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BIOCDx SIGNED

A miniature Bio-photonics Companion Diagnostics platform for reliable cancer diagnosis and treatment monitoring.

Total Cost €

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EC-Contrib. €

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Partnership

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 BIOCDx project word cloud

Explore the words cloud of the BIOCDx project. It provides you a very rough idea of what is the project "BIOCDx" about.

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Project "BIOCDx" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS 

Organization address
address: Patission Str. 42
city: ATHINA
postcode: 10682
website: www.iccs.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://biocdx.eu/
 Total cost 3˙648˙520 €
 EC max contribution 3˙163˙735 € (87%)
 Programme 1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
 Code Call H2020-ICT-2016-1
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS EL (ATHINA) coordinator 700˙985.00
2    LRE MEDICAL GMBH DE (NORDLINGEN) participant 710˙000.00
3    LIONIX INTERNATIONAL BV NL (ENSCHEDE) participant 559˙500.00
4    IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON EL (ATHINA) participant 550˙125.00
5    FUTURE DIAGNOSTICS SOLUTIONS BV NL (Wijchen) participant 328˙125.00
6    LEAD PHARMA HOLDING BV NL (OSS) participant 315˙000.00
7    CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT CH (NEUCHATEL) participant 0.00
8    LIONIX BV NL (ENSCHEDE) participant 0.00

Map

 Project objective

Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” detection platform by virtue of expression of the cancer stem cell-specific transcription factor TWIST1, which controls the expression of the bloodstream circulating biomarkers POSTN, PCOLCE and TGBI. Cancer stem cells represent the most aggressive/tumorigenic cell compartment within tumors. BIOCDx will combine advanced concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. BIOCDx will rely on ultrasensitive, photonic elements based on an array of 8 asymmetric MZI waveguides fabricated by TriPlex technology on silicon nitride substrates and will achieve a 100 fold improvement –with respect to current technologies- of sensitivity (<10-8 RIU). BIOCDx will emlploy a smart concept of signal multiplexing for lowering the number of photodetectors required in multi-analyte detection and allowing for a substantial reduction of chip size. A sandwich assay, enhanced with nanoparticles, will be developed, based on the use of two antibodies per protein, to detect all three circulating proteins. This will enhance the limit of detection (LOD) close to femtomolar and the reliability. BIOCDx photonic, nano-biochemical, fluidics and packaging platforms will be integrated into a portable, desktop PoC device. Its validation in preclinical and clinical setting will be performed in three cancer types: breast cancer, hormone-independent prostate cancer and melanoma.

 Deliverables

List of deliverables.
Data managment plan Open Research Data Pilot 2019-11-06 11:38:13
Project website launch Websites, patent fillings, videos etc. 2019-11-06 11:38:13

Take a look to the deliverables list in detail:  detailed list of BIOCDx deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 S. F. Graf, T. Volden, S. Berchtold, J. Goldowsky, N. Schmid, V. Revol, H. F. Knapp
Analysis Cartridge for Companion Diagnostics
published pages: 60, ISSN: , DOI:
CSEM Scientific and Technical Report 2017, yearly 2019-11-06

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The information about "BIOCDX" are provided by the European Opendata Portal: CORDIS opendata.

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