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NanoZfish

Restoration of motor dysfunction in vivo through nanomaterials based devices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NanoZfish project word cloud

Explore the words cloud of the NanoZfish project. It provides you a very rough idea of what is the project "NanoZfish" about.

burden    treatments    nervous    sclerosis    international    repairing    restoring    vitro    confocal    vivo    tested    first    carry    economic    recovery    environment    ultimate    techniques    university    independence    biocompatibility    larvae    microscopy    motoneurons    locomotion    functional    candidates    implant    patch    implantable    maladies    injury    improvement    treatment    nanomaterial    social    graphene    reverse    bioscience    models    sci    implanted    mutant    outstanding    neuronal    function    disorders    nanotechnology    als    inform    motor    healthy    alternative    cord    spinal    papers    central    author    innovative    tool    facilitated    ameliorating    neurons    nanodevices    defects    senior    efficacy    pattern    class    dysfunctions    cnt    slow    carbon    impair    nanotubes    shown    ideal    locomotor    generators    promise    clamping    amyotrophic    powerful    sod1    therapeutic    subjected    model    owing    leicester    fish    publishing    lesioned    lack    zebrafish    lateral   

Project "NanoZfish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEICESTER 

Organization address
address: UNIVERSITY ROAD
city: LEICESTER
postcode: LE1 7RH
website: www.le.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEICESTER UK (LEICESTER) coordinator 195˙454.00

Map

 Project objective

Spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) are nervous system maladies that impair the function of spinal central pattern generators for locomotion. These disorders carry a significant social and economic burden, owing to a lack of effective therapeutic treatments. In the field of nanotechnology, carbon nanotubes (CNT) have shown outstanding promise for the improvement of neuronal function in vitro and are thus ideal candidates for repairing or ameliorating spinal defects associated with these disorders. The ultimate goal of this project is to develop CNT as a tool for restoring motor dysfunctions associated with SCI and ALS. Specifically, I will use zebrafish larvae as an in vivo model for testing the therapeutic efficacy of this innovative class of implantable devices. I will implant CNT and graphene based devices in healthy, spinal cord lesioned and ALS zebrafish models and test their effects on spinal cord function with a range of powerful in vivo techniques. My project will address three specific aims. First, biocompatibility of implanted devices will be assessed using in vivo patch clamping of spinal motoneurons in healthy fish implanted with nanodevices. Second, I will implant CNT into fish that have been subjected to SCI. Nanomaterial-facilitated functional recovery will then be tested with in vivo patch clamping of spinal motor neurons, analysis of locomotor behaviour and confocal microscopy. Finally, I will use similar approaches to determine if implanted CNT can slow or reverse spinal cord defects in a SOD1 mutant zebrafish model of ALS. The project will advance our knowledge in an innovative field of bioscience research and help to inform the development of alternative approaches to the treatment of SCI and ALS. Embedded in an international environment, such as that of the University of Leicester, I will support my research activity through a greater level of independence, with the aim of publishing papers as senior author.

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The information about "NANOZFISH" are provided by the European Opendata Portal: CORDIS opendata.

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