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PrefrontalMap SIGNED

Organization and learning-associated dynamics of prefrontal synaptic connectivity

Total Cost €

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EC-Contrib. €

0

Partnership

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 PrefrontalMap project word cloud

Explore the words cloud of the PrefrontalMap project. It provides you a very rough idea of what is the project "PrefrontalMap" about.

directed    cell    assemblies    functional    connectivity    learning    undergo    subnetworks    gain    shown    electrophysiology    organization    cortex    variety    single    selective    mouse    architecture    innervation    manipulation    mpfc    densely    imaging    obtain    resolution    understand    hypothesis    projecting    inputs    little    circuitry    combine    circuit    platform    inhibitory    cortical    applicable    implications    populations    pertinent    vivo    thought    interconnected    reorganization    medial    uncover    neural    question    optical    structural    substantial    memory    interrogation    prefrontal    modulate    innovative    output    optogenetic    plays    vitro    calcium    synaptic    insights    regarding    consolidation    associative    neurons    neocortical    tightly    form    neuron    utilize    dependent    remodeling    subcortical    powerful    flexible    behavior    pyramidal    area    alter    connections    subcortically    circuits    how    maps    dynamics    local    networks   

Project "PrefrontalMap" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙880˙003 €
 EC max contribution 1˙880˙003 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙880˙003.00

Map

 Project objective

How does experience alter the functional architecture of synaptic connections in neural circuits? This question is particularly pertinent for the complex circuits of the medial prefrontal cortex (mPFC), a high-order associative neocortical area that plays a crucial role in flexible, goal-directed behavior. The mPFC is densely interconnected with cortical and subcortical circuits, and its neurons were shown to undergo substantial experience-dependent structural remodeling that is thought to support learning and memory consolidation. However, little is known regarding the synaptic organization of this complex circuit, and of the functional implications of its experience-dependent structural remodeling. In this proposal, we aim to uncover the organization and learning-associated dynamics of functional connectivity in the mouse mPFC.

To obtain high-resolution maps of cell type-specific synaptic connectivity in the mPFC, we will combine single-cell optogenetic manipulation with calcium imaging and electrophysiology in vitro, and establish the circuit-wide organization of connectivity within and between defined projecting neuron populations. We will test the hypothesis that pyramidal neurons projecting to subcortical targets form tightly interconnected subnetworks, and that inhibitory inputs to these networks, through selective innervation, can modulate information output from the mPFC.

To understand how learning changes the functional synaptic organization of the mPFC, we will establish an all-optical system for interrogation of synaptic connectivity in vivo. We will utilize this powerful platform to test the hypothesis that prefrontal-dependent learning is associated with reorganization of local-circuit functional connectivity among identified subcortically-projecting cell assemblies.

Our innovative technology will be widely applicable for neural circuit analysis in a variety of systems, and allow us to gain new insights into the complex circuitry of the mPFC.

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The information about "PREFRONTALMAP" are provided by the European Opendata Portal: CORDIS opendata.

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