Explore the words cloud of the Phosphoprocessors project. It provides you a very rough idea of what is the project "Phosphoprocessors" about.
The following table provides information about the project.
|Coordinator Country||Estonia [EE]|
|Total cost||1˙999˙288 €|
|EC max contribution||1˙999˙288 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-05-01 to 2020-04-30|
Take a look of project's partnership.
Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease. Our goal in this application is to elucidate the molecular basis of this important mechanism. We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation. We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to-C terminal direction along the disordered protein. The process is controlled by key parameters including the distance between phosphorylation sites, the distribution of serines and threonines in sites, and the position of docking motifs. According to our model, linear patterns of phosphorylation networks along the disordered protein segments determine the net phosphorylation rate of the protein. This concept provides a new interpretation of CDK signal processing, and it can explain how the temporal order of cell cycle events is achieved. The goals of this study are: 1) We will seek proof of the model by rewiring the patterns of budding yeast Cdk1 multisite networks according to the rules we have identified, so to change the order of cell cycle events. Next, we will restore the order by alternative wiring of the same switches; 2) To apply the proposed model in the context of different kinases and complex substrate arrangements, we will study the Cdk1-dependent multisite phosphorylation of kinetochore components, to understand the phospho-regulation of kinetochore formation, microtubule attachment and error correction; 3) We will apply multisite phosphorylation to design circuits for synthetic biology. A toolbox of synthetic parts based on multisite phosphorylation would revolutionize the field since the fast time scales and wide combinatorial possibilities.
|year||authors and title||journal||last update|
Alina Goldstein, Nurit Siegler, Darya Goldman, Haim Judah, Ervin Valk, Mardo KÃµivomÃ¤gi, Mart Loog, Larisa Gheber
Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase
published pages: 3395-3412, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2523-z
|Cellular and Molecular Life Sciences 74/18||2020-04-23|
Mihkel Ã–rd, Kaidi MÃ¶ll, Alissa Agerova, Rait Kivi, Ilona Faustova, Rainis Venta, Ervin Valk, Mart Loog
Multisite phosphorylation code of CDK
published pages: 649-658, ISSN: 1545-9993, DOI: 10.1038/s41594-019-0256-4
|Nature Structural & Molecular Biology 26/7||2020-04-23|
Christian Linke, Anastasia Chasapi, Alberto GonzÃ¡lez-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis
A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
published pages: , ISSN: 2056-7189, DOI: 10.1038/s41540-017-0008-1
|npj Systems Biology and Applications 3/1||2020-04-23|
Mihkel Ã–rd, Rainis Venta, Kaidi MÃ¶ll, Ervin Valk, Mart Loog
Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle
published pages: 76-89.e3, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.04.026
|Molecular Cell 75/1||2020-04-23|
Alina Goldstein, Darya Goldman, Ervin Valk, Mart Loog, Liam J. Holt, Larisa Gheber
Synthetic-Evolution Reveals Narrow Paths to Regulation of the Saccharomyces cerevisiae Mitotic Kinesin-5 Cin8
published pages: 1125-1138, ISSN: 1449-2288, DOI: 10.7150/ijbs.30543
|International Journal of Biological Sciences 15/6||2020-04-23|
Mihkel Ã–rd, Mart Loog
How the cell cycle clock ticks
published pages: 169-172, ISSN: 1059-1524, DOI: 10.1091/mbc.e18-05-0272
|Molecular Biology of the Cell 30/2||2020-04-23|
Jakobson L, Vaahtera L, TÃµldsepp K, Nuhkat M, Wang C, Wang YS, HÃµrak H, Valk E, Pechter P, Sindarovska Y, Tang J, Xiao C, Xu Y, Gerst Talas U, GarcÃa-Sosa AT, KangasjÃ¤rvi S, Maran U, Remm M, Roelfsema MR, Hu H, KangasjÃ¤rvi J, Loog M, Schroeder JI, Kollist H, BroschÃ© M.
Natural Variation in Arabidopsis Cvi-0 Accession Reveals an Important Role of MPK12 in Guard Cell CO2 Signaling.
published pages: , ISSN: 1544-9173, DOI:
Doncic A, Atay O, Valk E, Grande A, Bush A, Vasen G, Colman-Lerner A, Loog M, Skotheim JM.
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition.
published pages: , ISSN: 0092-8674, DOI:
HÃµrak H, Sierla M, TÃµldsepp K, Wang C, Wang YS, Nuhkat M, Valk E, Pechter P, Merilo E, SalojÃ¤rvi J, Overmyer K, Loog M, BroschÃ© M, Schroeder JI, KangasjÃ¤rvi J, Kollist H.
A Dominant Mutation in the HT1 Kinase Uncovers Roles of MAP Kinases and GHR1 in CO2-Induced Stomatal Closure.
published pages: , ISSN: 1040-4651, DOI:
Bhaduri S, Valk E, Winters MJ, Gruessner B, Loog M, Pryciak PM.
A Docking Interface in the Cyclin Cln2 Promotes Multi-site Phosphorylation of Substrates and Timely Cell-Cycle Entry
published pages: , ISSN: 0960-9822, DOI:
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHOSPHOPROCESSORS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PHOSPHOPROCESSORS" are provided by the European Opendata Portal: CORDIS opendata.