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TiMaScan SIGNED

Recirculated tissue macrophages (TiMa) in blood: Novel approach to early diagnosis and treatment monitoring in oncology

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 TiMaScan project word cloud

Explore the words cloud of the TiMaScan project. It provides you a very rough idea of what is the project "TiMaScan" about.

digest    diseases    requiring    imaging    risk    contents    phagosomal    prostate    applicable    potentially    accurate    population    diagnostic    ageing    debris    flowcytometric    blood    effectiveness    monocytes    body    cure    screening    scanning    performed    fulfilled    cytometry    cells    regular    macrophages    flow    unravel    timascan    tissue    free    sensitive    rates    protein    serum    infectious    biopsies    invasive    breast    vessels    timas    cleaning    consequently    care    assays    antibodies    life    building    recirculation    lymph    techniques    lung    migration    broadly    keep    monitoring    programs    flowcytometer    sufficient    cancer    phagocytosis    detection    quality    diagnosis    sensitivity    attempting    fragments    treatment    nodes    migrate    phagolysosomes    stream    digestion    technologies    1ml    total    health    minimally    colon    medical    immune    recirculate    completely    detected    death    local    disease    reduce    thereby    tool    rapid    neurodegenerative    diagnostics    oncology    specificity    apoptotic    phagocytize   

Project "TiMaScan" data sheet

The following table provides information about the project.

Coordinator
ACADEMISCH ZIEKENHUIS LEIDEN 

Organization address
address: ALBINUSDREEF 2
city: LEIDEN
postcode: 2333 ZA
website: www.lumc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-AdG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) coordinator 2˙500˙000.00

Map

 Project objective

In the ageing European population, cancer has become the most common cause of death. Consequently, screening programs aim at early detection of cancer, while scanning/imaging technologies, serum assays and regular biopsies aim at monitoring of treatment effectiveness to improve cure rates and increase quality-of-life, thereby also attempting to reduce health care costs. However, in many cases the screening and monitoring methods do not provide sufficient sensitivity and specificity. Consequently novel diagnostic techniques are required. Completely Novel Concept: Sensitive intra-tissue total body scanning is continuously performed by our immune cells, particularly by monocytes and macrophages. Tissue macrophages (TiMas) continuously phagocytize and digest apoptotic cells and tissue debris. In cancer, many more TiMas are present to keep the involved tissue debris-free. When TiMas have fulfilled their local tissue-cleaning task, they can migrate via lymph vessels to lymph nodes and potentially recirculate to the blood stream, where they can be detected by flow cytometry and evaluated for the contents of their phagolysosomes. With State-of-the-Art technologies, this high-risk project aims to unravel phagocytosis of cancer cells, their digestion into tissue-specific and/or cancer-specific protein fragments, the migration/recirculation of TiMas to blood, and the detection of intra-phagosomal protein fragments in blood TiMas by antibodies. Building on this information, flowcytometric scanning of blood TiMas (TiMaScan) will be developed into a novel tool for early diagnosis and treatment monitoring in oncology, focusing on colon, lung, breast and prostate cancer. TiMaScan diagnostics will be minimally-invasive (~1ml of blood), rapid, accurate, broadly available and cost-effective, only requiring a flowcytometer. The TiMaScan Concept might also be applicable for early diagnosis and disease monitoring in other medical fields, such as neurodegenerative and infectious diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Daniela Damasceno, Cristina Teodosio, Wouter B.L. van den Bossche, Martín Perez-Andres, Sonia Arriba-Méndez, Luis Muñoz-Bellvis, Alfonso Romero, Juan F. Blanco, Ana Remesal, Noemi Puig, Sergio Matarraz, José Luis Vicente-Villardón, Jacques J.M. van Dongen, Julia Almeida, Alberto Orfao
Distribution of subsets of blood monocytic cells throughout life
published pages: , ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.02.030
Journal of Allergy and Clinical Immunology 2019-08-05

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The information about "TIMASCAN" are provided by the European Opendata Portal: CORDIS opendata.

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