Explore the words cloud of the OPTOACOUSTOGENETICS project. It provides you a very rough idea of what is the project "OPTOACOUSTOGENETICS" about.
The following table provides information about the project.
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
|Coordinator Country||Germany [DE]|
|Total cost||1˙997˙715 €|
|EC max contribution||1˙997˙714 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2016-10-01 to 2021-09-30|
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|1||HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH||DE (NEUHERBERG)||coordinator||1˙997˙714.00|
Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. The progress is hampered by the limited capacity of state-of-the-art functional neuroimaging tools, which do not permit simultaneous monitoring of whole-brain activity with an adequate spatiotemporal resolution. Our recently developed five-dimensional optoacoustic tomography technique is ideally poised to overcome these limitations – it has shown excellent capacity for imaging intrinsic contrast in entire brains of vertebrates and rodents non-invasively; delivers unmatched temporal resolution in the milliseconds range for true volumetric imaging in real time; capable of label-free observations of hemodynamic changes and sensitive to genetic markers of neural activity. Yet, several fundamental challenges ought to be addressed before true potential of optoacoustic functional neuroimaging is unveiled. First, optoacoustic monitoring of fast neural activation under physiologically relevant stimuli and in real disease models has not been achieved. Furthermore, a variety of acoustic effects introduced by the skull compromise performance of optoacoustics in transcranial imaging of murine models, further hindering its clinical translation potential. Finally, technology needs to be developed that can deliver information from single neurons while maintaining high volumetric imaging speed. By resolving those challenges, the current project will yield a unique and groundbreaking functional neuroimaging method that can truly transform the existing paradigms in neuroscience by delivering real time information from hundreds of thousands or even millions of neurons simultaneously.
|year||authors and title||journal||last update|
X.L. DeÃ¡n-Ben, D. Razansky
Optoacoustic signal excitation with a tone-burst of short pulses
published pages: 1-5, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.06.001
Jake Turner, HÃ©ctor Estrada, Moritz Kneipp, Daniel Razansky
Universal weighted synthetic aperture focusing technique (W-SAFT) for scanning optoacoustic microscopy
published pages: 770, ISSN: 2334-2536, DOI: 10.1364/OPTICA.4.000770
Zhenyue Chen, XosÃ© LuÃs DeÃ¡n-Ben, Sven Gottschalk, Daniel Razansky
Performance of optoacoustic and fluorescence imaging in detecting deep-seated fluorescent agents
published pages: 2229, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002229
|Biomedical Optics Express 9/5||2019-06-18|
X. L. DeÃ¡n-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, D. Razansky
Advanced optoacoustic methods for multiscale imaging of in vivo dynamics
published pages: 2158-2198, ISSN: 0306-0012, DOI: 10.1039/c6cs00765a
|Chemical Society Reviews 46/8||2019-06-18|
X. L. DeÃ¡n-Ben, E. MerÄep, D. Razansky
Hybrid-array-based optoacoustic and ultrasound (OPUS) imaging of biological tissues
published pages: 203703, ISSN: 0003-6951, DOI: 10.1063/1.4983462
|Applied Physics Letters 110/20||2019-06-18|
Saak V. Ovsepian, Ivan Olefir, Gil Westmeyer, Daniel Razansky, Vasilis Ntziachristos
Pushing the Boundaries of Neuroimaging with Optoacoustics
published pages: 966-988, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.10.022
Benedict Mc Larney, Johannes Rebling, Zhenyue Chen, XosÃ© LuÃs DeÃ¡nâ€Ben, Sven Gottschalk, Daniel Razansky
Uniform light delivery in volumetric optoacoustic tomography
published pages: e201800387, ISSN: 1864-063X, DOI: 10.1002/jbio.201800387
|Journal of Biophotonics 12/6||2019-08-05|
HÃ©ctor Estrada, Sven Gottschalk, Michael Reiss, Volker Neuschmelting, Roland Goldbrunner, Daniel Razansky
Observation of Guided Acoustic Waves in a Human Skull
published pages: 2388-2392, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2018.05.019
|Ultrasound in Medicine & Biology 44/11||2019-08-05|
Sven Gottschalk, Oleksiy Degtyaruk, Benedict Mc Larney, Johannes Rebling, Magdalena Anastasia Hutter, XosÃ© LuÃs DeÃ¡n-Ben, Shy Shoham, Daniel Razansky
Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain
published pages: 392-401, ISSN: 2157-846X, DOI: 10.1038/s41551-019-0372-9
|Nature Biomedical Engineering 3/5||2019-08-05|
Yong Qian, Kiryl D. Piatkevich, Benedict Mc Larney, Ahmed S. Abdelfattah, Sohum Mehta, Mitchell H. Murdock, Sven Gottschalk, Rosana S. Molina, Wei Zhang, Yingche Chen, Jiahui Wu, Mikhail Drobizhev, Thomas E. Hughes, Jin Zhang, Eric R. Schreiter, Shy Shoham, Daniel Razansky, Edward S. Boyden, Robert E. Campbell
A genetically encoded near-infrared fluorescent calcium ion indicator
published pages: 171-174, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0294-6
|Nature Methods 16/2||2019-08-05|
Sven Gottschalk, Oleksiy Degtyaruk, Benedict Mc Larney, Johannes Rebling, XosÃ© Luis DeÃ¡n-Ben, Shy Shoham, Daniel Razansky
Isolated Murine Brain Model for Large-Scale Optoacoustic Calcium Imaging
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00290
|Frontiers in Neuroscience 13||2019-08-05|
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