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Redox Relays SIGNED

Detecting, understanding and exploiting intracellular redox signaling relays

Total Cost €


EC-Contrib. €






 Redox Relays project word cloud

Explore the words cloud of the Redox Relays project. It provides you a very rough idea of what is the project "Redox Relays" about.

regulation    links    functional    ubiquitous    protein    strategy    solution    efficiency    manipulation    nitrogen    proteins    und    cell    transmission    sulfur    modify    yield    equivalents    screening    healthspan    observation    tip    sphere    genes    unexplained    nuclear    supramolecular    assemble    basic    compartments    reporters    relay    resilience    composition    tag    thiol    relayed    glimpsed    suggests    endogenous    adaptations    chains    combination    mitochondrial    genetically    iceberg    couple    oxidants    signaling    proximity    assemblies    dynamically    tools    metabolism    conundrum    sense    vivo    species    regulating    profiling    oxygen    proteomics    nm    adaptive    cytosolic    cellular    encoded    relays    thiols    found    h2o2    peroxidases    redox    precision    manner    mediated    dissect    operate    give    molecular    uncover    neighboring    transcription    signals    organismal    coding    genetic    reactive    oxidizing    behavior    context    largely    mechanisms    reversibly    living    channeled    monitor    insights    specificity    gene    manipulate    systematically    fundamental    asymp    unknown   

Project "Redox Relays" data sheet

The following table provides information about the project.


Organization address
postcode: 69120

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙006˙250 €
 EC max contribution 2˙006˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Redox signaling is a process by which endogenous oxidants, derived from metabolism, reversibly modify particular thiols on particular proteins to change their functional behavior in an adaptive manner. However, the molecular mechanisms of redox signaling remain largely unknown. In particular, specificity and efficiency of redox signaling remain unexplained. The now emerging solution to this conundrum is that redox signaling is mediated and channeled by protein-to-protein redox relay chains that dynamically assemble in the cytosolic, nuclear and mitochondrial compartments. We and others have found that H2O2 signals are relayed through thiol peroxidases to neighboring proteins within supramolecular assemblies. Evidence now suggests that so far we have just glimpsed the ‘tip of the iceberg’, namely that redox relay chains are ubiquitous and also operate for reactive nitrogen and sulfur species. This project aims to systematically uncover, dissect, monitor and manipulate the redox relay chains that give specificity and efficiency to redox signaling. The basic strategy is to tag all protein-coding genes with genetically encoded reporters which –within the context of the living cell– sense the transmission of thiol oxidizing equivalents within their sphere of immediate proximity (≈10 nm). A combination of genetic screening, redox proteomics and transcription profiling will then allow to identify the composition of redox relays, their endogenous target proteins und their functional impact on gene regulation. The knowledge about the composition of redox relays will lead to precision tools for the observation and manipulation of defined redox signaling pathways in vivo. The project is expected to yield fundamental insights into the specific molecular links by which reactive oxygen, nitrogen and sulfur species couple changes in metabolism to cellular and organismal adaptations regulating resilience and healthspan.


year authors and title journal last update
List of publications.
2018 Daria Ezeriņa, Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano, Tobias P. Dick
N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production
published pages: 447-459.e4, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.01.011
Cell Chemical Biology 25/4 2019-06-11
2018 Sarah Stöcker, Michael Maurer, Thomas Ruppert, Tobias P Dick
A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation
published pages: 148-155, ISSN: 1552-4450, DOI: 10.1038/nchembio.2536
Nature Chemical Biology 14/2 2019-06-11

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