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MetaBiota

Crosstalk between microbiota metabolites and immune cells, the missing link to brain damage.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MetaBiota project word cloud

Explore the words cloud of the MetaBiota project. It provides you a very rough idea of what is the project "MetaBiota" about.

diet    microbial    setting    mice    fill    gain    sequencing    cell    sklodowska    neuroprotective    tools    methodological    microbiota    deaths    impaired    metabolites    knock    regulation    gap    strategies    discover    leader    death    throughput    april    intervention    nature       influences    panel    edge    me    thereby    paradigm    individual    outcome    dramatic    15    first    intestinal    critical    influence    function    immune    independent    mouse    severity    bacteria    prospective    altered    patients    marie    msc    host    implication    biology    million    reduce    infrastructure    issue    time    species    models    almost    gut    fellowship    therapies    treatment    modulation    bacterial    obtain    brain    interdisciplinary    modulate    curie    cutting    attempt    revealed    ischemic    metabolomic    precisely    investigator    stroke    efficient    reported    therapeutic    injury    medicine    relationship    accounting    analyze    training    eligible   

Project "MetaBiota" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.isd-research.de/liesz-lab
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

Stroke is the second most common cause of death in Europe: accounting for almost 1.1 million deaths each year, with only 15% of stroke patients being eligible for a specific treatment. I have reported–in this year Nature Medicine’s April issue–that microbiota influences the severity of stroke injury through an impaired intestinal immune function. These findings revealed for the first time the critical implication of the microbiota as a novel and relevant prospective target for therapeutic strategies in stroke. However, the development of efficient therapies requires to identify which bacterial species and bacterial products are involved in the modulation of the immune response and thereby influence stroke outcome. To fill in this knowledge gap, my proposal aims to identify how metabolites derived from gut bacteria modulate the intestinal immune response and thereby influence the brain in the setting of stroke. To investigate this novel paradigm, I will use cutting-edge metabolomic tools to precisely analyze a large panel of metabolites, high-throughput sequencing to identify bacterial species, specific knock-out mice and mouse models of altered-microbiota available at the host institution and its established collaboration partners. This is the first attempt to discover a relationship between microbial metabolites, immune cell regulation and severity of ischemic stroke. Information derived from this project will have the potential to enable development of a “neuroprotective” microbiota–by diet intervention–and reduce the dramatic consequences of stroke. The Marie Sklodowska-Curie individual fellowship (MSC IF) will allow me to obtain the required methodological knowledge, access to critical infrastructure and collaboration partners in order to achieve this interdisciplinary and ambitious objective. My overall goal will be to gain this training fellowship to become an independent investigator and a leader in the field of stroke and microbiota biology.

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The information about "METABIOTA" are provided by the European Opendata Portal: CORDIS opendata.

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