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GrapheneBiosensor SIGNED

Electrochemical Graphene Sensors as Early Alert Tools for Algal Toxin Detection in Water

Total Cost €

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EC-Contrib. €

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Partnership

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 GrapheneBiosensor project word cloud

Explore the words cloud of the GrapheneBiosensor project. It provides you a very rough idea of what is the project "GrapheneBiosensor" about.

massive    inhibiting    detect    toxin    conventional    poisonings    purpose    eutrophication    chromatography    algae    immune    biosensors    ms    liquid    physical    had    times    demanding    harmful    blue    cyanobacteria    candidate    concentration    exposure    worldwide    monitoring    episodes    quality    performance    ease    mass    pp2a    alternatives    drinking    situ    prevent    liver    followed    guideline    probably    contained    damage    potentials    agricultural    fit    potent    water    sophisticated    warming    electrochemically    graphene    aqueous    responsible    manufacturing    biochemical    consuming    frequently    sources    lr    hemorrhage    instruments    2a    portable    electrochemical    assays    functionalization    skills    organization    phosphatases    off    surface    intrahepatic    microcystins    area    expensive    death    algal    run    solutions    immunosensors    assigned    1998    ing    animals    acute    global    urban    sensitive    mc    anthropogenic    prolonged    broad    world    ppl    spectrometry    protein    mu    active    hplc    time    provisional    confirmed    electrical    conductivity    laboratory    occurrence    blooms    material    bodies    limit    microcystin    toxic    waste    bio    humans    detergents    rapid    health   

Project "GrapheneBiosensor" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-09-26   to  2019-11-07

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 195˙454.00

Map

 Project objective

Episodes of harmful blue algae blooms and the associated algal toxin microcystin-LR (MC-LR) occur frequently in bodies of water worldwide as consequences of eutrophication resulting from anthropogenic activities such as agricultural run-off, urban waste, and manufacturing of detergents and global warming. It had been confirmed that microcystins were responsible for some poisonings of animals and humans where water sources contained toxic cyanobacteria blooms. Microcystins were potent and specific in inhibiting protein phosphatases 1 and 2A (PPl, PP2A). Acute or prolonged exposure to microcystins would cause liver damage, followed by a massive intrahepatic hemorrhage and probably leading to death. In 1998, the provisional guideline concentration limit of 1 μg/L MC-LR in drinking water was assigned by the World Health Organization (WHO). The development of reliable methods for monitoring MC-LR in water resources is of great interest to determine the occurrence and to prevent exposure to the toxin. Several methods have been developed to detect MC-LR, such as high-performance liquid chromatography/mass spectrometry (HPLC/MS) , bio-, biochemical- and immune-assays, which require long processing times, sophisticated instruments, complex procedures, or high processing cost and are in general used in the laboratory, not in situ. A sensitive, specific, simple, and rapid method for monitoring MC-LR could help to prevent exposure to the toxin. The unique physical and electrochemical properties (e.g., high electrical conductivity, ease of functionalization, high electrochemically active surface area, and broad range of working potentials in aqueous solutions) of graphene make them a candidate material for developing novel and fit-for-purpose electrochemical biosensors/immunosensors as alternatives to the time-consuming, expensive, non-portable and often skills-demanding conventional methods of analysis involved in water quality assessment.

 Publications

year authors and title journal last update
List of publications.
2018 Wei Zhang, Mike B. Dixon, Christopher Saint, Kar Seng Teng, Hiroaki Furumai
Electrochemical Biosensing of Algal Toxins in Water: The Current State-of-the-Art
published pages: 1233-1245, ISSN: 2379-3694, DOI: 10.1021/acssensors.8b00359
ACS Sensors 3/7 2020-02-27
2018 Wei Zhang, Baoping Jia, Hiroaki Furumai
Fabrication of graphene film composite electrochemical biosensor as a pre-screening algal toxin detection tool in the event of water contamination
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28959-w
Scientific Reports 8/1 2020-02-27

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