MUSIC SIGNED
Multisystem Cell Therapy for Improvement of Urinary Continence
Total Cost €
0EC-Contrib. €
0Partnership
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0MUSIC project word cloud
Explore the words cloud of the MUSIC project. It provides you a very rough idea of what is the project "MUSIC" about.
Project "MUSIC" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT ZURICH
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Project website | http://www.music2020.ch |
| Total cost | 6˙623˙628 € |
| EC max contribution | 2˙349˙521 € (35%) |
| Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
| Code Call | H2020-SC1-2016-RTD |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT ZURICH | CH (ZURICH) | coordinator | 0.00 |
| 2 | SCINUS HOLDING BV | NL (BILTHOVEN) | participant | 1˙024˙600.00 |
| 3 | EBERHARD KARLS UNIVERSITAET TUEBINGEN | DE (TUEBINGEN) | participant | 575˙223.00 |
| 4 | COLLAGEN SOLUTIONS (UK) LIMITED | UK (GLASGOW) | participant | 562˙197.00 |
| 5 | PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG | AT (SALZBURG) | participant | 187˙500.00 |
| 6 | KUROS BIOSCIENCES BV | NL (BILTHOVEN) | participant | 0.00 |
Map
Project objective
'Stress Urinary Incontinence (SUI) is a disease affecting over 200 million people worldwide. It represents a condition with a prevalence of 20-50% in women, thereby creating an immense socio-economic burden. The currently available treatment strategies entail various complications and offer only short-term relief to the patients. Tissue engineering using autologous cells offers a feasible alternative for functional restoration of the damaged urinary sphincter muscle and represents an ideal treatment option that could reverse the underlying pathologic conditions. MUSIC aims at translating basic knowledge on regenerative medicine (RM) and stem cell therapy into the clinic by undertaking a 'first-in-man' multisystem study using autologous muscle precursor cells (MPCs) in a combination with neuromuscular electromagnetic stimulation (NMES) in 40 female patients. We will carry out the specific tasks to prove safety and efficacy of the proposed novel multilevel treatment as well as reproducibility of the therapeutic effect. Additional objectives are optimization of the advanced-therapy medicinal product (ATMP) towards totally xeno-free and facilitated manufacturing as well as the introduction of a novel injection technique for more efficient and precise implantation of the final product. Combining expertise, MUSIC features a unique infrastructure, including the knowledge of experts in the fields of RM, urology, cellular biology and biomaterials throughout Europe (CH, NL, UK, A, D). The MUSIC consortium has an exclusive opportunity to determine the validity of this MPC cellular treatment in combination with NMES and to further improve its feasibility and clinical efficacy. The ultimate goal is to significantly improve the patients` quality of life and to exploit a future commercial opportunity by expanding the know-how to various smaller RM centers and companies within Europe, thus, making personalized medicine using autologous cells a more feasible SUI treatment option.
'
Deliverables
| Definition of the best option for delivery of MPCs | Demonstrators, pilots, prototypes | 2020-02-07 12:51:28 |
| Cell jet injection established and evaluated in vitro and in vivo | Demonstrators, pilots, prototypes | 2020-02-07 12:51:25 |
| CE Certification of Injection Device | Documents, reports | 2019-11-25 11:25:55 |
| Project webpage online | Websites, patent fillings, videos etc. | 2019-11-25 11:25:55 |
Take a look to the deliverables list in detail: detailed list of MUSIC deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, Linda Krisch, Sarah Hochmann, Ravi Kalathur, Karin Pachler, Christina Kreutzer, Gerrit Erdmann, Eva Rohde, Dirk Strunk, Katharina Schallmoser Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43700-x |
Scientific Reports 9/1 | 2020-03-05 |
| 2019 |
Luise Jäger, Walter Linzenbold, Andreas Fech, Markus Enderle, Tanja Abruzzese, Arnulf Stenzl, Wilhelm K. Aicher A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex published pages: 594-602, ISSN: 0733-2467, DOI: 10.1002/nau.24261 |
Neurourology and Urodynamics 39/2 | 2020-03-05 |
| 2019 |
Sandra Laner-Plamberger, Michaela Oeller, Cornelia Mrazek, Arnulf Hartl, Alina Sonderegger, Eva Rohde, Dirk Strunk, Katharina Schallmoser Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate published pages: , ISSN: 1479-5876, DOI: 10.1186/s12967-019-02183-0 |
Journal of Translational Medicine 17/1 | 2020-03-05 |
| 2020 |
Désirée Forstner, Sabine Maninger, Olivia Nonn, Jacqueline Guettler, Gerit Moser, Gerd Leitinger, Elisabeth Pritz, Dirk Strunk, Katharina Schallmoser, Gunther Marsche, Akos Heinemann, Berthold Huppertz, Martin Gauster Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis published pages: 193-207, ISSN: 0946-2716, DOI: 10.1007/s00109-019-01866-x |
Journal of Molecular Medicine 98/2 | 2020-03-05 |
| 2018 |
D. Strunk, M. Lozano, D.C. Marks, Y. S. Loh, G. Gstraunthaler, H. Schennach, E. Rohde, S. Laner-Plamberger, M. Öller, J. Nystedt, R. Lotfi, M. Rojewski, H. Schrezenmeier, K. Bieback, R. Schäfer, T. Bakchoul, M. Waidmann, S.M. Jonsdottir-Buch, H. Montazeri, O.E. Sigurjonsson, P. Iudicone, D. Fioravanti, L. Pierelli, M. Introna, C. Capelli, A. Falanga, M. Takanashi, O. Lόpez-Villar, T. Burnouf, J. A. Reems, J. Pierce, A.M. Preslar, K. Schallmoser International Forum on GMP-grade human platelet lysate for cell propagation: summary published pages: 80-87, ISSN: 0042-9007, DOI: 10.1111/vox.12593 |
Vox Sanguinis 113/1 | 2019-11-25 |
| 2017 |
Andreas Reinisch, David Cruz Hernandez, Katharina Schallmoser, Ravindra Majeti Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice published pages: 2169-2188, ISSN: 1754-2189, DOI: 10.1038/nprot.2017.088 |
Nature Protocols 12/10 | 2019-11-25 |
| 2018 |
Michaela Oeller, Sandra Laner-Plamberger, Sarah Hochmann, Nina Ketterl, Martina Feichtner, Gabriele Brachtl, Anna Hochreiter, Cornelia Scharler, Lara Bieler, Pasquale Romanelli, Sebastien Couillard-Despres, Elisabeth Russe, Katharina Schallmoser, Dirk Strunk Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells published pages: 1421-1434, ISSN: 1838-7640, DOI: 10.7150/thno.21906 |
Theranostics 8/5 | 2019-11-25 |
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