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FINDER SIGNED

FINDER: FIghtiNg DEngue viRus, a novel strategy for the development of fully protective antiviralsthat act by disrupting the DENV NS3/NS5 interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FINDER project word cloud

Explore the words cloud of the FINDER project. It provides you a very rough idea of what is the project "FINDER" about.

drugs    multidisciplinary    ns5    strategies    competitiveness    lack    supervisor    interaction    spectrum    competencies    innovative    complementary    replication    molecule    researcher    hit    ns3    host    borne    protective    resistance    therapeutic    disrupt    vaccine    drug    proteins    endowed    biological    broad    strengthen    interface    ready    interactions    performed    characterization    gap    treatments    dengue    worldwide    prevalent    world    people    inhibitors    independent    library    hits    cavities    transfer    date    frequency    protein    denv    400    health    conserved    ing    screening    compounds    benefit    strategy    search    models    undesirable    public    arthropod    training    urgently    enzymes    anti    skills    virtual    line    animal    organisation    area    pathogen    viral    optimization    purpose    candidates    lower    trials    virus    million    antiviral    causing    enormous    druggable    fill    epidemics    clinical    infects    outcomes    finder    position    spreading    attaining    magnitude    small    candidate    risk    silico   

Project "FINDER" data sheet

The following table provides information about the project.

Coordinator
CARDIFF UNIVERSITY 

Organization address
address: NEWPORT ROAD 30-36
city: CARDIFF
postcode: CF24 ODE
website: www.cardiff.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 183˙454.00

Map

 Project objective

Dengue virus (DENV) is the most prevalent arthropod-borne viral pathogen and infects about 400 million people worldwide every year, causing epidemics that are spreading rapidly, with increased frequency and magnitude. To date, no specific treatments or a fully protective vaccine are available for dengue. In line with the Priority 3 of H2020, the development of effective therapeutic strategies against DENV is urgently needed. The purpose of FINDER is that of developing innovative anti-dengue candidate drugs able to disrupt the protein-protein interactions between the viral NS3 and NS5 proteins, two key and conserved enzymes of DENV replication complex. To this end, some druggable cavities at the NS3/NS5 interface will be identified and an in silico screening of a virtual small molecule library will be performed to search for potential inhibitors of NS3/NS5 interaction. After the selection and the biological characterization of the hits, a hit-to-lead optimization step will be carried out to find compounds with lead-like properties. Such drugs are expected to be endowed with broad-spectrum antiviral activity, a reduced risk for developing resistance and lower undesirable side-effects. Through a comprehensive dissemination and exploitation strategy, one or more drug candidates will be evaluated in the future in animal models and then in clinical trials. The outcomes of this project could fill the gap of the lack of effective anti-DENV drugs, resulting in an enormous impact on world-wide public health, as well as on the European competitiveness in this area. This project will also contribute to strengthen a wide set of skills of the applicant by a multidisciplinary training in the field of antiviral research, which will make him ready for attaining a position of independent researcher. In addition, the complementary competencies between the applicant and the supervisor will allow a two-way transfer of knowledge, leading to a benefit also for the Host Organisation.

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