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PrefrontalMap SIGNED

Organization and learning-associated dynamics of prefrontal synaptic connectivity

Total Cost €

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EC-Contrib. €

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Partnership

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 PrefrontalMap project word cloud

Explore the words cloud of the PrefrontalMap project. It provides you a very rough idea of what is the project "PrefrontalMap" about.

synaptic    consolidation    selective    understand    circuit    substantial    neuron    platform    mouse    networks    inhibitory    form    maps    question    undergo    flexible    thought    calcium    functional    regarding    local    structural    prefrontal    gain    densely    dynamics    behavior    tightly    pertinent    medial    neurons    innovative    alter    area    electrophysiology    subcortical    insights    connections    optogenetic    neocortical    utilize    innervation    optical    inputs    populations    subcortically    circuitry    variety    memory    circuits    architecture    directed    remodeling    modulate    resolution    learning    single    hypothesis    assemblies    manipulation    interrogation    little    subnetworks    how    applicable    shown    neural    implications    projecting    cell    organization    powerful    associative    plays    output    imaging    cortical    combine    mpfc    vivo    uncover    cortex    dependent    obtain    reorganization    pyramidal    interconnected    connectivity    vitro   

Project "PrefrontalMap" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙880˙003 €
 EC max contribution 1˙880˙003 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙880˙003.00

Map

 Project objective

How does experience alter the functional architecture of synaptic connections in neural circuits? This question is particularly pertinent for the complex circuits of the medial prefrontal cortex (mPFC), a high-order associative neocortical area that plays a crucial role in flexible, goal-directed behavior. The mPFC is densely interconnected with cortical and subcortical circuits, and its neurons were shown to undergo substantial experience-dependent structural remodeling that is thought to support learning and memory consolidation. However, little is known regarding the synaptic organization of this complex circuit, and of the functional implications of its experience-dependent structural remodeling. In this proposal, we aim to uncover the organization and learning-associated dynamics of functional connectivity in the mouse mPFC.

To obtain high-resolution maps of cell type-specific synaptic connectivity in the mPFC, we will combine single-cell optogenetic manipulation with calcium imaging and electrophysiology in vitro, and establish the circuit-wide organization of connectivity within and between defined projecting neuron populations. We will test the hypothesis that pyramidal neurons projecting to subcortical targets form tightly interconnected subnetworks, and that inhibitory inputs to these networks, through selective innervation, can modulate information output from the mPFC.

To understand how learning changes the functional synaptic organization of the mPFC, we will establish an all-optical system for interrogation of synaptic connectivity in vivo. We will utilize this powerful platform to test the hypothesis that prefrontal-dependent learning is associated with reorganization of local-circuit functional connectivity among identified subcortically-projecting cell assemblies.

Our innovative technology will be widely applicable for neural circuit analysis in a variety of systems, and allow us to gain new insights into the complex circuitry of the mPFC.

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The information about "PREFRONTALMAP" are provided by the European Opendata Portal: CORDIS opendata.

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