Opendata, web and dolomites

TiMaScan SIGNED

Recirculated tissue macrophages (TiMa) in blood: Novel approach to early diagnosis and treatment monitoring in oncology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TiMaScan project word cloud

Explore the words cloud of the TiMaScan project. It provides you a very rough idea of what is the project "TiMaScan" about.

breast    flow    local    sufficient    thereby    keep    population    total    biopsies    protein    quality    lymph    effectiveness    digest    stream    digestion    vessels    treatment    scanning    regular    diagnostic    requiring    detection    sensitivity    rapid    technologies    tissue    immune    macrophages    fragments    1ml    prostate    apoptotic    lung    cancer    tool    nodes    rates    cells    antibodies    invasive    applicable    diagnostics    health    medical    techniques    body    phagosomal    consequently    timascan    detected    phagocytosis    recirculation    neurodegenerative    accurate    blood    fulfilled    monitoring    serum    life    cleaning    diseases    diagnosis    completely    contents    minimally    reduce    unravel    programs    attempting    flowcytometric    care    migrate    sensitive    cure    ageing    monocytes    imaging    assays    phagocytize    colon    recirculate    timas    performed    disease    oncology    risk    death    potentially    free    specificity    screening    flowcytometer    broadly    debris    migration    cytometry    infectious    phagolysosomes    building   

Project "TiMaScan" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 2˙500˙000.00

Map

 Project objective

In the ageing European population, cancer has become the most common cause of death. Consequently, screening programs aim at early detection of cancer, while scanning/imaging technologies, serum assays and regular biopsies aim at monitoring of treatment effectiveness to improve cure rates and increase quality-of-life, thereby also attempting to reduce health care costs. However, in many cases the screening and monitoring methods do not provide sufficient sensitivity and specificity. Consequently novel diagnostic techniques are required. Completely Novel Concept: Sensitive intra-tissue total body scanning is continuously performed by our immune cells, particularly by monocytes and macrophages. Tissue macrophages (TiMas) continuously phagocytize and digest apoptotic cells and tissue debris. In cancer, many more TiMas are present to keep the involved tissue debris-free. When TiMas have fulfilled their local tissue-cleaning task, they can migrate via lymph vessels to lymph nodes and potentially recirculate to the blood stream, where they can be detected by flow cytometry and evaluated for the contents of their phagolysosomes. With State-of-the-Art technologies, this high-risk project aims to unravel phagocytosis of cancer cells, their digestion into tissue-specific and/or cancer-specific protein fragments, the migration/recirculation of TiMas to blood, and the detection of intra-phagosomal protein fragments in blood TiMas by antibodies. Building on this information, flowcytometric scanning of blood TiMas (TiMaScan) will be developed into a novel tool for early diagnosis and treatment monitoring in oncology, focusing on colon, lung, breast and prostate cancer. TiMaScan diagnostics will be minimally-invasive (~1ml of blood), rapid, accurate, broadly available and cost-effective, only requiring a flowcytometer. The TiMaScan Concept might also be applicable for early diagnosis and disease monitoring in other medical fields, such as neurodegenerative and infectious diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Daniela Damasceno, Cristina Teodosio, Wouter B.L. van den Bossche, Martín Perez-Andres, Sonia Arriba-Méndez, Luis Muñoz-Bellvis, Alfonso Romero, Juan F. Blanco, Ana Remesal, Noemi Puig, Sergio Matarraz, José Luis Vicente-Villardón, Jacques J.M. van Dongen, Julia Almeida, Alberto Orfao
Distribution of subsets of blood monocytic cells throughout life
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.02.030
Journal of Allergy and Clinical Immunology 2019-08-05

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TIMASCAN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TIMASCAN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

HEIST (2020)

High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials

Read More