization of chromatin looping in Capture Hi-C
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1706-3
Genome Biology 20/1 2019-08-30

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