Opendata, web and dolomites

GenEdiDS SIGNED

Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GenEdiDS project word cloud

Explore the words cloud of the GenEdiDS project. It provides you a very rough idea of what is the project "GenEdiDS" about.

manipulations    mostly    animal    disorders    ethical    share    gene    converging    educational    genetic    possibly    cas9    avoiding    nevertheless    diagnosed    genetically    psychiatric    therapy    downstream    deficits    originate    etiologies    act    safer    manipulation    involvement    rescue    brain    syndrome    technological    neuronal    performed    editing    mice    preclinical    ds    pharmacological    genes    viral    view    translational    later    crispr    21    postnatally    models    abnormalities    germline    minimize    triplicated    shown    lasting    options    prenatally    sequelae    treatments    impairment    chromosome    cells    positive    networks    free    intellectual    effect    cornerstone    drug    recover    indicating    treatment    cognitive    disability    of    stages    defective    extra    caused    intervention    chronic    utero    actions    nd    parallel    adults    neurodevelopmental    noxious    progenitors    limited    embryonic    life    light    developmental   

Project "GenEdiDS" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA 

Organization address
address: VIA MOREGO 30
city: GENOVA
postcode: 16163
website: www.iit.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA IT (GENOVA) coordinator 2˙000˙000.00

Map

 Project objective

Neurodevelopmental disorders (ND) are chronic psychiatric conditions with different etiologies, but most share a strong genetic component, defective brain development, and cognitive impairment. Currently, treatment options are very limited, and early educational intervention is the cornerstone for the management of cognitive impairment in most ND, indicating the positive effect of early actions during brain development. Among ND, Down syndrome (DS) is caused by the presence of an extra chromosome 21, and it represents the leading cause of genetically-defined intellectual disability. Different pharmacological treatments targeting one of the many pathways downstream of the triplicated genes have been shown to rescue cognitive impairment in DS animal models. Nevertheless, most of these preclinical studies have been performed postnatally and often in adults, possibly because of concerns of unwanted drug side effects that may have long-lasting noxious sequelae on a developing brain at embryonic stages. On the other hand, viral (but also non-viral) gene therapy approaches in animal models of ND have been mostly neglected because of technical and ethical issues, when considered in the light of future translational applications. Yet, DS is mostly diagnosed prenatally, when many of its brain developmental abnormalities originate. Here, we will investigate whether in utero manipulation of specific and possibly converging gene networks in neuronal progenitors of DS mice by CRISPR-Cas9 gene-editing technology, may recover brain development and cognitive deficits later in life. Specifically targeting neuronal progenitors will allow us to act at early stages of brain development, while avoiding the involvement of genetic editing of germline cells and all related ethical issues. In parallel, we will also develop safer (viral-free) technological approaches for genetic manipulations in utero to minimize technical issues in the view of potential future translational applications.

 Publications

year authors and title journal last update
List of publications.
2018 Andrzej W. Cwetsch, Bruno Pinto, Annalisa Savardi, Laura Cancedda
In vivo methods for acute modulation of gene expression in the central nervous system
published pages: 69-85, ISSN: 0301-0082, DOI: 10.1016/j.pneurobio.2018.04.008
Progress in Neurobiology 168 2019-06-06
2019 Shovan Naskar, Roberto Narducci, Edoardo Balzani, Andrzej W. Cwetsch, Valter Tucci, Laura Cancedda
The development of synaptic transmission is time-locked to early social behaviors in rats
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09156-3
Nature Communications 10/1 2019-06-06
2018 Joanna Szczurkowska, Francesca Pischedda, Bruno Pinto, Francesca Managò, Carola A Haas, Maria Summa, Rosalia Bertorelli, Francesco Papaleo, Michael K Schäfer, Giovanni Piccoli, Laura Cancedda
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice
published pages: , ISSN: 0006-8950, DOI: 10.1093/brain/awy190
Brain 2019-06-06

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENEDIDS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GENEDIDS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ORGANITRA (2019)

Transport of phosphorylated compounds across lipid bilayers by supramolecular receptors

Read More  

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More