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qBioNano

Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

qBioNano project word cloud

Explore the words cloud of the qBioNano project. It provides you a very rough idea of what is the project "qBioNano" about.

diseased proteins situated time london quantification spatiotemporally particle tissue rs tissues group nps alkyne polymers imperial governing combining urgent biology stevens environments cell imaging as platform visible fellow odowska icl invasive assembly interact layer lipids interdisciplinary interactions world sk destructive healthy bio lbl extensive cellular uniquely spheroids interfaces marie free materials molly quantifying prof engineered questions underlying spectroscopy first nano physiological microfluidic biostructures 3d mitochondria class highest assembled curie quality microfluidics view college nanoparticles physiologically biomaterials nuclei containing biological cells biomolecules live expertise label maintained spectra qbionano supervision runs raman science answer resolved combine

Project "qBioNano" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://qbionano.wordpress.com/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-08-21 to 2019-08-20

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

As a Marie SkÅ‚odowska-Curie Fellow in “qBioNano: Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy”, I will combine three emerging fields—layer-by-layer (LbL) assembly of nanoparticles (NPs), microfluidics, and live cell Raman spectroscopy (RS)—to enable 3D imaging and quantification of how NPs and cells interact under physiological conditions. This will allow, for the first time, non-invasive, non-destructive, label-free, spatiotemporally resolved study of a range of biomolecules (e.g., lipids and proteins) and biostructures (e.g., nuclei and mitochondria) at the same time as LbL assembled NPs to answer long-standing questions on particle-induced changes in cellular states and processes. The NPs will be produced through LbL assembly of alkyne-containing polymers (having Raman spectra clearly visible in biological environments), and—using microfluidic devices (where cells can be introduced and maintained in physiologically relevant environments)—I will study how these NPs affect both healthy and diseased cells and tissues (e.g., at cell-cell interfaces and using spheroids). This project will provide: (i) the first detailed view into the biology underlying cellular responses to LbL assembled NPs under physiological conditions, and (ii) a new platform offering insight into key cellular processes and responses governing how cells and tissues interact with, and respond to, engineered NPs. By combining my expertise in developing NPs, microfluidic systems and investigating bio-nano interactions, with the supervision of Prof. Molly Stevens at Imperial College London (ICL), who runs a world-class interdisciplinary biomaterials group with extensive experience in RS, materials science, and cell and tissue biology, this project is uniquely situated to address these urgent—but challenging—topics and deliver the highest quality results.

Publications

List of publications.
year	authors and title	journal	last update
2018	Matthew Faria, Mattias BjÃ¶rnmalm, Kristofer J. Thurecht, Stephen J. Kent, Robert G. Parton, Maria Kavallaris, Angus P. R. Johnston, J. Justin Gooding, Simon R. Corrie, Ben J. Boyd, Pall Thordarson, Andrew K. Whittaker, Molly M. Stevens, Clive A. Prestidge, Christopher J. H. Porter, Wolfgang J. Parak, Thomas P. Davis, Edmund J. Crampin, Frank Caruso Minimum information reporting in bioâ€“nano experimental literature published pages: 777-785, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0246-4	Nature Nanotechnology 13/9	2019-11-11
2019	Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias BjÃ¶rnmalm, Stuart T. Johnston, Kristian Kempe, Frank Caruso, Edmund J. Crampin Revisiting cellâ€“particle association in vitro: A quantitative method to compare particle performance published pages: 355-367, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.06.027	Journal of Controlled Release 307	2019-11-11

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The information about "QBIONANO" are provided by the European Opendata Portal: CORDIS opendata.