Opendata, web and dolomites

VIVAVE

Viral Vaccine Vectors in Personalized Medicine

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 VIVAVE project word cloud

Explore the words cloud of the VIVAVE project. It provides you a very rough idea of what is the project "VIVAVE" about.

humans    free    released    replication    melanoma    counterparts    stimulate    pipeline    genes    people    blocking    fills    animal    immune    time    poorly    faster    class    release    exceedingly    arising    depot    neoplastic    tissue    successful    therapies    stage    bout    iatrogenic    relapse    disease    rapid    lymphoma    cancer    lasting    surveillance    modified    maintained    pathogens    expressed    uniquely    minimal    host    tumor    versatile    developers    options    aggressive    generally    decades    therapy    virus    innocuous    tumors    few    immunity    deterrence    monitored    sustained    replicate    clinical    combines    aborted    profile    promotes    condemned    human    vaccines    strike    nuclei    millions    levels    establishes    worldwide    active    hence    vectors    life    infection    antigen    grow    infected    grows    residual    elimination    expensive    provides    latency    patients    relapses    viral    safe    cells    vector    vaccine    slowly    survive    culture   

Project "VIVAVE" data sheet

The following table provides information about the project.

Coordinator
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH 

Organization address
address: INHOFFENSTRASSE 7
city: BRAUNSCHWEIG
postcode: 38124
website: www.helmholtz-hzi.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 149˙858 €
 EC max contribution 149˙858 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH DE (BRAUNSCHWEIG) coordinator 149˙858.00

Map

 Project objective

Melanoma and lymphoma are tumors that strike millions of people worldwide and require aggressive and expensive therapies. Numerous therapies are already being used or in the pipeline, yet all of them focus on the rapid elimination of the active neoplastic process. They do not provide options for long-term surveillance and deterrence of minimal residual disease, that is, of cancer relapse arising from the few tumor cells that survive the aggressive bout of therapy. Therefore, even patients considered cancer-free upon successful therapy are monitored over decades for potential relapses and condemned to a life of uncertainty. I propose to develop a novel class of versatile tumor vaccines for long-term surveillance of tumors based on a modified virus vector. Our modified viral vector combines an exceedingly safe profile with robust and long-lasting immunity. Several developers have focused on human virus vaccine vectors that grow poorly in tissue culture, and as human pathogens, present iatrogenic concerns. Our modified viral vector system grows faster in animal cells than human counterparts, but cannot replicate in human cells. Therefore, our vector system is generally considered innocuous for humans. The replication in human cells is aborted at the early stage of infection, but immediate-early genes are expressed at robust levels, and thus may stimulate immune responses. Our modified viral vector system establishes latency and is maintained for life in the nuclei of infected cells, where they release low levels of antigen for the life of the host. Thus, it provides a depot of antigen that is slowly released over time and promotes the uniquely strong and sustained immunity. Our approach is unique in its design to provide long-term immune surveillance of tumor cells, and thus in blocking relapses. Hence, we propose to develop a unique product that fills an important clinical need.

 Publications

year authors and title journal last update
List of publications.
2019 Elham Beyranvand Nejad, Robert B. Ratts, Eleni Panagioti, Christine Meyer, Jennifer D. Oduro, Luka Cicin-Sain, Klaus Früh, Sjoerd H. van der Burg, Ramon Arens
Demarcated thresholds of tumor-specific CD8 T cells elicited by MCMV-based vaccine vectors provide robust correlates of protection
published pages: , ISSN: 2051-1426, DOI: 10.1186/s40425-019-0500-9
Journal for ImmunoTherapy of Cancer 7/1 2019-07-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "VIVAVE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "VIVAVE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

MuFLOART (2018)

Microbiological fluorescence observatory for antibiotic resistance tracking

Read More  

INSPIRE (2019)

System-wide discovery and analysis of inositol pyrophosphate signaling networks in plants

Read More