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GrapheneBiosensor SIGNED

Electrochemical Graphene Sensors as Early Alert Tools for Algal Toxin Detection in Water

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EC-Contrib. €

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 GrapheneBiosensor project word cloud

Explore the words cloud of the GrapheneBiosensor project. It provides you a very rough idea of what is the project "GrapheneBiosensor" about.

prevent    consuming    urban    drinking    ppl    active    detergents    responsible    algae    manufacturing    humans    toxin    water    lr    eutrophication    physical    phosphatases    sources    immunosensors    electrical    prolonged    conventional    immune    provisional    ease    mass    liquid    protein    mu    aqueous    monitoring    electrochemical    quality    animals    2a    anthropogenic    solutions    health    laboratory    functionalization    agricultural    microcystin    run    harmful    guideline    intrahepatic    liver    pp2a    electrochemically    biosensors    candidate    poisonings    situ    worldwide    demanding    fit    off    potent    potentials    bodies    sensitive    material    contained    mc    area    waste    blooms    acute    massive    limit    world    warming    biochemical    had    toxic    concentration    episodes    graphene    alternatives    chromatography    inhibiting    confirmed    algal    time    spectrometry    assays    instruments    ing    blue    1998    expensive    conductivity    surface    skills    broad    sophisticated    occurrence    cyanobacteria    microcystins    detect    organization    assigned    hemorrhage    damage    death    frequently    hplc    performance    times    bio    global    probably    followed    ms    portable    rapid    exposure    purpose   

Project "GrapheneBiosensor" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-26   to  2019-11-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 195˙454.00

Map

 Project objective

Episodes of harmful blue algae blooms and the associated algal toxin microcystin-LR (MC-LR) occur frequently in bodies of water worldwide as consequences of eutrophication resulting from anthropogenic activities such as agricultural run-off, urban waste, and manufacturing of detergents and global warming. It had been confirmed that microcystins were responsible for some poisonings of animals and humans where water sources contained toxic cyanobacteria blooms. Microcystins were potent and specific in inhibiting protein phosphatases 1 and 2A (PPl, PP2A). Acute or prolonged exposure to microcystins would cause liver damage, followed by a massive intrahepatic hemorrhage and probably leading to death. In 1998, the provisional guideline concentration limit of 1 μg/L MC-LR in drinking water was assigned by the World Health Organization (WHO). The development of reliable methods for monitoring MC-LR in water resources is of great interest to determine the occurrence and to prevent exposure to the toxin. Several methods have been developed to detect MC-LR, such as high-performance liquid chromatography/mass spectrometry (HPLC/MS) , bio-, biochemical- and immune-assays, which require long processing times, sophisticated instruments, complex procedures, or high processing cost and are in general used in the laboratory, not in situ. A sensitive, specific, simple, and rapid method for monitoring MC-LR could help to prevent exposure to the toxin. The unique physical and electrochemical properties (e.g., high electrical conductivity, ease of functionalization, high electrochemically active surface area, and broad range of working potentials in aqueous solutions) of graphene make them a candidate material for developing novel and fit-for-purpose electrochemical biosensors/immunosensors as alternatives to the time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality assessment.

 Publications

year authors and title journal last update
List of publications.
2018 Wei Zhang, Mike B. Dixon, Christopher Saint, Kar Seng Teng, Hiroaki Furumai
Electrochemical Biosensing of Algal Toxins in Water: The Current State-of-the-Art
published pages: 1233-1245, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00359
ACS Sensors 3/7 2020-02-27
2018 Wei Zhang, Baoping Jia, Hiroaki Furumai
Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28959-w
Scientific Reports 8/1 2020-02-27

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