EU H2020 Project "MICROBE (Metagenomic Investigation of Cow Reproductive Biology and Ecology)": description, partecipants, costs and EC-fundings

#	Pagina
attuale pagina	/open-h2020/projects/215206/index.html

MICROBE project word cloud

Explore the words cloud of the MICROBE project. It provides you a very rough idea of what is the project "MICROBE" about.

ecology dublin receptive cow transcriptome endometritis college lining dysbiosis hypotheses isolated interact prof broaden respected metagenomic lonergan uterus culture supervision usa expand disease either paul leadership sperm figure validate uterine transport cotter secondment metagenome microbe reproductive responsive negative merit pregnancy development usually oviduct inflammatory 4 attributed dr survival calving genomic ex functional 30 explore isolate butler embryo industries acquire missouri microbes completing scientist hypothesis annually university patrick hosted unknown bacteria interactions reintegrate billion dairy mechanisms cows mortality genetic genotypes 25 biology pathogens independent tissue low symbiosis populate divergent position investigation scope skills myself stephen teagasc fertility ireland rates disrupted vivo internationally postdoctoral endometrium pregnant examine microbiome goals

Project "MICROBE" data sheet

The following table provides information about the project.

Coordinator	TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY Organization address address: Oak Park city: Carlow postcode: R93 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	175˙866 €
EC max contribution	175˙866 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-05-28 to 2020-05-27

#	participants	country	role	EC contrib. [€]
1	TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY	IE (Carlow)	coordinator	175˙866.00

TEAGASC - AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY

IE (Carlow)

coordinator

175˙866.00

Project objective

Low rates of embryo survival can be attributed to endometritis, an inflammatory disease of the endometrium lining the uterus. The disease affects ~30% of cows, increases embryo mortality by 25%4, and costs the EU and USA dairy industries €2 billion annually. The endometrium and microbiome are usually in a state of symbiosis when the cow is either receptive to pregnancy or pregnant. This symbiosis is disrupted (dysbiosis) at calving when pathogens populate the uterus. Endometritis has long term negative effects on embryo survival, but the mechanisms of how endometrium-microbe interactions affect embryo survival are unknown. The goals of MICROBE: Metagenomic Investigation of Cow Reproductive Biology and Ecology (Figure) are to (1) establish myself as an independent, internationally respected scientist in reproductive biology; (2) reintegrate into a long-term research position in Ireland after completing postdoctoral research at the University of Missouri; and (3) acquire new technical skills to broaden the scope of my research, and to expand my leadership and project management capabilities. I will be hosted by Teagasc with supervision from Dr. Stephen Butler and Dr. Paul Cotter with a secondment at University College Dublin with Prof. Patrick Lonergan. I will explore whether the endometrium and microbiome interact to affect embryo survival by testing novel hypotheses. The research objectives are to (1) examine endometrium-microbe interactions at the level of the transcriptome and metagenome of dairy cows, and test the hypothesis that such interactions are responsive to genomic selection for fertility; (2) isolate and culture specific uterine microbes from two genotypes of dairy cows divergent in fertility; and (3) use ex-vivo tissue culture systems to validate novel functional mechanisms by which uterine bacteria isolated from cows divergent in genetic merit for fertility interact with the oviduct and endometrium during sperm transport and embryo development

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROBE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROBE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)