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qBioNano

Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 qBioNano project word cloud

Explore the words cloud of the qBioNano project. It provides you a very rough idea of what is the project "qBioNano" about.

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Project "qBioNano" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
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 Coordinator Country United Kingdom [UK]
 Project website https://qbionano.wordpress.com/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-08-21   to  2019-08-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 195˙454.00

Map

 Project objective

As a Marie SkÅ‚odowska-Curie Fellow in “qBioNano: Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy”, I will combine three emerging fields—layer-by-layer (LbL) assembly of nanoparticles (NPs), microfluidics, and live cell Raman spectroscopy (RS)—to enable 3D imaging and quantification of how NPs and cells interact under physiological conditions. This will allow, for the first time, non-invasive, non-destructive, label-free, spatiotemporally resolved study of a range of biomolecules (e.g., lipids and proteins) and biostructures (e.g., nuclei and mitochondria) at the same time as LbL assembled NPs to answer long-standing questions on particle-induced changes in cellular states and processes. The NPs will be produced through LbL assembly of alkyne-containing polymers (having Raman spectra clearly visible in biological environments), and—using microfluidic devices (where cells can be introduced and maintained in physiologically relevant environments)—I will study how these NPs affect both healthy and diseased cells and tissues (e.g., at cell-cell interfaces and using spheroids). This project will provide: (i) the first detailed view into the biology underlying cellular responses to LbL assembled NPs under physiological conditions, and (ii) a new platform offering insight into key cellular processes and responses governing how cells and tissues interact with, and respond to, engineered NPs. By combining my expertise in developing NPs, microfluidic systems and investigating bio-nano interactions, with the supervision of Prof. Molly Stevens at Imperial College London (ICL), who runs a world-class interdisciplinary biomaterials group with extensive experience in RS, materials science, and cell and tissue biology, this project is uniquely situated to address these urgent—but challenging—topics and deliver the highest quality results.

 Publications

year authors and title journal last update
List of publications.
2018 Matthew Faria, Mattias Björnmalm, Kristofer J. Thurecht, Stephen J. Kent, Robert G. Parton, Maria Kavallaris, Angus P. R. Johnston, J. Justin Gooding, Simon R. Corrie, Ben J. Boyd, Pall Thordarson, Andrew K. Whittaker, Molly M. Stevens, Clive A. Prestidge, Christopher J. H. Porter, Wolfgang J. Parak, Thomas P. Davis, Edmund J. Crampin, Frank Caruso
Minimum information reporting in bio–nano experimental literature
published pages: 777-785, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0246-4
Nature Nanotechnology 13/9 2019-11-11
2019 Matthew Faria, Ka Fung Noi, Qiong Dai, Mattias Björnmalm, Stuart T. Johnston, Kristian Kempe, Frank Caruso, Edmund J. Crampin
Revisiting cell–particle association in vitro: A quantitative method to compare particle performance
published pages: 355-367, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.06.027
Journal of Controlled Release 307 2019-11-11

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The information about "QBIONANO" are provided by the European Opendata Portal: CORDIS opendata.

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