EU H2020 Project "3DMUCHO (Investigation of 3D Functional Connectivity in Mouse Visual Cortex using..)": description, partecipants, costs and EC-fundings

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3DMUCHO project word cloud

Explore the words cloud of the 3DMUCHO project. It provides you a very rough idea of what is the project "3DMUCHO" about.

visual connect circuit acquire evidences calcium network imaging first time recordings connection examined sensory host underlying me cell cortex local versatile spanning employing optogenetics horizontally brain interdisciplinary point laboratory neuronal optical neuron excitation vivo attributes specificity volume patterning selectivity resolved functional determined mechanism enabled mapping photon fellowship functionally toolbox measuring population pairs innovative deep vertically mouse postsynaptic layers superficial tuning stronger single neuroscience 3d neurons selectively cortical integration activation combined pioneered permit relationship insights dimensional light presynaptic linearity connectivity precise simultaneous subnetwork manipulation unresolved individual probe planes sharing uncover render convergent holographic holography connecting

Project "3DMUCHO" data sheet

The following table provides information about the project.

Coordinator	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	173˙076 €
EC max contribution	173˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

#	participants	country	role	EC contrib. [€]
1	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS	FR (PARIS)	coordinator	173˙076.00

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

FR (PARIS)

coordinator

173˙076.00

Project objective

Cortical neurons respond selectively to sensory features. In mouse visual cortex, convergent evidences point towards stronger connectivity between neurons sharing similar feature selectivity in the superficial layers. The relationship between a three-dimensional (3D) subnetwork, where neurons connect horizontally and vertically to each other, and the functional specificity of individual neurons remain however unresolved. The main objective of this interdisciplinary project is to uncover the 3D functional connectivity in mouse visual cortex in vivo by employing the innovative optical methods pioneered in the host laboratory. Single-cell activation deep into the brain will be, for the first time, enabled using the novel technology of 3D depth-resolved holographic light-patterning and two-photon optogenetics. Combined with whole-cell recordings for measuring postsynaptic responses, precise presynaptic excitation with holography will permit mapping connection pairs within and across cortical planes. Simultaneous presynaptic multi-cell excitation of connecting neurons will test the integration linearity of the postsynaptic neuron. To probe functional connectivity, connection pairs will be examined from a functionally-identified neuronal population, whose tuning specificity to visual attributes is determined using calcium imaging. This fellowship will render me opportunities to acquire a versatile optical toolbox that is of general interest in neuroscience for connectivity mapping and circuit manipulation. Knowledge of local functional connectivity spanning a 3D cortical volume will further provide significant insights into the network mechanism underlying sensory processing.

Publications

List of publications.
year	authors and title	journal	last update
2018	I-Wen Chen, Eirini Papagiakoumou, Valentina Emiliani Towards circuit optogenetics published pages: 179-189, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.03.008	Current Opinion in Neurobiology 50	2019-09-25
2019	I-Wen Chen, Emiliano Ronzitti, Brian R. Lee, Tanya L. Daigle, Deniz Dalkara, Hongkui Zeng, Valentina Emiliani, Eirini Papagiakoumou In vivo sub-millisecond two-photon optogenetics with temporally focused patterned light published pages: 1785-18, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1785-18.2018	The Journal of Neuroscience	2019-09-25

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