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Dissecting Cross-Regulatory Interplays in Tumor-Associated Macrophages

Total Cost €


EC-Contrib. €






 X-TAM project word cloud

Explore the words cloud of the X-TAM project. It provides you a very rough idea of what is the project "X-TAM" about.

interplays    cytokines    dynamic    pharmacological    pathogenic    therapeutically    roles    genomics    underlie    macrophages    cancer    landscape    elucidate    thought    suppression    innate    vivo    invariably    tumor    epigenetic    biological    translate    time    successful    effect    strategies    models    specialized    completion    interplay    phenotypes    building    programs    cytotoxicity    repair    gene    screenings    regulation    determinants    incoherent    variety    biology    integrates    tissue    generally    micro    exposure    immune    consideration    ranging    innovative    cell    manipulate    generate    expression    individual    critical    activation    functional    uniquely    therapy    stimulation    reprogram    inflammatory    vitro    cutting    stimuli    pro    genomic    integrate    signals    transcriptional    macrophage    edge    homeostasis    platforms    concomitant    cells    manipulation    almost    plasticity    environmental    transitions    disease    central    post    context    exportable    anti    computational    paradigms    antagonistic    phenotype    biochemical    exploited   

Project "X-TAM" data sheet

The following table provides information about the project.


Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙498˙125 €
 EC max contribution 1˙498˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 1˙498˙125.00


 Project objective

Macrophages are specialized innate immune cells with central roles in homeostasis and disease. Upon exposure to micro-environmental stimuli, these cells can adopt a variety of phenotypes ranging from immune stimulation and cytotoxicity to immune suppression and tissue repair. Dynamic transitions between these functional properties in response to tumor signals is thought to underlie the generally pathogenic role of macrophages in cancer. At the same time, macrophage plasticity could be exploited to therapeutically reprogram the phenotype of these cells by pharmacological, cell and gene therapy approaches. Current models of macrophage activation are based on in-depth analyses of the effect of individual stimuli, such as pro- or anti-inflammatory cytokines, on the biochemical, cell biological, epigenetic, transcriptional and post-transcriptional landscape of macrophages. However, these studies do not take into consideration the interplay that these stimuli may have when present at the same time. This project aims to elucidate how macrophages integrate incoherent environmental stimuli at the genomic level, and translate them into context-specific gene expression programs. Because concomitant activation of antagonistic pro-inflammatory and anti-inflammatory pathways is almost invariably observed in cancer, we propose that these interplays are critical determinants of the biology of tumor-associated macrophages. Our approach integrates cutting-edge genomics and computational modelling with in vitro functional screenings and in vivo manipulation of macrophages, building on uniquely available gene therapy platforms. Successful completion of this project will generate widely exportable paradigms of gene regulation in the immune system, and deliver innovative cell and gene therapy strategies to manipulate the behaviour of macrophages in cancer.


year authors and title journal last update
List of publications.
2018 Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner, Luigi Naldini
Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05315-0
Nature Communications 9/1 2019-10-15
2019 Gioacchino Natoli, Renato Ostuni
Adaptation and memory in immune responses
published pages: 783-792, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0399-9
Nature Immunology 20/7 2019-10-15
2019 Alexandre P. Bénéchet, Giorgia De Simone, Pietro Di Lucia, Francesco Cilenti, Giulia Barbiera, Nina Le Bert, Valeria Fumagalli, Eleonora Lusito, Federica Moalli, Valentina Bianchessi, Francesco Andreata, Paola Zordan, Elisa Bono, Leonardo Giustini, Weldy V. Bonilla, Camille Bleriot, Kamini Kunasegaran, Gloria Gonzalez-Aseguinolaza, Daniel D. Pinschewer, Patrick T. F. Kennedy, Luigi Naldini, Mire
Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming
published pages: 200-205, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1620-6
Nature 574/7777 2019-10-15
2019 Lai Guan Ng, Renato Ostuni, Andrés Hidalgo
Heterogeneity of neutrophils
published pages: 255-265, ISSN: 1474-1733, DOI: 10.1038/s41577-019-0141-8
Nature Reviews Immunology 19/4 2019-10-15

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