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CYCLODE SIGNED

Cyclical and Linear Timing Modes in Development

Total Cost €

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EC-Contrib. €

0

Partnership

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 CYCLODE project word cloud

Explore the words cloud of the CYCLODE project. It provides you a very rough idea of what is the project "CYCLODE" about.

little    20    appropriate    recurring    stage    food    expression    larval    oscillations    regenerative    foresee    noise    worm    roundworm    fate    mrna    heterochronic    genomic    segmentation    additionally    microchamber    rhythmic    medicine    sequencing    temporal    apparent    gene    timers    genetic    regulatory    ratio    animal    global    times    unknown    cell    screens    biological    advancing    tools    nearly    resolution    discovery    transcriptome    reveal    cyclic    vertebrate    cyclical    stem    coupling    elegans    tracking    individual    timing    signal    proper    understand    manifestation    poorly    prototypic    computational    clock    perturbations    deprivation    linear    gain    organismal    fundamental    imaging    fates    live    architecture    timer    goals    nematode    events    coordinated    wiring    cells    clocks    genes    oscillates    elucidate    molting    components    mechanisms    choices    manipulations    developmental    gained    vivo    combination    employing    patterning    worms   

Project "CYCLODE" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙358˙625 €
 EC max contribution 2˙358˙625 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙358˙625.00

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 Project objective

Organismal development requires proper timing of events such as cell fate choices, but the mechanisms that control temporal patterning remain poorly understood. In particular, we know little of the cyclical timers, or ‘clocks’, that control recurring events such as vertebrate segmentation or nematode molting. Furthermore, it is unknown how cyclical timers are coordinated with the global, or linear, timing of development, e.g. to ensure an appropriate number of cyclical repeats. We propose to elucidate the components, wiring, and properties of a prototypic developmental clock by studying developmental timing in the roundworm C. elegans. We build on our recent discovery that nearly 20% of the worm’s transcriptome oscillates during larval development – an apparent manifestation of a clock that times the various recurring events that encompass each larval stage. Our aims are i) to identify components of this clock using genetic screens, ii) to gain insight into the system’s architecture and properties by employing specific perturbations such as food deprivation, and iii) to understand the coupling of this cyclic clock to the linear heterochronic timer through genetic manipulations. To achieve our ambitious goals, we will develop tools for mRNA sequencing of individual worms and for their developmental tracking and microchamber-based imaging. These important advances will increase temporal resolution, enhance signal-to-noise ratio, and achieve live tracking of oscillations in vivo. Our combination of genetic, genomic, imaging, and computational approaches will provide a detailed understanding of this clock, and biological timing mechanisms in general. As heterochronic genes and rhythmic gene expression are also important for controlling stem cell fates, we foresee that the results gained will additionally reveal regulatory mechanisms of stem cells, thus advancing our fundamental understanding of animal development and future applications in regenerative medicine.


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