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NanoZfish

Restoration of motor dysfunction in vivo through nanomaterials based devices

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NanoZfish project word cloud

Explore the words cloud of the NanoZfish project. It provides you a very rough idea of what is the project "NanoZfish" about.

independence    impair    publishing    defects    cnt    patch    function    slow    environment    model    nervous    disorders    recovery    tool    dysfunctions    facilitated    microscopy    nanotechnology    reverse    nanotubes    healthy    owing    leicester    bioscience    motoneurons    implant    sod1    implantable    shown    class    therapeutic    author    functional    central    locomotor    economic    outstanding    larvae    carbon    nanodevices    ultimate    zebrafish    neurons    graphene    papers    ideal    implanted    pattern    sci    social    biocompatibility    cord    tested    mutant    lateral    vitro    alternative    carry    ameliorating    university    lack    vivo    efficacy    clamping    sclerosis    spinal    als    inform    treatment    powerful    restoring    repairing    generators    treatments    techniques    fish    promise    senior    injury    improvement    maladies    models    candidates    neuronal    burden    confocal    nanomaterial    locomotion    motor    first    international    amyotrophic    innovative    lesioned    subjected   

Project "NanoZfish" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEICESTER 

Organization address
address: UNIVERSITY ROAD
city: LEICESTER
postcode: LE1 7RH
website: www.le.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEICESTER UK (LEICESTER) coordinator 195˙454.00

Map

 Project objective

Spinal cord injury (SCI) and amyotrophic lateral sclerosis (ALS) are nervous system maladies that impair the function of spinal central pattern generators for locomotion. These disorders carry a significant social and economic burden, owing to a lack of effective therapeutic treatments. In the field of nanotechnology, carbon nanotubes (CNT) have shown outstanding promise for the improvement of neuronal function in vitro and are thus ideal candidates for repairing or ameliorating spinal defects associated with these disorders. The ultimate goal of this project is to develop CNT as a tool for restoring motor dysfunctions associated with SCI and ALS. Specifically, I will use zebrafish larvae as an in vivo model for testing the therapeutic efficacy of this innovative class of implantable devices. I will implant CNT and graphene based devices in healthy, spinal cord lesioned and ALS zebrafish models and test their effects on spinal cord function with a range of powerful in vivo techniques. My project will address three specific aims. First, biocompatibility of implanted devices will be assessed using in vivo patch clamping of spinal motoneurons in healthy fish implanted with nanodevices. Second, I will implant CNT into fish that have been subjected to SCI. Nanomaterial-facilitated functional recovery will then be tested with in vivo patch clamping of spinal motor neurons, analysis of locomotor behaviour and confocal microscopy. Finally, I will use similar approaches to determine if implanted CNT can slow or reverse spinal cord defects in a SOD1 mutant zebrafish model of ALS. The project will advance our knowledge in an innovative field of bioscience research and help to inform the development of alternative approaches to the treatment of SCI and ALS. Embedded in an international environment, such as that of the University of Leicester, I will support my research activity through a greater level of independence, with the aim of publishing papers as senior author.

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The information about "NANOZFISH" are provided by the European Opendata Portal: CORDIS opendata.

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