Explore the words cloud of the SAMNets project. It provides you a very rough idea of what is the project "SAMNets" about.
The following table provides information about the project.
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
|Coordinator Country||Ireland [IE]|
|Total cost||187˙866 €|
|EC max contribution||187˙866 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2017-05-01 to 2019-04-30|
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|1||UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN||IE (DUBLIN)||coordinator||187˙866.00|
Cell life is not the property of any single protein or gene; rather it emerges from concerted actions of multiple molecules in cellular networks. Current proposal is focused on Signal Transduction Networks (STN) connecting the environment to cell responses. A major challenge is to understand how STN integrate and process environmental signals in a robust and reliable way and how they “compute” cell fate decisions depending on genetic background. To answer this question, the study will be focused on three interconnecting STNs: the Survival (PI3K/PTEN/AKT), Apoptotic (RASSF1/MST/LATS) and Mitogenic (EGFR/RAS/RAF/MEK/ERK) pathways, the SAM network. In the scope of current proposal the methods of signalling network reconstruction will be improved and the SAM network topology will be reconstructed in the panel of cell lines. Based on available data and reconstructed network topology the mechanistic site-specific dynamic model of SAM network will be developed and validated. Model predictions of dependence of signalling outputs behaviour on different perturbations (like small molecule inhibitors and their combinations) and background (mutations and protein expression levels) will be validated. The signalling outputs will be experimentally correlated to the cell fate decisions.
The developed models will relate mutational information to treatment responses in the context of different expression landscapes and they will explain and predict mechanisms of intrinsic and acquired drug resistances, which often cannot be picked up by only intuitive reasoning. During the project the applicant will get training in a range of modern computational modelling, biochemical and molecular biology techniques used to study intracellular signalling networks. As a result, he will acquire skills of efficient integration of wet and dry parts of systems biology which will uniquely qualify him in the field significantly enhancing his career prospects.
|year||authors and title||journal||last update|
Keesha E. Erickson, Oleksii S. Rukhlenko, Richard G. Posner, William S. Hlavacek, Boris N. Kholodenko
New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling
published pages: 162-173, ISSN: 1044-579X, DOI: 10.1016/j.semcancer.2018.02.008
|Seminars in Cancer Biology 54||2019-09-04|
Oleksii S. Rukhlenko, Fahimeh Khorsand, Aleksandar Krstic, Jan Rozanc, Leonidas G. Alexopoulos, Nora Rauch, Keesha E. Erickson, William S. Hlavacek, Richard G. Posner, Silvia GÃ³mez-Coca, Edina Rosta, Cheree Fitzgibbon, David Matallanas, Jens Rauch, Walter Kolch, Boris N. Kholodenko
Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling
published pages: 161-179.e14, ISSN: 2405-4712, DOI: 10.1016/j.cels.2018.06.002
|Cell Systems 7/2||2019-09-04|
Daniel Lill, Oleksii S. Rukhlenko, Anthony James Mc Elwee, Eugene Kashdan, Jens Timmer, Boris N. Kholodenko
Mapping connections in signaling networks with ambiguous modularity
published pages: , ISSN: 2056-7189, DOI: 10.1038/s41540-019-0096-1
|npj Systems Biology and Applications 5/1||2019-09-04|
Keesha E. Erickson, Oleksii S. Rukhlenko, Md Shahinuzzaman, Kalina P. Slavkova, Yen Ting Lin, Ryan Suderman, Edward C. Stites, Marian Anghel, Richard G. Posner, Dipak Barua, Boris N. Kholodenko, William S. Hlavacek
Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor
published pages: e1006706, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1006706
|PLOS Computational Biology 15/1||2019-09-04|
Tapesh Santra, Oleksii Rukhlenko, Vadim Zhernovkov, Boris N. Kholodenko
Reconstructing static and dynamic models of signaling pathways using Modular Response Analysis
published pages: 11-21, ISSN: 2452-3100, DOI: 10.1016/j.coisb.2018.02.003
|Current Opinion in Systems Biology 9||2019-09-04|
Caterina Thomaseth, Dirk Fey, Tapesh Santra, Oleksii S. Rukhlenko, Nicole E. Radde, Boris N. Kholodenko
Impact of measurement noise, experimental design, and estimation methods on Modular Response Analysis based network reconstruction
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-34353-3
|Scientific Reports 8/1||2019-09-04|
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The information about "SAMNETS" are provided by the European Opendata Portal: CORDIS opendata.
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