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PANBioRA SIGNED

Personalized And/Or Generalized Integrated Biomaterial Risk Assessment

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PANBioRA" data sheet

The following table provides information about the project.

Coordinator
STEINBEIS 2I GMBH 

Organization address
address: KIENESTRASSE 35
city: STUTTGART
postcode: 70174
website: www.steinbeis-europa.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://panbiora.eu
 Total cost 7˙992˙471 €
 EC max contribution 7˙992˙471 € (100%)
 Programme 1. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    STEINBEIS 2I GMBH DE (STUTTGART) coordinator 499˙625.00
2    PROTIP MEDICAL FR (STRASBOURG) participant 961˙000.00
3    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 754˙261.00
4    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 708˙756.00
5    STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH DE (STUTTGART) participant 587˙500.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 554˙763.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 499˙662.00
8    ELVESYS FR (PARIS) participant 406˙875.00
9    AALTO KORKEAKOULUSAATIO SR FI (ESPOO) participant 401˙990.00
10    PROTOBIOS OU EE (TALLINN) participant 400˙000.00
11    CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE BE (LIEGE) participant 399˙637.00
12    DUBLIN CITY UNIVERSITY IE (DUBLIN) participant 392˙962.00
13    TURGUT OZAL EDUCATION SHA AL (TIRANA) participant 321˙375.00
14    DOLMEN DESIGN AND INNOVATION LIMITED IE (DUBLIN) participant 319˙375.00
15    STREINBEIS ADVANCED RISK TECHNOLOGIES INSTITUTE DOO KRAGUJEVAC RS (KRAGUJEVAC) participant 310˙000.00
16    BIODEVICE SYSTEMS SRO CZ (PRAHA) participant 296˙875.00
17    PRO-ACTIVE BE (WATERLOO) participant 177˙812.00

Map

 Project objective

PANBioRA aims at providing a comprehensive solution for the time- and cost-effective risk assessment of i) new biomaterials under health or disease states or ii) a given biomaterial for each patient in a personalized manner. It will standardize the evaluation of biomaterials and open the venue for pre-implantation, personalized diagnostics for biomaterial based applications. PANBioRA will provide a modular platform to assess risks at different aspects and length scales. This comprises antibody response, cytotoxicity/genotoxicity at cell level, systemic and local effects at tissue and connected tissues (organ-on-a-chip) level. Moreover, physicochemical and biomechanical characterisation as well as predictive modelling at systems level will complement the system. This will be achieved by connecting testing modules in a structure supported by web-based modelling and risk radar tools together with a biomechanical testing system. The platform will incorporate standardized protocols yielding significantly more information than the current methods for biomaterial risk assessment. Its accuracy will be demonstrated using known reference materials and validated in a pre-clinical setting. PANBioRA will for the first time, predict the patient specific response to a given biomaterial before its implantation. This measure will allow for the selection of the best suitable material, minimizing side effects and improving health outcomes. It will also accelerate the process of validation of the biocompatibility of new devices by providing an automated, comprehensive process for the parallel assessment of risks at different scales aiding new biomaterial discovery and commercialisation. Altogether, PANBioRA will lead to a substantial economic impact due to a reduction of the amount of tests, decrease in healthcare costs due to complications. It will provide the necessary tools proper risk management related to biomaterials.

 Deliverables

List of deliverables.
CI and project website Documents, reports 2020-04-24 05:21:37

Take a look to the deliverables list in detail:  detailed list of PANBioRA deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Varvara Gribova, Fouzia Boulmedais, Agnès Dupret-Bories, Cynthia Calligaro, Bernard Senger, Nihal Engin Vrana, Philippe Lavalle
Polyanionic Hydrogels as Reservoirs for Polycationic Antibiotic Substitutes Providing Prolonged Antibacterial Activity
published pages: , ISSN: 1944-8244, DOI: 10.1021/acsami.9b23140
ACS Applied Materials & Interfaces 2020-04-24
2020 Gaëtan Lutzweiler, Julien Barthes, Nihal Engin Vrana, Michel Rawiso, Benoît Louis, Josselin Mayingi, Albane Carre, Wiebke Drenckhan, Pierre Schaaf
Adjustment of Cell Adhesion on Polyurethane Structures via Control of the Hard/Soft Segment Ratio
published pages: 2000093, ISSN: 1438-7492, DOI: 10.1002/mame.202000093
Macromolecular Materials and Engineering 2020-04-24
2019 Pramod Kumar, Sait Ciftci, Julien Barthes, Helena Knopf‐Marques, Céline Blandine Muller, Christian Debry, Nihal E. Vrana, Amir M. Ghaemmaghami
A composite Gelatin/hyaluronic acid hydrogel as an ECM mimic for developing mesenchymal stem cell‐derived epithelial tissue patches
published pages: 45-57, ISSN: 1932-6254, DOI: 10.1002/term.2962
Journal of Tissue Engineering and Regenerative Medicine 14/1 2020-04-24
2019 Ivan Siutsou, Lydie Ploux, Nihal Engin Vrana, Vitaly Goranov
The Mathematical approach to disclose low Cytotoxicity of material from in vitro co-culture experiment
published pages: , ISSN: , DOI:
8th International Conference on Computational Bioengineering (ICCB2019) 2020-04-24
2019 Šušteršič, Tijana
\"PANBioRA Mini-Symposium: \"\"MULTISCALE MODELLING OF EXPERIMENTAL DATA RELATED TO BIOMATERIAL RISK ASSESSMENT\"
published pages: , ISSN: , DOI: 10.5281/zenodo.3452648
Proceeding of VIII International Conference on Computational Bioengineering 1 2020-04-24
2019 Ivana Ščigalková, Julie Bystroňová, Lenka Kovářová, Martin Pravda, Vladimír Velebný, Vladimir Riabov, Harald Klüter, Julia Kzhyshkowska, Nihal Engin Vrana
The effect of healing phenotype-inducing cytokine formulations within soft hydrogels on encapsulated monocytes and incoming immune cells
published pages: 21396-21404, ISSN: 2046-2069, DOI: 10.1039/c9ra02878a
RSC Advances 9/37 2020-04-24
2020 Julien Barthes, Martina Cazzola, Celine Muller, Camille Dollinger, Christian Debry, Sara Ferraris, Silvia Spriano, Nihal E. Vrana
Controlling porous titanium/soft tissue interactions with an innovative surface chemical treatment: Responses of macrophages and fibroblasts
published pages: 110845, ISSN: 0928-4931, DOI: 10.1016/j.msec.2020.110845
Materials Science and Engineering: C 2020-04-24
2019 Vulović, Aleksandra; Filipović, Nenad
Effect of hip implant surface modification on shear stress distribution
published pages: 64-65, ISSN: , DOI: 10.5281/zenodo.3452769
Proceeding of VIII International Conference on Computational Bioengineering 1 2020-04-24
2020 Gaëtan Lutzweiler, Jean Farago, Emeline Oliveira, Léandro Jacomine, Ozan Erverdi, Nihal Engin Vrana, Aouatef Testouri, Pierre Schaaf, Wiebke Drenckhan
Validation of Milner\'s visco-elastic theory of sintering for the generation of porous polymers with finely tuned morphology
published pages: 1810-1824, ISSN: 1744-683X, DOI: 10.1039/c9sm01991j
Soft Matter 16/7 2020-04-24
2019 Milad Fathi‐Achachelouei, Dilek Keskin, Erhan Bat, Nihal E. Vrana, Aysen Tezcaner
Dual growth factor delivery using PLGA nanoparticles in silk fibroin/PEGDMA hydrogels for articular cartilage tissue engineering
published pages: , ISSN: 1552-4973, DOI: 10.1002/jbm.b.34544
Journal of Biomedical Materials Research Part B: Applied Biomaterials 2020-04-24
2019 Alexander Makhaniok, Constantin-Edi Tanase, Amir Ghaemmaghami, Nihal Engin Vrana, Vitaly Goranov
Mathematical simulation of biodegradable material cytotoxicity in 3D hepatocellular systems in vitro.
published pages: , ISSN: , DOI:
8th International Conference on Computational Bioengineering (ICCB2019) 2020-04-24
2019 Vulovć, Aleksandra; Filipović, Nenad
EFFECT OF THE FEMORAL BONE MATERIAL PROPERTIES ON THE NUMERICAL SIMULATION RESULTS
published pages: , ISSN: , DOI: 10.5281/zenodo.3351178
1 2020-04-24
2019 Marko N. Živanović, Dalibor D. Nikolić, Nenad D. Filipović
USE OF POLYETHYLENE GLYCOL AND POLYCAPROLACTONE IN 3DBIOPRINT SCAFFOLD PRODUCTION
published pages: , ISSN: , DOI:
7th International Congress of Serbian Society of Mechanics 2020-04-24
2019 Šušteršič, T., Simsek, G. M., Vrana, N. E., Filipović, N.
Computational Modelling Of Corrosion Process In Medical Implant Surfaces
published pages: , ISSN: , DOI:
7th International Congress of Serbian Society of Mechanics 2020-04-24
2019 G. Lutzweiler, J. Barthes, G. Koenig, H. Kerdjoudj, J. Mayingi, F. Boulmedais, P. Schaaf, W. Drenckhan, N. E. Vrana
Modulation of Cellular Colonization of Porous Polyurethane Scaffolds via the Control of Pore Interconnection Size and Nanoscale Surface Modifications
published pages: 19819-19829, ISSN: 1944-8244, DOI: 10.1021/acsami.9b04625
ACS Applied Materials & Interfaces 11/22 2020-04-24
2019 M. Nikolic, T. Sustersic, C.B. Muller4, Y.S. Zhang, N. E. Vrana, N. Filipovic
Monocyte Behaviour Under Perfusion Conditions for Development of Granuloma on-a-chip
published pages: , ISSN: , DOI:
2020-04-24
2019 M. Gasik, A. Zühlke, N. E. Vrana, J. Barthes
Comparison of Properties of Conventional & 3D-printed Titanium & TheirMechano-Regulative Potential
published pages: , ISSN: , DOI:
2020-04-24
2019 Milad Fathi-Achachelouei, Helena Knopf-Marques, Cristiane Evelise Ribeiro da Silva, Julien Barthès, Erhan Bat, Aysen Tezcaner, Nihal Engin Vrana
Use of Nanoparticles in Tissue Engineering and Regenerative Medicine
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00113
Frontiers in Bioengineering and Biotechnology 7 2020-04-24
2019 Nihal Engin Vrana, Amir M. Ghaemmaghami, Pinar Zorlutuna
Editorial: Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and in vitro Models for Biomaterial Testing
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00015
Frontiers in Bioengineering and Biotechnology 7 2020-04-24
2019 Vulović, A., Filipović, N.
Numerical analysis of two hip implant surfaces
published pages: , ISSN: , DOI: 10.5281/zenodo.3351176
2020-04-24
2019 Tijana Sustersic, Milica Nikolic, Nihal Engin Vrana, Nenad Filipovic
Discrete modelling of liver cell aggregation using partial differential equations
published pages: , ISSN: , DOI:
CMBEBIH 16. – 18. May 2019. Banja Luk 2020-04-24
2019 Melanie Ungemach, Timo Doll, Nihal Engin Vrana
How to Predict Adverse Immune Reactions to Implantable Biomaterials?
published pages: 517-520, ISSN: 0014-2980, DOI: 10.1002/eji.201970045
European Journal of Immunology 49/4 2020-04-24
2018 Ferouka I., Šušteršič T., Živanović M., Filipović N.
Discrete simulation of electrospinning jet’s evolution
published pages: 107, ISSN: , DOI:
Belgrade BioInformatics Conference 2018 (BelBi 2018) 2020-04-24
2019 E. Vähä-Pietilä
Behaviour of Hydrogel Biomaterials under Dynamic Thermo-Mechanical Conditions
published pages: , ISSN: , DOI:
2020-04-24
2019 Helena Knopf-Marques, Julien Barthes, Sarah Lachaal, Angela Mutschler, Céline Muller, Florent Dufour, Morgane Rabineau, Edwin-Joffrey Courtial, Julie Bystroňová, Christophe Marquette, Philippe Lavalle, Nihal Engin Vrana
Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)
published pages: 109898, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.109898
Materials Science and Engineering: C 104 2020-04-24
2018 Arso M. Vukicevic, Gordana R. Jovicic, Milos N. Jovicic, Vladimir L. Milicevic, Nenad D. Filipovic
Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression
published pages: 169-176, ISSN: 1025-5842, DOI: 10.1080/10255842.2018.1431220
Computer Methods in Biomechanics and Biomedical Engineering 21/2 2020-04-24
2018 Nihal Engin Vrana
Biomaterials and Immune Response Complications, Mechanisms and Immunomodulation
published pages: , ISSN: , DOI:
2020-04-24
2018 Julien Barthes, Camille Dollinger, Celine B. Muller, Urmas Liivas, Agnes Dupret-Bories, Helena Knopf-Marques, Nihal E. Vrana
Immune Assisted Tissue Engineering via Incorporation of Macrophages in Cell-Laden Hydrogels Under Cytokine Stimulation
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00108
Frontiers in Bioengineering and Biotechnology 6 2020-04-24
2018 Milica Nikolic, Tijana Sustersic, Nenad Filipovic
In vitro Models and On-Chip Systems: Biomaterial Interaction Studies With Tissues Generated Using Lung Epithelial and Liver Metabolic Cell Lines
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00120
Frontiers in Bioengineering and Biotechnology 6 2020-04-24
2018 Michael Gasik, Alexandra Zühlke, Anne-Marie Haaparanta, Virpi Muhonen, Kaisa Laine, Yevgen Bilotsky, Minna Kellomäki, Ilkka Kiviranta
The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration
published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00187
Frontiers in Bioengineering and Biotechnology 6 2020-04-24
2018 Milica Nikolic, Tijana Sustersic, Igor Saveljic, Nihal Engin Vrana and Nenad Filipovic
Modelling of Monocytes Behaviour inside the Bioreactor (at BelBi 2018, Belgrade, Serbia)
published pages: 123, ISSN: 2334-6590, DOI:
Belgrade, Serbia, Book of Abstracts, Biologia Serbica Vol. 40, No. 1 2020-04-24
2018 Tijana Šušteršič, Liliana Liverani, Aldo R. Boccaccini, Slobodan Savić and Nenad Filipović
Numerical simulation of electrospinning using PAK and ANSYS software
published pages: 130, ISSN: 2334-6590, DOI:
Belgrade, Serbia, Book of Abstracts, Biologia Serbica, Vol. 40, No. 1 2020-04-24
2018 Živanović M, Cepeda Y, Filipović N
Optimization of Electrospinning Procedure for Generating the Scaffold for Production of Artificial Blood Vessel
published pages: 617-618, ISSN: 0391-3988, DOI:
The International Journal of Artificial Organs Vol. 41, No. 9 2020-04-24
2018 I. Ferouka, T. Šušteršič, M. Živanović, N. Filipović
Mathematical Modelling of Polymer Trajectory during Electrospinning
published pages: , ISSN: 1820-6530, DOI: 10.24874/jsscm.2018.12.02.02
Jorunal of the Serbian Society for Computational Mechanics Vol 12, No 2 2020-04-24
2019 Tijana Šušteršič, Liliana Liverani, Aldo R Boccaccini, Slobodan Savić, Aco Janićijević, Nenad Filipović
Numerical simulation of electrospinning process in commercial and in-house software PAK
published pages: 25305, ISSN: 2053-1591, DOI: 10.1088/2053-1591/aaeb08
Materials Research Express 6/2 2020-04-24
2019 Fatemeh Sharifi, Su Su Htwe, Martina Righi, Hua Liu, Anna Pietralunga, Ozlem Yesil-Celiktas, Sushila Maharjan, Byung-Hyun Cha, Su Ryon Shin, Mehmet Remzi Dokmeci, Nihal Engin Vrana, Amir M. Ghaemmaghami, Ali Khademhosseini, Yu Shrike Zhang
A Foreign Body Response-on-a-Chip Platform
published pages: 1801425, ISSN: 2192-2640, DOI: 10.1002/adhm.201801425
Advanced Healthcare Materials 2020-04-24
2018 Neerajha Nagarajan, Agnes Dupret-Bories, Erdem Karabulut, Pinar Zorlutuna, Nihal Engin Vrana
Enabling personalized implant and controllable biosystem development through 3D printing
published pages: , ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.02.004
Biotechnology Advances 2020-04-24

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