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MICROBE SIGNED

Metagenomic Investigation of Cow Reproductive Biology and Ecology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MICROBE project word cloud

Explore the words cloud of the MICROBE project. It provides you a very rough idea of what is the project "MICROBE" about.

culture    sperm    cow    missouri    pregnant    interactions    isolated    genetic    interact    survival    internationally    dr    position    ex    biology    reproductive    figure    genotypes    unknown    disrupted    ireland    inflammatory    embryo    secondment    fertility    investigation    functional    butler    cotter    dairy    explore    receptive    lining    industries    teagasc    responsive    populate    either    hosted    ecology    symbiosis    university    expand    scope    pregnancy    billion    low    uterine    cows    merit    uterus    endometritis    leadership    30    transcriptome    usa       genomic    patrick    metagenome    postdoctoral    mechanisms    paul    oviduct    validate    negative    prof    endometrium    skills    examine    microbiome    lonergan    supervision    attributed    isolate    dublin    metagenomic    reintegrate    bacteria    transport    microbe    mortality    development    independent    broaden    usually    pathogens    divergent    respected    hypotheses    microbes    acquire    dysbiosis    myself    calving    hypothesis    college    annually    tissue    rates    completing    vivo    goals    stephen    25    disease    scientist   

Project "MICROBE" data sheet

The following table provides information about the project.

Coordinator
TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY 

Organization address
address: Oak Park
city: Carlow
postcode: R93
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-28   to  2020-05-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY IE (Carlow) coordinator 175˙866.00

Map

 Project objective

Low rates of embryo survival can be attributed to endometritis, an inflammatory disease of the endometrium lining the uterus. The disease affects ~30% of cows, increases embryo mortality by 25%4, and costs the EU and USA dairy industries €2 billion annually. The endometrium and microbiome are usually in a state of symbiosis when the cow is either receptive to pregnancy or pregnant. This symbiosis is disrupted (dysbiosis) at calving when pathogens populate the uterus. Endometritis has long term negative effects on embryo survival, but the mechanisms of how endometrium-microbe interactions affect embryo survival are unknown. The goals of MICROBE: Metagenomic Investigation of Cow Reproductive Biology and Ecology (Figure) are to (1) establish myself as an independent, internationally respected scientist in reproductive biology; (2) reintegrate into a long-term research position in Ireland after completing postdoctoral research at the University of Missouri; and (3) acquire new technical skills to broaden the scope of my research, and to expand my leadership and project management capabilities. I will be hosted by Teagasc with supervision from Dr. Stephen Butler and Dr. Paul Cotter with a secondment at University College Dublin with Prof. Patrick Lonergan. I will explore whether the endometrium and microbiome interact to affect embryo survival by testing novel hypotheses. The research objectives are to (1) examine endometrium-microbe interactions at the level of the transcriptome and metagenome of dairy cows, and test the hypothesis that such interactions are responsive to genomic selection for fertility; (2) isolate and culture specific uterine microbes from two genotypes of dairy cows divergent in fertility; and (3) use ex-vivo tissue culture systems to validate novel functional mechanisms by which uterine bacteria isolated from cows divergent in genetic merit for fertility interact with the oviduct and endometrium during sperm transport and embryo development

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The information about "MICROBE" are provided by the European Opendata Portal: CORDIS opendata.

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