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FINDER SIGNED

FINDER: FIghtiNg DEngue viRus, a novel strategy for the development of fully protective antiviralsthat act by disrupting the DENV NS3/NS5 interaction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FINDER project word cloud

Explore the words cloud of the FINDER project. It provides you a very rough idea of what is the project "FINDER" about.

organisation    innovative    line    proteins    conserved    interactions    characterization    strengthen    viral    benefit    ns5    urgently    enzymes    epidemics    people    anti    resistance    performed    host    animal    small    infects    strategies    arthropod    date    treatments    competitiveness    enormous    drug    disrupt    purpose    interface    hit    pathogen    replication    health    hits    area    fill    search    strategy    dengue    lower    therapeutic    interaction    inhibitors    public    multidisciplinary    cavities    biological    researcher    risk    independent    trials    transfer    endowed    virus    ready    vaccine    screening    lack    library    broad    drugs    world    complementary    finder    400    compounds    competencies    candidates    ing    molecule    training    outcomes    worldwide    antiviral    candidate    optimization    models    frequency    skills    druggable    protective    ns3    spectrum    causing    supervisor    borne    million    position    clinical    silico    undesirable    virtual    prevalent    denv    spreading    magnitude    attaining    gap    protein   

Project "FINDER" data sheet

The following table provides information about the project.

Coordinator
CARDIFF UNIVERSITY 

Organization address
address: NEWPORT ROAD 30-36
city: CARDIFF
postcode: CF24 ODE
website: www.cardiff.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CARDIFF UNIVERSITY UK (CARDIFF) coordinator 183˙454.00

Map

 Project objective

Dengue virus (DENV) is the most prevalent arthropod-borne viral pathogen and infects about 400 million people worldwide every year, causing epidemics that are spreading rapidly, with increased frequency and magnitude. To date, no specific treatments or a fully protective vaccine are available for dengue. In line with the Priority 3 of H2020, the development of effective therapeutic strategies against DENV is urgently needed. The purpose of FINDER is that of developing innovative anti-dengue candidate drugs able to disrupt the protein-protein interactions between the viral NS3 and NS5 proteins, two key and conserved enzymes of DENV replication complex. To this end, some druggable cavities at the NS3/NS5 interface will be identified and an in silico screening of a virtual small molecule library will be performed to search for potential inhibitors of NS3/NS5 interaction. After the selection and the biological characterization of the hits, a hit-to-lead optimization step will be carried out to find compounds with lead-like properties. Such drugs are expected to be endowed with broad-spectrum antiviral activity, a reduced risk for developing resistance and lower undesirable side-effects. Through a comprehensive dissemination and exploitation strategy, one or more drug candidates will be evaluated in the future in animal models and then in clinical trials. The outcomes of this project could fill the gap of the lack of effective anti-DENV drugs, resulting in an enormous impact on world-wide public health, as well as on the European competitiveness in this area. This project will also contribute to strengthen a wide set of skills of the applicant by a multidisciplinary training in the field of antiviral research, which will make him ready for attaining a position of independent researcher. In addition, the complementary competencies between the applicant and the supervisor will allow a two-way transfer of knowledge, leading to a benefit also for the Host Organisation.

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The information about "FINDER" are provided by the European Opendata Portal: CORDIS opendata.

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