Explore the words cloud of the GenEdiDS project. It provides you a very rough idea of what is the project "GenEdiDS" about.
The following table provides information about the project.
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
|Coordinator Country||Italy [IT]|
|Total cost||2˙000˙000 €|
|EC max contribution||2˙000˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-10-01 to 2022-09-30|
Take a look of project's partnership.
|1||FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA||IT (GENOVA)||coordinator||2˙000˙000.00|
Neurodevelopmental disorders (ND) are chronic psychiatric conditions with different etiologies, but most share a strong genetic component, defective brain development, and cognitive impairment. Currently, treatment options are very limited, and early educational intervention is the cornerstone for the management of cognitive impairment in most ND, indicating the positive effect of early actions during brain development. Among ND, Down syndrome (DS) is caused by the presence of an extra chromosome 21, and it represents the leading cause of genetically-defined intellectual disability. Different pharmacological treatments targeting one of the many pathways downstream of the triplicated genes have been shown to rescue cognitive impairment in DS animal models. Nevertheless, most of these preclinical studies have been performed postnatally and often in adults, possibly because of concerns of unwanted drug side effects that may have long-lasting noxious sequelae on a developing brain at embryonic stages. On the other hand, viral (but also non-viral) gene therapy approaches in animal models of ND have been mostly neglected because of technical and ethical issues, when considered in the light of future translational applications. Yet, DS is mostly diagnosed prenatally, when many of its brain developmental abnormalities originate. Here, we will investigate whether in utero manipulation of specific and possibly converging gene networks in neuronal progenitors of DS mice by CRISPR-Cas9 gene-editing technology, may recover brain development and cognitive deficits later in life. Specifically targeting neuronal progenitors will allow us to act at early stages of brain development, while avoiding the involvement of genetic editing of germline cells and all related ethical issues. In parallel, we will also develop safer (viral-free) technological approaches for genetic manipulations in utero to minimize technical issues in the view of potential future translational applications.
|year||authors and title||journal||last update|
Andrzej W. Cwetsch, Bruno Pinto, Annalisa Savardi, Laura Cancedda
In vivo methods for acute modulation of gene expression in the central nervous system
published pages: 69-85, ISSN: 0301-0082, DOI: 10.1016/j.pneurobio.2018.04.008
|Progress in Neurobiology 168||2019-06-06|
Shovan Naskar, Roberto Narducci, Edoardo Balzani, Andrzej W. Cwetsch, Valter Tucci, Laura Cancedda
The development of synaptic transmission is time-locked to early social behaviors in rats
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09156-3
|Nature Communications 10/1||2019-06-06|
Joanna Szczurkowska, Francesca Pischedda, Bruno Pinto, Francesca ManagÃ², Carola A Haas, Maria Summa, Rosalia Bertorelli, Francesco Papaleo, Michael K SchÃ¤fer, Giovanni Piccoli, Laura Cancedda
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice
published pages: , ISSN: 0006-8950, DOI: 10.1093/brain/awy190
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENEDIDS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "GENEDIDS" are provided by the European Opendata Portal: CORDIS opendata.