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Hybrid Volumetric Optoacoustic-Ultrasound Tomography for Noninvasive Large-Scale Recording of Brain Activity with High Spatiotemporal Resolution

Total Cost €


EC-Contrib. €






 OPTOACOUSTOGENETICS project word cloud

Explore the words cloud of the OPTOACOUSTOGENETICS project. It provides you a very rough idea of what is the project "OPTOACOUSTOGENETICS" about.

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Project "OPTOACOUSTOGENETICS" data sheet

The following table provides information about the project.


Organization address
postcode: 85764

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙997˙715 €
 EC max contribution 1˙997˙714 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Non-invasive observation of fast spatiotemporal activity patterns of large neural populations distributed over entire brains is a longstanding goal of neuroscience. Not only would such abilities significantly promote our knowledge on brain function and its pathophysiology but they are also expected to accelerate development of novel therapies targeting neurological and neuropsychiatric disorders. The progress is hampered by the limited capacity of state-of-the-art functional neuroimaging tools, which do not permit simultaneous monitoring of whole-brain activity with an adequate spatiotemporal resolution. Our recently developed five-dimensional optoacoustic tomography technique is ideally poised to overcome these limitations – it has shown excellent capacity for imaging intrinsic contrast in entire brains of vertebrates and rodents non-invasively; delivers unmatched temporal resolution in the milliseconds range for true volumetric imaging in real time; capable of label-free observations of hemodynamic changes and sensitive to genetic markers of neural activity. Yet, several fundamental challenges ought to be addressed before true potential of optoacoustic functional neuroimaging is unveiled. First, optoacoustic monitoring of fast neural activation under physiologically relevant stimuli and in real disease models has not been achieved. Furthermore, a variety of acoustic effects introduced by the skull compromise performance of optoacoustics in transcranial imaging of murine models, further hindering its clinical translation potential. Finally, technology needs to be developed that can deliver information from single neurons while maintaining high volumetric imaging speed. By resolving those challenges, the current project will yield a unique and groundbreaking functional neuroimaging method that can truly transform the existing paradigms in neuroscience by delivering real time information from hundreds of thousands or even millions of neurons simultaneously.


year authors and title journal last update
List of publications.
2018 X.L. Deán-Ben, D. Razansky
Optoacoustic signal excitation with a tone-burst of short pulses
published pages: 1-5, ISSN: 2213-5979, DOI: 10.1016/j.pacs.2018.06.001
Photoacoustics 11 2019-08-29
2017 Jake Turner, Héctor Estrada, Moritz Kneipp, Daniel Razansky
Universal weighted synthetic aperture focusing technique (W-SAFT) for scanning optoacoustic microscopy
published pages: 770, ISSN: 2334-2536, DOI: 10.1364/OPTICA.4.000770
Optica 4/7 2019-06-18
2018 Zhenyue Chen, Xosé Luís Deán-Ben, Sven Gottschalk, Daniel Razansky
Performance of optoacoustic and fluorescence imaging in detecting deep-seated fluorescent agents
published pages: 2229, ISSN: 2156-7085, DOI: 10.1364/BOE.9.002229
Biomedical Optics Express 9/5 2019-06-18
2017 X. L. Deán-Ben, S. Gottschalk, B. Mc Larney, S. Shoham, D. Razansky
Advanced optoacoustic methods for multiscale imaging of in vivo dynamics
published pages: 2158-2198, ISSN: 0306-0012, DOI: 10.1039/c6cs00765a
Chemical Society Reviews 46/8 2019-06-18
2017 X. L. Deán-Ben, E. Merčep, D. Razansky
Hybrid-array-based optoacoustic and ultrasound (OPUS) imaging of biological tissues
published pages: 203703, ISSN: 0003-6951, DOI: 10.1063/1.4983462
Applied Physics Letters 110/20 2019-06-18
2017 Saak V. Ovsepian, Ivan Olefir, Gil Westmeyer, Daniel Razansky, Vasilis Ntziachristos
Pushing the Boundaries of Neuroimaging with Optoacoustics
published pages: 966-988, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2017.10.022
Neuron 96/5 2019-06-18
2019 Benedict Mc Larney, Johannes Rebling, Zhenyue Chen, Xosé Luís Deán‐Ben, Sven Gottschalk, Daniel Razansky
Uniform light delivery in volumetric optoacoustic tomography
published pages: e201800387, ISSN: 1864-063X, DOI: 10.1002/jbio.201800387
Journal of Biophotonics 12/6 2019-08-05
2018 Héctor Estrada, Sven Gottschalk, Michael Reiss, Volker Neuschmelting, Roland Goldbrunner, Daniel Razansky
Observation of Guided Acoustic Waves in a Human Skull
published pages: 2388-2392, ISSN: 0301-5629, DOI: 10.1016/j.ultrasmedbio.2018.05.019
Ultrasound in Medicine & Biology 44/11 2019-08-05
2019 Sven Gottschalk, Oleksiy Degtyaruk, Benedict Mc Larney, Johannes Rebling, Magdalena Anastasia Hutter, Xosé Luís Deán-Ben, Shy Shoham, Daniel Razansky
Rapid volumetric optoacoustic imaging of neural dynamics across the mouse brain
published pages: 392-401, ISSN: 2157-846X, DOI: 10.1038/s41551-019-0372-9
Nature Biomedical Engineering 3/5 2019-08-05
2019 Yong Qian, Kiryl D. Piatkevich, Benedict Mc Larney, Ahmed S. Abdelfattah, Sohum Mehta, Mitchell H. Murdock, Sven Gottschalk, Rosana S. Molina, Wei Zhang, Yingche Chen, Jiahui Wu, Mikhail Drobizhev, Thomas E. Hughes, Jin Zhang, Eric R. Schreiter, Shy Shoham, Daniel Razansky, Edward S. Boyden, Robert E. Campbell
A genetically encoded near-infrared fluorescent calcium ion indicator
published pages: 171-174, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0294-6
Nature Methods 16/2 2019-08-05
2019 Sven Gottschalk, Oleksiy Degtyaruk, Benedict Mc Larney, Johannes Rebling, Xosé Luis Deán-Ben, Shy Shoham, Daniel Razansky
Isolated Murine Brain Model for Large-Scale Optoacoustic Calcium Imaging
published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2019.00290
Frontiers in Neuroscience 13 2019-08-05

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