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TiMaScan SIGNED

Recirculated tissue macrophages (TiMa) in blood: Novel approach to early diagnosis and treatment monitoring in oncology

Total Cost €

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EC-Contrib. €

0

Partnership

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 TiMaScan project word cloud

Explore the words cloud of the TiMaScan project. It provides you a very rough idea of what is the project "TiMaScan" about.

contents    prostate    flow    serum    monitoring    flowcytometric    minimally    care    specificity    ageing    diseases    digest    monocytes    sensitive    life    diagnosis    cure    requiring    potentially    performed    breast    programs    infectious    medical    sufficient    rates    blood    detection    macrophages    imaging    phagosomal    unravel    population    consequently    phagolysosomes    apoptotic    vessels    reduce    completely    colon    cytometry    sensitivity    attempting    invasive    cancer    applicable    thereby    fragments    protein    timascan    timas    health    recirculation    broadly    nodes    techniques    immune    migration    disease    accurate    building    regular    digestion    rapid    debris    cleaning    phagocytosis    local    1ml    treatment    neurodegenerative    phagocytize    diagnostics    risk    lung    scanning    death    oncology    body    stream    free    technologies    lymph    migrate    total    keep    biopsies    flowcytometer    screening    recirculate    diagnostic    quality    antibodies    effectiveness    cells    fulfilled    assays    tool    tissue    detected   

Project "TiMaScan" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 2˙500˙000.00

Map

 Project objective

In the ageing European population, cancer has become the most common cause of death. Consequently, screening programs aim at early detection of cancer, while scanning/imaging technologies, serum assays and regular biopsies aim at monitoring of treatment effectiveness to improve cure rates and increase quality-of-life, thereby also attempting to reduce health care costs. However, in many cases the screening and monitoring methods do not provide sufficient sensitivity and specificity. Consequently novel diagnostic techniques are required. Completely Novel Concept: Sensitive intra-tissue total body scanning is continuously performed by our immune cells, particularly by monocytes and macrophages. Tissue macrophages (TiMas) continuously phagocytize and digest apoptotic cells and tissue debris. In cancer, many more TiMas are present to keep the involved tissue debris-free. When TiMas have fulfilled their local tissue-cleaning task, they can migrate via lymph vessels to lymph nodes and potentially recirculate to the blood stream, where they can be detected by flow cytometry and evaluated for the contents of their phagolysosomes. With State-of-the-Art technologies, this high-risk project aims to unravel phagocytosis of cancer cells, their digestion into tissue-specific and/or cancer-specific protein fragments, the migration/recirculation of TiMas to blood, and the detection of intra-phagosomal protein fragments in blood TiMas by antibodies. Building on this information, flowcytometric scanning of blood TiMas (TiMaScan) will be developed into a novel tool for early diagnosis and treatment monitoring in oncology, focusing on colon, lung, breast and prostate cancer. TiMaScan diagnostics will be minimally-invasive (~1ml of blood), rapid, accurate, broadly available and cost-effective, only requiring a flowcytometer. The TiMaScan Concept might also be applicable for early diagnosis and disease monitoring in other medical fields, such as neurodegenerative and infectious diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Daniela Damasceno, Cristina Teodosio, Wouter B.L. van den Bossche, Martín Perez-Andres, Sonia Arriba-Méndez, Luis Muñoz-Bellvis, Alfonso Romero, Juan F. Blanco, Ana Remesal, Noemi Puig, Sergio Matarraz, José Luis Vicente-Villardón, Jacques J.M. van Dongen, Julia Almeida, Alberto Orfao
Distribution of subsets of blood monocytic cells throughout life
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.02.030
Journal of Allergy and Clinical Immunology 2019-08-05

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The information about "TIMASCAN" are provided by the European Opendata Portal: CORDIS opendata.

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