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PrefrontalMap SIGNED

Organization and learning-associated dynamics of prefrontal synaptic connectivity

Total Cost €

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EC-Contrib. €

0

Partnership

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 PrefrontalMap project word cloud

Explore the words cloud of the PrefrontalMap project. It provides you a very rough idea of what is the project "PrefrontalMap" about.

undergo    optogenetic    subcortically    cell    local    utilize    learning    circuitry    single    platform    mouse    circuits    combine    flexible    behavior    selective    interconnected    mpfc    pyramidal    consolidation    neuron    area    dependent    neural    medial    remodeling    directed    vivo    innovative    modulate    form    implications    applicable    optical    shown    interrogation    alter    structural    circuit    connectivity    neurons    inputs    densely    gain    subcortical    vitro    resolution    reorganization    output    little    innervation    functional    manipulation    connections    question    maps    organization    inhibitory    prefrontal    plays    cortical    subnetworks    dynamics    assemblies    thought    insights    synaptic    how    calcium    electrophysiology    regarding    cortex    associative    substantial    projecting    uncover    memory    hypothesis    populations    obtain    tightly    variety    neocortical    powerful    understand    architecture    imaging    pertinent    networks   

Project "PrefrontalMap" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙880˙003 €
 EC max contribution 1˙880˙003 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙880˙003.00

Map

 Project objective

How does experience alter the functional architecture of synaptic connections in neural circuits? This question is particularly pertinent for the complex circuits of the medial prefrontal cortex (mPFC), a high-order associative neocortical area that plays a crucial role in flexible, goal-directed behavior. The mPFC is densely interconnected with cortical and subcortical circuits, and its neurons were shown to undergo substantial experience-dependent structural remodeling that is thought to support learning and memory consolidation. However, little is known regarding the synaptic organization of this complex circuit, and of the functional implications of its experience-dependent structural remodeling. In this proposal, we aim to uncover the organization and learning-associated dynamics of functional connectivity in the mouse mPFC.

To obtain high-resolution maps of cell type-specific synaptic connectivity in the mPFC, we will combine single-cell optogenetic manipulation with calcium imaging and electrophysiology in vitro, and establish the circuit-wide organization of connectivity within and between defined projecting neuron populations. We will test the hypothesis that pyramidal neurons projecting to subcortical targets form tightly interconnected subnetworks, and that inhibitory inputs to these networks, through selective innervation, can modulate information output from the mPFC.

To understand how learning changes the functional synaptic organization of the mPFC, we will establish an all-optical system for interrogation of synaptic connectivity in vivo. We will utilize this powerful platform to test the hypothesis that prefrontal-dependent learning is associated with reorganization of local-circuit functional connectivity among identified subcortically-projecting cell assemblies.

Our innovative technology will be widely applicable for neural circuit analysis in a variety of systems, and allow us to gain new insights into the complex circuitry of the mPFC.

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The information about "PREFRONTALMAP" are provided by the European Opendata Portal: CORDIS opendata.

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