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CerebellumTherapy

Sensorimotor plasticity in the cerebellar microcircuit and its therapeutic potential

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CerebellumTherapy project word cloud

Explore the words cloud of the CerebellumTherapy project. It provides you a very rough idea of what is the project "CerebellumTherapy" about.

theories    independent    probes    performing    underlie    learning    unknown    bridge    photon    substantial    circuit    outputs    issue    technique    modifications    disease    cortex    cerebellar    operation    cellular    interrogation    inputs    malfunctioning    simultaneously    optogenetics    roles    drive    red    modifying    combining    characterised    resolution    underestimated    neural    fluorescent    human    debilitating    modal    wild    perturb    applicable    optogenetic    insights    mostly    autism    function    refinement    therapeutic    anatomy    causal    probe    intervention    neurons    modulating    ideal    tackle    first    motor    sensory    relevance    imaging    cerebellum    pervasive    causing    structure    unprecedented    ultimately    adaptive    manipulations    experimental    brain    circuits    green    restore    disorders    association    neuronal    action    contribution    dysregulated    mice    model    characterise    satisfactory    colour    deficits    record    clinical    operate    expression    manipulation   

Project "CerebellumTherapy" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.dendrites.org/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Neural circuits operate to drive behaviour and can cause debilitating brain disorders when malfunctioning. However, how circuit activity is causing learning and action and which modifications underlie the development of a disease is mostly unknown. The cerebellum is an ideal structure to tackle this issue because of its well-characterised anatomy, established motor learning and control theories, and relevance to pervasive brain disorders like autism. However, our cellular and circuit-level understanding of the cerebellar roles in learning and modulating behaviour and in modifying disease is still not satisfactory, therefore the therapeutic potential of cerebellar intervention is underestimated. In this proposal, I will address this potential by combining multi-colour two-photon imaging and optogenetic interrogation in the cerebellar cortex of wild type and disease model mice performing a multi-sensory association task. My first goal is to characterise the circuit operation of the cerebellum at unprecedented resolution. I will record two identified neuronal inputs simultaneously using independent expression of green and red fluorescent probes in neurons in the cerebellar cortex to investigate how multi-modal sensory inputs are associated during motor adaptation. The second goal is to define detailed cerebellar circuit deficits by using above methods in autism model mice. Finally, I will establish the causal roles of these neuronal inputs for this adaptive behaviour. I will perturb these motor control- and learning-related neuronal inputs and outputs using optogenetics to probe their unique contribution. I will apply similar optogenetic manipulations to restore the function of the dysregulated cerebellar circuit in autism model mice. Ultimately, I will build a bridge between this experimental technique and a human-applicable method. Together, this project will provide substantial insights into the implementation and refinement of clinical cerebellar manipulation.

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The information about "CEREBELLUMTHERAPY" are provided by the European Opendata Portal: CORDIS opendata.

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