Opendata, web and dolomites

MetaBiota

Crosstalk between microbiota metabolites and immune cells, the missing link to brain damage.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MetaBiota project word cloud

Explore the words cloud of the MetaBiota project. It provides you a very rough idea of what is the project "MetaBiota" about.

individual    throughput    training    nature    intervention    critical    dramatic    almost    tools    gain    thereby    sklodowska    function    infrastructure    microbial    gap    mouse    methodological    modulation    host    death    msc    cell    diet    medicine    biology    patients    knock    sequencing    therapies    first    me    eligible    relationship    regulation    leader    influences    cutting    modulate    revealed    severity    marie    attempt    influence    models    gut    brain    altered    issue    analyze    microbiota    efficient    interdisciplinary    investigator    treatment    million    species    strategies    implication    panel    outcome    reduce    neuroprotective    bacteria    15    deaths    impaired    ischemic    fellowship    time    intestinal       precisely    fill    injury    discover    immune    metabolomic    independent    april    stroke    prospective    reported    edge    therapeutic    mice    setting    accounting    paradigm    curie    bacterial    obtain    metabolites   

Project "MetaBiota" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.isd-research.de/liesz-lab
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Stroke is the second most common cause of death in Europe: accounting for almost 1.1 million deaths each year, with only 15% of stroke patients being eligible for a specific treatment. I have reported–in this year Nature Medicine’s April issue–that microbiota influences the severity of stroke injury through an impaired intestinal immune function. These findings revealed for the first time the critical implication of the microbiota as a novel and relevant prospective target for therapeutic strategies in stroke. However, the development of efficient therapies requires to identify which bacterial species and bacterial products are involved in the modulation of the immune response and thereby influence stroke outcome. To fill in this knowledge gap, my proposal aims to identify how metabolites derived from gut bacteria modulate the intestinal immune response and thereby influence the brain in the setting of stroke. To investigate this novel paradigm, I will use cutting-edge metabolomic tools to precisely analyze a large panel of metabolites, high-throughput sequencing to identify bacterial species, specific knock-out mice and mouse models of altered-microbiota available at the host institution and its established collaboration partners. This is the first attempt to discover a relationship between microbial metabolites, immune cell regulation and severity of ischemic stroke. Information derived from this project will have the potential to enable development of a “neuroprotective” microbiota–by diet intervention–and reduce the dramatic consequences of stroke. The Marie Sklodowska-Curie individual fellowship (MSC IF) will allow me to obtain the required methodological knowledge, access to critical infrastructure and collaboration partners in order to achieve this interdisciplinary and ambitious objective. My overall goal will be to gain this training fellowship to become an independent investigator and a leader in the field of stroke and microbiota biology.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METABIOTA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "METABIOTA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

POSPORI (2019)

Polymer Optical Sensors for Prolonged Overseeing the Robustness of civil Infrastructures

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

EGeoCC (2019)

Ethnic geography and civil conflict

Read More