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GrapheneBiosensor SIGNED

Electrochemical Graphene Sensors as Early Alert Tools for Algal Toxin Detection in Water

Total Cost €

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EC-Contrib. €

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Partnership

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 GrapheneBiosensor project word cloud

Explore the words cloud of the GrapheneBiosensor project. It provides you a very rough idea of what is the project "GrapheneBiosensor" about.

portable    potent    area    demanding    microcystins    blooms    purpose    active    acute    ease    times    massive    quality    biosensors    ing    provisional    electrochemically    detect    conventional    spectrometry    anthropogenic    algal    global    waste    1998    bodies    liquid    candidate    microcystin    assays    death    animals    urban    protein    responsible    concentration    instruments    frequently    manufacturing    ppl    chromatography    monitoring    immune    followed    time    confirmed    liver    exposure    pp2a    skills    hplc    physical    prevent    limit    drinking    biochemical    material    inhibiting    electrical    mu    phosphatases    situ    humans    sophisticated    rapid    worldwide    graphene    harmful    2a    bio    alternatives    had    toxin    sources    guideline    performance    warming    laboratory    run    electrochemical    probably    conductivity    hemorrhage    broad    eutrophication    mc    world    episodes    agricultural    immunosensors    solutions    water    expensive    potentials    consuming    lr    toxic    surface    organization    contained    aqueous    detergents    prolonged    health    cyanobacteria    algae    functionalization    mass    sensitive    poisonings    damage    occurrence    off    assigned    ms    blue    intrahepatic    fit   

Project "GrapheneBiosensor" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-26   to  2019-11-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 195˙454.00

Map

 Project objective

Episodes of harmful blue algae blooms and the associated algal toxin microcystin-LR (MC-LR) occur frequently in bodies of water worldwide as consequences of eutrophication resulting from anthropogenic activities such as agricultural run-off, urban waste, and manufacturing of detergents and global warming. It had been confirmed that microcystins were responsible for some poisonings of animals and humans where water sources contained toxic cyanobacteria blooms. Microcystins were potent and specific in inhibiting protein phosphatases 1 and 2A (PPl, PP2A). Acute or prolonged exposure to microcystins would cause liver damage, followed by a massive intrahepatic hemorrhage and probably leading to death. In 1998, the provisional guideline concentration limit of 1 μg/L MC-LR in drinking water was assigned by the World Health Organization (WHO). The development of reliable methods for monitoring MC-LR in water resources is of great interest to determine the occurrence and to prevent exposure to the toxin. Several methods have been developed to detect MC-LR, such as high-performance liquid chromatography/mass spectrometry (HPLC/MS) , bio-, biochemical- and immune-assays, which require long processing times, sophisticated instruments, complex procedures, or high processing cost and are in general used in the laboratory, not in situ. A sensitive, specific, simple, and rapid method for monitoring MC-LR could help to prevent exposure to the toxin. The unique physical and electrochemical properties (e.g., high electrical conductivity, ease of functionalization, high electrochemically active surface area, and broad range of working potentials in aqueous solutions) of graphene make them a candidate material for developing novel and fit-for-purpose electrochemical biosensors/immunosensors as alternatives to the time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality assessment.

 Publications

year authors and title journal last update
List of publications.
2018 Wei Zhang, Mike B. Dixon, Christopher Saint, Kar Seng Teng, Hiroaki Furumai
Electrochemical Biosensing of Algal Toxins in Water: The Current State-of-the-Art
published pages: 1233-1245, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00359
ACS Sensors 3/7 2020-02-27
2018 Wei Zhang, Baoping Jia, Hiroaki Furumai
Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28959-w
Scientific Reports 8/1 2020-02-27

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