Opendata, web and dolomites

NanoZfish

Restoration of motor dysfunction in vivo through nanomaterials based devices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 NanoZfish project word cloud

Explore the words cloud of the NanoZfish project. It provides you a very rough idea of what is the project "NanoZfish" about.

subjected    nanotechnology    ideal    environment    reverse    tool    tested    candidates    function    functional    innovative    models    generators    biocompatibility    defects    graphene    injury    outstanding    motor    amyotrophic    mutant    lesioned    nanodevices    shown    microscopy    carbon    implanted    carry    disorders    neurons    confocal    clamping    cnt    maladies    implantable    spinal    locomotion    nanotubes    central    sclerosis    therapeutic    neuronal    motoneurons    ultimate    university    larvae    recovery    lack    efficacy    independence    repairing    inform    bioscience    class    fish    author    burden    implant    pattern    first    international    nervous    promise    leicester    powerful    vivo    techniques    restoring    locomotor    alternative    sci    treatments    publishing    patch    treatment    dysfunctions    ameliorating    economic    senior    zebrafish    owing    facilitated    sod1    nanomaterial    papers    vitro    lateral    social    als    healthy    slow    model    impair    improvement    cord   

Project "NanoZfish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEICESTER 

Organization address
address: UNIVERSITY ROAD
city: LEICESTER
postcode: LE1 7RH
website: www.le.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEICESTER UK (LEICESTER) coordinator 195˙454.00

Map

 Project objective

Spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) are nervous system maladies that impair the function of spinal central pattern generators for locomotion. These disorders carry a significant social and economic burden, owing to a lack of effective therapeutic treatments. In the field of nanotechnology, carbon nanotubes (CNT) have shown outstanding promise for the improvement of neuronal function in vitro and are thus ideal candidates for repairing or ameliorating spinal defects associated with these disorders. The ultimate goal of this project is to develop CNT as a tool for restoring motor dysfunctions associated with SCI and ALS. Specifically, I will use zebrafish larvae as an in vivo model for testing the therapeutic efficacy of this innovative class of implantable devices. I will implant CNT and graphene based devices in healthy, spinal cord lesioned and ALS zebrafish models and test their effects on spinal cord function with a range of powerful in vivo techniques. My project will address three specific aims. First, biocompatibility of implanted devices will be assessed using in vivo patch clamping of spinal motoneurons in healthy fish implanted with nanodevices. Second, I will implant CNT into fish that have been subjected to SCI. Nanomaterial-facilitated functional recovery will then be tested with in vivo patch clamping of spinal motor neurons, analysis of locomotor behaviour and confocal microscopy. Finally, I will use similar approaches to determine if implanted CNT can slow or reverse spinal cord defects in a SOD1 mutant zebrafish model of ALS. The project will advance our knowledge in an innovative field of bioscience research and help to inform the development of alternative approaches to the treatment of SCI and ALS. Embedded in an international environment, such as that of the University of Leicester, I will support my research activity through a greater level of independence, with the aim of publishing papers as senior author.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "NANOZFISH" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "NANOZFISH" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

STUDYES (2019)

Structure and Ultrafast Dynamics in Deep Eutectic Solvents

Read More