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BIOCDx SIGNED

A miniature Bio-photonics Companion Diagnostics platform for reliable cancer diagnosis and treatment monitoring.

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

BIOCDx project word cloud

Explore the words cloud of the BIOCDx project. It provides you a very rough idea of what is the project "BIOCDx" about.

photonic reader circulating size fold biochemical improvement nanoparticles twist1 treatment protein point sensitivity smart substantial independent femtomolar disruptive compactness emlploy analyte fabricated portable bloodstream therapeutic mzi preclinical stem controls triplex device silicon care imaging assay options substrates array techniques validation biomarkers biocdx micro proteins monitoring current diagnosis photodetectors diagnostic poc lowering cancer hormone fluidics expression tumorigenic multiplexing sandwich platform lt melanoma close respect limit postn rely riu packaging performed platforms tumors detection nitride nano breast scientific signal cells waveguides proper ultrasensitive enhanced cell companion tool diagnostics guarantee prostate chip overcome lod antibodies reliability setting fluidic combine breakthroughs compartment transcription detect pcolce tgbi aggressive technologies desktop limitations types virtue asymmetric clinical specificity

Project "BIOCDx" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS Organization address address: Patission Str. 42 city: ATHINA postcode: 10682 website: www.iccs.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://biocdx.eu/
Total cost	3˙648˙520 €
EC max contribution	3˙163˙735 € (87%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2016-1
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS Organization address address: Patission Str. 42 city: ATHINA postcode: 10682 website: www.iccs.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	coordinator	700˙985.00
2	LRE MEDICAL GMBH LRE MEDICAL GMBH Organization address address: HOFER STRASSE 5 city: NORDLINGEN postcode: 86720 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NORDLINGEN)	participant	710˙000.00
3	LIONIX INTERNATIONAL BV LIONIX INTERNATIONAL BV Organization address address: HENGELOSESTRAAT 500 city: ENSCHEDE postcode: 7521 AN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	559˙500.00
4	IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Organization address address: SORANOU EFESIOU 4 city: ATHINA postcode: 115 27 website: www.bioacademy.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	550˙125.00
5	FUTURE DIAGNOSTICS SOLUTIONS BV FUTURE DIAGNOSTICS SOLUTIONS BV Organization address address: NIEUWEWEG 279 city: Wijchen postcode: 6603 BN website: www.future-diagnostics.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Wijchen)	participant	328˙125.00
6	LEAD PHARMA HOLDING BV LEAD PHARMA HOLDING BV Organization address address: KLOOSTERSTRAAT 9 city: OSS postcode: 5349 AB website: www.leadpharma.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (OSS)	participant	315˙000.00
7	CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT Organization address address: RUE JAQUET DROZ 1 city: NEUCHATEL postcode: 2000 website: www.csem.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (NEUCHATEL)	participant	0.00
8	LIONIX BV LIONIX BV Organization address address: HENGELOSESTRAAT 500 city: ENSCHEDE postcode: 7521 AN website: www.lionixbv.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	participant	0.00

Map

Project objective

Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” detection platform by virtue of expression of the cancer stem cell-specific transcription factor TWIST1, which controls the expression of the bloodstream circulating biomarkers POSTN, PCOLCE and TGBI. Cancer stem cells represent the most aggressive/tumorigenic cell compartment within tumors. BIOCDx will combine advanced concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. BIOCDx will rely on ultrasensitive, photonic elements based on an array of 8 asymmetric MZI waveguides fabricated by TriPlex technology on silicon nitride substrates and will achieve a 100 fold improvement –with respect to current technologies- of sensitivity (<10-8 RIU). BIOCDx will emlploy a smart concept of signal multiplexing for lowering the number of photodetectors required in multi-analyte detection and allowing for a substantial reduction of chip size. A sandwich assay, enhanced with nanoparticles, will be developed, based on the use of two antibodies per protein, to detect all three circulating proteins. This will enhance the limit of detection (LOD) close to femtomolar and the reliability. BIOCDx photonic, nano-biochemical, fluidics and packaging platforms will be integrated into a portable, desktop PoC device. Its validation in preclinical and clinical setting will be performed in three cancer types: breast cancer, hormone-independent prostate cancer and melanoma.

Deliverables

List of deliverables.
Data managment plan	Open Research Data Pilot	2019-11-06 11:38:13
Project website launch	Websites, patent fillings, videos etc.	2019-11-06 11:38:13

Take a look to the deliverables list in detail: detailed list of BIOCDx deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	S. F. Graf, T. Volden, S. Berchtold, J. Goldowsky, N. Schmid, V. Revol, H. F. Knapp Analysis Cartridge for Companion Diagnostics published pages: 60, ISSN: , DOI:	CSEM Scientific and Technical Report 2017, yearly	2019-11-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIOCDX" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

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The information about "BIOCDX" are provided by the European Opendata Portal: CORDIS opendata.

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