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SymMech

Unravelling the mechanisms behind bacterial symbiosis in insects

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EC-Contrib. €

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Partnership

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 Outcomes and results

 SymMech project word cloud

Explore the words cloud of the SymMech project. It provides you a very rough idea of what is the project "SymMech" about.

reduce    symbiosis    inducing    lethality    thriving    arsenophonus    host    male    little    mechanisms    hypothesis    protection    permit    strategies    symbioisis    utilize    interference    vector    biological    knockout    lifestyle    responsible    microbiological    eliminate    tradis    combined    tools    solid    grown    alteration    ground    acquisition    predator    culturable    strains    pathogen    mediated    molecular    raised    diseases    modify    additionally    symbiont    first    elucidation    parasitoid    specialised    sk    elucidate    life    classic    bacterial    amongst    niches    vitripennis    dependent    nasoniae    endosymbionts    arthropods    nasonia    transmission    nutrient    gene    hosts    insect    offspring    chemical    identification    engineer    possibility    pests    plants    performing    function    wasp    independent    manipulation    enormous    killing    desired    competing    few    genes    competence    reproductive    diminish    son    invertebrates    infects    borne    outside    humans    strategy    screens    distributed    microorganisms    symbiotic    impeding    biology    phenotype    bacterium    time    symbionts   

Project "SymMech" data sheet

The following table provides information about the project.

Coordinator		 THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website https://sites.google.com/site/hurstlab/home/greg
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-mediated alteration of host biology. Both objectives are crucial for the development of novel biological and chemical tools against major vector-borne diseases and pests.

 Publications

year authors and title journal last update
List of publications.
2019 Pol Nadal‐Jimenez, Joanne S. Griffin, Lianne Davies, Crystal L. Frost, Marco Marcello, Gregory D. D. Hurst
Genetic manipulation allows in vivo tracking of the life cycle of the son‐killer symbiont, Arsenophonus nasoniae , and reveals patterns of host invasion, tropism and pathology
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14724 		Environmental Microbiology 2019-09-02

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