BIOCDx SIGNED
A miniature Bio-photonics Companion Diagnostics platform for reliable cancer diagnosis and treatment monitoring.
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0BIOCDx project word cloud
Explore the words cloud of the BIOCDx project. It provides you a very rough idea of what is the project "BIOCDx" about.
Project "BIOCDx" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS
Organization address contact info |
| Coordinator Country | Greece [EL] |
| Project website | http://biocdx.eu/ |
| Total cost | 3˙648˙520 € |
| EC max contribution | 3˙163˙735 € (87%) |
| Programme |
1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT)) |
| Code Call | H2020-ICT-2016-1 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUTE OF COMMUNICATION AND COMPUTER SYSTEMS | EL (ATHINA) | coordinator | 700˙985.00 |
| 2 | LRE MEDICAL GMBH | DE (NORDLINGEN) | participant | 710˙000.00 |
| 3 | LIONIX INTERNATIONAL BV | NL (ENSCHEDE) | participant | 559˙500.00 |
| 4 | IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON | EL (ATHINA) | participant | 550˙125.00 |
| 5 | FUTURE DIAGNOSTICS SOLUTIONS BV | NL (Wijchen) | participant | 328˙125.00 |
| 6 | LEAD PHARMA HOLDING BV | NL (OSS) | participant | 315˙000.00 |
| 7 | CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT | CH (NEUCHATEL) | participant | 0.00 |
| 8 | LIONIX BV | NL (ENSCHEDE) | participant | 0.00 |
Map
Project objective
Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” detection platform by virtue of expression of the cancer stem cell-specific transcription factor TWIST1, which controls the expression of the bloodstream circulating biomarkers POSTN, PCOLCE and TGBI. Cancer stem cells represent the most aggressive/tumorigenic cell compartment within tumors. BIOCDx will combine advanced concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. BIOCDx will rely on ultrasensitive, photonic elements based on an array of 8 asymmetric MZI waveguides fabricated by TriPlex technology on silicon nitride substrates and will achieve a 100 fold improvement –with respect to current technologies- of sensitivity (<10-8 RIU). BIOCDx will emlploy a smart concept of signal multiplexing for lowering the number of photodetectors required in multi-analyte detection and allowing for a substantial reduction of chip size. A sandwich assay, enhanced with nanoparticles, will be developed, based on the use of two antibodies per protein, to detect all three circulating proteins. This will enhance the limit of detection (LOD) close to femtomolar and the reliability. BIOCDx photonic, nano-biochemical, fluidics and packaging platforms will be integrated into a portable, desktop PoC device. Its validation in preclinical and clinical setting will be performed in three cancer types: breast cancer, hormone-independent prostate cancer and melanoma.
Deliverables
| Data managment plan | Open Research Data Pilot | 2019-11-06 11:38:13 |
| Project website launch | Websites, patent fillings, videos etc. | 2019-11-06 11:38:13 |
Take a look to the deliverables list in detail: detailed list of BIOCDx deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
S. F. Graf, T. Volden, S. Berchtold, J. Goldowsky, N. Schmid, V. Revol, H. F. Knapp Analysis Cartridge for Companion Diagnostics published pages: 60, ISSN: , DOI: |
CSEM Scientific and Technical Report 2017, yearly | 2019-11-06 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIOCDX" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "BIOCDX" are provided by the European Opendata Portal: CORDIS opendata.