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Recirculated tissue macrophages (TiMa) in blood: Novel approach to early diagnosis and treatment monitoring in oncology

Total Cost €


EC-Contrib. €






 TiMaScan project word cloud

Explore the words cloud of the TiMaScan project. It provides you a very rough idea of what is the project "TiMaScan" about.

tool    programs    fulfilled    neurodegenerative    cytometry    lung    treatment    consequently    cure    invasive    contents    diagnosis    disease    tissue    total    unravel    reduce    minimally    population    specificity    flowcytometer    digest    attempting    monocytes    completely    cells    requiring    prostate    diseases    detected    techniques    cancer    debris    sensitivity    ageing    timas    monitoring    applicable    breast    screening    quality    phagocytize    risk    sensitive    free    protein    body    macrophages    assays    scanning    phagosomal    stream    broadly    care    cleaning    death    effectiveness    recirculation    digestion    technologies    blood    local    diagnostics    infectious    medical    accurate    1ml    building    serum    lymph    performed    flowcytometric    thereby    flow    fragments    colon    keep    life    health    recirculate    immune    antibodies    nodes    phagocytosis    vessels    biopsies    rates    phagolysosomes    migration    timascan    diagnostic    sufficient    potentially    imaging    regular    rapid    oncology    detection    apoptotic    migrate   

Project "TiMaScan" data sheet

The following table provides information about the project.


Organization address
city: LEIDEN
postcode: 2333 ZA

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 2˙500˙000.00


 Project objective

In the ageing European population, cancer has become the most common cause of death. Consequently, screening programs aim at early detection of cancer, while scanning/imaging technologies, serum assays and regular biopsies aim at monitoring of treatment effectiveness to improve cure rates and increase quality-of-life, thereby also attempting to reduce health care costs. However, in many cases the screening and monitoring methods do not provide sufficient sensitivity and specificity. Consequently novel diagnostic techniques are required. Completely Novel Concept: Sensitive intra-tissue total body scanning is continuously performed by our immune cells, particularly by monocytes and macrophages. Tissue macrophages (TiMas) continuously phagocytize and digest apoptotic cells and tissue debris. In cancer, many more TiMas are present to keep the involved tissue debris-free. When TiMas have fulfilled their local tissue-cleaning task, they can migrate via lymph vessels to lymph nodes and potentially recirculate to the blood stream, where they can be detected by flow cytometry and evaluated for the contents of their phagolysosomes. With State-of-the-Art technologies, this high-risk project aims to unravel phagocytosis of cancer cells, their digestion into tissue-specific and/or cancer-specific protein fragments, the migration/recirculation of TiMas to blood, and the detection of intra-phagosomal protein fragments in blood TiMas by antibodies. Building on this information, flowcytometric scanning of blood TiMas (TiMaScan) will be developed into a novel tool for early diagnosis and treatment monitoring in oncology, focusing on colon, lung, breast and prostate cancer. TiMaScan diagnostics will be minimally-invasive (~1ml of blood), rapid, accurate, broadly available and cost-effective, only requiring a flowcytometer. The TiMaScan Concept might also be applicable for early diagnosis and disease monitoring in other medical fields, such as neurodegenerative and infectious diseases.


year authors and title journal last update
List of publications.
2019 Daniela Damasceno, Cristina Teodosio, Wouter B.L. van den Bossche, Martín Perez-Andres, Sonia Arriba-Méndez, Luis Muñoz-Bellvis, Alfonso Romero, Juan F. Blanco, Ana Remesal, Noemi Puig, Sergio Matarraz, José Luis Vicente-Villardón, Jacques J.M. van Dongen, Julia Almeida, Alberto Orfao
Distribution of subsets of blood monocytic cells throughout life
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.02.030
Journal of Allergy and Clinical Immunology 2019-08-05

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The information about "TIMASCAN" are provided by the European Opendata Portal: CORDIS opendata.

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