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SymMech

Unravelling the mechanisms behind bacterial symbiosis in insects

Total Cost €

0

EC-Contrib. €

0

Partnership

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 SymMech project word cloud

Explore the words cloud of the SymMech project. It provides you a very rough idea of what is the project "SymMech" about.

diseases    desired    vitripennis    biological    predator    responsible    plants    culturable    thriving    grown    mediated    sk    elucidation    acquisition    biology    permit    possibility    killing    classic    endosymbionts    pests    chemical    hosts    tools    arsenophonus    first    time    infects    combined    identification    alteration    gene    microbiological    molecular    screens    reproductive    insect    strategies    lifestyle    utilize    symbiosis    solid    niches    borne    reduce    pathogen    diminish    son    transmission    function    outside    bacterium    elucidate    symbioisis    interference    additionally    specialised    nutrient    knockout    competing    symbionts    invertebrates    life    raised    male    enormous    arthropods    lethality    humans    impeding    inducing    bacterial    mechanisms    modify    engineer    eliminate    strategy    distributed    hypothesis    symbiont    vector    manipulation    parasitoid    independent    phenotype    symbiotic    offspring    amongst    microorganisms    ground    performing    nasoniae    tradis    dependent    protection    genes    host    nasonia    little    competence    strains    wasp    few   

Project "SymMech" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF LIVERPOOL 

Organization address
address: BROWNLOW HILL 765 FOUNDATION BUILDING
city: LIVERPOOL
postcode: L69 7ZX
website: www.liverpool.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://sites.google.com/site/hurstlab/home/greg
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) coordinator 183˙454.00

Map

 Project objective

Bacterial endosymbionts are widely distributed amongst invertebrates and have an enormous impact upon the biology of their hosts, being responsible for nutrient acquisition, predator protection and interference with the host reproductive strategies. Their ability to reduce vector competence has raised the possibility of using endosymbionts as a strategy to eliminate or diminish vector-borne pathogen transmission to humans and plants. A crucial step in manipulation of symbionts is the elucidation of the genes involved in symbiosis. Symbionts are highly adapted to hosts, thriving in highly specialised niches with little interference from competing microorganisms. The genes that permit this lifestyle are not known in any case, because most symbionts cannot be grown outside their host, thus impeding classic microbiological loss of function screens to elucidate the molecular mechanisms responsible for symbioisis. In this project, I will utilize Arsenophonus nasoniae, one of the few culturable symbionts, to establish for the first time the genes and systems required for symbiotic life. This bacterium infects the parasitoid wasp Nasonia vitripennis inducing lethality in the male offspring (son-killing = sk). The major objective of this project is to elucidate by the first time genes that are essential for the symbiosis between a bacterium and an insect using hypothesis-independent TraDis approach combined with hypothesis-dependent gene knockout approaches. Identification of the genes involved in symbiosis may allow us to modify the host range of symbionts or engineer strains that produce the desired phenotype. Additionally, this project will provide solid ground for the identification of genes involved in reproductive manipulation of arthropods allowing performing symbiont-mediated alteration of host biology. Both objectives are crucial for the development of novel biological and chemical tools against major vector-borne diseases and pests.

 Publications

year authors and title journal last update
List of publications.
2019 Pol Nadal‐Jimenez, Joanne S. Griffin, Lianne Davies, Crystal L. Frost, Marco Marcello, Gregory D. D. Hurst
Genetic manipulation allows in vivo tracking of the life cycle of the son‐killer symbiont, Arsenophonus nasoniae , and reveals patterns of host invasion, tropism and pathology
published pages: , ISSN: 1462-2912, DOI: 10.1111/1462-2920.14724
Environmental Microbiology 2019-09-02

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