Opendata, web and dolomites

Redox Relays SIGNED

Detecting, understanding and exploiting intracellular redox signaling relays

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Redox Relays project word cloud

Explore the words cloud of the Redox Relays project. It provides you a very rough idea of what is the project "Redox Relays" about.

endogenous    genetic    resilience    sense    proteins    basic    peroxidases    largely    gene    assemblies    composition    behavior    cell    tip    supramolecular    organismal    cytosolic    und    profiling    relay    oxidants    context    links    adaptations    h2o2    vivo    monitor    give    conundrum    proteomics    mechanisms    neighboring    tools    metabolism    found    yield    protein    modify    sphere    cellular    manipulation    strategy    encoded    adaptive    relays    reporters    species    reactive    manipulate    functional    transcription    mediated    compartments    glimpsed    chains    genetically    screening    living    combination    oxidizing    molecular    redox    thiols    nm    sulfur    iceberg    precision    reversibly    coding    relayed    solution    regulation    regulating    unknown    mitochondrial    healthspan    channeled    tag    efficiency    operate    signals    equivalents    systematically    dynamically    nuclear    transmission    suggests    unexplained    thiol    proximity    nitrogen    asymp    couple    manner    oxygen    uncover    fundamental    observation    ubiquitous    specificity    assemble    genes    dissect    signaling    insights   

Project "Redox Relays" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙006˙250 €
 EC max contribution 2˙006˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 2˙006˙250.00

Map

 Project objective

Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In particular, specificity and efficiency of redox signaling remain unexplained. The now emerging solution to this conundrum is that redox signaling is mediated and channeled by protein-to-protein redox relay chains that dynamically assemble in the cytosolic, nuclear and mitochondrial compartments. We and others have found that H2O2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies. Evidence now suggests that so far we have just glimpsed the ‘tip of the iceberg’, namely that redox relay chains are ubiquitous and also operate for reactive nitrogen and sulfur species. This project aims to systematically uncover, dissect, monitor and manipulate the redox relay chains that give specificity and efficiency to redox signaling. The basic strategy is to tag all protein-coding genes with genetically encoded reporters which –within the context of the living cell– sense the transmission of thiol oxidizing equivalents within their sphere of immediate proximity (≈10 nm). A combination of genetic screening, redox proteomics and transcription profiling will then allow to identify the composition of redox relays, their endogenous target proteins und their functional impact on gene regulation. The knowledge about the composition of redox relays will lead to precision tools for the observation and manipulation of defined redox signaling pathways in vivo. The project is expected to yield fundamental insights into the specific molecular links by which reactive oxygen, nitrogen and sulfur species couple changes in metabolism to cellular and organismal adaptations regulating resilience and healthspan.

 Publications

year authors and title journal last update
List of publications.
2018 Daria Ezeriņa, Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano, Tobias P. Dick
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production
published pages: 447-459.e4, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.01.011
Cell Chemical Biology 25/4 2019-06-11
2018 Sarah Stöcker, Michael Maurer, Thomas Ruppert, Tobias P Dick
A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation
published pages: 148-155, ISSN: 1552-4450, DOI: 10.1038/nchembio.2536
Nature Chemical Biology 14/2 2019-06-11

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REDOX RELAYS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REDOX RELAYS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

RESOURCE Q (2019)

Efficient Conversion of Quantum Information Resources

Read More  

PGErepro (2019)

How to break Mendel’s laws? The role of sexual conflict in the evolution of unusual transmission genetics

Read More