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Metagenomic Investigation of Cow Reproductive Biology and Ecology

Total Cost €


EC-Contrib. €






 MICROBE project word cloud

Explore the words cloud of the MICROBE project. It provides you a very rough idea of what is the project "MICROBE" about.

endometrium    receptive    industries    leadership    validate    hosted    dysbiosis    skills    either    responsive    attributed    butler    investigation    reintegrate    college    microbe    patrick    microbes    figure    ecology    usa    functional    interactions    hypothesis    mortality    respected       pregnant    transcriptome    pathogens    dairy    cotter    transport    goals    pregnancy    supervision    expand    completing    prof    vivo    hypotheses    billion    survival    dr    genetic    tissue    ireland    metagenome    mechanisms    development    uterine    symbiosis    disrupted    lining    disease    genotypes    microbiome    secondment    biology    myself    missouri    bacteria    university    annually    lonergan    negative    endometritis    scope    calving    low    ex    inflammatory    oviduct    explore    postdoctoral    uterus    populate    unknown    examine    internationally    embryo    cows    teagasc    metagenomic    isolated    30    scientist    merit    interact    acquire    divergent    usually    stephen    broaden    fertility    position    sperm    25    reproductive    paul    rates    cow    independent    genomic    culture    dublin    isolate   

Project "MICROBE" data sheet

The following table provides information about the project.


Organization address
address: Oak Park
city: Carlow
postcode: R93
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-05-28   to  2020-05-27


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Low rates of embryo survival can be attributed to endometritis, an inflammatory disease of the endometrium lining the uterus. The disease affects ~30% of cows, increases embryo mortality by 25%4, and costs the EU and USA dairy industries €2 billion annually. The endometrium and microbiome are usually in a state of symbiosis when the cow is either receptive to pregnancy or pregnant. This symbiosis is disrupted (dysbiosis) at calving when pathogens populate the uterus. Endometritis has long term negative effects on embryo survival, but the mechanisms of how endometrium-microbe interactions affect embryo survival are unknown. The goals of MICROBE: Metagenomic Investigation of Cow Reproductive Biology and Ecology (Figure) are to (1) establish myself as an independent, internationally respected scientist in reproductive biology; (2) reintegrate into a long-term research position in Ireland after completing postdoctoral research at the University of Missouri; and (3) acquire new technical skills to broaden the scope of my research, and to expand my leadership and project management capabilities. I will be hosted by Teagasc with supervision from Dr. Stephen Butler and Dr. Paul Cotter with a secondment at University College Dublin with Prof. Patrick Lonergan. I will explore whether the endometrium and microbiome interact to affect embryo survival by testing novel hypotheses. The research objectives are to (1) examine endometrium-microbe interactions at the level of the transcriptome and metagenome of dairy cows, and test the hypothesis that such interactions are responsive to genomic selection for fertility; (2) isolate and culture specific uterine microbes from two genotypes of dairy cows divergent in fertility; and (3) use ex-vivo tissue culture systems to validate novel functional mechanisms by which uterine bacteria isolated from cows divergent in genetic merit for fertility interact with the oviduct and endometrium during sperm transport and embryo development

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The information about "MICROBE" are provided by the European Opendata Portal: CORDIS opendata.

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