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MUSIC SIGNED

Multisystem Cell Therapy for Improvement of Urinary Continence

Total Cost €

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EC-Contrib. €

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Partnership

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 MUSIC project word cloud

Explore the words cloud of the MUSIC project. It provides you a very rough idea of what is the project "MUSIC" about.

sphincter    totally    introduction    medicinal    additional    muscle    neuromuscular    autologous    implantation    xeno    economic    restoration    centers    urinary    therapy    ideal    therapeutic    nl    offers    cell    damaged    precise    reverse    worldwide    efficient    music    safety    underlying    burden    technique    biomaterials    smaller    combining    man    mpcs    cells    effect    strategies    mpc    injection    multilevel    feasibility    infrastructure    experts    optimization    commercial    complications    urology    engineering    expanding    translating    cellular    free    million    socio    uk    women    female    companies    manufacturing    stress    thereby    clinical    patients    functional    final    atmp    undertaking    facilitated    combination    nmes    regenerative    exclusive    stimulation    50    200    significantly    option    quality    sui    efficacy    people    incontinence    tissue    opportunity    ultimate    expertise    prevalence    relief    alternative    clinic    entail    life    feasible    biology    medicine    electromagnetic    multisystem    stem    basic    ch    reproducibility    validity    rm    immense    carry    personalized    first    disease    treatment    pathologic    prove    precursor   

Project "MUSIC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT ZURICH 

Organization address
address: RAMISTRASSE 71
city: ZURICH
postcode: 8006
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website http://www.music2020.ch
 Total cost 6˙623˙628 €
 EC max contribution 2˙349˙521 € (35%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2016-RTD
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT ZURICH CH (ZURICH) coordinator 0.00
2    SCINUS HOLDING BV NL (BILTHOVEN) participant 1˙024˙600.00
3    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 575˙223.00
4    COLLAGEN SOLUTIONS (UK) LIMITED UK (GLASGOW) participant 562˙197.00
5    PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG AT (SALZBURG) participant 187˙500.00
6    KUROS BIOSCIENCES BV NL (BILTHOVEN) participant 0.00

Map

 Project objective

'Stress Urinary Incontinence (SUI) is a disease affecting over 200 million people worldwide. It represents a condition with a prevalence of 20-50% in women, thereby creating an immense socio-economic burden. The currently available treatment strategies entail various complications and offer only short-term relief to the patients. Tissue engineering using autologous cells offers a feasible alternative for functional restoration of the damaged urinary sphincter muscle and represents an ideal treatment option that could reverse the underlying pathologic conditions. MUSIC aims at translating basic knowledge on regenerative medicine (RM) and stem cell therapy into the clinic by undertaking a 'first-in-man' multisystem study using autologous muscle precursor cells (MPCs) in a combination with neuromuscular electromagnetic stimulation (NMES) in 40 female patients. We will carry out the specific tasks to prove safety and efficacy of the proposed novel multilevel treatment as well as reproducibility of the therapeutic effect. Additional objectives are optimization of the advanced-therapy medicinal product (ATMP) towards totally xeno-free and facilitated manufacturing as well as the introduction of a novel injection technique for more efficient and precise implantation of the final product. Combining expertise, MUSIC features a unique infrastructure, including the knowledge of experts in the fields of RM, urology, cellular biology and biomaterials throughout Europe (CH, NL, UK, A, D). The MUSIC consortium has an exclusive opportunity to determine the validity of this MPC cellular treatment in combination with NMES and to further improve its feasibility and clinical efficacy. The ultimate goal is to significantly improve the patients` quality of life and to exploit a future commercial opportunity by expanding the know-how to various smaller RM centers and companies within Europe, thus, making personalized medicine using autologous cells a more feasible SUI treatment option.

'

 Deliverables

List of deliverables.
Definition of the best option for delivery of MPCs Demonstrators, pilots, prototypes 2020-02-07 12:51:28
Cell jet injection established and evaluated in vitro and in vivo Demonstrators, pilots, prototypes 2020-02-07 12:51:25
CE Certification of Injection Device Documents, reports 2019-11-25 11:25:55
Project webpage online Websites, patent fillings, videos etc. 2019-11-25 11:25:55

Take a look to the deliverables list in detail:  detailed list of MUSIC deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43700-x
Scientific Reports 9/1 2020-03-05
2019 Luise Jäger, Walter Linzenbold, Andreas Fech, Markus Enderle, Tanja Abruzzese, Arnulf Stenzl, Wilhelm K. Aicher
A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex
published pages: 594-602, ISSN: 0733-2467, DOI: 10.1002/nau.24261
Neurourology and Urodynamics 39/2 2020-03-05
2019 Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser
Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate
published pages: , ISSN: 1479-5876, DOI: 10.1186/s12967-019-02183-0
Journal of Translational Medicine 17/1 2020-03-05
2020 Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster
Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis
published pages: 193-207, ISSN: 0946-2716, DOI: 10.1007/s00109-019-01866-x
Journal of Molecular Medicine 98/2 2020-03-05
2018 D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J. A. Reems, J. Pierce, A.M. Preslar, K. Schallmoser
International Forum on GMP-grade human platelet lysate for cell propagation: summary
published pages: 80-87, ISSN: 0042-9007, DOI: 10.1111/vox.12593
Vox Sanguinis 113/1 2019-11-25
2017 Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice
published pages: 2169-2188, ISSN: 1754-2189, DOI: 10.1038/nprot.2017.088
Nature Protocols 12/10 2019-11-25
2018 Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk
Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells
published pages: 1421-1434, ISSN: 1838-7640, DOI: 10.7150/thno.21906
Theranostics 8/5 2019-11-25

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