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NGN-PET SIGNED

Modelling Neuron-Glia Networks into a drug discovery platform for Pain Efficacious Treatments - Sofia ref.: 116072

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NGN-PET project word cloud

Explore the words cloud of the NGN-PET project. It provides you a very rough idea of what is the project "NGN-PET" about.

mechanism    components    carefully    tools    quality    academic    subsequently    pet    patients    altered    frequently    treatments    translation    treat    recapitulate    models    interplay    neuron    discovery    model    pharmaceutical    predictive    technologies    rodent    glial    human    translate    ipscs    solutions    central    validation    neurons    assays    underlying    co    np    disciplinary    compound    neuronal    nerve    pain    vitro    molecular    rat    understand    hence    vivo    hts    pose    interdisciplinary    cell    team    interactions    expertise    peripheral    chronic    schwann    basis    chemotherapy    life    demands    drug    preclinical    builds    injury    decipher    ngn    microglia    pathological    nociceptors    disease    identification    throughput    circuitry    knowhow    stem    cells    tool    cultures    therapies    platforms    screening    situation    activates    industrial    interrogated    therapeutic    mechanisms    forming    poorly    cellular    neuropathic    chronification   

Project "NGN-PET" data sheet

The following table provides information about the project.

Coordinator
AXXAM SPA 

Organization address
address: VIA MEUCCI 3
city: BRESSO MILANO
postcode: 20091
website: www.axxam.com

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://ngn-pet.com/
 Total cost 3˙050˙000 €
 EC max contribution 1˙500˙000 € (49%)
 Programme 1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
 Code Call H2020-JTI-IMI2-2015-07-two-stage
 Funding Scheme IMI2-RIA
 Starting year 2017
 Duration (year-month-day) from 2017-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AXXAM SPA IT (BRESSO MILANO) coordinator 450˙000.00
2    KING'S COLLEGE LONDON UK (LONDON) participant 450˙000.00
3    LIFE AND BRAIN GMBH DE (BONN) participant 450˙000.00
4    NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN DE (REUTLINGEN) participant 150˙000.00
5    ESTEVE PHARMACEUTICALS, SA ES (BARCELONA) participant 0.00
6    GRUNENTHAL GMBH DE (AACHEN) participant 0.00

Map

 Project objective

Chronic Neuropathic Pain is frequently associated with peripheral nerve injury or disease. Peripheral injury activates both neuronal and glial components of the peripheral and central cellular circuitry. While it is widely known that the subsequently altered interactions between neurons and glial cells contribute to pain development and to its chronification, the underlying mechanisms are poorly understood. Developing mechanism-based therapies targeting neuron-glial interactions to treat chronic pain will be crucial for improving the quality of life of many patients. Hence the development of novel therapeutic solutions represents a major challenge that demands a multi-disciplinary approach to decipher and understand pathological mechanisms and to translate them into predictive tools for drug development. The NGN-PET consortium addresses this challenge by forming a highly interdisciplinary team that builds upon expertise in areas of academic research on pain mechanisms, industrial knowhow on human stem cell-based tool development, HTS technologies and drug discovery. To achieve its goal we will develop preclinical model systems and assays which recapitulate the human in vivo situation and which can be interrogated for the identification, validation of molecular targets and the development new treatments. A focus of the project will be chemotherapy induced NP and the interplay between nociceptors, microglia and Schwann cells. NGN-PET will carefully characterize rodent in vivo and in vitro models to identify these mechanisms, and will develop rat and human iPSCs based in vitro systems of neuron-glial co-cultures that can be interrogated for targets and used for compound identification and validation. NGN-PET will thus pose the basis for the translation of these model systems into high throughput screening platforms for pharmaceutical research and drug discovery.

 Deliverables

List of deliverables.
Interim dissemination and outreach report Documents, reports 2020-04-08 22:25:47
Data Management Plan Documents, reports 2020-04-08 22:25:47

Take a look to the deliverables list in detail:  detailed list of NGN-PET deliverables.

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