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SymMech

Unravelling the mechanisms behind bacterial symbiosis in insects

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EC-Contrib. €

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Partnership

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 Outcomes and results

 SymMech project word cloud

Explore the words cloud of the SymMech project. It provides you a very rough idea of what is the project "SymMech" about.

solid    genes    offspring    niches    culturable    phenotype    tradis    arthropods    son    enormous    competing    eliminate    raised    knockout    classic    sk    biological    manipulation    symbionts    molecular    reduce    grown    protection    symbiosis    microbiological    elucidate    symbiotic    arsenophonus    desired    mechanisms    life    ground    identification    interference    outside    vector    nasonia    biology    symbiont    competence    combined    first    pests    few    insect    elucidation    modify    endosymbionts    inducing    strategies    invertebrates    thriving    utilize    acquisition    symbioisis    hypothesis    diseases    host    tools    plants    nasoniae    diminish    lifestyle    bacterium    independent    male    responsible    bacterial    killing    microorganisms    function    possibility    lethality    vitripennis    wasp    impeding    engineer    gene    borne    humans    performing    distributed    screens    dependent    alteration    hosts    specialised    transmission    infects    chemical    mediated    predator    reproductive    parasitoid    little    strategy    permit    time    pathogen    amongst    nutrient    additionally    strains   

Project "SymMech" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://sites.google.com/site/hurstlab/home/greg
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-mediated alteration of host biology. Both objectives are crucial for the development of novel biological and chemical tools against major vector-borne diseases and pests.

 Publications

year authors and title journal last update
List of publications.
2019 Pol Nadal‐Jimenez, Joanne S. Griffin, Lianne Davies, Crystal L. Frost, Marco Marcello, Gregory D. D. Hurst
Genetic manipulation allows in vivo tracking of the life cycle of the son‐killer symbiont, Arsenophonus nasoniae , and reveals patterns of host invasion, tropism and pathology
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14724 		Environmental Microbiology 2019-09-02

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