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CYCLODE SIGNED

Cyclical and Linear Timing Modes in Development

Total Cost €

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EC-Contrib. €

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Partnership

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 CYCLODE project word cloud

Explore the words cloud of the CYCLODE project. It provides you a very rough idea of what is the project "CYCLODE" about.

genetic    ratio    manifestation    worm    microchamber    rhythmic    vivo    oscillates    fate    elucidate    oscillations    timer    deprivation    noise    computational    stage    tracking    coupling    genomic    unknown    segmentation    little    understand    timing    wiring    global    vertebrate    coordinated    imaging    times    worms    perturbations    animal    temporal    gene    reveal    heterochronic    expression    prototypic    poorly    apparent    goals    developmental    regenerative    food    additionally    medicine    transcriptome    manipulations    cyclic    employing    patterning    nematode    recurring    fundamental    20    appropriate    clock    signal    cell    combination    events    biological    foresee    architecture    stem    screens    larval    advancing    linear    sequencing    organismal    resolution    genes    gained    mrna    cyclical    roundworm    timers    proper    regulatory    individual    molting    live    choices    components    fates    elegans    mechanisms    cells    discovery    clocks    nearly    gain    tools   

Project "CYCLODE" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙358˙625 €
 EC max contribution 2˙358˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙358˙625.00

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 Project objective

Organismal development requires proper timing of events such as cell fate choices, but the mechanisms that control temporal patterning remain poorly understood. In particular, we know little of the cyclical timers, or ‘clocks’, that control recurring events such as vertebrate segmentation or nematode molting. Furthermore, it is unknown how cyclical timers are coordinated with the global, or linear, timing of development, e.g. to ensure an appropriate number of cyclical repeats. We propose to elucidate the components, wiring, and properties of a prototypic developmental clock by studying developmental timing in the roundworm C. elegans. We build on our recent discovery that nearly 20% of the worm’s transcriptome oscillates during larval development – an apparent manifestation of a clock that times the various recurring events that encompass each larval stage. Our aims are i) to identify components of this clock using genetic screens, ii) to gain insight into the system’s architecture and properties by employing specific perturbations such as food deprivation, and iii) to understand the coupling of this cyclic clock to the linear heterochronic timer through genetic manipulations. To achieve our ambitious goals, we will develop tools for mRNA sequencing of individual worms and for their developmental tracking and microchamber-based imaging. These important advances will increase temporal resolution, enhance signal-to-noise ratio, and achieve live tracking of oscillations in vivo. Our combination of genetic, genomic, imaging, and computational approaches will provide a detailed understanding of this clock, and biological timing mechanisms in general. As heterochronic genes and rhythmic gene expression are also important for controlling stem cell fates, we foresee that the results gained will additionally reveal regulatory mechanisms of stem cells, thus advancing our fundamental understanding of animal development and future applications in regenerative medicine.


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